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1. 发明授权

US08840922B2 Transdermally absorbable donepezil-containing preparation 有权
标题翻译：透皮吸收多奈哌齐制剂
公开(公告)号：US08840922B2
公开(公告)日：2014-09-23
申请号：US13503198
申请日：2010-10-18
申请人： Satoshi Kawakami , Masahiro Yamaji
发明人： Satoshi Kawakami , Masahiro Yamaji
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K31/445 , A61K9/7053
摘要： Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.
摘要翻译：提供多奈哌齐的透皮吸收制剂，其可以长期可持续地施用多奈哌齐，并且可以提供多奈哌齐和多奈哌齐持续释放性质的血液水平的快速增加。含多奈哌齐的透皮吸收制剂是通过将多奈哌齐作为活性成分溶解在含有疏水性聚合物和吸收促进剂的粘合剂贴片基中制成的透皮吸收制剂。吸收促进剂是选自月桂醇，柠檬酸三乙酯，肉豆蔻酸异丙酯，乳酸鲸蜡酯，油醇，脱水山梨糖醇单油酸酯，聚乙二醇单硬脂酸酯，月桂醇，N-甲基-2-吡咯烷酮和三醋精中的一种或两种以上。

2. 发明申请

US20120207816A1 Transdermally Absorbable Donepezil-Containing Preparation 有权
标题翻译：经皮可吸收的多奈哌齐制剂
公开(公告)号：US20120207816A1
公开(公告)日：2012-08-16
申请号：US13503198
申请日：2010-10-18
申请人： Satoshi Kawakami , Masahiro Yamaji
发明人： Satoshi Kawakami , Masahiro Yamaji
IPC分类号： A61K31/445 , A61P25/28 , A61K9/70
CPC分类号： A61K31/445 , A61K9/7053
摘要： Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.
摘要翻译：提供多奈哌齐的透皮吸收制剂，其可以长期可持续地施用多奈哌齐，并且可以提供多奈哌齐和多奈哌齐持续释放性质的血液水平的快速增加。含多奈哌齐的透皮吸收制剂是通过将多奈哌齐作为活性成分溶解在含有疏水性聚合物和吸收促进剂的粘合剂贴片基中制成的透皮吸收制剂。吸收促进剂是选自月桂醇，柠檬酸三乙酯，肉豆蔻酸异丙酯，乳酸鲸蜡酯，油醇，脱水山梨糖醇单油酸酯，聚乙二醇单硬脂酸酯，月桂醇，N-甲基-2-吡咯烷酮和三醋精中的一种或两种以上。

3. 发明授权

US08747885B2 External patches containing etofenamate 有权
标题翻译：含有依托芬那定的外用补片
公开(公告)号：US08747885B2
公开(公告)日：2014-06-10
申请号：US11793231
申请日：2004-12-15
申请人： Tomohiro Ishima , Hiroyuki Yamasaki , Masahiro Yamaji
发明人： Tomohiro Ishima , Hiroyuki Yamasaki , Masahiro Yamaji
IPC分类号： A61K9/70 , A61M35/00
CPC分类号： A61K31/24 , A61K9/7053 , A61K9/7076 , A61K31/245 , A61K47/14 , A61K47/18
摘要： The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.
摘要翻译：本发明提供具有较低刺激性的药物具有优异的皮肤渗透性和治疗效果的贴剂。在其中将含有粘合剂基料和药物的粘合剂层与背衬层压的外部贴剂中，其中粘合剂基底含有5-50重量％的合成橡胶聚合物的外部粘合剂，10-60重量％的粘合剂树脂和25-60重量％的液体石蜡，药物是依托芬那定。根据本发明，可以获得具有较低刺激性的药物具有优异的皮肤渗透性和治疗效果的贴剂。

4. 发明申请

US20080089926A1 External Patches Containing Etofenamate 有权
标题翻译：外用贴剂含有依托芬那定
公开(公告)号：US20080089926A1
公开(公告)日：2008-04-17
申请号：US11793231
申请日：2004-12-15
申请人： Tomohiro Ishima , Hiroyuki Yamasaki , Masahiro Yamaji
发明人： Tomohiro Ishima , Hiroyuki Yamasaki , Masahiro Yamaji
IPC分类号： A61K9/70 , A61K31/245
CPC分类号： A61K31/24 , A61K9/7053 , A61K9/7076 , A61K31/245 , A61K47/14 , A61K47/18
摘要： The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.
摘要翻译：本发明提供具有较低刺激性的药物具有优异的皮肤渗透性和治疗效果的贴剂。在其中将含有粘合剂基料和药物的粘合剂层与背衬层压的外部贴剂中，其中粘合剂基底含有5-50重量％的合成橡胶聚合物的外部粘合剂，10-60重量％的粘合剂树脂和25-60重量％的液体石蜡，药物是依托芬那定。根据本发明，可以获得具有较低刺激性的药物具有优异的皮肤渗透性和治疗效果的贴剂。

5. 发明授权

US08029820B2 Patches containing tulobuterol 有权
标题翻译：补丁含有杜洛替罗
公开(公告)号：US08029820B2
公开(公告)日：2011-10-04
申请号：US10524858
申请日：2004-06-16
申请人： Sadanobu Shirai , Masahiro Yamaji , Osamu Yoshimoto , Mamoru Naruse , Kenichi Hattori , Takako Sueda
发明人： Sadanobu Shirai , Masahiro Yamaji , Osamu Yoshimoto , Mamoru Naruse , Kenichi Hattori , Takako Sueda
IPC分类号： A61F13/02
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/137 , A61K47/12
摘要： A patch containing tulobuterol in the low concentration and having the stable release-controllability, prepared by laminating an adhesive layer consisting of a rubber, an adhesive resin and a plasticizer on a backing, wherein 1 to 4 w/w % of tulobuterol in the lower concentration as an active ingredient and 0.1 to 3 w/w % of a higher fatty acid as a drug-releasing controlling agent are contained in the adhesive layer.
摘要翻译：一种含有低浓度的杜洛特罗并具有稳定的释放控制性的贴片，其通过将由橡胶，粘合剂树脂和增塑剂组成的粘合剂层层压在背衬上，其中在下部的1至4w / w％的十四氟醇作为药物释放控制剂的浓度作为活性成分和0.1〜3w / w％的高级脂肪酸被包含在粘合剂层中。

6. 发明申请

US20090297590A1 KETOTIFEN TRANSDERMAL DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OPHTHALMIC DISEASE 审中-公开
标题翻译： KETOTIFEN TRANSDERMAL DRUG DELIVERY系统和治疗眼底疾病的方法
公开(公告)号：US20090297590A1
公开(公告)日：2009-12-03
申请号：US12236392
申请日：2008-09-23
申请人： Masahiro Yamaji , Adchara Pongpeerapat
发明人： Masahiro Yamaji , Adchara Pongpeerapat
IPC分类号： A61K9/70 , A61P37/06
CPC分类号： A61K31/4535 , A61F2013/00646 , A61K9/7061
摘要： A ketotifen transdermal drug delivery system is provided. In certain embodiments, the system includes a support layer and a plaster layer provided on the support, wherein the plaster layer contains ketotifen freebase. Also provided are methods of using the delivery systems, e.g., for treatment of ophthalmic diseases, and kits containing the delivery systems.
摘要翻译：提供酮替芬透皮药物递送系统。在某些实施方案中，该系统包括支撑层和设置在载体上的膏药层，其中所述膏药层含有酮替芬游离碱。还提供了使用递送系统的方法，例如用于治疗眼科疾病，以及包含递送系统的试剂盒。

7. 发明授权

US08486442B2 External patch containing estrogen and/or progestogen 失效
标题翻译：含有雌激素和/或孕激素的外部补片
公开(公告)号：US08486442B2
公开(公告)日：2013-07-16
申请号：US10556851
申请日：2004-05-13
申请人： Kunihiko Matsushita , Kenichi Hattori , Masahiro Yamaji
发明人： Kunihiko Matsushita , Kenichi Hattori , Masahiro Yamaji
IPC分类号： A61F13/00 , A61L15/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/565 , A61K31/57 , A61L15/585 , A61K2300/00 , C08L39/06 , C08L53/02
摘要： An external patch capable of stable prolonged release and transdermal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt. % of styrene/isoprene/styrene block copolymer, 20 to 70 wt. % of tackifier resin, 10 to 60 wt. % of softener and 1 to 20 wt. % of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.
摘要翻译：能够稳定地延长释放和透皮吸收包含在压敏粘合剂层中的活性成分激素（雌激素和/或孕激素）的外部贴剂，该外部贴片确保对皮肤的低刺激性。特别地，包括支撑体并且叠加在其上的压敏粘合剂层的外部贴片，其特征在于，所述压敏粘合剂层包含作为不可或缺的成分的5至50wt。％的苯乙烯/异戊二烯/苯乙烯嵌段共聚物，20〜70重量％％增粘树脂，10〜60wt。软化剂％和1〜20重量％％的聚乙烯吡咯烷酮，并含有作为活性成分的雌激素和/或孕激素。

8. 发明授权

US08124122B2 Female hormone-containing patch 有权
标题翻译：含雌激素的补片
公开(公告)号：US08124122B2
公开(公告)日：2012-02-28
申请号：US10524065
申请日：2003-08-07
申请人： Takaya Sugahara , Sadanobu Shirai , Masahiro Yamaji
发明人： Takaya Sugahara , Sadanobu Shirai , Masahiro Yamaji
IPC分类号： A61F13/00 , A61F13/02
CPC分类号： A61K9/7061 , A61K9/0014 , A61K31/57 , A61K47/14
摘要： Provided herein is a female hormone-containing patch wherein an active ingredient is highly soluble in a pressure-sensitive adhesive layer and the active ingredient is not adsorbed to a backing, and the patch per se can follow the irregularities on the skin surface or body movements. The patch is an external patch containing, as a female hormone, a follicular hormone estradiol and/or its derivative or a progestational hormone norethisterone and/or its derivative. The external patch comprises an acrylic pressure-sensitive adhesive containing 0.01 to 1% by weight of an isocyanate-based crosslinking agent as an essential ingredient.
摘要翻译：本文提供的阴含激素的贴剂，其中的活性成分是在压敏粘合剂层和所述活性成分的溶解性高未吸附到背衬，和补片本身可以按照在皮肤表面或身体运动的凹凸。该贴片是含有一种外用贴剂，作为雌激素，卵泡激素雌二醇和/或它的衍生物或孕激素炔诺酮和/或它的衍生物。的外用贴剂包括含有以重量计异氰酸酯系交联剂0.01〜1％作为必要成分的丙烯酸类压敏粘合剂。

9. 发明申请

US20090022778A1 EXTERNAL PLASTER CONTAINING FLURBIPROFEN 有权
标题翻译：含外加塑料的外用塑料
公开(公告)号：US20090022778A1
公开(公告)日：2009-01-22
申请号：US11817210
申请日：2005-02-28
申请人： Masahiro Yamaji , Takaya Sugawara
发明人： Masahiro Yamaji , Takaya Sugawara
IPC分类号： A61F13/02 , A61K31/192
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/192
摘要： In a plaster for external use for transdermal absorption in which an adhesive layer is laminated on a plastic backing, the adhesive layer contains a styrene-isoprene-styrene block copolymer (SIS), a tackifying resin and a softener which are essential ingredients, and further contains flurbiprofen blended as an active ingredient. The present plaster for external use is a flurbiprofen containing plaster for external use enabling long-term stable release of contained flurbiprofen, and having excellent stability and very high drug releasing property.
摘要翻译：在用于透皮吸收的外用石膏中，其中粘合剂层层压在塑料背衬上，粘合剂层含有作为必需成分的苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物（SIS），增粘树脂和软化剂，进一步含有氟比洛芬作为活性成分。目前用于外用的石膏是含氟比洛芬的外用石膏，能够长期稳定地释放所含的氟比洛芬，具有优异的稳定性和非常高的药物释放性能。

10. 发明申请

US20060127464A1 Female hormone-containing patch 有权
标题翻译：含雌激素的补片
公开(公告)号：US20060127464A1
公开(公告)日：2006-06-15
申请号：US10524065
申请日：2003-08-07
申请人： Takaya Sugawara , Sadanobu Shirai , Masahiro Yamaji
发明人： Takaya Sugawara , Sadanobu Shirai , Masahiro Yamaji
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/0014 , A61K31/57 , A61K47/14
摘要： Provided herein is a female hormone-containing patch wherein an active ingredient is highly soluble in a pressure-sensitive adhesive layer and the active ingredient is not adsorbed to a backing, and the patch per se can follow the irregularities on the skin surface or body movements. The patch is an external patch containing, as a female hormone, a follicular hormone estradiol and/or its derivative or a progestational hormone norethisterone and/or its derivative. The external patch comprises an acrylic pressure-sensitive adhesive containing 0.01 to 1% by weight of an isocyanate-based crosslinking agent as an essential ingredient.
摘要翻译：本文提供了一种含雌激素的贴剂，其中活性成分高度可溶于压敏粘合剂层，并且活性成分不吸附到背衬上，并且贴片本身可以遵循皮肤表面上的不规则或身体运动。贴剂是含有雌激素，卵泡激素雌二醇和/或其衍生物或孕激素炔诺酮和/或其衍生物的外部补片。外部贴剂包含含有0.01〜1重量％的异氰酸酯系交联剂作为必要成分的丙烯酸类压敏粘合剂。

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