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1. 发明授权

US07660676B2 Nucleic acid base sequence determining method and inspecting system 有权
标题翻译：核酸碱基序列测定方法及检测系统
公开(公告)号：US07660676B2
公开(公告)日：2010-02-09
申请号：US10315143
申请日：2002-12-10
申请人： Satoshi Hirata , Satoshi Mitsuyama , Hitoshi Matsuo , Shinichi Fukuzono , Hiroyuki Suzuki
发明人： Satoshi Hirata , Satoshi Mitsuyama , Hitoshi Matsuo , Shinichi Fukuzono , Hiroyuki Suzuki
IPC分类号： G06F19/00
CPC分类号： G01N27/44721
摘要： When the nucleic-acid base sequence of A, C, G, and T (or U) is determined by interpreting fluorescent-light intensity waveform data acquired by measuring nucleic-acid fragments, it is desirable to determine, with a high-accuracy, the base sequence at a location at which the data interpretation is difficult. In order to accomplish this object, the data interpretation is performed by making reference to information acquired by performing the statistical processing to plural pieces of fluorescent-light intensity waveform data corresponding to already-known base sequences. This method allows the determination of the nucleic-acid base sequence at the above-described location.
摘要翻译：当通过解释通过测量核酸片段获得的荧光强度波形数据来确定A，C，G和T（或U）的核酸碱基序列时，希望以高精度确定在数据解释困难的位置的基本序列。为了实现该目的，通过参照通过对与已知的碱基序列相对应的多个荧光强度波形数据进行统计处理获得的信息来进行数据解释。该方法允许在上述位置确定核酸碱基序列。

2. 发明授权

US08150645B2 Automatic analzyer 有权
标题翻译：自动分析仪
公开(公告)号：US08150645B2
公开(公告)日：2012-04-03
申请号：US12362818
申请日：2009-01-30
申请人： Kumiko Kamihara , Tomonori Mimura , Shinichi Fukuzono
发明人： Kumiko Kamihara , Tomonori Mimura , Shinichi Fukuzono
IPC分类号： G06F17/18
CPC分类号： G01N35/00663 , Y10T436/101666
摘要： Measurement of the uncertainty used for quality control typically involves a plurality of factors. When the uncertainty exceeds a clinical permissible value, time is required for a medical technologist to investigate and to determine the factor causing the uncertainty. It is thus beneficial to automatically investigate factors in complicated uncertainty, particularly from the view point of reagents and samples which are subject to quality change and that are prone to affect the measurement quality. Quality control samples having a plurality of concentration levels are measured to calculate the average, coefficient of variation, standard deviation, and other numerical values. When quality control samples having n (n≧2) different concentration levels are measured, variation patterns determine the factor causing the uncertainty, the factor being specific to each of 3n different combinations of variation patterns.
摘要翻译：用于质量控制的不确定度的测量通常涉及多个因素。当不确定性超过临床允许值时，医疗技术人员需要时间调查并确定导致不确定性的因素。因此，自动调查复杂不确定因素的因素是有益的，特别是从质量变化的试剂和样品的角度出发，容易影响测量质量。测量具有多个浓度水平的质量控制样品以计算平均值，变异系数，标准偏差和其它数值。当测量具有n（n≥2）不同浓度水平的质量控制样品时，变化模式确定导致不确定性的因素，该因子特异于3n个不同组合的变化模式。

3. 发明授权

US07592137B2 Genetic testing kits and a method of bladder cancer 有权
标题翻译：遗传检测试剂盒和膀胱癌的方法
公开(公告)号：US07592137B2
公开(公告)日：2009-09-22
申请号：US10854327
申请日：2004-05-27
申请人： Koshi Maeda , Shinichi Fukuzono , Takayuki Kanda , Kokichi Sugano
发明人： Koshi Maeda , Shinichi Fukuzono , Takayuki Kanda , Kokichi Sugano
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C07H21/04 , C12Q1/6886 , C12Q2600/156
摘要： A deletion in the end region of the long arm of a Chromosome 9 is efficiently detected.A genetic testing kit of bladder cancer according to the present invention includes a primer allowing for efficient amplification of a region containing a site of genetic polymorphism present in the ABO blood group gene of Chromosome 9. In the site of genetic polymorphism present in the ABO blood group gene, the frequency of heterozygote (heterozygosity) in the population is extremely high. Therefore, by detecting LOH using a polymorphic site present in the ABO blood group gene, it is possible to reliably detect a deletion near the polymorphic site, in other words, a deletion near the end of the long arm of Chromosome 9.
摘要翻译：有效地检测染色体9的长臂的末端区域的缺失。根据本发明的膀胱癌的遗传检测试剂盒包括允许有效扩增含有染色体9的ABO血型基因中存在的遗传多态性位点的区域的引物。在存在于ABO血液中的遗传多态性位点群体基因，种群中杂合子（杂合性）的频率极高。因此，通过使用ABO血型基因中存在的多态性位点检测LOH，可以可靠地检测多态性位点附近的缺失，换句话说，在染色体9的长臂末端附近的缺失。

4. 发明授权

US5445948A Process for culturing recombinant cells 失效
标题翻译：培养重组细胞的方法
公开(公告)号：US5445948A
公开(公告)日：1995-08-29
申请号：US124075
申请日：1993-09-21
申请人： Norio Shimizu , Shinichi Fukuzono , Nobuko Nishimura , Kiyoshi Fujimori , Yoji Odawara
发明人： Norio Shimizu , Shinichi Fukuzono , Nobuko Nishimura , Kiyoshi Fujimori , Yoji Odawara
IPC分类号： C12N15/09 , C12M1/12 , C12N1/00 , C12N1/10 , C12N1/16 , C12N1/20 , C12N1/21 , C12N1/38 , C12N5/00 , C12N5/10 , C12N9/38 , C12N15/00 , C12N15/70 , C12P1/00 , C12R1/19 , C12P21/00 , C12N15/03 , C12N15/71
CPC分类号： C12N1/38 , C12N15/70 , C12N9/2471 , C12P1/00 , C12Y302/01023
摘要： This invention relates to an efficient process for culturing recombinant cells which comprises a step of removing a cell proliferation inhibiting substance and/or a substance which inhibits induction of the desired product and a step of inducing production of the desired product.
摘要翻译：本发明涉及一种培养重组细胞的有效方法，其包括除去细胞增殖抑制物质和/或抑制所需产物诱导的物质的步骤和诱导产生所需产物的步骤。

5. 发明授权

US09229015B2 Accuracy management method 有权
标题翻译：精准管理方法
公开(公告)号：US09229015B2
公开(公告)日：2016-01-05
申请号：US13141984
申请日：2009-11-19
申请人： Qing Li , Tomonori Mimura , Shinichi Fukuzono , Naomi Ishii
发明人： Qing Li , Tomonori Mimura , Shinichi Fukuzono , Naomi Ishii
IPC分类号： G01N35/00 , G01D18/00 , G01N35/02
CPC分类号： G01N35/00693 , G01D18/00 , G01N35/00613 , G01N35/00712 , G01N35/025 , Y10T436/10 , Y10T436/11
摘要： There is provided a comprehensive accuracy management method attained by including the steps of: displaying operation event information in time series in an accuracy management result chart or a calibration result chart on the same screen; accumulating a characteristic daily measurement value fluctuation pattern on the basis of a kind of an operation event; displaying the latest fluctuation pattern of measurement results and the daily measurement value fluctuation pattern in superposition with each other to warn of fluctuations which differ from the daily measurement value fluctuation pattern; and estimating and reporting the cause of the fluctuations.
摘要翻译：提供了一种全面的准确度管理方法，其包括以下步骤：在同一屏幕上的精度管理结果图表或校准结果图表中以时间序列显示操作事件信息; 基于操作事件的种类积累特征的日测量值波动模式; 显示测量结果的最新波动模式和每日测量值波动模式相互叠加以警告与日测量值波动模式不同的波动; 并估计和报告波动的原因。

6. 发明申请

US20120261260A1 ELECTROLYTE ANALYZER 有权
标题翻译：电解分析仪
公开(公告)号：US20120261260A1
公开(公告)日：2012-10-18
申请号：US13514187
申请日：2010-11-10
申请人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
发明人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
IPC分类号： G01N27/26
CPC分类号： G01N27/333
摘要： Electrolyte analyzers are used in a variety of ways, and problems vary from reagent deterioration due to reagent replenishment, mixing of foreign substances during reagent replenishment, electrode deterioration due to the passage of the validity date, to the operator's inputting errors. It is thus necessary to judge abnormalities of measured values resulting from such inappropriate usage, based on the fluctuation patterns of the results of daily electrolyte calibration.The fluctuation patterns of each measured item are extracted from the results of daily electrolyte calibration. The electromotive force balance ratio between the internal standard solution and high/low-concentration standard solutions is calculated as well as its fluctuation pattern. The obtained fluctuation patterns are compared against atypical fluctuation patterns stored in the electrolyte analyzer. When any of the extracted patterns matches any of the atypical patterns, the analyzer activates an alarm.
摘要翻译：以各种方式使用电解质分析仪，由于试剂补充，试剂补充期间的异物混合，有效期限以后的电极劣化，操作者的输入错误，试剂劣化的问题变化。因此，基于每日电解质校准的结果的波动模式，需要判断由这种不当使用引起的测量值的异常。从日常电解质校准的结果中提取每个测量项目的波动模式。计算内标溶液与高/低浓度标准溶液之间的电动势平衡比及其波动模式。将获得的波动模式与存储在电解质分析仪中的非典型波动模式进行比较。当任何提取的图案与任何非典型图案匹配时，分析仪启动报警。

7. 发明申请

US20050009072A1 Genetic testing kits and a method of bladder cancer 有权
标题翻译：遗传检测试剂盒和膀胱癌的方法
公开(公告)号：US20050009072A1
公开(公告)日：2005-01-13
申请号：US10854327
申请日：2004-05-27
申请人： Koshi Maeda , Shinichi Fukuzono , Takayuki Kanda , Kokichi Sugano
发明人： Koshi Maeda , Shinichi Fukuzono , Takayuki Kanda , Kokichi Sugano
IPC分类号： G01N33/574 , C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C07H21/04 , C12Q1/6886 , C12Q2600/156
摘要： A deletion in the end region of the long arm of a Chromosome 9 is efficiently detected. A genetic testing kit of bladder cancer according to the present invention includes a primer allowing for efficient amplification of a region containing a site of genetic polymorphism present in the ABO blood group genes of Chromosome 9. In the site of genetic polymorphism present in the ABO blood group genes, the frequency of heterozygote (heterozygosity) in the population is extremely high. Therefore, by detecting LOH using a polymorphic site present in the ABO blood group genes, it is possible to reliably detect a deletion near the polymorphic site, in other words, a deletion near the end of the long arm of Chromosome 9.
摘要翻译：有效地检测染色体9的长臂的末端区域的缺失。根据本发明的膀胱癌的遗传检测试剂盒包括允许有效扩增含有染色体9的ABO血型基因中存在的遗传多态性位点的区域的引物。在存在于ABO血液中的遗传多态性位点群体基因，杂种（杂合性）在群体中的频率极高。因此，通过使用存在于ABO血型基因中的多态性位点检测LOH，可以可靠地检测多态性位点附近的缺失，换句话说，在染色体9的长臂末端附近的缺失。

8. 发明授权

US06808633B1 Centrifugal separator and sample preparation device using the separator 失效
标题翻译：离心分离器和使用分离器的样品制备装置
公开(公告)号：US06808633B1
公开(公告)日：2004-10-26
申请号：US10018430
申请日：2001-12-20
申请人： Kazunori Okano , Katsuji Murakawa , Shinichi Fukuzono , Yukiko Ikeda
发明人： Kazunori Okano , Katsuji Murakawa , Shinichi Fukuzono , Yukiko Ikeda
IPC分类号： B01D1100
CPC分类号： B01L3/5021 , B04B1/02 , B04B5/0407 , B04B5/0442 , B04B5/10 , B04B7/08 , Y10T436/111666 , Y10T436/25375 , Y10T436/255
摘要： A centrifugal separator of the invention has a centrifugal rotor (10-1), with symmetric rotation axes, having single sample separation chamber in it for centrifuging samples contained in sample solutions, an upper opening passing through to said sample separation chamber in the upper part, members of frameworks capable of being coupled to said upper opening, a rotation driving means, assuming that the direction of said symmetric rotation axis is the first direction, for driving said centrifugal rotor around said rotation axis in the first direction, wherein assuming that two directions intersecting with said first direction are the second and third directions, the length of said sample preparation chamber in said third direction is longer than the length of said sample preparation chamber in said second direction. Since one kind of sample is handled in one centrifugal rotor, the centrifugal separator of the invention allows discrete treatment (sequential treatment) suitable for the flow system, in which individual samples can be treated independently, making easy automation of sample preparation revolving centrifugation.
摘要翻译：本发明的离心分离机具有对称旋转轴的离心转子（10-1），在其中具有单个样品分离室，用于离心样品溶液中包含的样品，上部开口穿过上部样品分离室假定所述对称旋转轴的方向为第一方向的旋转驱动装置，用于沿所述第一方向围绕所述旋转轴驱动所述离心转子，其中，假定所述两个与第一方向相交的方向是第二和第三方向，所述样品制备室在所述第三方向上的长度比所述第二方向上的样品制备室的长度长。由于在一个离心转子中处理了一种样品，本发明的离心分离器允许适用于流动系统的独立处理（顺序处理），其中可以独立地处理各个样品，从而容易地自动进行样品制备旋转离心。

9. 发明授权

US4891310A Method of controlling culture 失效
标题翻译：控制文化的方法
公开(公告)号：US4891310A
公开(公告)日：1990-01-02
申请号：US843613
申请日：1986-03-25
申请人： Norio Shimizu , Shinichi Fukuzono , Nobuko Nishimura , Yoji Odawara , Tomoaki Sumitani
发明人： Norio Shimizu , Shinichi Fukuzono , Nobuko Nishimura , Yoji Odawara , Tomoaki Sumitani
IPC分类号： C12M1/36 , C12N1/00 , C12N1/20 , C12N1/21 , C12N9/38 , C12P21/02 , C12R1/19 , C12R1/545
CPC分类号： C12M41/34 , C12N9/2471 , C12P21/02 , C12Y302/01023 , C07K2319/00 , C07K2319/02 , C07K2319/61
摘要： A method of controlling culture wherein cells are aerobically cultured to produce metabolite is characterized by adding substrate and/or inducer to the culture broth, judging the endpoint of the growth of the cells and/or the production of the metabolite or terminating the culture under the guidance of a change in the ratio of the first parameter based on the amount of carbon dioxide evolved by the cell culture to the second parameter based on the amount of oxygen consumed by the cell culture. The ratio is a respiratory quotient, for instance.
摘要翻译：一种控制培养的方法，其中细胞被有氧培养以产生代谢物，其特征在于向培养液中加入底物和/或诱导物，判断细胞生长的终点和/或代谢物的产生或终止培养物基于由细胞培养物消耗的氧气的量，基于由细胞培养物产生的二氧化碳的量与第二参数的第一参数的比率的变化的指导。该比例是呼吸商，例如。

10. 发明授权

US08871080B2 Management system for an electrolyte analyzer 有权
标题翻译：电解质分析仪管理系统
公开(公告)号：US08871080B2
公开(公告)日：2014-10-28
申请号：US13514187
申请日：2010-11-10
申请人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
发明人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
IPC分类号： G01N27/333
CPC分类号： G01N27/333
摘要： Electrolyte analyzers are used in a variety of ways, and problems vary from reagent deterioration due to reagent replenishment, mixing of foreign substances during reagent replenishment, electrode deterioration due to the passage of the validity date, to the operator's inputting errors. It is thus necessary to judge abnormalities of measured values resulting from such inappropriate usage, based on the fluctuation patterns of the results of daily electrolyte calibration. The fluctuation patterns of each measured item are extracted from the results of daily electrolyte calibration. The electromotive force balance ratio between the internal standard solution and high/low-concentration standard solutions is calculated as well as its fluctuation pattern. The obtained fluctuation patterns are compared against atypical fluctuation patterns stored in the electrolyte analyzer. When any of the extracted patterns matches any of the atypical patterns, the analyzer activates an alarm.
摘要翻译：以各种方式使用电解质分析仪，由于试剂补充，试剂补充期间的异物混合，有效期限以后的电极劣化，操作者的输入错误，试剂劣化的问题变化。因此，基于每日电解质校准的结果的波动模式，需要判断由这种不当使用引起的测量值的异常。从日常电解质校准的结果中提取每个测量项目的波动模式。计算内标溶液与高/低浓度标准溶液之间的电动势平衡比及其波动模式。将获得的波动模式与存储在电解质分析仪中的非典型波动模式进行比较。当任何提取的图案与任何非典型图案匹配时，分析仪启动报警。

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