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    • 10. 发明授权
    • Platinum complex, process for preparing same and antitumor agent
    • 铂复合物,其制备方法和抗肿瘤剂
    • US4980347A
    • 1990-12-25
    • US337573
    • 1989-04-13
    • Masaji OhnoMasato MutohGo HataKeiichi MatsunagaSatoshi Hanada
    • Masaji OhnoMasato MutohGo HataKeiichi MatsunagaSatoshi Hanada
    • C07F15/00
    • C07F15/0093
    • A platinum complex represented by the formula: ##STR1## where X is ##STR2## wherein R.sup.1 is a (C1-18) alkyl group, a (C1-18)alkenyl group or a group --Z--R.sup.4 in which Z is --CH.dbd.CH-- or a (C1-5)alkylene group, and R.sup.4 is a phenyl group, a hydroxyphenyl group, a (C7-12)alkoxyphenyl group, a halogenophenyl group, a nitrophenyl group, or (C8-13)alkoxycarbonylphenyl group, a cyclohexyl group having a (C1-5)alkyl substituent, ##STR3## R.sup.2 is hydrogen or a (C1-18)alkyl group, R.sup.3 is hydrogen or a (C1-3) alkyl group, R.sup.2 and R.sup.3 are linked together to form a (C2-7)alkylene group; the dotted line indicates that the bond may be either a single bond or a double bond; the chain line indicates a conjugated system; the 1,2-diaminocyclohexane moiety has a cis-, trans-l- or trans-d-configuration; and Y is an anion. This platinum complex is useful in the treatment of tumors.
    • 由下式表示的铂络合物:其中X为,其中R1为(C1-18)烷基,(C1-18)烯基或-Z-R4基团,其中Z 是-CH = CH-或(C1-5)亚烷基,R4是苯基,羟基苯基,(C7-12)烷氧基苯基,卤代苯基,硝基苯基或(C8-13) 烷氧基羰基苯基,具有(C1-5)烷基取代基的环己基,R2是氢或(C1-18)烷基,R3是氢或(C1-3)烷基,R2和R3连接 一起形成(C2-7)亚烷基; 虚线表示该键可以是单键或双键; 链线表示共轭系统; 1,2-二氨基环己烷部分具有顺式,反式-1-或反式-d构型; Y为阴离子。 该铂络合物可用于治疗肿瘤。