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1. 发明申请

US20090080750A1 PASSIVE MR VISUALISATION OF INTERVENTIONAL INSTRUMENTS 审中-公开
标题翻译：传统仪器的被动MR可视化
公开(公告)号：US20090080750A1
公开(公告)日：2009-03-26
申请号：US12297649
申请日：2007-04-17
申请人： Sascha Krueger , Steffen Weiss , Hannes Dahnke , Tobias Richard Schaeffter
发明人： Sascha Krueger , Steffen Weiss , Hannes Dahnke , Tobias Richard Schaeffter
IPC分类号： G06K9/00
CPC分类号： G01R33/286
摘要： The invention relates to a device for magnetic resonance imaging of a body (7), wherein the device (1) is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence comprising RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image (21) therefrom, c) calculate a susceptibility gradient map (22) from the MR echo signals or from the MR image (21), the susceptibility gradient map (22) indicating local susceptibility induced magnetic field gradients, d) determine the position of an interventional instrument (16) having paramagnetic or ferromagnetic properties from the susceptibility gradient map (22).
摘要翻译：本发明涉及一种用于身体（7）的磁共振成像的装置，其中所述装置（1）被布置成：a）通过对所述主体（7）的至少一部分进行承受来产生一系列MR回波信号（20）涉及包括RF脉冲和切换磁场梯度的MR成像序列，b）获取用于重构MR图像（21）的MR回波信号，c）从MR回波信号或从MR回波信号计算磁敏度梯度图（22）图像（21），表示局部敏感性感应磁场梯度的磁敏度梯度图（22），d）从磁敏度梯度图（22）确定具有顺磁性或铁磁性质的介入仪器（16）的位置。

2. 发明申请

US20100142785A1 POSITIVE CONTRAST MR SUSCEPTIBILITY IMAGING 审中-公开
标题翻译：积极对比可疑成像
公开(公告)号：US20100142785A1
公开(公告)日：2010-06-10
申请号：US12597750
申请日：2008-04-30
申请人： Hannes Dahnke , Wei Liu , Edward Brian Welch , Tobias Richard Schaeffter
发明人： Hannes Dahnke , Wei Liu , Edward Brian Welch , Tobias Richard Schaeffter
IPC分类号： G06K9/40 , G06K9/00
CPC分类号： G01R33/48 , G01R33/281 , G01R33/286 , G01R33/5601 , G01R33/5608
摘要： A method for generating an image comprises: acquiring a magnetic resonance image (DI); generating a magnetic susceptibility gradient vector map (DΔχ) from the magnetic resonance image; and filtering the magnetic susceptibility gradient vector map to generate a magnetic susceptibility gradient image (96, 110) depicting magnetic susceptibility gradient information including at least some magnetic susceptibility gradient directional information.
摘要翻译：一种用于产生图像的方法包括：获取磁共振图像（DI）; 从磁共振图像生成磁化率梯度矢量图（D＆Dgr;χ）; 以及过滤所述磁化率梯度矢量图以产生描绘包括至少一些磁化率梯度方向信息的磁化率梯度信息的磁化率梯度图像（96,110）。

3. 发明授权

US07999543B2 MR method for spatially-resolved determination of relaxation parameters 有权
标题翻译：用于空间分辨确定松弛参数的MR方法
公开(公告)号：US07999543B2
公开(公告)日：2011-08-16
申请号：US11908812
申请日：2006-03-10
申请人： Hannes Dahnke , Tobias Schaffter
发明人： Hannes Dahnke , Tobias Schaffter
IPC分类号： G01V3/00
CPC分类号： G01R33/50
摘要： An MR method and apparatus determines spatially resolved relaxation parameters of a subject in an examination zone, voxel by voxel. A first MR scan sequence is applied to generate a series of first MR data sets having different echo times. A second MR scan sequence is applied to generate at least one further MR data set having an enhanced spatial resolution and reduced time resolution in comparison with the first MR data sets from the first sequence. MR combination images are generated using the first MR data sets derived from the first sequence for a portion within the k-space and the further MR data set acquired outside this portion by the second sequence. The relaxation parameters are determined from the MR combination images.
摘要翻译： MR方法和装置确定检查区域中的受试者的空间分辨的松弛参数，体素的体素。应用第一MR扫描序列来生成具有不同回波时间的一系列第一MR数据集。与来自第一序列的第一MR数据集相比，应用第二MR扫描序列以生成具有增强的空间分辨率和降低的时间分辨率的至少一个另外的MR数据集。使用从第一序列导出的用于k空间内的部分的第一MR数据集和通过第二序列在该部分之外获取的另外的MR数据集来生成MR组合图像。松弛参数由MR组合图像确定。

4. 发明申请

US20080077006A1 Mr Method of Determining Local Relaxation Time Values Using Calibrated Phantom 失效
标题翻译：使用校准Phantom确定局部松弛时间值的方法
公开(公告)号：US20080077006A1
公开(公告)日：2008-03-27
申请号：US11573897
申请日：2005-08-19
申请人： Ulrich Katscher , Hannes Dahnke
发明人： Ulrich Katscher , Hannes Dahnke
IPC分类号： A61B5/055
CPC分类号： G01R33/50 , G01R33/58
摘要： The invention relates to an MR method of determining local relaxation time values (T1, T2) of an examination object (5). Firstly, two or more MR images (3, 4) of the examination object (5) are recorded, each with different time parameter sets (TR1, TE1, TR2, TE2) of an imaging sequence. MR images (6, 7) of a phantom are likewise recorded, wherein the same time parameter sets (TR1, TE1, TR2, TE2) of the imaging sequence are used and wherein the phantom has a known spatial distribution of relaxation time values (T1, T2). The local relaxation time values (T1, T2) of the examination object (5) are determined by comparing image values of the MR images (3, 4) of the examination object (5) with image values of the MR images (6, 7) of the phantom and by assigning image values of the MR images of the phantom to relaxation time values (T1, T2) according to the known spatial distribution of relaxation time values (T1, T2) of the phantom.
摘要翻译：本发明涉及一种用于确定检查对象（5）的局部弛豫时间值（T 1，T 2> 2）的MR方法。首先，记录检查对象（5）的两个或更多个MR图像（3,4），每个具有不同的时间参数组（TR <1> 1，TE 1，TR 2/2，TE 2 2）。同样地记录了体模的MR图像（6,7），其中相同的时间参数组（TR＆lt; 1＆gt;，TE＆lt; 1＆gt;，TR＆lt; 2＆，TE 2 2），并且其中，所述体模具有已知的弛豫时间值的空间分布（T 1，T 2，N 2，）。通过比较检查对象（5）的MR图像（3,4）的图像值来确定检查对象（5）的局部弛豫时间值（T 1，T 2，2）检查对象（5），其具有所述体模的MR图像（6,7）的图像值，并且通过将所述体模的MR图像的图像值分配给弛豫时间值（T 1>，T

5. 发明授权

US08175678B2 Multiple contrast agent injection for imaging 有权
标题翻译：多重造影剂注射成像
公开(公告)号：US08175678B2
公开(公告)日：2012-05-08
申请号：US12066510
申请日：2006-09-07
申请人： Hannes Dahnke , Tobias Schaeffter
发明人： Hannes Dahnke , Tobias Schaeffter
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B6/481 , A61K49/1818 , B82Y5/00 , G01R33/50 , G01R33/5601 , G01R33/56366
摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.
摘要翻译：通过造影剂的准确定量强烈支持基于MRI的分子成像。根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。这可以通过MRI弛豫测定来准确地确定肿瘤血管。

6. 发明申请

US20090227860A1 MR METHOD FOR THE QUANTITATIVE DETERMINATION OF LOCAL RELAXATION TIME VALUES 审中-公开
标题翻译：用于定量确定局部放松时间值的方法
公开(公告)号：US20090227860A1
公开(公告)日：2009-09-10
申请号：US11573408
申请日：2005-08-08
申请人： Hannes Dahnke , Tobias Schaeffter
发明人： Hannes Dahnke , Tobias Schaeffter
IPC分类号： A61B5/055
CPC分类号： G01R33/50 , G01R33/281 , G01R33/56536 , G01R33/56563
摘要： The invention relates to an MR method for the quantitative determination of local relaxation time values in an examination volume. Firstly, a plurality of echo signals (1, 2, 3) with different echo time values (t1, t2, t3) are recorded in a phase-sensitive manner. From these echo signals (1, 2, 3), complex MR images (4, 5, 6) are then reconstructed for the different echo time values (t1, t2, t3). Next, local resonant frequency values (7) are calculated for each image point from the echo-time-dependent change in the phases of the complex image values, and then preliminary local magnetic field inhomogeneity values (8) are calculated from the local resonant frequency values (7). The invention proposes that the local relaxation time values (10) be determined from the echo-time-dependent change in the amplitudes of the image values and correction of the local relaxation time values (10) be carried out taking account of final local magnetic field inhomogeneity values. The preliminary magnetic field inhomogeneity values (8) are used as start values for an iterative optimization procedure (19) for determining the final local magnetic field inhomogeneity values.
摘要翻译：本发明涉及用于定量测定检查体积中局部弛豫时间值的MR方法。首先，以相敏的方式记录具有不同回波时间值（t1，t2，t3）的多个回波信号（1,2,3）。然后，根据这些回波信号（1,2,3），对于不同的回波时间值（t1，t2，t3）重构复数MR图像（4,5,6）。接下来，从复图像值的相位的回波 - 时间相关的变化中，针对每个图像点计算局部谐振频率值（7），然后从局部谐振频率计算初步局部磁场不均匀性值（8）值（7）。本发明提出，根据图像值幅度的回波 - 时间相关的变化确定局部弛豫时间值（10），并且考虑到最终局部磁场来执行局部弛豫时间值（10）的校正不均匀性值。将初步磁场不均匀性值（8）用作用于确定最终局部磁场不均匀性值的迭代优化程序（19）的起始值。

7. 发明申请

US20090130023A1 Multiple Contrast Agent Injection For Imaging 有权
标题翻译：多个造影剂注射成像
公开(公告)号：US20090130023A1
公开(公告)日：2009-05-21
申请号：US12066510
申请日：2006-09-07
申请人： Hannes Dahnke , Tobias Schaeffter
发明人： Hannes Dahnke , Tobias Schaeffter
IPC分类号： A61K49/06 , G01V3/00
CPC分类号： A61B5/055 , A61B6/481 , A61K49/1818 , B82Y5/00 , G01R33/50 , G01R33/5601 , G01R33/56366
摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.
摘要翻译：通过造影剂的准确定量强烈支持基于MRI的分子成像。根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。这可以通过MRI弛豫测定来准确地确定肿瘤血管。

8. 发明申请

US20100067771A1 ENERGY RESOLVED IMAGING 审中-公开
标题翻译：能量决议成像
公开(公告)号：US20100067771A1
公开(公告)日：2010-03-18
申请号：US12516601
申请日：2007-11-13
申请人： Hannes Dahnke , Michael Grass , Emiel Peeters
发明人： Hannes Dahnke , Michael Grass , Emiel Peeters
IPC分类号： G06K9/00 , G01N23/04 , C12N5/00
CPC分类号： A61B6/482 , A61B6/12 , A61B6/4042 , A61B6/4241 , A61B6/4441 , A61B6/466 , A61L27/3843 , A61L27/50
摘要： A medical imaging method includes energy-resolving x-ray projection data indicative of a contrast labeled scaffold seeded with biological cells for growing tissue and reconstructing the energy-resolved projection data to generate energy-resolved image data indicative of the contrast labeled scaffold.
摘要翻译：医学成像方法包括能量分辨X射线投影数据，其指示用生长组织接种生物细胞的对比标记的支架，并重建能量分辨投影数据，以产生指示对比度标记支架的能量分辨图像数据。

9. 发明申请

US20100002926A1 DETERMINATION OF SUSCEPTIBILITY-INDUCED MAGNETIC FIELD GRADIENTS BY MAGNETIC RESONANCE 审中-公开
标题翻译：通过磁共振测定可挠性诱导磁场梯度
公开(公告)号：US20100002926A1
公开(公告)日：2010-01-07
申请号：US12522396
申请日：2008-01-15
申请人： Hannes Dahnke , Tobias Schaeffter , Peter Van Der Meulen
发明人： Hannes Dahnke , Tobias Schaeffter , Peter Van Der Meulen
IPC分类号： G06K9/00
CPC分类号： G01R33/56536 , G01R33/243 , G01R33/281 , G01R33/286 , G01R33/3875 , G01R33/48 , G01R33/5601
摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SPx, SPy, SPz) from subsets of the MR image data set, the echo shift parameters (SPx, SPy, SPz) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).
摘要翻译：本发明涉及一种用于身体（7）的磁共振成像的装置。装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6）朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14）从信号样本。根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重建MR图像数据集（21）的MR回波信号，c）通过从MR图像数据集的子集计算回波移位参数（SPx，SPy，SPz）来计算梯度图（22），回波指示在k空间中回波位置的磁场梯度引起的移位的移位参数（SPx，SPy，SPz），其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

10. 发明授权

US07471085B2 Determination of relaxation rate changes for MR molecular imaging 有权
标题翻译：确定MR分子成像的松弛率变化
公开(公告)号：US07471085B2
公开(公告)日：2008-12-30
申请号：US11912686
申请日：2006-04-13
申请人： Hannes Dahnke , Tobias Schaffter
发明人： Hannes Dahnke , Tobias Schaffter
IPC分类号： G01V3/00
CPC分类号： G01R33/50 , G01R33/4806
摘要： MR based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, a determination unit of an examination apparatus is adapted for determining an error propagation function, wherein the error propagation function is then used as a weighting function for an accurate determination Of AR2*. This leads to an improved examination result.
摘要翻译：基于MR的分子成像被对比剂的准确定量强烈支持。根据本发明的示例性实施例，检查装置的确定单元适于确定误差传播函数，其中误差传播函数然后被用作加权函数，用于准确地确定AR2 *。这导致了改进的检查结果。

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