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1. 发明授权

US09302967B2 Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma 有权
标题翻译：取代的导管胆固醇作为IL-4和IL-5的抑制剂用于治疗支气管哮喘
公开(公告)号：US09302967B2
公开(公告)日：2016-04-05
申请号：US14110869
申请日：2012-04-11
申请人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Choudhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Pradyot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury
发明人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Choudhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Pradyot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury
IPC分类号： A61K31/14 , A61K31/05 , C07C39/19 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50
CPC分类号： C07C39/19 , A61K31/05 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50
摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.
摘要翻译：本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。通式1的化合物可用于减少血管周围和支气管炎。

2. 发明申请

US20140135393A1 SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA 审中-公开
标题翻译：作为IL-4和IL-5的抑制剂作为治疗性胆碱性哮喘的替代物
公开(公告)号：US20140135393A1
公开(公告)日：2014-05-15
申请号：US14110869
申请日：2012-04-11
申请人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Balaram Ghosh , Parasuraman Jaisankar , Bikas Pal , Nahid Ali , Siddhartha Roy , Bholanath Paul , Arjun Ram , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Chowdhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Prayot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury
发明人： Santu Bandyopadhyay , Balaram Ghosh , Parasuraman Jaisankar , Bikas Chandra Pal , Siddhartha Roy , Balaram Ghosh , Parasuraman Jaisankar , Bikas Pal , Nahid Ali , Siddhartha Roy , Bholanath Paul , Arjun Ram , Siddhartha Roy , Bholanath Paul , Arjun Ram , Ulaganathan Mabalirajan , Nahid Ali , Arun Bandopadhyay , Aditya Konar , Jayashree Bagchi Chakraborty , Indrani Chowdhury Mukherjee , Jaydeep Chaudhuri , Sanjit Kumar Mahato , Anirban Manna , Roma Sinha , Prayot Bhattacharya , Jayaraman Vinayagam , Deba Prasad Jana , Sushovan Chowdhury
IPC分类号： C07C39/19 , C07C251/40 , C07D317/50 , C07C255/36 , C07C69/732 , C07C69/017 , C07C251/66
CPC分类号： C07C39/19 , A61K31/05 , A61K31/15 , A61K31/215 , A61K31/277 , A61K31/36 , C07C69/017 , C07C69/732 , C07C251/40 , C07C251/66 , C07C255/36 , C07D317/50
摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.
摘要翻译：本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。通式1的化合物可用于减少血管周围和支气管炎。

3. 发明申请

US20120190738A1 INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) 有权
标题翻译：磷脂酰肌醇三激酶（PI3）和氧化氮（NO）的诱导剂的抑制剂
公开(公告)号：US20120190738A1
公开(公告)日：2012-07-26
申请号：US13144263
申请日：2010-01-12
申请人： Santu Bandyopadhyay , Bikas Chandra Pal , Jaisankar Parasuraman , Siddhartha Roy , Jayashree Bagchi Chakrabotry , Indrani Choudhury Mukherjee , Sanjit Kumar Mahato , Aditya Konar , Srabanti Rakshit , Labanya Mandal , Dipyaman Ganguly , Kausik Paul , Anirban Manna , Jayaraman Vinayagam , Churala Pal
发明人： Santu Bandyopadhyay , Bikas Chandra Pal , Jaisankar Parasuraman , Siddhartha Roy , Jayashree Bagchi Chakrabotry , Indrani Choudhury Mukherjee , Sanjit Kumar Mahato , Aditya Konar , Srabanti Rakshit , Labanya Mandal , Dipyaman Ganguly , Kausik Paul , Anirban Manna , Jayaraman Vinayagam , Churala Pal
IPC分类号： A61K31/36 , A61K31/225 , C07C215/54 , A61K31/138 , C07C255/33 , A61P35/02 , A61K31/15 , C07D317/50 , C07C39/10 , A61K31/05 , A61P35/00 , C07C69/353 , A61K31/277
CPC分类号： C07D317/06 , C07C251/40 , C07C251/66 , C07C255/36 , C07C255/38
摘要： The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.
摘要翻译：本发明涉及通过抑制PI3-Akt途径或诱导NO而治疗恶性肿瘤的通式I化合物。本发明还涉及通式I的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

4. 发明授权

US09290473B2 Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO) 有权
标题翻译：磷脂酰肌醇-3-激酶（PI3）和一氧化氮（NO）诱导剂的抑制剂
公开(公告)号：US09290473B2
公开(公告)日：2016-03-22
申请号：US13144263
申请日：2010-01-12
申请人： Santu Bandyopadhyay , Bikas Chandra Pal , Jaisankar Parasuraman , Siddhartha Roy , Jayashree Bagchi Chakrabotry , Indrani Choudhury Mukherjee , Sanjit Kumar Mahato , Aditya Konar , Srabanti Rakshit , Labanya Mandal , Dipyaman Ganguly , Kausik Paul , Anirban Manna , Jayaraman Vinayagam , Churala Pal
发明人： Santu Bandyopadhyay , Bikas Chandra Pal , Jaisankar Parasuraman , Siddhartha Roy , Jayashree Bagchi Chakrabotry , Indrani Choudhury Mukherjee , Sanjit Kumar Mahato , Aditya Konar , Srabanti Rakshit , Labanya Mandal , Dipyaman Ganguly , Kausik Paul , Anirban Manna , Jayaraman Vinayagam , Churala Pal
IPC分类号： A61K31/36 , C07C215/54 , C07C255/33 , C07C39/10 , C07D317/06 , C07C251/40 , C07C251/66 , C07C255/36 , C07C255/38
CPC分类号： C07D317/06 , C07C251/40 , C07C251/66 , C07C255/36 , C07C255/38
摘要： The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.
摘要翻译：本发明涉及用于通过抑制PI3-Akt途径和或诱导NO来治疗恶性肿瘤的通式1的化合物。本发明还涉及通式1的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

5. 发明申请

US20110142969A1 EXTRACT OF PIPER BETEL LEAVES FOR THE TREATMENT OF HUMAN MALIGNANCIES BY INDUCING OXIDATIVE STRESS 审中-公开
标题翻译：通过诱导氧化应激来提取用于治疗人类恶性肿瘤的贝特
公开(公告)号：US20110142969A1
公开(公告)日：2011-06-16
申请号：US12808964
申请日：2008-12-02
申请人： Santu Bandyopadhyay , Bikas Chandra Pal , Jayashree Bagchi Chakraborty , Srabanti Rakshit , Labanya Mandal , Kausik Paul , Nabendu Biswas , Anirban Manna
发明人： Santu Bandyopadhyay , Bikas Chandra Pal , Jayashree Bagchi Chakraborty , Srabanti Rakshit , Labanya Mandal , Kausik Paul , Nabendu Biswas , Anirban Manna
IPC分类号： A61K36/67 , A61P35/00
CPC分类号： A61K36/67
摘要： This invention relates to method of treating human malignancies of different origin that are sensitive to oxidative stress by administering effective amount of extract of Piper betel leaves along with a pharmaceutically acceptable additives
摘要翻译：本发明涉及治疗对氧化应激敏感的不同来源的恶性肿瘤的方法，其中通过施用有效量的Pi叶提取物以及药学上可接受的添加剂

6. 发明申请

US20100297760A1 PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译：药物组合物和治疗前列腺癌的方法
公开(公告)号：US20100297760A1
公开(公告)日：2010-11-25
申请号：US12714016
申请日：2010-02-26
申请人： Swati Sinha , Bikas Chandra Pal , Samir Bhattacharya
发明人： Swati Sinha , Bikas Chandra Pal , Samir Bhattacharya
IPC分类号： C12N5/02
CPC分类号： A61K31/407 , A61K36/185 , A61K36/75 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions and methods for treatment of prostate cancer in a subject. The pharmaceutical composition includes a therapeutically effective amount of compound mahanine, or derivatives, or analogues, or pharmaceutically acceptable salt thereof. The present invention is further directed to a method of isolating compound mahanine from Murraya koenigii.
摘要翻译：本发明涉及用于治疗受试者的前列腺癌的药物组合物和方法。药物组合物包括治疗有效量的化合物mahanine或其衍生物或类似物或其药学上可接受的盐。本发明进一步涉及从柯氏乳杆菌（Murraya koenigii）分离化合物mahanine的方法。

7. 发明授权

US08637679B2 Process for the isolation of organic compounds useful for the treatment of cancer 有权
标题翻译：用于分离可用于治疗癌症的有机化合物的方法
公开(公告)号：US08637679B2
公开(公告)日：2014-01-28
申请号：US13416930
申请日：2012-03-09
申请人： Chitra Mandal , Bikas Chandra Pal , Kaushik Bhattacharya , Suman Kumar Samanta , Sayantani Sarkar , Ranjita Das
发明人： Chitra Mandal , Bikas Chandra Pal , Kaushik Bhattacharya , Suman Kumar Samanta , Sayantani Sarkar , Ranjita Das
IPC分类号： C07D491/052
CPC分类号： A61K31/407 , A61K36/75 , A61K2236/39 , C07D491/052
摘要： The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) from Murraya koenigii for the treatment of glioblastoma and cervical carcinoma. Mahanimbine exhibited anti-cancer activity against lymphoid leukemia, myeloid leukemia, glioma, cervical carcinoma, pancreatic, colon and lung cancers in nineteen cells of different genetic status. C-3 hydroxy and NH groups are responsible contributing groups for their cytotoxicity. Mahanine reduced the doses of cisplatin and paclitaxel in cervical cancer showing better efficacy and useful as an adjunct chemotherapeutic agent to reduce toxicity these two drugs. A new cheap process for this preparation was established. EtOAc extract containing alkaloids enriched with mahanimbine and mahanine, is active against glioma and cervical cancers. Mahanine is targeting the chaperone Hsp90 which led to the proteasome-dependent degradation of several Hsp90-client proteins in diverse carcinoma types, glioblastoma, cervical carcinoma and pancreatic adenocarcinoma irrespective of their tissue origins thereby killing the cancer cells.
摘要翻译：本发明涉及两种主要成分，来自Murraya koenigii的mahanine和mahanimbine（dehydroxy-mahanine）用于治疗胶质母细胞瘤和宫颈癌。 Mahanimbine在不同遗传状态的19个细胞中表现出针对淋巴样白血病，骨髓性白血病，神经胶质瘤，宫颈癌，胰腺癌，结肠癌和肺癌的抗癌活性。 C-3羟基和NH基团是它们的细胞毒性的负责贡献的组。 Mahanine降低了子宫颈癌中顺铂和紫杉醇的剂量，显示出更好的疗效，作为辅助化疗药物有用，以降低这两种药物的毒性。建立了一个新的廉价程序，用于此准备工作。含有富马那霉素和马哈尼碱的生物碱的乙酸乙酯提取物对胶质瘤和宫颈癌有活性。 Mahanine针对分子伴侣Hsp90，导致多种癌症类型，胶质母细胞瘤，宫颈癌和胰腺腺癌中的几种Hsp90-客户蛋白的蛋白酶体依赖性降解，而不管其组织来源如何，从而杀死癌细胞。

8. 发明申请

US20130065932A1 PROCESS FOR THE ISOLATION OF ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER 有权
标题翻译：分离用于治疗癌症的有机化合物的方法
公开(公告)号：US20130065932A1
公开(公告)日：2013-03-14
申请号：US13416930
申请日：2012-03-09
申请人： Chitra Mandal , Bikas Chandra Pal , Kaushik Bhattacharya , Suman Kumar Samanta , Sayantani Sarkar , Ranjita Das
发明人： Chitra Mandal , Bikas Chandra Pal , Kaushik Bhattacharya , Suman Kumar Samanta , Sayantani Sarkar , Ranjita Das
IPC分类号： A61K31/407 , A61P35/00 , C07D491/052
CPC分类号： A61K31/407 , A61K36/75 , A61K2236/39 , C07D491/052
摘要： The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) from Murraya koenigii for the treatment of glioblastoma and cervical carcinoma. Mahanimbine exhibited anti-cancer activity against lymphoid leukemia, myeloid leukemia, glioma, cervical carcinoma, pancreatic, colon and lung cancers in nineteen cells of different genetic status. C-3 hydroxy and NH groups are responsible contributing groups for their cytotoxicity. Mahanine reduced the doses of cisplatin and paclitaxel in cervical cancer showing better efficacy and useful as an adjunct chemotherapeutic agent to reduce toxicity these two drugs. A new cheap process for this preparation was established. EtOAc extract containing alkaloids enriched with mahanimbine and mahanine, is active against glioma and cervical cancers. Mahanine is targeting the chaperone Hsp90 which led to the proteasome-dependent degradation of several Hsp90-client proteins in diverse carcinoma types, glioblastoma, cervical carcinoma and pancreatic adenocarcinoma irrespective of their tissue origins thereby killing the cancer cells.
摘要翻译：本发明涉及两种主要成分，来自Murraya koenigii的mahanine和mahanimbine（dehydroxy-mahanine）用于治疗胶质母细胞瘤和宫颈癌。 Mahanimbine在不同遗传状态的19个细胞中表现出针对淋巴样白血病，骨髓性白血病，神经胶质瘤，宫颈癌，胰腺癌，结肠癌和肺癌的抗癌活性。 C-3羟基和NH基团是它们的细胞毒性的负责贡献组。 Mahanine降低了子宫颈癌中顺铂和紫杉醇的剂量，显示出更好的疗效，作为辅助化疗药物有用，以降低这两种药物的毒性。建立了一个新的廉价程序，用于此准备工作。含有富马那霉素和马哈尼碱的生物碱的乙酸乙酯提取物对胶质瘤和宫颈癌有活性。 Mahanine针对分子伴侣Hsp90，导致多种癌症类型，胶质母细胞瘤，宫颈癌和胰腺腺癌中的几种Hsp90-客户蛋白的蛋白酶体依赖性降解，而不管其组织来源如何，从而杀死癌细胞。

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