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1. 发明授权

US5588431A Inversion recovery MRI 失效
标题翻译：反转恢复MRI
公开(公告)号：US5588431A
公开(公告)日：1996-12-31
申请号：US516243
申请日：1995-08-17
申请人： Sanjay Mani , Dwight G. Nishimura , Steven M. Conolly , John M. Pauly
发明人： Sanjay Mani , Dwight G. Nishimura , Steven M. Conolly , John M. Pauly
IPC分类号： A61B5/026 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5635 , A61B5/0263 , G01R33/5602
摘要： Multiple inversion recovery flow imaging employs at least four spin inversion pulses following saturation of static nuclei spins to null nuclei in static material having different spin-lattice relaxation times (T.sub.1) with the inversion pulses being spaced in time to substantially reduce the longitudinal magnetization of the T.sub.1 species present. The saturation of static nuclei spins includes applying a sequence of saturation pulses with adjacent pulses being separated by a diphasing gradient to avoid refocusing coherence. The detection of signals includes applying at least one RF read-out pulse near the nulling point.
摘要翻译：多反转恢复流成像在静态核自旋饱和之后采用至少四个自旋反转脉冲，使具有不同自旋晶格弛豫时间（T1）的静态材料中的零核，其中反转脉冲在时间上间隔开，从而基本上减小了 T1种存在。静态核自旋的饱和度包括施加饱和脉冲序列，其中相邻脉冲被双相梯度分离以避免重新聚焦相干。信号的检测包括在零点附近应用至少一个RF读出脉冲。

2. 发明授权

US5150053A Magnetic resonance imaging of short T.sub.2 species with improved contrast 失效
标题翻译：短T2物种的磁共振成像具有改善的对比度
公开(公告)号：US5150053A
公开(公告)日：1992-09-22
申请号：US645859
申请日：1991-01-25
申请人： John M. Pauly , Steven M. Conolly , Dwight G. Nishimura
发明人： John M. Pauly , Steven M. Conolly , Dwight G. Nishimura
IPC分类号： A61B5/055 , G01R33/48 , G01R33/50 , G01R33/56 , G01R33/561
CPC分类号： G01R33/446 , G01R33/50 , G01R33/56
摘要： Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero. Contrast between the imaged short T.sub.2 species and longer T.sub.2 species can be enhanced by first applying an RF signal having sufficient amplitude to excite the longer T.sub.2 species but insufficient amplitude to excite the short T.sub.2 species whereby the longer T.sub.2 species are tipped by the RF signal. A magnetic gradient can then be applied to dephase the tipped nuclei of the longer T.sub.2 species. The imaging signals are then obtained from magnetic resonance signals from the short T.sub.2 species.
摘要翻译：获得具有短自旋 - 自旋弛豫时间（T2）的成像物质的磁共振信号，而不需要重新聚焦波瓣。在施加每个RF激励脉冲之后，对具有磁共振信号的物种施加一系列RF激励脉冲。然后将磁共振信号组合以提供成像信号。在一个实施例中，每个RF激励脉冲是常规切片选择脉冲的一半，其中每个脉冲被转换为零。可以通过首先施加具有足够振幅的RF信号来激发较长的T2物种但不足的幅度来激发短的T2物种，从而通过RF信号使更长的T2物种倾斜，可以增强成像的短T2物种与较长的T2物种之间的对比。然后可以应用磁梯度来去除较长T2物种的尖端核。然后从来自短T2物种的磁共振信号获得成像信号。

3. 发明授权

US5189371A Method and means for magnetic resonance imaging and spectroscopy using two-dimensional selective adiabatic PI pulses 失效
标题翻译：用于磁共振成像和使用二维选择性绝热PI脉冲的光谱的方法和装置
公开(公告)号：US5189371A
公开(公告)日：1993-02-23
申请号：US742785
申请日：1991-08-08
申请人： Steven M. Conolly , John M. Pauly
发明人： Steven M. Conolly , John M. Pauly
IPC分类号： G01R33/48
CPC分类号： G01R33/446
摘要： Two-dimensional selective adiabatic pulses invert magnetization from a square region in the xy plane with insensitivity to RF variations. Two-dimensional adiabatic pulses can also invert selectively in frequency and in one spatial dimension. The pulses are useful for both MR imaging and spectroscopy.
摘要翻译：二维选择性绝热脉冲从xy平面中的正方形区域反转磁化，对RF变化不敏感。二维绝热脉冲也可以在频率和一个空间维度上选择性地反转。这些脉冲对于MR成像和光谱都是有用的。

4. 发明授权

US07288936B2 RF pulses for long T2 suppression in MRI 有权
标题翻译：射频脉冲在MRI中长T2抑制
公开(公告)号：US07288936B2
公开(公告)日：2007-10-30
申请号：US11180339
申请日：2005-07-12
申请人： Peder E. Larson , John M. Pauly , Steven M. Conolly
发明人： Peder E. Larson , John M. Pauly , Steven M. Conolly
IPC分类号： G01V3/00
CPC分类号： G01R33/446
摘要： In imaging a first species having a short T2 magnetic resonance parameter in the presence of a second and third species having longer T2 parameters, a method of suppressing signals from the longer T2 species comprises the steps of: a) applying a RF saturation pulse with multiple suppression bands for the second and third species to excite nuclei spins of the longer T2 species with the magnitude of the RF pulse being sufficiently low so as not to excite nuclei spins of the short T2 species, the RF saturation pulse being sufficiently long to rotate the longer T2 species nuclei spins into a transverse plane, and b) dephasing the longer T2 species nuclei spins in the transverse plane. An imaging pulse sequence is then applied to image the short T2 species. Alternatively, the method can comprise the steps of a) applying a first inversion pulse for selective inverting species of the second longer T2 species, b) obtaining first image signals after step a, c) applying a second inversion pulse for selectively inverting species of the third longer T2 species, d) obtaining second image signals after step c), and e) combining the first image signals and the second image signal to image the first short T2 species with the longer second and third species cancelling in the combination. In each of these methods, either the second or third longer T2 species can be suppressed without suppressing the other by applying the RF saturation or inversion pulse only to the species to be suppressed.
摘要翻译：在具有较长T2参数的第二和第三物种存在下成像具有短T2磁共振参数的第一物种时，抑制来自较长T2物种的信号的方法包括以下步骤：a）施加具有多个第二和第三物种的抑制带激发较长T2物种的核心旋转，其中RF脉冲的幅度足够低，以便不激发短T2物质的核旋转，RF饱和脉冲足够长以旋转更长的T2物种核转入横向平面，并且b）在横向平面中去除更长的T2种类核自旋。然后应用成像脉冲序列对短T2物种进行成像。或者，该方法可以包括以下步骤：a）施加用于第二较长T2种类的选择性反转种类的第一反转脉冲，b）在步骤a之后获得第一图像信号，c）施加第二反转脉冲以选择性地反转第三较长的T2物种，d）在步骤c）之后获得第二图像信号，以及e）组合第一图像信号和第二图像信号以对组合中较长的第二和第三个物种进行消除的第一短T2物种进行成像。在这些方法的每一种中，通过仅对要抑制的物质施加RF饱和或反转脉冲，可以抑制第二或第三较长的T2物种，而不会抑制另一个。

5. 发明授权

US06806708B1 Multi-coil reconstruction of MRI signals using linear phase multiplied data with separate demodulators for each coil 有权
标题翻译：使用线性相位相乘数据对MRI信号进行多线圈重建，每个线圈采用单独的解调器
公开(公告)号：US06806708B1
公开(公告)日：2004-10-19
申请号：US10464296
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5611
摘要： Imaging time using PILS is reduced by using multiple coils with localized sensitivities with each coil having a separate demodulation channel thereby permitting parallel signal processing and image reconstruction. Images from the multiple coils are then combined to form an image with a larger field of view (FOV).
摘要翻译：使用PILS的成像时间通过使用具有局部灵敏度的多个线圈来减少，每个线圈具有单独的解调信道，从而允许并行信号处理和图像重建。然后将来自多个线圈的图像组合以形成具有较大视场（FOV）的图像。

6. 发明授权

US07277597B2 Partial k-space reconstruction for radial k-space trajectories in magnetic resonance imaging 有权
标题翻译：磁共振成像中径向k空间轨迹的部分k空间重建
公开(公告)号：US07277597B2
公开(公告)日：2007-10-02
申请号：US10464236
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G06K9/36
CPC分类号： G01R33/4824 , G01R33/561
摘要： A modified projection on convex sets (POCS) algorithm and method for partial k-space reconstruction using low resolution phase maps for scaling full sets of reconstructed k-space data. The algorithm can be used with partial k-space trajectories in which the trajectories share a common point such as the origin of k-space, including variable-density spiral trajectories, projection reconstruction trajectories with a semicircle region acquisition, and projection reconstruction trajectories with every other spike acquired.
摘要翻译：使用低分辨率相位图进行局部k空间重建的凸集（POCS）算法和方法的改进投影，用于缩放全套重建的k空间数据。该算法可以与部分k空间轨迹一起使用，其中轨迹共享公共点，例如k空间的起点，包括可变密度螺旋轨迹，具有半圆区域获取的投影重建轨迹，以及每个其他穗获得。

7. 发明授权

US5025216A Magnetic resonance imaging of short T.sub.2 species 失效
标题翻译：短T2物种的磁共振成像
公开(公告)号：US5025216A
公开(公告)日：1991-06-18
申请号：US386901
申请日：1989-07-28
申请人： John M. Pauly , Dwight G. Nishimura
发明人： John M. Pauly , Dwight G. Nishimura
IPC分类号： G01R33/48 , G01R33/50 , G01R33/561
CPC分类号： G01R33/446 , G01R33/50
摘要： Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero.
摘要翻译：获得具有短自旋 - 自旋弛豫时间（T2）的成像物质的磁共振信号，而不需要重新聚焦波瓣。在施加每个RF激励脉冲之后，对具有磁共振信号的物种施加一系列RF激励脉冲。然后将磁共振信号组合以提供成像信号。在一个实施例中，每个RF激励脉冲是常规切片选择脉冲的一半，其中每个脉冲被转换为零。

8. 发明授权

US5957843A Partial flyback echo-planar imaging 失效
标题翻译：部分反激回波平面成像
公开(公告)号：US5957843A
公开(公告)日：1999-09-28
申请号：US515090
申请日：1995-08-14
申请人： Gerard T. Luk Pat , Craig H. Meyer , John M. Pauly , Dwight G. Nishimura
发明人： Gerard T. Luk Pat , Craig H. Meyer , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01R33/561 , A61B5/055
CPC分类号： G01R33/5615 , G01R33/5616
摘要： Flyback imaging is combined with echo planar imaging (EPI) for improved readout flow properties. For increases in imaging time of 50% or less, significant improvements in imaging are realized. The partial flyback improves partial-Fourier EPI and inside-out EPI and can be applied to any EPI trajectory.
摘要翻译：反激成像与回波平面成像（EPI）相结合，可提高读数流动特性。对于50％以下的成像时间的增加，可以实现成像的显着改善。部分回扫提高了部分傅里叶EPI和内向外EPI，并且可以应用于任何EPI轨迹。

9. 发明授权

US06452387B1 Catalyzing the transient response in steady-state MRI sequences 有权
标题翻译：在稳态MRI序列中催化瞬时反应
公开(公告)号：US06452387B1
公开(公告)日：2002-09-17
申请号：US09801424
申请日：2001-03-07
申请人： Brain A. Hargreaves , Shreyas Vasanawala , John M. Pauly , Dwight G. Nishimura
发明人： Brain A. Hargreaves , Shreyas Vasanawala , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5613
摘要： A steady-state condition for tipped nuclear spins is accelerated or catalyzed by first determining magnetization magnitude of the steady state and the scaling magnetization along one axis (Mz) to at least approximate the determined magnetization magnitude. Then the scaled magnetization is rotated to coincide with a real-valued eigenvector extension of the tipped steady-state magnetization. Any error vector will then decay to the steady-state condition without oscillation. In one embodiment, the magnetic resonance imaging utilizes steady-state free precession (SSFP). The scaling and rotating steps are followed by the steps of applying read-out magnetic gradients and detecting magnetic resonance signals from the tipped nuclear spins. The magnetization magnitude is determined by eigenvector analysis, and the eigenvector extension is a real-valued eigenvector determined in the analysis.
摘要翻译：通过首先确定稳态的磁化强度和沿着一个轴（Mz）的缩放磁化强度至少接近确定的磁化强度，来加速或催化尖端核自旋的稳态条件。然后，缩放的磁化被旋转以与尖端稳态磁化的实数特征向量延伸一致。任何误差矢量都会衰减到稳态，而不会产生振荡。在一个实施例中，磁共振成像利用稳态自由进动（SSFP）。缩放和旋转步骤之后是应用读出磁梯度并从尖端核自旋检测磁共振信号的步骤。磁化强度由特征向量分析确定，特征向量扩展是在分析中确定的实值特征向量。

10. 发明授权

US06307368B1 Linear combination steady-state free precession MRI 有权
标题翻译：线性组合稳态自由进动MRI
公开(公告)号：US06307368B1
公开(公告)日：2001-10-23
申请号：US09312025
申请日：1999-05-14
申请人： Shreyas S. Vasanawala , John M. Pauly , Dwight G. Nishimura
发明人： Shreyas S. Vasanawala , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5613 , G01R33/446
摘要： A fast, spectrally-selective steady-state free precession (SSFP) imaging method is presented. Combining k-space data from SSFP sequences with certain phase schedules of radiofrequency excitation pulses permits manipulation of the spectral selectivity of the image. For example, lipid and water can be rapidly resolved. The contrast of each image depends on both T1 and T2, and the relative contribution of the two relaxation mechanisms to image contrast can be controlled by adjusting the flip angle. Several applications of the technique are presented, including fast musculoskeletal imaging, brain imaging, and angiography. The technique is referred to herein as linear combination steady-state free precession (LCSSFP) and fluctuating equilibrium magnetic resonance (FEMR).
摘要翻译：提出了一种快速，频谱选择性的稳态自由进动（SSFP）成像方法。将来自SSFP序列的k空间数据与射频激发脉冲的某些相位调度组合允许操纵图像的光谱选择性。例如，脂质和水可以快速解决。每个图像的对比度取决于T1和T2，并且可以通过调整翻转角度来控制两个松弛机制对图像对比度的相对贡献。提出了该技术的几个应用，包括快速肌肉骨骼成像，脑成像和血管造影。该技术在此被称为线性组合稳态自由进动（LCSSFP）和波动平衡磁共振（FEMR）。

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