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1. 发明授权

US5957843A Partial flyback echo-planar imaging 失效
标题翻译：部分反激回波平面成像
公开(公告)号：US5957843A
公开(公告)日：1999-09-28
申请号：US515090
申请日：1995-08-14
申请人： Gerard T. Luk Pat , Craig H. Meyer , John M. Pauly , Dwight G. Nishimura
发明人： Gerard T. Luk Pat , Craig H. Meyer , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01R33/561 , A61B5/055
CPC分类号： G01R33/5615 , G01R33/5616
摘要： Flyback imaging is combined with echo planar imaging (EPI) for improved readout flow properties. For increases in imaging time of 50% or less, significant improvements in imaging are realized. The partial flyback improves partial-Fourier EPI and inside-out EPI and can be applied to any EPI trajectory.
摘要翻译：反激成像与回波平面成像（EPI）相结合，可提高读数流动特性。对于50％以下的成像时间的增加，可以实现成像的显着改善。部分回扫提高了部分傅里叶EPI和内向外EPI，并且可以应用于任何EPI轨迹。

2. 发明授权

US06806708B1 Multi-coil reconstruction of MRI signals using linear phase multiplied data with separate demodulators for each coil 有权
标题翻译：使用线性相位相乘数据对MRI信号进行多线圈重建，每个线圈采用单独的解调器
公开(公告)号：US06806708B1
公开(公告)日：2004-10-19
申请号：US10464296
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5611
摘要： Imaging time using PILS is reduced by using multiple coils with localized sensitivities with each coil having a separate demodulation channel thereby permitting parallel signal processing and image reconstruction. Images from the multiple coils are then combined to form an image with a larger field of view (FOV).
摘要翻译：使用PILS的成像时间通过使用具有局部灵敏度的多个线圈来减少，每个线圈具有单独的解调信道，从而允许并行信号处理和图像重建。然后将来自多个线圈的图像组合以形成具有较大视场（FOV）的图像。

3. 发明授权

US07277597B2 Partial k-space reconstruction for radial k-space trajectories in magnetic resonance imaging 有权
标题翻译：磁共振成像中径向k空间轨迹的部分k空间重建
公开(公告)号：US07277597B2
公开(公告)日：2007-10-02
申请号：US10464236
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G06K9/36
CPC分类号： G01R33/4824 , G01R33/561
摘要： A modified projection on convex sets (POCS) algorithm and method for partial k-space reconstruction using low resolution phase maps for scaling full sets of reconstructed k-space data. The algorithm can be used with partial k-space trajectories in which the trajectories share a common point such as the origin of k-space, including variable-density spiral trajectories, projection reconstruction trajectories with a semicircle region acquisition, and projection reconstruction trajectories with every other spike acquired.
摘要翻译：使用低分辨率相位图进行局部k空间重建的凸集（POCS）算法和方法的改进投影，用于缩放全套重建的k空间数据。该算法可以与部分k空间轨迹一起使用，其中轨迹共享公共点，例如k空间的起点，包括可变密度螺旋轨迹，具有半圆区域获取的投影重建轨迹，以及每个其他穗获得。

4. 发明授权

US5025216A Magnetic resonance imaging of short T.sub.2 species 失效
标题翻译：短T2物种的磁共振成像
公开(公告)号：US5025216A
公开(公告)日：1991-06-18
申请号：US386901
申请日：1989-07-28
申请人： John M. Pauly , Dwight G. Nishimura
发明人： John M. Pauly , Dwight G. Nishimura
IPC分类号： G01R33/48 , G01R33/50 , G01R33/561
CPC分类号： G01R33/446 , G01R33/50
摘要： Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero.
摘要翻译：获得具有短自旋 - 自旋弛豫时间（T2）的成像物质的磁共振信号，而不需要重新聚焦波瓣。在施加每个RF激励脉冲之后，对具有磁共振信号的物种施加一系列RF激励脉冲。然后将磁共振信号组合以提供成像信号。在一个实施例中，每个RF激励脉冲是常规切片选择脉冲的一半，其中每个脉冲被转换为零。

5. 发明授权

US5150053A Magnetic resonance imaging of short T.sub.2 species with improved contrast 失效
标题翻译：短T2物种的磁共振成像具有改善的对比度
公开(公告)号：US5150053A
公开(公告)日：1992-09-22
申请号：US645859
申请日：1991-01-25
申请人： John M. Pauly , Steven M. Conolly , Dwight G. Nishimura
发明人： John M. Pauly , Steven M. Conolly , Dwight G. Nishimura
IPC分类号： A61B5/055 , G01R33/48 , G01R33/50 , G01R33/56 , G01R33/561
CPC分类号： G01R33/446 , G01R33/50 , G01R33/56
摘要： Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero. Contrast between the imaged short T.sub.2 species and longer T.sub.2 species can be enhanced by first applying an RF signal having sufficient amplitude to excite the longer T.sub.2 species but insufficient amplitude to excite the short T.sub.2 species whereby the longer T.sub.2 species are tipped by the RF signal. A magnetic gradient can then be applied to dephase the tipped nuclei of the longer T.sub.2 species. The imaging signals are then obtained from magnetic resonance signals from the short T.sub.2 species.
摘要翻译：获得具有短自旋 - 自旋弛豫时间（T2）的成像物质的磁共振信号，而不需要重新聚焦波瓣。在施加每个RF激励脉冲之后，对具有磁共振信号的物种施加一系列RF激励脉冲。然后将磁共振信号组合以提供成像信号。在一个实施例中，每个RF激励脉冲是常规切片选择脉冲的一半，其中每个脉冲被转换为零。可以通过首先施加具有足够振幅的RF信号来激发较长的T2物种但不足的幅度来激发短的T2物种，从而通过RF信号使更长的T2物种倾斜，可以增强成像的短T2物种与较长的T2物种之间的对比。然后可以应用磁梯度来去除较长T2物种的尖端核。然后从来自短T2物种的磁共振信号获得成像信号。

6. 发明授权

US5588431A Inversion recovery MRI 失效
标题翻译：反转恢复MRI
公开(公告)号：US5588431A
公开(公告)日：1996-12-31
申请号：US516243
申请日：1995-08-17
申请人： Sanjay Mani , Dwight G. Nishimura , Steven M. Conolly , John M. Pauly
发明人： Sanjay Mani , Dwight G. Nishimura , Steven M. Conolly , John M. Pauly
IPC分类号： A61B5/026 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5635 , A61B5/0263 , G01R33/5602
摘要： Multiple inversion recovery flow imaging employs at least four spin inversion pulses following saturation of static nuclei spins to null nuclei in static material having different spin-lattice relaxation times (T.sub.1) with the inversion pulses being spaced in time to substantially reduce the longitudinal magnetization of the T.sub.1 species present. The saturation of static nuclei spins includes applying a sequence of saturation pulses with adjacent pulses being separated by a diphasing gradient to avoid refocusing coherence. The detection of signals includes applying at least one RF read-out pulse near the nulling point.
摘要翻译：多反转恢复流成像在静态核自旋饱和之后采用至少四个自旋反转脉冲，使具有不同自旋晶格弛豫时间（T1）的静态材料中的零核，其中反转脉冲在时间上间隔开，从而基本上减小了 T1种存在。静态核自旋的饱和度包括施加饱和脉冲序列，其中相邻脉冲被双相梯度分离以避免重新聚焦相干。信号的检测包括在零点附近应用至少一个RF读出脉冲。

7. 发明授权

US06452387B1 Catalyzing the transient response in steady-state MRI sequences 有权
标题翻译：在稳态MRI序列中催化瞬时反应
公开(公告)号：US06452387B1
公开(公告)日：2002-09-17
申请号：US09801424
申请日：2001-03-07
申请人： Brain A. Hargreaves , Shreyas Vasanawala , John M. Pauly , Dwight G. Nishimura
发明人： Brain A. Hargreaves , Shreyas Vasanawala , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5613
摘要： A steady-state condition for tipped nuclear spins is accelerated or catalyzed by first determining magnetization magnitude of the steady state and the scaling magnetization along one axis (Mz) to at least approximate the determined magnetization magnitude. Then the scaled magnetization is rotated to coincide with a real-valued eigenvector extension of the tipped steady-state magnetization. Any error vector will then decay to the steady-state condition without oscillation. In one embodiment, the magnetic resonance imaging utilizes steady-state free precession (SSFP). The scaling and rotating steps are followed by the steps of applying read-out magnetic gradients and detecting magnetic resonance signals from the tipped nuclear spins. The magnetization magnitude is determined by eigenvector analysis, and the eigenvector extension is a real-valued eigenvector determined in the analysis.
摘要翻译：通过首先确定稳态的磁化强度和沿着一个轴（Mz）的缩放磁化强度至少接近确定的磁化强度，来加速或催化尖端核自旋的稳态条件。然后，缩放的磁化被旋转以与尖端稳态磁化的实数特征向量延伸一致。任何误差矢量都会衰减到稳态，而不会产生振荡。在一个实施例中，磁共振成像利用稳态自由进动（SSFP）。缩放和旋转步骤之后是应用读出磁梯度并从尖端核自旋检测磁共振信号的步骤。磁化强度由特征向量分析确定，特征向量扩展是在分析中确定的实值特征向量。

8. 发明授权

US06307368B1 Linear combination steady-state free precession MRI 有权
标题翻译：线性组合稳态自由进动MRI
公开(公告)号：US06307368B1
公开(公告)日：2001-10-23
申请号：US09312025
申请日：1999-05-14
申请人： Shreyas S. Vasanawala , John M. Pauly , Dwight G. Nishimura
发明人： Shreyas S. Vasanawala , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5613 , G01R33/446
摘要： A fast, spectrally-selective steady-state free precession (SSFP) imaging method is presented. Combining k-space data from SSFP sequences with certain phase schedules of radiofrequency excitation pulses permits manipulation of the spectral selectivity of the image. For example, lipid and water can be rapidly resolved. The contrast of each image depends on both T1 and T2, and the relative contribution of the two relaxation mechanisms to image contrast can be controlled by adjusting the flip angle. Several applications of the technique are presented, including fast musculoskeletal imaging, brain imaging, and angiography. The technique is referred to herein as linear combination steady-state free precession (LCSSFP) and fluctuating equilibrium magnetic resonance (FEMR).
摘要翻译：提出了一种快速，频谱选择性的稳态自由进动（SSFP）成像方法。将来自SSFP序列的k空间数据与射频激发脉冲的某些相位调度组合允许操纵图像的光谱选择性。例如，脂质和水可以快速解决。每个图像的对比度取决于T1和T2，并且可以通过调整翻转角度来控制两个松弛机制对图像对比度的相对贡献。提出了该技术的几个应用，包括快速肌肉骨骼成像，脑成像和血管造影。该技术在此被称为线性组合稳态自由进动（LCSSFP）和波动平衡磁共振（FEMR）。

9. 发明授权

US5427101A Diminishing variance process for real-time reduction of motion artifacts in MRI 失效
标题翻译：减少MRI中运动伪像的实时方差过程
公开(公告)号：US5427101A
公开(公告)日：1995-06-27
申请号：US286049
申请日：1994-08-04
申请人： Todd S. Sachs , Craig H. Meyer , Dwight G. Nishimura
发明人： Todd S. Sachs , Craig H. Meyer , Dwight G. Nishimura
IPC分类号： G01R33/56 , G01R33/567 , A61B5/055
CPC分类号： G01R33/56509 , G01R33/5676 , G01R33/5608
摘要： A method whereby motion can be detected in real time during the acquisition of MRI data. This enables the implementation of several algorithms to reduce or eliminate this motion from an image as it is being acquired. The method is an extension of the acceptance/rejection method algorithm called the diminishing variance algorithm (DVA). With this method, a complete set of preliminary data is acquired along with information about the relative motion position of each frame of data. After all the preliminary data is acquired, the position information is used to determine which lines are most corrupted by motion. Frames of data are then reacquired, starting with the most corrupted frame. The position information is continually updated in an iterative process, therefore each subsequent reacquisition is always done on the worst frame of data. The algorithm has been implemented on several different types of sequences, and preliminary in vivo studies indicate that motion artifacts are dramatically reduced.
摘要翻译：可以在获取MRI数据期间实时地检测运动的方法。这使得能够实现几种算法以在图像被获取时减少或消除该运动。该方法是称为递减方差算法（DVA）的接受/拒绝方法算法的扩展。利用该方法，获取一组完整的初步数据以及关于每帧数据的相对运动位置的信息。在获取所有初步数据之后，位置信息用于确定哪些行被运动损坏最多。然后重新获取数据帧，从最坏的帧开始。位置信息在迭代过程中不断更新，因此每个后续的重新捕获总是在最差的数据帧上完成。该算法已经在几种不同类型的序列上实现，并且初步的体内研究表明，运动伪像被大大减少。

10. 发明申请

US20080297152A1 SYSTEM AND METHOD OF PARALLEL IMAGING WITH CALIBRATION TO A SEPARATE COIL 有权
标题翻译：用于校准到单独线圈的并行成像的系统和方法
公开(公告)号：US20080297152A1
公开(公告)日：2008-12-04
申请号：US11757571
申请日：2007-06-04
申请人： Anja C.S. Brau , Philip James Beatty , Dwight G. Nishimura
发明人： Anja C.S. Brau , Philip James Beatty , Dwight G. Nishimura
IPC分类号： G01R33/56
CPC分类号： G01R33/5611
摘要： An RF coil assembly includes a plurality of RF source coils and an RF target coil separate from the plurality of RF source coils. A computer is programmed to acquire MR data of an imaging object from each of the plurality of RF source coils and to acquire MR data of the imaging object from the RF target coil. The computer is further programmed to calculate a set of weights based on a relationship between MR data acquired from each RF source coil and MR data acquired from the RF target coil and to reconstruct an image based on an application of the set of weights to at least a portion of the MR data acquired from each of the plurality of RF source coils.
摘要翻译： RF线圈组件包括多个RF源线圈和与多个RF源线圈分离的RF目标线圈。计算机被编程为从多个RF源线圈中的每一个获取成像对象的MR数据，并从RF目标线圈获取成像对象的MR数据。计算机还被编程为基于从每个RF源线圈获取的MR数据与从RF目标线圈获取的MR数据之间的关系来计算一组权重，并且基于该组权重的应用至少重构图像从多个RF源线圈中的每一个获取的MR数据的一部分。

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