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1. 发明申请

US20090203095A1 NOVEL ENGINEERED MICROORGANISM PRODUCING HOMO-SUCCINIC ACID AND METHOD FOR PREPARING SUCCINIC ACID USING THE SAME 有权
标题翻译：生产同型酸的新型工程化微生物及其制备方法
公开(公告)号：US20090203095A1
公开(公告)日：2009-08-13
申请号：US12359322
申请日：2009-01-25
申请人： Sang Yup LEE , Sung Won LIM , Hyohak SONG
发明人： Sang Yup LEE , Sung Won LIM , Hyohak SONG
IPC分类号： C12P7/46 , C12N1/21 , C12N15/87
CPC分类号： C12P7/46 , C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12N15/902 , C12Y203/01054 , Y02P20/52
摘要： The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive mutant microorganism is useful to produce succinic acid for industrial use.
摘要翻译：本发明涉及一种突变体微生物，其选自人嗜血杆菌属（Mannheimia），放线杆菌属（Actinobacillus）和放线虫属（Anaerobiospirillum）属，产生同型琥珀酸，以及使用其制备均琥珀酸的方法，更具体地说，涉及突变体通过破坏编码乳酸脱氢酶（ldhA）的基因，编码磷酸转乙酰酶（pta）的基因和编码乙酸激酶（ackA）的基因而获得的在厌氧条件下产生很少或不存在其它有机酸的微生物，产生高浓度的琥珀酸），而不破坏编码丙酮酸甲酸裂合酶（pfl）的基因，以及使用其生产琥珀酸的方法。与生产琥珀酸的现有菌株相比，本发明的突变微生物具有生长速度快和琥珀酸生产率少的特性，同时产生很少或不含有机酸。因此，本发明的突变微生物可用于生产用于工业用途的琥珀酸。

2. 发明申请

US20130164805A1 Recombinant Microorganisms Having Enhanced Propanol and Method for Preparing Propanol Using the Same 有权
标题翻译：具有增强丙醇的重组微生物和使用其制备丙醇的方法
公开(公告)号：US20130164805A1
公开(公告)日：2013-06-27
申请号：US13537988
申请日：2012-06-29
申请人： Sang Yup LEE , Yong Jun CHOI , Jin Hwan PARK
发明人： Sang Yup LEE , Yong Jun CHOI , Jin Hwan PARK
IPC分类号： C12P7/04
CPC分类号： C12P7/04 , C12N15/52
摘要： The present invention relates to mutant microorganisms having the ability to produce propanol in high concentration and high yield, and to a method of producing propanol using the same. More particularly, the invention relates to mutant microorganisms having the ability to produce propanol in high concentration and high yield, which have introduced therein genes that encodes enzymes which are involved in the biosynthesis of propanol from threonine, and to a method of producing propanol using the same
摘要翻译：本发明涉及具有以高浓度和高收率生产丙醇的能力的突变微生物以及使用其制备丙醇的方法。更具体地，本发明涉及具有以高浓度和高产率生产丙醇的能力的突变微生物，其中引入了编码参与苏氨酸生物合成丙醇的酶的基因，以及使用该方法生产丙醇的方法相同

3. 发明申请

US20090142804A1 Process For Preparing Serine-Rich Protein Employing Cysteine Synthase (CYSK) Gene 审中-公开
标题翻译：制备使用半胱氨酸合酶（CYSK）基因的富含丝氨酸蛋白的方法
公开(公告)号：US20090142804A1
公开(公告)日：2009-06-04
申请号：US12271003
申请日：2008-11-14
申请人： Sang Yup LEE , Mee-Jung Han
发明人： Sang Yup LEE , Mee-Jung Han
IPC分类号： C12P21/04 , C12N1/21
CPC分类号： C07K14/5434 , C07K14/5759 , C12N15/70 , C12P21/02
摘要： The present invention relates to a process for preparing a serine-rich foreign protein comprising culturing a bacterium containing the cysteine synthase (cysK) gene and a gene encoding the serine-rich foreign protein. The present invention comprises the steps of culturing a bacterium transformed with an expression vector containing a gene encoding a serine-rich foreign protein and an expression vector containing the cysK gene, or a bacterium transformed with an expression vector containing the cysK gene and a gene encoding a serine-rich foreign protein and isolating the foreign protein therefrom. The present invention is expected to be widely used to increase the production yield of a serine-rich foreign protein.
摘要翻译：本发明涉及一种制备富含丝氨酸的外源蛋白的方法，包括培养含有半胱氨酸合成酶（cysK）基因的细菌和编码富含丝氨酸的外源蛋白的基因。本发明包括以下步骤：培养用含有编码富含丝氨酸的外源蛋白的基因的表达载体转化的细菌和含有cysK基因的表达载体或用含有cysK基因的表达载体转化的细菌和编码富含丝氨酸的外源蛋白质并从其中分离外来蛋白质。预期本发明被广泛用于提高富含丝氨酸的外源蛋白质的产量。

4. 发明申请

US20210217063A1 SALES SUPPORT MARKETING SYSTEM 有权
公开(公告)号：US20210217063A1
公开(公告)日：2021-07-15
申请号：US17059171
申请日：2019-04-25
申请人： Sang Yup LEE
发明人： Sang Yup LEE
IPC分类号： G06Q30/02 , G06F40/186 , G06F40/14
摘要： The present invention relates to a marketing system that supports sales of goods by interlocking a customer terminal and an administrator terminal, which comprises: a central server (100) which provides an event page production tool to the administrator terminal, receives information about an event page, and transmits the received event page to the customer terminal; an administrator terminal (200) for receiving the event page production tool from the central server to input corresponding variables to produce an event page; and a customer terminal for receiving the event page produced by the administrator terminal from the central server and inputting necessary information while performing a process provided by the event page. The event page (400) includes a main image (410) displayed on a main screen and one or more movement buttons (420) displayed on a portion of the main screen, wherein the main image and the movement button are linked to each url and when the main image or the movement button image is inputted, the main image and the movement button move to the corresponding url, so that an event page can be produced in a short time, thereby enabling efficient marketing of the event page.

5. 发明申请

US20100320086A1 FLEXIBLE BIOSENSOR AND MANUFACTURING METHOD FOR THE SAME 审中-公开
标题翻译：灵活的生物传感器及其制造方法
公开(公告)号：US20100320086A1
公开(公告)日：2010-12-23
申请号：US12779705
申请日：2010-05-13
申请人： Keonjae LEE , Sang Yong LEE , Seung Jun KIM , Hyeon Kyun YOO , Seok Jae LEE , Chi Won AHN , Jae Hong PARK , Tae Jung PARK , Sang Yup LEE
发明人： Keonjae LEE , Sang Yong LEE , Seung Jun KIM , Hyeon Kyun YOO , Seok Jae LEE , Chi Won AHN , Jae Hong PARK , Tae Jung PARK , Sang Yup LEE
IPC分类号： G01N27/26 , B05D5/12
CPC分类号： G01N33/5438
摘要： Provided are a flexible biosensor using a gold binding substance and a method for manufacturing the same.The flexible biosensor includes: a flexible substrate; a silicon substrate which is formed on the flexible substrate and on which source and drain regions doped with a first type impurity are formed with a predetermined gap; and source, drain and gate electrodes which are formed on the silicon substrate and comprise gold, wherein, on the gate electrode, a fused protein which is formed by fusion with a gold binding substance specifically binding to gold is immobilized. Since the biosensor is embodied on a flexible substrate, it may effectively overcome the limitation of the existing biosensor embodied on a silicon substrate.
摘要翻译：提供使用金结合物质的柔性生物传感器及其制造方法。柔性生物传感器包括：柔性基底; 形成在柔性基板上并在其上以预定间隙形成掺杂有第一类型杂质的源极和漏极区域的硅衬底; 以及形成在硅衬底上并包含金的源极，漏极和栅电极，其中在栅电极上固定通过与特异性结合金的金结合物质的融合而形成的融合蛋白。由于生物传感器体现在柔性基板上，所以可以有效地克服在硅衬底上体现的现有生物传感器的限制。

6. 发明申请

US20100317790A1 GRAPHENE COMPOSITE NANOFIBER AND PREPARATION METHOD THEREOF 有权
标题翻译：石墨复合纳米纤维及其制备方法
公开(公告)号：US20100317790A1
公开(公告)日：2010-12-16
申请号：US12712653
申请日：2010-02-25
申请人： Sung-Yeon JANG , Ho Seok PARK , Seong Mu JO , Dong Young KIM , Won Hi HONG , Sang Yup LEE , Tae Jung PARK , Bong Gill CHOI
发明人： Sung-Yeon JANG , Ho Seok PARK , Seong Mu JO , Dong Young KIM , Won Hi HONG , Sang Yup LEE , Tae Jung PARK , Bong Gill CHOI
IPC分类号： C08K3/04 , B29C47/00
CPC分类号： D01F9/14 , B82Y30/00 , B82Y40/00 , C01B32/194 , C01B32/23 , D01D5/0069 , D01D5/0076 , D01D5/14 , D01F1/10
摘要： Disclosed are a graphene composite nanofiber and a preparation method thereof. The graphene composite nanofiber is produced by dispersing graphenes to at least one of a surface and inside of a polymer nanofiber or a carbon nanofiber having a diameter of 1˜1000 nm, and the graphenes include at least one type of monolayer graphenes, and multilayer graphenes having a thickness of 10 nm or less. The graphene composite nanofiber can be applied to various industrial fields, e.g., a light emitting display, a micro resonator, a transistor, a sensor, a transparent electrode, a fuel cell, a solar cell, a secondary cell, and a composite material, owing to a unique structure and property of graphene.
摘要翻译：公开了一种石墨烯复合纳米纤维及其制备方法。石墨烯复合纳米纤维通过将石墨烯分散在聚合物纳米纤维或直径为1〜1000nm的碳纳米纤维的表面和内部的至少一个中，并且所述石墨烯包括至少一种类型的单层石墨烯和多层石墨烯厚度为10nm以下。石墨烯复合纳米纤维可以应用于各种工业领域，例如发光显示器，微谐振器，晶体管，传感器，透明电极，燃料电池，太阳能电池，二次电池和复合材料，由于石墨烯的独特结构和性质。

7. 发明申请

US20100286381A1 DIAGNOSTIC METHOD FOR CANCER CHARACTERIZED IN THE DETECTION OF THE DELETION OF G-CSF EXON 3 审中-公开
标题翻译：检测G-CSF外显子3检测中的癌症诊断方法
公开(公告)号：US20100286381A1
公开(公告)日：2010-11-11
申请号：US12830085
申请日：2010-07-02
申请人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

8. 发明申请

US20120246586A1 MOBILE TERMINAL AND OBJECT CHANGE SUPPORT METHOD FOR THE SAME 审中-公开
标题翻译：移动终端和对象更改支持方法
公开(公告)号：US20120246586A1
公开(公告)日：2012-09-27
申请号：US13417489
申请日：2012-03-12
申请人： Nam Jo HEO , Sang Yup LEE , Yong Seok KIM , Kwang Sub SON
发明人： Nam Jo HEO , Sang Yup LEE , Yong Seok KIM , Kwang Sub SON
IPC分类号： G06F3/048
CPC分类号： G06F3/0488 , G06F3/0481 , G06F3/04817 , G06F3/04845 , G06F3/04886
摘要： A mobile terminal and a method of supporting an object change for the same are provided. The mobile terminal includes a display unit for outputting at least one object, and a control unit for controlling at least one of directly displaying, in response to a signal for changing the output object into a second object having a similar function but being of a different type than the output object, the second object on the display unit without a screen transition, and for outputting, in response to a signal for changing the output object into a second object having a similar function but being of a different type than the output object, a guide frame on the display unit so as to facilitate change of the output object without a screen transition.
摘要翻译：提供了移动终端和支持其对象改变的方法。移动终端包括用于输出至少一个对象的显示单元，以及控制单元，用于控制响应于将输出对象改变成具有相似功能但具有不同的功能的第二对象的信号的至少一个类型比输出对象，显示单元上没有屏幕转换的第二对象，并且用于响应于用于将输出对象改变为具有类似功能但是与输出对象不同类型的第二对象的信号，在显示单元上的引导框架，以便于在没有屏幕转换的情况下改变输出对象。

9. 发明申请

US20120118827A1 METHOD OF CONCENTRATING LOW TITER FERMENTATION BROTHS USING FORWARD OSMOSIS 审中-公开
标题翻译：使用前瞻性OSMOSIS浓缩低温发酵菌的方法
公开(公告)号：US20120118827A1
公开(公告)日：2012-05-17
申请号：US13294040
申请日：2011-11-10
申请人： Ho Nam CHANG , Jin-dal-rae CHOI , Sang Yup LEE , Jeong Wook LEE , Sunwon PARK , Woohyun KIM , Tae-woo KIM , Kwonsu JUNG , Gwon-woo PARK , Wanji KONG , Sung Gap IM
发明人： Ho Nam CHANG , Jin-dal-rae CHOI , Sang Yup LEE , Jeong Wook LEE , Sunwon PARK , Woohyun KIM , Tae-woo KIM , Kwonsu JUNG , Gwon-woo PARK , Wanji KONG , Sung Gap IM
IPC分类号： B01D61/00
CPC分类号： B01D61/002 , B01D2315/14 , C12M47/10
摘要： The present invention relates to a method for concentrating law titer fermentation broth, and more particularly to a method for concentrating a fermentation broth using forward osmosis. The method comprises: introducing the fermentation broth and an osmolyte into a feed chamber and a draw chamber, respectively, which are included in a concentration system and are divided from each other by a forward osmosis membrane, and subjecting the introduced fermentation broth to forward osmosis, thereby concentrating the fermentation broth in the feed chamber. The method can maximize the concentration of the low titer fermentation broth while minimizing energy consumption and operating cost, and thus can contribute to the industrialization of new technology.
摘要翻译：本发明涉及一种浓缩法律滴定发酵液的方法，更具体地涉及使用正向渗透浓缩发酵液的方法。该方法包括：将发酵液和渗透剂分别引入到包含在浓缩体系中的进料室和萃取室中，并通过正向渗透膜彼此分离，并使引入的发酵液向前渗透从而将发酵液浓缩在进料室中。该方法可以最大限度地降低低滴度发酵液的浓度，同时最大限度地降低能耗和运行成本，从而有助于新技术的产业化。

10. 发明申请

US20100167956A1 DNA CHIP FOR DETECTION OF ESCHERICHIA COLI 审中-公开
标题翻译：用于检测ESCHERICHIA COLI的DNA芯片
公开(公告)号：US20100167956A1
公开(公告)日：2010-07-01
申请号：US12522390
申请日：2007-01-08
申请人： Sang Yup LEE , Seung Min YOO , So Youn SHIN , Ki-Chang Keum , Nae-Choon YOO , Won-Min YOO , June-Myung KIM , Jun Yong CHOI
发明人： Sang Yup LEE , Seung Min YOO , So Youn SHIN , Ki-Chang Keum , Nae-Choon YOO , Won-Min YOO , June-Myung KIM , Jun Yong CHOI
IPC分类号： C40B40/08 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present invention relates to nucleic acid probes specific to E. coli, which is useful for detecting and identifying E. coli in a biological sample. More particularly, the present invention relates to a DNA chip for detecting and identifying E. coli, on which nucleic acid probes derived from 23 S rRNA gene of E. coli are immobilized. The application of the DNA chip according to the present invention allows time-saving and accurate diagnosis of bacterial infection compared with the conventional of bacterial culture methods. In addition, it is not affected by antibiotics addition in clinical practice, thus leading to more accurate diagnosis.
摘要翻译：本发明涉及对大肠杆菌特异性的核酸探针，其可用于检测和鉴定生物样品中的大肠杆菌。更具体地，本发明涉及用于检测和鉴定大肠杆菌的DNA芯片，其上固定有大肠杆菌23S rRNA基因的核酸探针。根据本发明的DNA芯片的应用与常规的细菌培养方法相比，可以节省细菌感染的准确诊断。此外，临床实践中不受抗生素添加的影响，从而导致更准确的诊断。

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