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1. 发明申请

US20090260971A1 METHOD OF PREPARING FLUOROALKYL COMPOUNDS USING RADIATION 审中-公开
标题翻译：使用辐射制备氟代醇化合物的方法
公开(公告)号：US20090260971A1
公开(公告)日：2009-10-22
申请号：US12244536
申请日：2008-10-02
申请人： Sang Wook Kim , Min Goo Hur , Seung Dae Yang , Kook Hyun Yu
发明人： Sang Wook Kim , Min Goo Hur , Seung Dae Yang , Kook Hyun Yu
IPC分类号： B01J19/12
CPC分类号： C07C303/30 , C07B59/001 , C07B2200/05 , C07C29/62 , C07C309/73 , C07C31/38
摘要： Disclosed herein is a method of preparing a fluoroalkyl compound using radiation, including: mixing an alkyl compound having a leaving group with tetrabutylammonium fluoride (TBAF) in the presence of a reaction solvent at room temperature to form a mixed solution (step 1); and applying radiation to the mixed solution while stirring it to prepare a fluoroalkyl compound (step 2). The method of preparing a fluoroalkyl compound using radiation is advantageous in that fluoroalkyl compounds can be easily prepared in a short reaction time at room temperature, in that the method is safe because it is not required to use fluorine gas, which is harmful to the human body, in that the method can be usefully used to prepare fluoroalkyl compounds because the yield of fluoroalkyl compounds obtained using the method is higher than when using conventional SN2 reaction methods, and in that fluorine 18F, which is a radioactive isotope, can be easily introduced into alkyl compounds.
摘要翻译：本文公开了使用辐射制备氟烷基化合物的方法，其包括：在室温下，在反应溶剂存在下，将具有离去基团的烷基化合物与四丁基氟化铵（TBAF）混合以形成混合溶液（步骤1）。并在搅拌下对混合溶液施加辐射以制备氟烷基化合物（步骤2）。使用辐射制备氟代烷基化合物的方法的优点在于，氟烷基化合物可以在室温下在短的反应时间内容易地制备，因为该方法是安全的，因为不需要使用对人体有害的氟气因为该方法可用于制备氟烷基化合物，因为使用该方法获得的氟烷基化合物的产率高于使用常规SN2反应方法时的产率，并且可以容易地引入作为放射性同位素的氟18F 转化成烷基化合物。

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