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1. 发明授权

US09284588B2 Promoters for expressing genes in a fungal cell 有权
标题翻译：在真菌细胞中表达基因的启动子
公开(公告)号：US09284588B2
公开(公告)日：2016-03-15
申请号：US13885145
申请日：2011-12-15
申请人： Sandra Merino , Debbie Yaver
发明人： Sandra Merino , Debbie Yaver
IPC分类号： C12P21/00 , C12N9/08 , C12N15/80
CPC分类号： C12N15/80 , C12N9/0065 , C12P21/00
摘要： The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.
摘要翻译：本发明涉及分离的启动子和构建体，载体和包含与编码多肽的多核苷酸可操作地连接的此类启动子的真菌宿主细胞。本发明还涉及生产这种多肽的方法。

2. 发明申请

US20130288298A1 Promoters for Expressing Genes in a Fungal cell 有权
标题翻译：在真菌细胞中表达基因的启动子
公开(公告)号：US20130288298A1
公开(公告)日：2013-10-31
申请号：US13885145
申请日：2011-12-15
申请人： Sandra Merino , Debbie Yaver
发明人： Sandra Merino , Debbie Yaver
IPC分类号： C12P21/00
CPC分类号： C12N15/80 , C12N9/0065 , C12P21/00
摘要： The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.
摘要翻译：本发明涉及分离的启动子和构建体，载体和包含与编码多肽的多核苷酸可操作地连接的此类启动子的真菌宿主细胞。本发明还涉及生产这种多肽的方法。

3. 发明授权

US09969993B2 Filamentous fungal host cells and methods of recombinantly producing proteins 有权
公开(公告)号：US09969993B2
公开(公告)日：2018-05-15
申请号：US12130838
申请日：2008-05-30
申请人： Sandra Merino , Keith McFarland , Joel Cherry , Sarah Teter
发明人： Sandra Merino , Keith McFarland , Joel Cherry , Sarah Teter
IPC分类号： A61K38/00 , C12N9/42 , C07K14/37 , C12P7/10 , C12P19/14 , C12P19/16
CPC分类号： C12N9/2437 , C07K14/37 , C12N9/2445 , C12P7/10 , C12P19/14 , C12P19/16 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions.

4. 发明授权

US08986974B2 Methods for producing polypeptidies in protease-deficient mutants of trichoderma 有权
标题翻译：在木霉蛋白酶缺陷突变体中产生多肽的方法
公开(公告)号：US08986974B2
公开(公告)日：2015-03-24
申请号：US13516433
申请日：2010-12-17
申请人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
发明人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
IPC分类号： C12N1/15 , C12N9/58 , C12N15/80 , C12P21/02
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及母体木霉菌株的突变体，其包含编码多肽的多核苷酸和选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶抑制蛋白酶基因的一个或多个（若干）基因，如丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（若干）基因被修饰，使得突变菌株缺乏产生一种或多种（若干）选自与母本木霉属菌株相比，分别在相同的条件下培养时由第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二天冬氨酸蛋白酶组成的组条件。本发明还涉及在这种突变体中产生多肽的方法和用于产生这种突变体的方法。

5. 发明申请

US20060218671A1 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same 有权
标题翻译：具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US20060218671A1
公开(公告)日：2006-09-28
申请号：US11327821
申请日：2006-01-06
申请人： Kimberly Brown , Paul Harris , Alfredo Lopez De Leon , Sandra Merino
发明人： Kimberly Brown , Paul Harris , Alfredo Lopez De Leon , Sandra Merino
IPC分类号： A01H5/00 , C11D3/386 , C07H21/04 , C12P21/06 , C12P19/02 , C12N9/42 , C12N15/82 , C12N5/04
CPC分类号： C12Y302/01091 , C11D3/38636 , C12N9/2437
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

6. 发明申请

US20050176571A1 Centrifuge with removable core for scalable centrifugation 有权
标题翻译：离心机可移动核心进行可扩展的离心
公开(公告)号：US20050176571A1
公开(公告)日：2005-08-11
申请号：US10497417
申请日：2002-11-25
申请人： Sandra Merino , Steven Dalessio , Robin Otten
发明人： Sandra Merino , Steven Dalessio , Robin Otten
IPC分类号： B04B1/00 , B04B5/04 , B04B7/08 , B04B13/00 , B04B7/12
CPC分类号： B04B5/10 , B04B1/00 , B04B5/0442 , B04B7/08 , B04B7/12 , B04B13/00 , B04B2005/0464
摘要： The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product. A second rotor assembly of said plurality of rotor assemblies includes a second core having a second core configuration which is contained with a rotor housing of the second rotor assembly to define a second volume capacity of such that product passing through the second rotor assembly having the second volume capacity during rotation of the second rotor assembly in the centrifuge apparatus achieves a second particle separation of the product. It is observed that the second particle separation is a linear change with respect to the first particle separation.
摘要翻译：本发明涉及一种离心机装置。离心机设备可根据待分离的产品在某些预定参数下操作并且可与多个转子组件一起使用。例如，所述多个转子组件的第一转子组件包括具有第一芯构造的第一芯体，该第一芯体构造包含在第一转子组件的转子壳体内，以限定第一体积容积，使得产品通过第一转子组件在离心机设备中的第一转子组件的旋转期间具有第一体积容量实现了产品的第一颗粒分离。所述多个转子组件的第二转子组件包括具有第二芯构造的第二芯体，该第二芯体构造包含有第二转子组件的转子壳体，以限定第二体积容积，使得穿过具有第二转子组件的第二转子组件的产品在离心机设备中的第二转子组件旋转期间的体积容量实现了产品的第二颗粒分离。观察到第二颗粒分离是相对于第一颗粒分离的线性变化。

7. 发明申请

US20100041536A9 Centrifuge with removable core for scalable centrifugation 有权
公开(公告)号：US20100041536A9
公开(公告)日：2010-02-18
申请号：US10497417
申请日：2002-11-25
申请人： Sandra Merino , Steven Dalessio , Robin Otten
发明人： Sandra Merino , Steven Dalessio , Robin Otten
IPC分类号： B04B7/12
CPC分类号： B04B5/10 , B04B1/00 , B04B5/0442 , B04B7/08 , B04B7/12 , B04B13/00 , B04B2005/0464
摘要： The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product. A second rotor assembly of said plurality of rotor assemblies includes a second core having a second core configuration which is contained with a rotor housing of the second rotor assembly to define a second volume capacity of such that product passing through the second rotor assembly having the second volume capacity during rotation of the second rotor assembly in the centrifuge apparatus achieves a second particle separation of the product. It is observed that the second particle separation is a linear change with respect to the first particle separation.

8. 发明申请

US20080299613A1 Compositions for degrading cellulosic material 有权
标题翻译：降解纤维素材料的组合物
公开(公告)号：US20080299613A1
公开(公告)日：2008-12-04
申请号：US12130838
申请日：2008-05-30
申请人： Sandra Merino , Keith McFarland , Joel Cherry , Sarah Teter
发明人： Sandra Merino , Keith McFarland , Joel Cherry , Sarah Teter
IPC分类号： C12P21/04 , C12N1/14 , C12N9/42 , C12P1/00
CPC分类号： C12N9/2437 , C07K14/37 , C12N9/2445 , C12P7/10 , C12P19/14 , C12P19/16 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions.
摘要翻译：本发明涉及用于降解或转化含纤维素材料的纤维素分解组合物以及制备和使用该组合物的方法。

9. 发明授权

US07220565B2 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same 有权
标题翻译：具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US07220565B2
公开(公告)日：2007-05-22
申请号：US11327821
申请日：2006-01-06
申请人： Kimberly Brown , Paul Harris , Alfredo Lopez De Leon , Sandra Merino
发明人： Kimberly Brown , Paul Harris , Alfredo Lopez De Leon , Sandra Merino
IPC分类号： C12N9/42 , C12N1/20 , C12P19/02 , C12P21/06 , C12P19/34 , C11D3/00 , C07H21/04
CPC分类号： C12Y302/01091 , C11D3/38636 , C12N9/2437
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

10. 发明申请

US20060258524A1 Centrifuge with removable core for scalable centrifugation 有权
公开(公告)号：US20060258524A1
公开(公告)日：2006-11-16
申请号：US11342390
申请日：2006-01-30
申请人： Sandra Merino , Steven Dalessio , Robin Otten
发明人： Sandra Merino , Steven Dalessio , Robin Otten
IPC分类号： B04B7/12
CPC分类号： B04B5/10 , B04B1/00 , B04B5/0442 , B04B7/08 , B04B7/12 , B04B13/00 , B04B2005/0464
摘要： The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product. A second rotor assembly of said plurality of rotor assemblies includes a second core having a second core configuration which is contained with a rotor housing of the second rotor assembly to define a second volume capacity such that product passing through the second rotor assembly having the second volume capacity during rotation of the second rotor assembly in the centrifuge apparatus achieves a second particle separation of the product. It is observed that the second particle separation is a linear change with respect to the first particle separation.

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