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1. 发明申请

US20060225550A1 Control system method of operation for electric power tools 审中-公开
标题翻译：电动工具控制系统运行方式
公开(公告)号：US20060225550A1
公开(公告)日：2006-10-12
申请号：US11385067
申请日：2006-03-21
申请人： Sam Walters , Michael Powell
发明人： Sam Walters , Michael Powell
IPC分类号： B23D45/02
CPC分类号： G07C9/00142 , B27B5/29 , G07C1/10 , Y10T83/121 , Y10T83/207 , Y10T83/7763
摘要： A control system for electric power tools to automatically control the operation of the machine and related systems. The control system includes a keypad for restricting operation of the machine to authorized users armed with knowledge of assigned access codes, while providing automated control of various machine components and systems. The system further includes electrical power output control for controlling power supplied to the machine and associated systems, a timer to limit operating time, and audio/visual warning beacons. Upon entering a security code, the control system functions to activate the machine by providing electrical power to any primary and secondary electric motors, lighting systems, power supply outlets, dust collection systems, and audio or visual safety warning systems. An internal timer disconnects the electrical power supply after a predetermined amount of time, e.g. 5 minutes, thereby insuring that the machine is not inadvertently left on.
摘要翻译：一种用于电动工具的控制系统，用于自动控制机器及相关系统的运行。该控制系统包括用于将机器的操作限制在具有分配的访问代码知识的授权用户的键盘上，同时提供对各种机器部件和系统的自动控制。该系统还包括用于控制供应给机器和相关系统的功率的电力输出控制，限制操作时间的定时器和音频/视觉警告信标。在输入安全代码后，控制系统通过向任何一次和二次电动机，照明系统，电源插座，灰尘收集系统以及音频或视觉安全警告系统提供电力来起作用来激活机器。内部定时器在预定的时间量之后断开电源，例如， 5分钟，从而确保机器不会无意中留下。

2. 发明授权

US09435797B2 Detection of autoantibodies reactive with pancreatic islet cell antigenic molecules and/or insulin 有权
标题翻译：检测与胰岛细胞抗原分子和/或胰岛素反应的自身抗体
公开(公告)号：US09435797B2
公开(公告)日：2016-09-06
申请号：US13412419
申请日：2012-03-05
申请人： Bernard Rees Smith , Jadwiga Furmaniak , Michael Powell
发明人： Bernard Rees Smith , Jadwiga Furmaniak , Michael Powell
IPC分类号： G01N33/573 , G01N33/538 , G01N33/543 , G01N33/564
CPC分类号： G01N33/564 , C12Y301/01048 , C12Y301/03048 , C12Y401/01015 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/573 , G01N2333/916 , G01N2333/988 , G01N2496/00 , G01N2800/042
摘要： A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogs, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilized to a solid phase, the second is labeled.
摘要翻译：一种筛选从动物受试者获得的分析物自身抗体与一种或多种选自胰岛细胞抗原分子（GAD，1A2）和胰岛素或一种或多种变体，类似物，衍生物或片段的抗原分子反应的体液样品的方法以及用于这种方法的试剂盒。加入样品后，一个或多个包含第一个来源的抗原分子的复合物 - 分析自身抗体 - 第二个来源的非抗原分子！将第一来源的抗原分子固定在固相上，第二个被标记。

3. 发明授权

US08669226B2 Antimicrobial compositions and methods of use thereof 有权
标题翻译：抗微生物组合物及其使用方法
公开(公告)号：US08669226B2
公开(公告)日：2014-03-11
申请号：US13267977
申请日：2011-10-07
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Martin Neville Shelton
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Martin Neville Shelton
IPC分类号： A61K38/10 , A61K38/04 , A61K38/00 , A61K38/17 , C07K7/00 , C07K7/06 , C07K7/08 , A61P31/04 , A61P31/00 , A01N63/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译：本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。

4. 发明授权

US08551943B2 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles 有权
标题翻译：通过抑制微粒分泌来治疗辅助剂或癌症的组合物和方法
公开(公告)号：US08551943B2
公开(公告)日：2013-10-08
申请号：US13621597
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61P31/12 , A61P31/18 , A61K39/00 , A61K39/21 , C12N5/22
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译：公开了抑制细胞释放微粒的新型肽。肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。

5. 发明授权

US08476237B2 Compositions and methods for treating cancer by inhibiting the secretion of microparticles 有权
标题翻译：通过抑制微粒分泌来治疗癌症的组合物和方法
公开(公告)号：US08476237B2
公开(公告)日：2013-07-02
申请号：US13621618
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61K38/00 , A61K39/00 , A61K35/12 , A61P35/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and methods for treating tumors using the novel peptides.
摘要翻译：公开了抑制细胞释放微粒的新型肽。还公开了编码肽的多核苷酸，携带多核苷酸的表达载体和使用新肽治疗肿瘤的方法。

6. 发明申请

US20120225955A1 DETECTION OF AUTOANTIBODIES REACTIVE WITH PANCREATIC ISLET CELL ANTIGENIC MOLECULES AND/OR INSULIN 审中-公开
标题翻译：检测与胰岛细胞抗原分子和/或胰岛素反应的自身抗体
公开(公告)号：US20120225955A1
公开(公告)日：2012-09-06
申请号：US13412419
申请日：2012-03-05
申请人： Bernard Rees SMITH , Jadwiga Furmaniak , Michael Powell
发明人： Bernard Rees SMITH , Jadwiga Furmaniak , Michael Powell
IPC分类号： G01N33/566 , A61K35/00
CPC分类号： G01N33/564 , C12Y301/01048 , C12Y301/03048 , C12Y401/01015 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/573 , G01N2333/916 , G01N2333/988 , G01N2496/00 , G01N2800/042
摘要： A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.
摘要翻译：一种筛选从动物受试者获得的分析物自身抗体与一种或多种选自胰岛细胞抗原分子（GAD，1A2）和胰岛素或一种或多种变体，类似物，衍生物或片段的抗原分子反应的体液样品的方法以及用于这种方法的试剂盒。加入样品后，加入一种或多种复合物，其中包含“第一个来源的抗原分子！将第一来源的抗原分子固定在固相上，第二个被标记。

7. 发明授权

US08075902B2 Diagnosis and treatment of cancer related to human dormancy 有权
标题翻译：与人类休眠相关的癌症的诊断和治疗
公开(公告)号：US08075902B2
公开(公告)日：2011-12-13
申请号：US12006462
申请日：2008-01-02
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： G01N33/78 , C07G13/00 , C07G11/00 , A01N59/12 , A61K31/00
CPC分类号： A61K45/06 , A61K31/12 , A61K31/13 , A61K31/19 , A61K31/20 , A61K31/35 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/4965 , A61K31/522 , A61K31/65 , A61K31/70 , A61K31/715 , A61K31/727 , A61K2300/00
摘要： New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
摘要翻译：用于诊断的新装置和方法以及用于治疗癌症的组合物和方法使用可逆转休眠和休眠途径的抗微生物剂和试剂的组合。我们意外地发现令人惊讶的是，低剂量的抗冬眠化合物可以在体外基本上抑制癌细胞生长，并且可以成功地治疗癌症，包括转移性癌症。我们也意外地发现，抗微生物剂和抗HDS化合物可以以协同的方式增加癌细胞生长的抑制程度。我们得出结论，用抗微生物剂和抗HDS化合物的联合治疗可以有效治疗癌症患者。

8. 发明授权

US07811529B2 Hydrogen generation apparatus and method for using same 有权
标题翻译：氢发生装置及其使用方法
公开(公告)号：US07811529B2
公开(公告)日：2010-10-12
申请号：US10476015
申请日：2002-04-23
申请人： Michael Powell , Charles J. Call
发明人： Michael Powell , Charles J. Call
IPC分类号： B01J7/02
CPC分类号： C01B3/384 , B01J19/2475 , B01J19/249 , B01J2219/2453 , B01J2219/2458 , B01J2219/2459 , B01J2219/2462 , B01J2219/2465 , B01J2219/2475 , B01J2219/2479 , B01J2219/2481 , B01J2219/2485 , B01J2219/2486 , B01J2219/2487 , B01J2219/2495 , B01J2219/2497 , C01B3/047 , C01B3/323 , C01B3/501 , C01B2203/0233 , C01B2203/0405 , C01B2203/041 , C01B2203/042 , C01B2203/0465 , C01B2203/047 , C01B2203/048 , C01B2203/066 , C01B2203/0811 , C01B2203/0822 , C01B2203/0827 , C01B2203/0844 , C01B2203/0866 , C01B2203/0883 , C01B2203/1011 , C01B2203/1035 , C01B2203/1041 , C01B2203/1082 , C01B2203/1205 , C01B2203/1223 , C01B2203/1235 , C01B2203/1241 , C01B2203/1288 , C01B2203/146 , C01B2203/16 , C01B2203/1604 , H01M8/0612 , H01M8/0631 , Y02E60/364 , Y02P20/128
摘要： A compact hydrogen generator for use with fuel cells and other applications includes a hydrogen membrane reactor having a combustion chamber and a reaction chamber. The two chambers are have a fluid connection and a heat exchange relationship with one another. The hydrogen generation apparatus also includes a fuel supply, a fuel supply line for transporting fuel from the fuel supply to the reaction chamber, an oxygen supply, an oxygen supply line for transporting oxygen form the oxygen supply to the combustion chamber, as well as a tail gas supply line for transporting tail gas supply line for transporting tail gases form the reaction chamber, a combustion by-product line for transporting combustion by-products for the combustion chamber, and a reaction product line for transporting hydrogen from the reaction chamber.
摘要翻译：用于燃料电池和其它应用的小型氢气发生器包括具有燃烧室和反应室的氢膜反应器。两个腔室之间具有流体连接和热交换关系。氢气发生装置还包括燃料供给装置，用于将燃料从燃料供给输送到反应室的燃料供给管路，供氧装置，用于输送氧气的氧供给管路，形成向燃烧室供给的氧气，以及用于输送用于输送尾气的尾气供应管线的尾气供应管路形成反应室，用于输送用于燃烧室的燃烧副产物的燃烧副产物线，以及用于从反应室输送氢气的反应产物线。

9. 发明授权

US07581662B2 Multi-compartment spray dispenser with common pressurizer 有权
标题翻译：多间隔室喷雾器，带通用加压器
公开(公告)号：US07581662B2
公开(公告)日：2009-09-01
申请号：US11019073
申请日：2004-12-21
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： B65D83/00
CPC分类号： B05B9/0816 , B05B12/14 , B05B12/1472
摘要： A multi-compartment spray dispenser with common pressurizer includes a single container divided into four sub-chambers, each of which is separate from each of the other sub-chambers. Each sub-chamber has its own separate outlet. A pumping mechanism is common to the sub-chambers and causes pressurization of the sub-chambers simultaneously. When it is desired to dispense liquid from one of the sub-chambers, a hose connection is coupled to the hose connection on the container, thereby opening a flow path for liquid through a hose connected to the hose connector and a nozzle having an actuating valve. Should flow of liquid slow, it is easy to re-pressurize the sub-chamber through operation of the pumping mechanism.
摘要翻译：具有公共加压器的多室喷雾分配器包括分成四个子室的单个容器，每个子室与每个其它子室分开。每个子室都有自己独立的出口。泵送机构对于子室是共同的，并且同时引起子室的加压。当希望从一个子室中分配液体时，软管连接件连接到容器上的软管连接件上，从而通过连接到软管连接器的软管打开液体流动路径，并且具有致动阀。液体流动缓慢时，通过泵送机构的操作，容易对副室重新加压。

10. 发明授权

US07485298B2 Diagnosis and treatment of human dormancy-related sequellae 有权
标题翻译：人类休眠相关后遗症的诊断和治疗
公开(公告)号：US07485298B2
公开(公告)日：2009-02-03
申请号：US11206564
申请日：2005-08-18
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： A61K39/00 , A61K38/22 , A61K38/27 , C12Q1/00
CPC分类号： G01N33/6896 , G01N33/78 , Y02A50/57
摘要： New methods for diagnosis and treatment of human dormancy syndrome-related sequellae are provided. Human dormancy syndrome (HDS) is characterized by elevated serum ratio of rT3/fT3 compared to a population of normal subjects. HDS includes fibromyalgia, chronic fatigue, cancer, autoimmune disease, obesity and related dormancy conditions. Dormancy and HDS-related sequellae are imposed on humans by infection with lipopolysaccharide (LPS; or endotoxin)-producing organisms, especially those that are intracellular and those that create antigens that stimulate the TLR pathways. In such instances, the elimination or neutralization of the LPS signal along with the infectious source is required to impact the sequellae of HDS. Treatment includes use of novel and non-obvious doses of antibiotics, optionally including agents that decrease the adverse effects of endotoxin.
摘要翻译：提供了用于诊断和治疗人类休眠综合征相关后遗症的新方法。人类休眠综合征（HDS）的特征在于rT3 / fT3与正常人群的血清比例升高。 HDS包括纤维肌痛，慢性疲劳，癌症，自身免疫性疾病，肥胖和相关的休眠状况。休眠和HDS相关的后遗症通过感染脂多糖（LPS或内毒素）生产的生物体，特别是细胞内的生物体和那些产生刺激TLR途径的抗原的生物体对人体施加。在这种情况下，需要消除或中和LPS信号以及感染源来影响HDS的后遗症。治疗包括使用新颖和非明显剂量的抗生素，任选地包括降低内毒素的不利影响的试剂。

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