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1. 发明授权

US09645160B2 Automatic analysis device 有权
公开(公告)号：US09645160B2
公开(公告)日：2017-05-09
申请号：US14116177
申请日：2012-05-09
申请人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
发明人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
IPC分类号： G01N35/02 , G01N21/51 , G01N21/82 , G01N21/47 , G01N35/04
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.

2. 发明申请

US20140140890A1 AUTOMATIC ANALYSIS DEVICE 有权
标题翻译：自动分析装置
公开(公告)号：US20140140890A1
公开(公告)日：2014-05-22
申请号：US14116177
申请日：2012-05-09
申请人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
发明人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
IPC分类号： G01N35/02
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.
摘要翻译：自动分析装置测量作为反应过程数据的散射光量的时间序列数据，并且从光量的变化定量地确定分析物的浓度。自动分析装置具有从通过使用多个不同角度的光接收器的测量获得的反应过程数据中选择要用于定量确定的反应过程数据的功能。作为使用该功能的结果，从根据分析物的浓度以不同角度通过使用多个光接收器的测量获得的反应过程数据中选择数据，以及在灵敏度的情况下是否优先考虑高灵敏度优先或动态范围，并显示定量确定的结果。

3. 发明授权

US09664678B2 Automated analyzer and analyzing method 有权
公开(公告)号：US09664678B2
公开(公告)日：2017-05-30
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N21/51 , G01N33/543 , G01N21/82 , G01N35/02 , G01N21/47 , G01N35/04
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.

4. 发明申请

US20140220705A1 AUTOMATED ANALYZER AND ANALYZING METHOD 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US20140220705A1
公开(公告)日：2014-08-07
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.
摘要翻译：使用测量散射光的方法，分析仪提供适合于使用高灵敏度进行乳胶免疫测定的试剂的条件。使用波长在0.65〜0.75μm范围内的照射光，从反应溶液产生的散射光以相对于照射方向为15°〜35°的受光角度被接受反应容器该试剂含有平均峰值粒径为0.3μm〜0.43μm的胶乳粒子，抗体被致敏。反应溶液含有胶乳颗粒，其浓度为具有0.7μm波长的照射光的吸光度为0.25atm至1.10abs，以及由胶乳颗粒通过抗原凝集而引起的散射光量的变化样品被测量和量化。

5. 发明授权

US08852511B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08852511B2
公开(公告)日：2014-10-07
申请号：US13382316
申请日：2010-07-05
申请人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
发明人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC分类号： G01N33/00 , G01N21/51
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
摘要翻译：适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。

6. 发明申请

US20060039823A1 Chemical analysis apparatus 审中-公开
标题翻译：化学分析仪
公开(公告)号：US20060039823A1
公开(公告)日：2006-02-23
申请号：US11204344
申请日：2005-08-16
申请人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
发明人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
IPC分类号： G01N35/00
CPC分类号： G01N35/1016 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2300/0654 , B01L2300/0867 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N2035/00158 , G01N2035/00237 , G01N2035/102
摘要： A chemical analysis apparatus is equipped with analysis sections having openings, means for supplying samples or reagents from the openings, means for combining and mixing samples with reagents to obtain droplets as liquids to be measured, and means for measuring the physical properties of the liquids to be measured during reaction or after completion of reaction. Furthermore, plate members are provided facing each other in analysis sections and a plurality of electrodes are provided on the plate member faces that face each other. Voltage is applied from the plurality of electrodes to the droplets of the samples and the reagents.
摘要翻译：化学分析装置配备有具有开口的分析部分，用于从开口供应样品或试剂的装置，用于将样品与试剂混合并混合以获得待测量液体的液滴的装置，以及用于测量液体的物理性质的装置在反应期间或反应完成后测量。此外，在分析部分中彼此面对地设置板构件，并且在彼此相对的板构件面上设置多个电极。电压从多个电极施加到样品和试剂的液滴。

7. 发明申请

US20060097155A1 Substrate for transporting liquid, a system for analysis and a method for analysis 有权
标题翻译：用于输送液体的基材，分析系统和分析方法
公开(公告)号：US20060097155A1
公开(公告)日：2006-05-11
申请号：US11258230
申请日：2005-10-26
申请人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： H01J49/00
CPC分类号： G01N21/253 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0654 , B01L2300/0816 , B01L2300/0845 , B01L2300/089 , B01L2400/0427 , G01N35/08 , Y10T436/2575
摘要： Conventional liquid transport substrates having a fluid channel formed along an array of electrodes have a problem in which throughput decreases, depending on driving conditions. In order to avoid two-way passage in a fluid channel from the inlet to a measuring section and a fluid channel from the measuring section to the outlet, the measuring section is located in the middle of the fluid channel connecting the inlet and the outlet, so that manipulation from the inlet to the outlet takes place in one direction on the substrate. Even when analyzing a large number of sample droplets, by transport of the droplets substantially in one direction, it is possible to complete measurement in a short time.
摘要翻译：具有沿着电极阵列形成的流体通道的常规液体输送基板具有根据驱动条件的生产率下降的问题。为了避免从入口到测量部分的流体通道和从测量部分到出口的流体通道的双向通道，测量部分位于连接入口和出口的流体通道的中间，使得从入口到出口的操作在基板上沿一个方向发生。即使当分析大量的样品液滴时，通过基本上沿一个方向输送液滴，可以在短时间内完成测量。

8. 发明申请

US20120282139A1 BLOOD COAGULATION ANALYZER 有权
标题翻译：血液凝聚分析仪
公开(公告)号：US20120282139A1
公开(公告)日：2012-11-08
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

9. 发明授权

US07342662B2 Sample analyzer 失效
标题翻译：样品分析仪
公开(公告)号：US07342662B2
公开(公告)日：2008-03-11
申请号：US11132291
申请日：2005-05-19
申请人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： G01N21/00
CPC分类号： G01N21/3151 , G01N21/5907
摘要： The adverse effect on measurement accuracy brought about by the transmission of light beams through portions of a liquid sample with different concentrations, i.e., a concentration distribution in the vertical direction of a container, is prevented by using semiconductor light sources of two different types with different wavelengths. The semiconductor light sources (2, 4) of two different types are housed in the same package (5) such that a detector (9) can capture the light beams emitted by the light sources after their optical axes have intersected with one another. The multiple light beams can be thus caused to pass through portions with substantially the same concentration and therefore can be detected without being influenced by the difference in concentration of the sample in the container.
摘要翻译：通过使用具有不同浓度的液体样品的一部分（即，容器的垂直方向上的浓度分布），通过使用具有不同浓度的两种不同类型的半导体光源来传输光束所产生的对测量精度的不利影响波长。两种不同类型的半导体光源（2,4）被容纳在相同的封装（5）中，使得检测器（9）在光轴彼此相交之后能够捕获由光源发射的光束。因此，可以使多个光束通过具有基本相同浓度的部分，因此可以不受样品在容器中的浓度差的影响而被检测。

10. 发明授权

US09395298B2 Blood coagulation analyzer 有权
标题翻译：凝血分析仪
公开(公告)号：US09395298B2
公开(公告)日：2016-07-19
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N33/50 , G01N21/00 , G01N21/51 , G01N33/49 , G01N33/86 , G01N21/53 , G01N21/82 , G01N33/18
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

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