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    • 5. 发明申请
    • NOVEL USE OF ERYTHROID DIFFERENTIATION REGULATOR 1 AS AN AGENT FOR TREATING CANCER
    • 艾滋病毒分化调节剂1作为治疗癌症的药物的新用途
    • US20130217635A1
    • 2013-08-22
    • US13637155
    • 2011-03-23
    • Dae Ho ChoSa Ik BangJeong Min ParkMin Kyung JungHa Rum LeeYoo Rim ParkSeung Beom ParkJuah SonYoun Kyung Houh
    • Dae Ho ChoSa Ik BangJeong Min ParkMin Kyung JungHa Rum LeeYoo Rim ParkSeung Beom ParkJuah SonYoun Kyung Houh
    • A61K38/17
    • A61K38/1709A61K48/00C07K14/4702
    • The present invention relates to a novel use of erythroid differentiation regulator 1 (Erdr1) as an agent for treating cancer. More particularly, it relates to an use of Erdr1 or an expression vector including a polynucleotide encoding the same for preventing and inhibiting cancer metastasis, an use of Erdr1 or an expression vector including a polynucleotide encoding the same for preventing and treating cancer, an use of an antibody specific for Erdr1 for diagnosing cancer, or a method for screening agents for regulating cancer metastasis or cancer cells migration. The Erdr1 is negatively regulated by IL-18 expression and it suppresses migration, invasion and metastasis of cancer or tumor cell by expression of HSP90 and generation of ROI. And an Erdr1 recombinant protein promotes NK-cell killing activity against cancer cell. Accordingly, the Erdr1 and an expression vector comprising polynucleotide encoding the same and recombinant protein suppress cancer metastasis and bring an effect on activation of immune cells, and therefore can be useful for preventing, treating and diagnosing cancer.
    • 本发明涉及红细胞分化调节剂1(Erdr1)作为癌症治疗剂的新用途。 更具体地,涉及使用Erdr1或包含编码该多核苷酸的表达载体来预防和抑制癌症转移,使用Erdr1或包含编码该多核苷酸的表达载体来预防和治疗癌症的用途 用于诊断癌症的Erdr1特异性抗体或用于调节癌症转移或癌细胞迁移的筛选剂的方法。 Erdr1受IL-18表达负调控,通过HSP90的表达和ROI的产生抑制癌症或肿瘤细胞的迁移,侵袭和转移。 并且Erdr1重组蛋白促进针对癌细胞的NK细胞杀伤活性。 因此,Erdr1和包含编码该多核苷酸的多核苷酸的表达载体和重组蛋白抑制癌症转移并对免疫细胞的活化产生影响,因此可用于预防,治疗和诊断癌症。
    • 10. 发明授权
    • Portable display device
    • 便携式显示设备
    • US07751182B2
    • 2010-07-06
    • US11603097
    • 2006-11-22
    • Jeong Min Park
    • Jeong Min Park
    • G06F1/16
    • G06F1/1626G06F1/1656
    • A portable display device having improved durability includes: a mold frame mounting a first display panel and a back light assembly thereon; at least one printed circuit board, arranged on one surface of the mold frame, to supply control signals to the first display panel; and a protruding portion, surrounding and wrapping at least two sides of the at least one printed circuit board, and extending from at least two side surfaces of the mold frame, the at least two side surfaces of the mold frame being connected together.
    • 具有改进耐用性的便携式显示装置包括:在其上安装第一显示面板和背光组件的模架; 布置在所述模架的一个表面上的至少一个印刷电路板,用于向所述第一显示面板提供控制信号; 以及突出部分,围绕和包裹所述至少一个印刷电路板的至少两侧,并且从所述模架的至少两个侧表面延伸,所述模框的所述至少两个侧表面连接在一起。