专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US3734946A Serine derivatives 失效
标题翻译：丝氨酸衍生物
公开(公告)号：US3734946A
公开(公告)日：1973-05-22
申请号：US3734946D
申请日：1969-12-23
申请人： SQUIBB & SONS INC
发明人： ONDETTI M , PLUSCEC J , SHEEHAN J , JORPES J , MUTT V
IPC分类号： A61K38/00 , C07K14/595 , C07C125/06
CPC分类号： C07K14/595 , A61K38/00
摘要： NOVEL PEPTIDE AMIDES OF THE GENERAL FORMULA

R-MET-GLY-TRP-MET-ASP-PHE-NH2

WHEREIN R REPRESENTS L-ASPARTYL-O-SULFATE-L-TYROSYL, LASPARTYL-L-ARGINYL-L-ASPARTYL-O-SULFATE-L-TYROSYL, OR ISOLEUCYL-L-CERYL-L-ASPARTYL-L-ARGINYL-L-ASPARTYL - O-SULFATEL-TYROSYL, AND INTERMEDIATES IN THE PRODUCTION THEREOF. THE PEPTIDE AMIDES OF THIS INVENTION AS WELL AS THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVE BEEN FOUND TO POSSESS CHOLECYSTOKININ ACTIVITY.

2. 发明授权

US3839315A Novel peptides having cholecystokinin activity and intermediates therefor 失效
标题翻译：具有CHOLECYSTOKININ活性的新型肽及其中间体
公开(公告)号：US3839315A
公开(公告)日：1974-10-01
申请号：US72655868
申请日：1968-05-03
申请人： SQUIBB & SONS INC , SHEEHAN J , ONDETTI M , PLUSCEC J
发明人： ONDETTI M , JORPES J , MUTT V , PLUSCEC J , SHEEHAN J
IPC分类号： C07K1/113 , A61K38/00 , C07K5/072 , C07K5/113 , C07K7/06 , C07K14/595 , C07C103/52
CPC分类号： C07K5/06113 , A61K38/00 , C07K5/1021 , C07K14/595 , Y02P20/55
摘要： Novel peptide amides of the general formula
摘要翻译：通式R-Met-Gly-Trp-Met-Asp-Phe-NH 2的新型肽酰胺，其中R表示L-天冬氨酰基-O-硫酸盐-L-酪氨酰基，L-天冬氨酰基-L-精氨酰-L-天冬氨酰基-O 硫酸盐-L-酪氨酰基或异亮氨酰-L-丝氨酰-L-天冬氨酰-L-精氨酰-L-天冬氨酰基-O-硫酸盐-L-酪氨酰基，以及其生产中的中间体。已经发现本发明的肽酰胺及其药学上可接受的盐具有胆囊收缩素活性。

3. 发明授权

US3832337A Peptide enzyme inhibitors 失效
标题翻译：肽类酶抑制剂
公开(公告)号：US3832337A
公开(公告)日：1974-08-27
申请号：US25871472
申请日：1972-06-01
申请人： SQUIBB & SONS INC
发明人： ONDETTI M , PLUSCEC J
IPC分类号： A61K8/64 , A61K38/00 , A61Q17/04 , C07K5/04 , C07K5/113 , C07K5/117 , C07K7/04 , C07K7/06 , A61K27/00 , C07C103/52
CPC分类号： A61Q17/04 , A61K8/64 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/06
摘要： WHEREIN Y IS LYS OR GLU, 11. AN UNDECAPEPTIDE OF THE FORMULA

PGLU-TRP-PRO-ARG-PRO-V-PRO-W-ILE-PRO-PRO

WHEREIN V IS THR OR GLY AND W IS GLN OR GLU, 12 A. TRIDECAPEPTIDE OF THE FORMULA
PGLU-TRP-PRO-NLE-T-PRO-PRO

WHEREIN T IS AS DEFINED ABOVE,

PGLU-TRP-PRO-ARG-PRO-GLU-PHE-PRO-PRO, PGLU-TRP-PRO-ARG-PRO-LYS-PHE-ALA-PRO, PGLU-TRP-PRO-D-ARG-PRO-GLN-ILLE-PRO-PRO, PGLU-TRP-PRO-AGR-PRO-GLN-PHE-PRO-PRO, PGLU-TRP-PRO-GLY-PRO-GLU-ILE-PRO-PRO, PGLU-LYS-PHE-ALA-PRO-GLN-ILE-PRO-PRO,

10. A DECAPEPTIDE OF THE FORMULA

PGLU-K-TRP-PRO-ARG-PRO-GLN-ILE-PRO-PRO

WHEREIN K, P AND Q ARE AS DEFINED ABOVE,
PGLU-U-TRP-PRO-ARG-PRO-GLN-ILE-PRO-PRO

THE ENZYMATIC CONVERSION OF ANGIOSTENSIN I INTO ANTIOTENSIN II IS INHIBITED BY A PEPTIDE OR AN ACYLATED PEPTIDE HAVING ONE OF THE FOLLOWING AMINO ACID SEQUENCES:

1. AN ACYLATED TRIPEPTIDE OF THE FORMULA

CHC-PHE-ALA-PRO

WHEREIN CAC IS CHLOROACETIC ACID, 2. A TETRAPEPTIDE OF THE FORMULA

PGLU-TRP-ALA-PRO OR PGLU-LYS-TRP-PRO,

3. AN ACYLATED TETRAPEPTIDE OF THE FORMULA

DAC-FLY-ALA-PRO OR A-LYS-PHE-ALA-PRO

WHEREIN DAC IS DIAZOACETIC ACID, AND A IS CHLOROACETIC ACID, CYCLOBUTYLCARBOXYLIC ACID, CYCLOPENTYLCARBOXYLIC ACID OR CYCLOHEXYLCARBOXYLIC ACID, 4. A PENTAPEPTIDE OF THE FORMULA

PGLU-C-TRP-ALA-PRO

WHEREIN B IS LYS, NLE, GLU OR GIN,

PGLU-C-TRP-ALA-PRO

WHEREIN C IS NLE, HIS, ORN OR ARG, N''PGLU-LYS-TRP-ALA-PRO,PGLU-LYS-E-ALA-PRO WHEREIN E IS HIS , ILE, PRO, SER OR 3-AMINO-4-PHENYL-BUTYRIC ACID,

PGLU-LYS-PHE-F-PRO

WHEREIN G IS ALA, ASP OR GLU,

PGLU-LYS-PHE-ALA-G

WHEREIN W IS AS DEFINED ABOVE.

WHEREIN G IS ALA, ASP OR GLU,

PGLU-LYS-TRP-H

WHEREIN H IS ILE-PRO, THR-PRO-ALA-GLY OR ALA-SAR,

PGLU-TRP-PRO-J-PRO

WHEREIN J IS HIS, LYS OR GLY, 5. AN ACYLATED PENTAPEPTIDE OF THE FORMULA

DAC-GLY-GLY-PHE-ALA-PRO

WHEREIN DAC IS DIAZOACETIC ACID, 6. A HEXAPEPTIDE OF THE FORMULA

PGLU-LYS-PHE-ALA-PRO-PRO, PGLU-K-TRP-PRO-ARG-PRO

WHEREIN K IS ASN, NLE OR SER,

PGLU-NLE-TRP-PRO-L-PRO

WHEREIN L IS HIS OR GLY,

PGLU-ASN-TRP-PRO-M-PRO

WHEREIN M IS LYS OR GLY, 7. AN OCTAPEPTIDE OF THE FORMULA

PGLU-ILE-PRO-PRO-LYS-PHE-ALA-PRO,

8. AN ACYLATED OCTAPEPTIDE OF THE FORMULA

N-O-PRO-ARG-PRO-GLN-ILE-PRO-PRO

WHEREIN N IS CYCLOBUTYLCARBOXYLIC ACID, CYCLOPENTYLCARBOXYLIC ACID OR CYCLOHEXYLCARBOXYLIC ACID AND O IS TRP, TYR,

-TYR(-BZL)-

PHE, GLY, LEU, OR D-TRP,

N-TRP-PRO-GLY-PRO-LYS-SHPHE-ALA-PRO

WHEREIN N IS AS DEFINED ABOVE AND SHPE IS 3-AMINO-4 PHENYLBUTYRIC ACID, 9. A NONAPEPTIDE OF THE FORMULA

PGLU-TRP-PRO-P-PRO-Q-ILE-PRO-PRO

WHEREIN P IS ARG, HIS, LYS OR GLY AND Q IS GLN OR ASN,

PGLU-TRP-PRO-R-PRO-S-T-ALA-PRO

WHEREIN R IS ARG OR ORN, S IS NLE OR GLN AND T IS ILE OR PHE,

PGLU-TRP-PRO-ORN-PRO-S-T-PRO-PRO

WHEREIN S AND T ARE AS DEFINED ABOVE,

PGLU-O-PRO-ARG-PRO-GLN-ILE-PRO-PRO

WHEREIN O IS AS DEFINED ABOVE,
PGLU-GLY-GLY-TRP-PRO-ARG-PRO-GLY-PRO-W-ILEPRO-PRO

4. 发明授权

US3714172A Process for preparing 2-acetamido-3-benzyloxy or 3-benzylthio-pyridides and derivatives thereof 失效
标题翻译：制备2-乙酰氨基-3-苄氧基或3-苯甲酰基 - 吡啶及其衍生物的方法
公开(公告)号：US3714172A
公开(公告)日：1973-01-30
申请号：US3714172D
申请日：1971-06-18
申请人： SQUIBB & SONS INC
发明人： YALE H , PLUSCEC J
IPC分类号： C07D213/65 , C07D213/70 , C07D213/73 , C07D31/50
CPC分类号： C07D213/70 , C07D213/65 , C07D213/73
摘要： AN IMPROVED PROCESS FOR PREPARING COMPOUNDS OF THE FORMULA

1-(0HC-NH-C
WHEREIN X IS OXY OR THIO; ONE Y IS AZA; THE REMAINING Y IS

R AND R'' ARE THE SAME OR DIFFERENT AND REPRESENT HYDROGEN, HALOGE, LOWER ALKYL, LOWER ALKOXY, TRIFLUOROMETHYL, TRIFLUOROMETHYLMERCAPTO, TRIFLUOROMETHOXY OR N,N'' - DIMETHYLAMINOSULFONYL; AND X'' IS CHLORO OR BROMO, IS DISCLOSED. THESE COMPOUNDS ARE USEFUL IN THE PREPARATION OF DIHYDROPYRIDOBENZOXAZEPINES AND DIHYDROPRIDOBENZOTHIAZEPINES.

5. 发明授权

US3778429A Method of sulfating a tyrosine moiety 失效
标题翻译：。TING。。。。。。。。。
公开(公告)号：US3778429A
公开(公告)日：1973-12-11
申请号：US3778429D
申请日：1969-12-23
申请人： SQUIBB & SONS INC
发明人： ONDETTI M , PLUSCEC J , SHEEHAN J , JORPES J , MUTT V
IPC分类号： C07K1/06 , C07C103/52
CPC分类号： C07K1/06
摘要： DISCLOSED HEREIN IS A METHOD OF SULFATING THE HYDROXYL GROUP OF AN L-TYROSINE MOIETY BY TREATING SAID MOIETY WITH A MIXTURE OF POTASSIUM BISULFATE AND CONCENTRATED SULFURIC ACID.

6. 发明授权

US3723406A Novel peptides having cholecystokinin activity and intermediates therefor 失效
标题翻译：具有CHOLECYSTOKININ活性的新型肽及其中间体
公开(公告)号：US3723406A
公开(公告)日：1973-03-27
申请号：US3723406D
申请日：1969-12-23
申请人： SQUIBB & SONS INC
发明人： ONDETTI M , JORPES J , MUTT V , PLUSCEC J , SHEEHAN J
IPC分类号： A61K38/00 , C07K14/595 , C07C103/52 , C07G7/00
CPC分类号： C07K14/595 , A61K38/00
摘要： Novel peptide amides of the general formula
摘要翻译：通式R-Met-Gly-Trp-Met-Asp-Phe-NH 2的新型肽酰胺，其中R表示L-天冬氨酰基-O-硫酸盐-L-酪氨酰基，L-天冬氨酰基-L-精氨酰-L-天冬氨酰基-O 硫酸盐-L-酪氨酰基或异亮氨酰-L-丝氨酰-L-天冬氨酰-L-精氨酰-L-天冬氨酰基-O-硫酸盐-L-酪氨酰基，以及其生产中的中间体。已经发现本发明的肽酰胺及其药学上可接受的盐具有胆囊收缩素活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式