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1. 发明申请

US20150202327A1 MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM 有权
标题翻译：使用分支的胶囊聚合物和药物运输系统的分子装配
公开(公告)号：US20150202327A1
公开(公告)日：2015-07-23
申请号：US14425429
申请日：2013-09-03
申请人： SHIMADZU CORPORATION , KYOTO UNIVERSITY
发明人： Isao Hara , Eiichi Ozeki , Shunsaku Kimura , Akira Makino
IPC分类号： A61K49/00 , A61K9/51
CPC分类号： A61K49/0054 , A61K9/5153 , A61K47/50 , A61K47/51 , A61K47/593 , A61K49/0034 , A61K49/0089 , A61K49/12 , A61K49/124 , A61K51/0404 , A61K51/06
摘要： The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.
摘要翻译：本发明提供一种分子组合物，其取决于包封在其中的标记试剂或药物的种类或目的在靶位点的保留时间，以及可抑制ABC现象并且可以多次施用的分子组装短跨度一种分子组合物，其包含：支链型两亲嵌段聚合物A，其包含含有肌氨酸的支链亲水嵌段和包含聚乳酸链的疏水嵌段; 和包含功能部位和聚乳酸链的功能性物质F，其中构成所述两亲性嵌段聚合物A的疏水性嵌段的聚乳酸链包含L-乳酸单元，所述功能性物质F中所含的聚乳酸链包含D 或者构成两亲性嵌段聚合物A的疏水性嵌段的聚乳酸链包含D-乳酸单元，功能性物质F中所含的聚乳酸链包含L-乳酸单元。

2. 发明授权

US11224578B2 Medicinal agent-containing molecular assembly which uses amphiphilic block polymer 有权
公开(公告)号：US11224578B2
公开(公告)日：2022-01-18
申请号：US16334175
申请日：2016-09-20
申请人： SHIMADZU CORPORATION , KYOTO UNIVERSITY
发明人： Isao Hara , Eiichi Ozeki , Shunsaku Kimura , Takayuki Sato
IPC分类号： A61K9/51 , A61K47/14 , A61K47/34 , A61K9/107 , A61K33/243 , B82Y5/00 , C08L77/00
摘要： Provided is a molecular assembly (for example, a polymeric micelle nanoparticle) which is capable of efficiently encapsulating a fat-soluble drug. A molecular assembly comprising: an amphiphilic block polymer A1 comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit; a hydrophobic polymer A2 having a lactic acid unit; a fatty acid triglyceride; and a fat-soluble drug. Examples of the fat-soluble drug include miriplatin.

3. 发明授权

US09623122B2 Molecular assembly using branched amphiphilic block polymer, and drug transportation system 有权
公开(公告)号：US09623122B2
公开(公告)日：2017-04-18
申请号：US14425429
申请日：2013-09-03
申请人： SHIMADZU CORPORATION , KYOTO UNIVERSITY
发明人： Isao Hara , Eiichi Ozeki , Shunsaku Kimura , Akira Makino
IPC分类号： A61K31/74 , A61K49/00 , A61K9/51 , A61K47/48 , A61K51/04 , A61K49/12 , A61K51/06
CPC分类号： A61K49/0054 , A61K9/5153 , A61K47/50 , A61K47/51 , A61K47/593 , A61K49/0034 , A61K49/0089 , A61K49/12 , A61K49/124 , A61K51/0404 , A61K51/06
摘要： The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.

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