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1. 发明授权

US09329111B2 Sample preparation apparatus 有权
标题翻译：样品制备装置
公开(公告)号：US09329111B2
公开(公告)日：2016-05-03
申请号：US13007331
申请日：2011-01-14
申请人： Ryuichiro Ebi , Koki Tajima , Tokihiro Kosaka
发明人： Ryuichiro Ebi , Koki Tajima , Tokihiro Kosaka
IPC分类号： G01N9/30 , B01D45/00 , B01D35/00 , G01N1/40 , G01N15/14 , G01N35/00
CPC分类号： G01N1/4077 , G01N15/14 , G01N2001/4088 , G01N2035/00495
摘要： A sample preparation apparatus comprising: a filter which separates predetermined cells from a liquid sample containing a plurality types of cells; a rotor which includes a magnetic body and detaches the predetermined cells attached to the filter by rotation; a driving unit which rotates the rotor using a magnetic force; and a rotation information acquiring unit which acquires a rotation information of the rotor when the driving unit rotates the rotor. A method and a computer program product are also disclosed.
摘要翻译：一种样品制备装置，包括：将预定细胞与含有多种细胞的液体样品分离的过滤器; 转子，其包括磁体并通过旋转分离附着到过滤器上的预定细胞; 使用磁力使转子旋转的驱动单元; 以及旋转信息获取单元，其在所述驱动单元旋转所述转子时获取所述转子的旋转信息。还公开了一种方法和计算机程序产品。

2. 发明申请

US20110176934A1 SAMPLE PREPARATION APPARATUS, SAMPLE PREPARATION METHOD, AND COMPUTER PROGRAM 有权
标题翻译：样品制备装置，样品制备方法和计算机程序
公开(公告)号：US20110176934A1
公开(公告)日：2011-07-21
申请号：US13007331
申请日：2011-01-14
申请人： Ryuichiro Ebi , Koki Tajima , Tokihiro Kosaka
发明人： Ryuichiro Ebi , Koki Tajima , Tokihiro Kosaka
IPC分类号： F04B49/06 , B01D35/00
CPC分类号： G01N1/4077 , G01N15/14 , G01N2001/4088 , G01N2035/00495
摘要： A sample preparation apparatus comprising: a filter which separates predetermined cells from a liquid sample containing a plurality types of cells; a rotor which includes a magnetic body and detaches the predetermined cells attached to the filter by rotation; a driving unit which rotates the rotor using a magnetic force; and a rotation information acquiring unit which acquires a rotation information of the rotor when the driving unit rotates the rotor. A method and a computer program product are also disclosed.
摘要翻译：一种样品制备装置，包括：将预定细胞与含有多种细胞的液体样品分离的过滤器; 转子，其包括磁体并通过旋转分离附着到过滤器上的预定细胞; 使用磁力使转子旋转的驱动单元; 以及旋转信息获取单元，其在所述驱动单元旋转所述转子时获取所述转子的旋转信息。还公开了一种方法和计算机程序产品。

3. 发明授权

US5506673A Particle analyzer 失效
标题翻译：粒子分析仪
公开(公告)号：US5506673A
公开(公告)日：1996-04-09
申请号：US332040
申请日：1994-11-01
申请人： Tokihiro Kosaka , Kaoru Takarada
发明人： Tokihiro Kosaka , Kaoru Takarada
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14
CPC分类号： G01N15/14 , G01N15/12 , G01N15/1012 , G01N2015/1037
摘要： A particle analyzer includes a flow cell for enclosing an electrolyte flow containing particles in a sheathed flow, the flow cell including a first and second cells which are interconnected through an orifice, the sheathed flow flowing through the orifice from the first cell to the second cell, a first and second electrodes provided in the first and second cells, respectively and a voltage application device for applying voltage between the first and second electrodes. The particle analyzer further includes a resistance detection device for detecting a variation of electric resistance between the first and second electrodes when the particle passes through the orifice to output the detected variation as a resistance detection signal. A first diameter calculation device is included for calculating each diameter of the particles based on the detected variation of electric resistance. Further a light source device for emitting a light beam to the particles enclosed in the sheathed flow and a light detection device for detecting each intensity of scatter light of the particles irradiated with the light beam to output the detected intensity as a scatter light detection signal are included. Finally, the particle analyzer includes a refractive index calculation device for calculating a refractive index of the particle based on the resistance detection signal and the scatter light detection signal and a second diameter calculation device for calculating each diameter of the particles based on the calculated refractive index and the scatter light detection signal.
摘要翻译：颗粒分析仪包括用于封闭在护套流中含有颗粒的电解质流的流动池，所述流动池包括通过孔相互连接的第一和第二电池，所述护套流动通过所述孔从所述第一电池流到所述第二电池分别设置在第一和第二单元中的第一和第二电极以及用于在第一和第二电极之间施加电压的电压施加装置。粒子分析仪还包括电阻检测装置，用于当粒子通过孔口时检测第一和第二电极之间的电阻变化，以输出检测到的变化作为电阻检测信号。包括第一直径计算装置，用于基于检测到的电阻变化来计算颗粒的每个直径。另外，用于将光束发射到封装在护套流中的颗粒的光源装置和用于检测被光束照射的颗粒的散射光的每个强度的光检测装置，以输出检测的强度作为散射光检测信号，包括。最后，粒子分析仪包括用于基于电阻检测信号和散射光检测信号计算粒子的折射率的折射率计算装置和用于基于计算出的折射率计算颗粒的每个直径的第二直径计算装置和散射光检测信号。

4. 发明授权

US5448349A Particle analyzing apparatus and method wherein an optical deflector optically tracks a particle 失效
标题翻译：粒子分析装置和方法，其中光学偏转器光学跟踪颗粒
公开(公告)号：US5448349A
公开(公告)日：1995-09-05
申请号：US139159
申请日：1993-10-21
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01N15/14 , G01N21/00 , G01N33/49
CPC分类号： G01N15/1459 , G01N15/1463
摘要： A particle image analyzing apparatus including, a flow cell for enclosing a solution containing a particle to be analyzed in a sheathed flow to form the solution into a sample solution flow, an irradiation optical system for emitting light to irradiate the sample solution flow, a one dimension image sensor for receiving the light transmitted through the particle to scan the particle and output an image signal, an optical deflection device, including a variable deflection angle, for deflecting the emitted light introduced into the sample solution flow, a controller for controlling the deflection angle of the optical deflection device to permit the emitted light to optically track and irradiate the particle, and a signal processor for processing the output image signal of the image sensor to analyze the particle.
摘要翻译：一种颗粒图像分析装置，包括：流过池，用于将包含要被分析的颗粒的溶液封装在套管中以形成溶液流入样品溶液流;照射光学系统，用于发射光以照射样品溶液流; 尺寸图像传感器，用于接收透射通过粒子的光以扫描粒子并输出图像信号，包括可变偏转角的光学偏转装置，用于偏转引入样品溶液流的发射光;控制器，用于控制偏转光学偏转装置的角度，以允许发射的光线光学跟踪和照射颗粒;以及信号处理器，用于处理图像传感器的输出图像信号以分析颗粒。

5. 发明授权

US5272354A Apparatus for imaging particles in a liquid flow 失效
标题翻译：用于在液体流中成像颗粒的装置
公开(公告)号：US5272354A
公开(公告)日：1993-12-21
申请号：US933737
申请日：1992-08-24
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01J1/44 , G01N15/14 , G01N21/17 , G01N33/49 , G01N15/06
CPC分类号： G01N15/1427 , G01N15/1459 , G01N15/1463 , G01J2001/4493 , G01N2015/1465 , G01N2015/1477
摘要： An apparatus for imaging and analyzing particle components in a sample liquid flow containing particle components such as blood and urine, or fine particles of organic high polymer in suspension or the like. A conventional particle imaging flow cytometer is combined with a light source such as a lamp with small coherence, and an image intensifier with gate function of high response, so that a clear particle image without a deflection or interference fringe is obtained. Thus, in the apparatus having the still imaging function, by using the image intensifier with a high speed gate function, even with a light source of a long luminous time such as a lamp, a clear still image of a particle flowing at high speed is obtained.

6. 发明授权

US5159403A Flow cell mechanism in flow imaging cytometer 失效
标题翻译：流动成像测量仪中的流动细胞机制
公开(公告)号：US5159403A
公开(公告)日：1992-10-27
申请号：US671531
申请日：1991-03-19
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01N15/14 , G01N21/05
CPC分类号： G01N15/1459 , G01N15/1463 , G01N2015/1452 , G01N2021/058
摘要： A flow imaging cytomer for imaging the dimensions and shapes of particle components in a flow of a specimen solution has a slender filament serving as a focusing reference provided in a flat imaging zone through which the specimen solution flows in order for the particle components to be imaged. By imaging the filament-shaped focusing reference and adjusting position in accordance with the sharpness of an image of the reference, the particle components in the specimen solution can be brought into sharp focus.

7. 发明授权

US5159397A Flow imaging cytometer 失效
公开(公告)号：US5159397A
公开(公告)日：1992-10-27
申请号：US755304
申请日：1991-09-05
申请人： Tokihiro Kosaka , Shinichi Ogino
发明人： Tokihiro Kosaka , Shinichi Ogino
IPC分类号： G01N15/14 , G01N21/49 , G01N21/63 , G01N21/78 , G01N33/48
CPC分类号： G01N15/1463 , G01N15/1427 , G01N15/1459 , G01N2015/1413 , G01N2015/144
摘要： An imaging flow cytometer is provided with a continuous-emission light source for continuously monitoring cells passing through the image capturing area of a video camera for cell-image capturing, and with an excitation light source for picking up a fluorescent image of a cell. When a line sensor monitoring cell passage through the cytometer senses such cell passage, the cell is irradiated with strobe light and then, after waiting for the cell to move a fixed distance, with the excitation light. Thus, a particle analyzer is provided in which an image by white light resulting from the strobe light and a fluorescent image resulting from the excitation light can be captured simultaneously by a single video camera in either upper and lower halves or right and left halves of one imaged frame.

8. 发明申请

US20100111384A1 Specimen processing apparatus 有权
标题翻译：标本处理装置
公开(公告)号：US20100111384A1
公开(公告)日：2010-05-06
申请号：US12590012
申请日：2009-10-30
申请人： Takaaki Nagai , Tokihiro Kosaka , Yuichi Hamada
发明人： Takaaki Nagai , Tokihiro Kosaka , Yuichi Hamada
IPC分类号： G06K9/00
CPC分类号： G01N1/30 , G01N35/026 , G01N35/1011 , G01N35/1079 , G01N2035/00742 , G01N2035/1013 , G01N2035/1025
摘要： The present invention is to present a specimen processing apparatus, comprising: an imaging device for imaging a cap of a covered specimen container containing a specimen; an aspirating device including a specimen aspirating tube, moving the specimen aspirating tube so as to pass the specimen aspirating tube through the cap of the covered specimen container and aspirating the specimen contained in the covered specimen container via the specimen aspirating tube; an aspiration controller for controlling a movement of the specimen aspirating tube into the covered specimen container based on an image obtained by the imaging device; and a specimen processing device for processing the specimen aspirated by the aspirating device.
摘要翻译：本发明的目的在于提供一种检体处理装置，其特征在于，包括：成像装置，对包含标本的被覆盖标本容器的盖进行成像; 抽吸装置，其包括试样抽吸管，移动试样抽吸管，使试样抽吸管通过被覆盖的试样容器的盖，并通过试样抽吸管抽吸容纳在被覆盖的试样容器中的试样; 吸入控制器，用于基于由所述成像装置获得的图像来控制所述检体吸入管向被覆盖的标本容器的移动; 以及用于处理由抽吸装置吸出的试样的检体处理装置。

9. 发明授权

US5644388A Imaging flow cytometer nearly simultaneously capturing a plurality of images 失效
标题翻译：成像流式细胞仪几乎同时捕获多个图像
公开(公告)号：US5644388A
公开(公告)日：1997-07-01
申请号：US424076
申请日：1995-04-19
申请人： Yasunori Maekawa , Tokihiro Kosaka
发明人： Yasunori Maekawa , Tokihiro Kosaka
IPC分类号： G01N21/64 , G01N15/02 , G01N15/14 , G01N33/49 , G01N21/00 , G01J3/30 , G01N33/48
CPC分类号： G01N15/147
摘要： A sample liquid containing particles are caused to flow through a transparent flow cell. An image capturing device is used to capture different images for a single particle existing in an image capturing area of the flow cell. The image capturing device further preferably captures different images of the single particle from different directions. Further, the image capturing device can capture different images at different focal positions. The different images can include fluorescence images and chemiluminescence images.
摘要翻译：使含有颗粒的样品液体流过透明流通池。图像捕获装置用于捕获存在于流动池的图像捕获区域中的单个颗粒的不同图像。图像捕获装置还优选地从不同方向捕获单个颗粒的不同图像。此外，图像捕获装置可以捕获不同焦点位置处的不同图像。不同的图像可以包括荧光图像和化学发光图像。

10. 发明授权

US5428441A Apparatus for analyzing particle images 失效
标题翻译：用于分析粒子图像的装置
公开(公告)号：US5428441A
公开(公告)日：1995-06-27
申请号：US989062
申请日：1992-12-11
申请人： Shinichi Ogino , Tokihiro Kosaka
发明人： Shinichi Ogino , Tokihiro Kosaka
IPC分类号： C12M1/34 , G01N15/14 , G01N21/64 , G01N33/48 , G01N33/49 , G01N33/487
CPC分类号： G01N15/1459 , G01N15/1427 , G01N2015/0065 , G01N2015/144 , G01N2015/1443 , G01N2015/1488 , G01N2021/6473
摘要： An apparatus for analyzing particle images by passing a sample liquid containing blood corpuscles, cells, microorganisms and other particles in a sheath flow, detecting the target particles, and taking the still images thereof efficiently in a simple construction. A sample containing fluorescence dyed particles is passed in a flow cell, the particles in the flow cell are irradiated with light of a specific wavelength, and the fluorescence emitted from the particles is detected by a photo detector to judge whether they are target particles or not in the particle passing judging circuit, and the white images or fluorescent images of the target particles are taken.
摘要翻译：一种用于通过将含有血小样，细胞，微生物和其它颗粒的样品液体通过鞘流分析来检测颗粒图像的装置，检测目标颗粒，并以简单的结构有效地取出静止图像。含有荧光染色颗粒的样品在流动池中通过，流动池中的颗粒用特定波长的光照射，并通过光电检测器检测从颗粒发射的荧光，以判断它们是否为目标颗粒在粒子通过判定电路中，取出目标粒子的白色图像或荧光图像。

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