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    • 3. 发明授权
    • Game apparatus
    • 游戏机
    • US08075400B2
    • 2011-12-13
    • US11632022
    • 2005-06-23
    • Shigenobu MatsuyamaRyo UedaToru Takeda
    • Shigenobu MatsuyamaRyo UedaToru Takeda
    • A63F9/24A63F13/00
    • A63F13/90A63F9/00A63F13/00A63F13/213A63F13/42A63F2300/1087A63F2300/205A63F2300/302A63F2300/8005
    • A game machine comprises a monitor for displaying a screen image for prompting a manipulation input, a control panel unit provided with push buttons and adapted to accept manipulations from a game player so as to make progress on a game, a movement mechanism unit disposed at a bottom of a base segment to provide turning and traveling to the control panel unit , an apparatus-body drive control section 107 for controlling the drive of the movement mechanism unit, and a control instruction section or for outputting a given drive control instruction generated during game play to the drive control section, whereby a motion for positional displacement of a manipulation input unit is instructed in line with a game progress or a game result to exert an influence on a difficulty level of a game so as to enhance amusement of the game.
    • 游戏机包括:显示器,用于显示用于提示操作输入的屏幕图像;控制面板单元,其设置有按钮,并且适于接受游戏者的操作以便在游戏中取得进展;移动机构单元, 底部,以提供转向和行进到控制面板单元,用于控制移动机构单元的驱动的装置体驱动控制部分107,以及控制指令部分或用于输出在游戏过程中产生的给定驱动控制指令 播放到驱动控制部分,由此根据游戏进行或游戏结果指示操纵输入单元的位置移动运动,以对游戏的难度等级产生影响,从而增强游戏的娱乐性。
    • 4. 发明申请
    • Game Apparatus
    • 游戏装置
    • US20080032796A1
    • 2008-02-07
    • US11632022
    • 2005-06-23
    • Shigenobu MatsuyamaRyo UedaToru Takeda
    • Shigenobu MatsuyamaRyo UedaToru Takeda
    • A63F9/24
    • A63F13/90A63F9/00A63F13/00A63F13/213A63F13/42A63F2300/1087A63F2300/205A63F2300/302A63F2300/8005
    • A game machine comprises a monitor for displaying a screen image for prompting a manipulation input, a control panel unit provided with push buttons and adapted to accept manipulations from a game player so as to make progress on a game, a movement mechanism unit disposed at a bottom of a base segment to provide turning and traveling to the control panel unit, an apparatus-body drive control section 107 for controlling the drive of the movement mechanism unit, and a control instruction section or for outputting a given drive control instruction generated during game play to the drive control section, whereby a motion for positional displacement of a manipulation input unit is instructed in line with a game progress or a game result to exert an influence on a difficulty level of a game so as to enhance amusement of the game.
    • 游戏机包括:显示器,用于显示用于提示操作输入的屏幕图像;控制面板单元,其设置有按钮,并且适于接受游戏者的操作以便在游戏中取得进展;移动机构单元, 底部,以提供转向和行进到控制面板单元,用于控制移动机构单元的驱动的装置体驱动控制部分107,以及控制指令部分或用于输出在游戏过程中产生的给定驱动控制指令 播放到驱动控制部分,由此根据游戏进行或游戏结果指示操纵输入单元的位置移动运动,以对游戏的难度等级产生影响,从而增强游戏的娱乐性。
    • 6. 发明申请
    • Human glioma antigen originating in testis
    • 源自睾丸的人神经胶质瘤抗原
    • US20050043512A1
    • 2005-02-24
    • US10496860
    • 2002-11-29
    • Masahiro TodaYutaka KawakamiRyo Ueda
    • Masahiro TodaYutaka KawakamiRyo Ueda
    • A61P35/00C07K14/47C07K16/30C12N1/21C12N15/12G01N33/574C12Q1/68A61K39/00C07H21/04
    • C07K14/47A61K2121/00C07K14/4748C07K16/3053G01N33/57488
    • The present invention provides a testis-derived antigenic protein having an immunity induction activity comparable to a glioma antigenic protein and a gene encoding the same, etc., which can be applied to diagnosis and treatment of glioma. A testis-derived antigenic protein having an immunity induction activity comparable to a glioma antigenic protein and a gene encoding the same which can be applied to diagnosis and treatment of glioma are prepared by the steps of: extracting total RNA from testis, synthesizing cDNA, and constructing a λ phage cDNA library by introducing the cDNA into a λ phage vector and infecting Escherichia coli with the vector; reacting thus constructed λ phage cDNA library with the serum of a glioma patient, and using a labeled anti-IgG antibody to detect positive clones that react with the antibody in the serum; repeating the screening process several times on the detected positive clones to confirm the antibody reactivity; and isolating an antigen from the confirmed positive clones and performing serum screening using the isolated antigen and a glioma patient serum and a serum of a healthy individual, etc.
    • 本发明提供具有与神经胶质瘤抗原蛋白质相当的免疫诱导活性的睾丸衍生抗原蛋白及其编码基因的基因等,可用于诊断和治疗神经胶质瘤。 通过以下步骤制备具有与神经胶质瘤抗原蛋白质相当的免疫诱导活性的睾丸衍生抗原蛋白和可用于诊断和治疗神经胶质瘤的基因,其可以从睾丸提取总RNA,合成cDNA和 通过将cDNA引入λ噬菌体载体并用载体感染大肠杆菌构建λ噬菌体cDNA文库; 将如此构建的λ噬菌体cDNA文库与胶质瘤患者的血清反应,并使用标记的抗-IgG抗体检测与血清中的抗体反应的阳性克隆; 在检测到的阳性克隆上重复筛选过程数次,以确认抗体反应性; 并从确认的阳性克隆中分离抗原,并使用分离的抗原和神经胶质瘤患者血清和健康个体的血清等进行血清筛选。