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1. 发明授权

US06727381B2 Process for producing vitamin A ester 有权
标题翻译：生产维生素A酯的方法
公开(公告)号：US06727381B2
公开(公告)日：2004-04-27
申请号：US10039056
申请日：2002-01-03
申请人： Runpu Shen , Shiqing Pi , Bin Xie , Hongjun Huang
发明人： Runpu Shen , Shiqing Pi , Bin Xie , Hongjun Huang
IPC分类号： C07C6702
CPC分类号： C07C403/12 , C07C2601/16 , C07F9/4018
摘要： The invention relates to a process for producing all trans-vitamin A ester (I). According to the present invention, vitamin A ester (I) can simply be synthesized in good yields and high purity by the reaction of phosphonate compound (IV) with aldehyde (II) in an organic solvent in the presence of a base.
摘要翻译：本发明涉及一种生产全部维生素A酯（I）的方法。根据本发明，通过膦酸酯化合物（IV）与醛（II）在有机溶剂中在碱的存在下的反应，可以简单地以高产率和高纯度合成维生素A酯（I）。

2. 发明授权

US08536361B2 1,4,6,10-tetra-double bond pentadec-carbon phosphonate, preparation method thereof, and preparation method of lycopene using the same 有权
标题翻译： 1,4,6,10-四 - 双键十五碳酸膦酸酯，其制备方法以及使用其的番茄红素的制备方法
公开(公告)号：US08536361B2
公开(公告)日：2013-09-17
申请号：US13576659
申请日：2011-01-30
申请人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
发明人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
IPC分类号： C07F9/142
CPC分类号： C07F9/4015 , C07C1/34 , C07C11/21
摘要： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
摘要翻译：提供式（4）的1,4,6,10-四 - 双十五碳 - 碳膦酸酯及其制备方法。制备方法包括：使式（2）的假紫罗酮与锍盐反应以制备式（9）的环氧化物，然后使式（9）的环氧化物与溴化镁反应以制备式（C） 3）; 将式（3）的C-14醛缩合成四烷基亚甲基二膦酸盐，得到式（4）的1,4,6,10-四 - 双十五碳酸膦酸酯。此外，还提供了通式（4）的1,4,6,10-四 - 双十五碳碳酸膦酸酯的番茄红素的制备方法。本发明方法路线短，原料易得，成本低。

3. 发明申请

US20120310002A1 1,4,6,10-Tetra-Double Bond Pentadec-Carbon Phosphonate, Preparation Method Thereof, And Preparation Method Of Lycopene Using The Same 有权
标题翻译： 1,4,6,10-四 - 双键十五碳膦酸酯及其制备方法及其使用番茄红素的制备方法
公开(公告)号：US20120310002A1
公开(公告)日：2012-12-06
申请号：US13576659
申请日：2011-01-30
申请人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
发明人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
IPC分类号： C07C1/34 , C07F9/40
CPC分类号： C07F9/4015 , C07C1/34 , C07C11/21
摘要： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
摘要翻译：提供式（4）的1,4,6,10-四 - 双十五碳 - 碳膦酸酯及其制备方法。制备方法包括：使式（2）的假紫罗酮与锍盐反应以制备式（9）的环氧化物，然后使式（9）的环氧化物与溴化镁反应以制备式（C） 3）; 将式（3）的C-14醛缩合成四烷基亚甲基二膦酸盐，得到式（4）的1,4,6,10-四 - 双十五碳酸膦酸酯。此外，还提供了通式（4）的1,4,6,10-四 - 双十五碳碳酸膦酸酯的番茄红素的制备方法。本发明方法路线短，原料易得，成本低。

4. 发明申请

US20120065406A1 Improved Preparation Method for D-Biotin 审中-公开
标题翻译：改进D-生物素的制备方法
公开(公告)号：US20120065406A1
公开(公告)日：2012-03-15
申请号：US13321606
申请日：2010-05-20
申请人： Yajin Pan , Shiqing Pi , Wenzhen Ding , Lixin Gu , Angfeng Wei , Yimin He
发明人： Yajin Pan , Shiqing Pi , Wenzhen Ding , Lixin Gu , Angfeng Wei , Yimin He
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention discloses the improved preparation method for D-Biotin. If the composite method takes the malonic acid diester as the raw material, the finial biotin will be generated with impurities. The features of the invention refers to the improved preparation method for D-Biotin includes: firstly, (3aS,4S,6aR)-1,3-dibenzyl-4-(ω,ω,ω-3 -alkoxycarbonyl bytyl)-4H-1H-thiophene[3,4-d]iminazole-2,4(1H)-ketone is got after the methane tricarboxylic acid trialkyl ester and (3aR,8aS,8bS)-1,3-dibenzyl-2-oxo-10H-iminazole[3,4-d]thiophene[1,2-a]sulfuryl halide have the condensation reaction in the alkaline environment and then D-Biotin can be got after the reaction process of hydrolysis, decarboxylation and closed loop. The invention succeeds in greatly improving the biotin quality from the original basis and simultaneously avoids the generation of impurities and the occurrence of side reaction.
摘要翻译：本发明公开了改进的D-生物素制备方法。如果复合方法以丙二酸二酯为原料，则会使杂质生成最终生物素。本发明的特征是改进的D-生物素的制备方法，包括：首先，（3aS，4S，6aR）-1,3-二苄基-4-（ω，ω，ω-3-烷氧基羰基）在甲烷三羧酸三烷基酯和（3aR，8aS，8bS）-1,3-二苄基-2-氧代-10H-哒嗪酮后得到1H-噻吩[3,4-d]亚氨基-1,2（1H） - 酮亚胺唑[3,4-d]噻吩[1,2-a]磺酰卤在碱性环境中具有缩合反应，然后在水解，脱羧和闭环反应过程后得到D-生物素。本发明成功地从原始基础上大大提高了生物素质量，同时避免了杂质的产生和副反应的发生。

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