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1. 发明授权

US07258977B1 Process for typing of HCV isolates 失效
公开(公告)号：US07258977B1
公开(公告)日：2007-08-21
申请号：US10412290
申请日：2003-04-14
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/707
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position -291 to nucleotide at position -66 of the 5′ untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.

2. 发明授权

US06495670B1 Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US06495670B1
公开(公告)日：2002-12-17
申请号：US09378900
申请日：1999-08-23
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C07H2102
CPC分类号： C12Q1/707 , C12Q1/6834 , C12Q2563/131 , C12Q2545/101 , C12Q2525/101 , C12Q2531/113
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position −291 to nucleotide at position −66 of the 5′ untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针与上述定义的探针互补，检测可能形成于所述探针和HCV核苷酸序列之间的复合物分离鉴定。

3. 发明申请

US20100120121A1 Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US20100120121A1
公开(公告)日：2010-05-13
申请号：US11826099
申请日：2007-07-12
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12N7/01 , C07H21/00
CPC分类号： C12Q1/707
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position −291 to nucleotide at position −66 of the 5′ untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针与上述探针互补，检测可能在所述探针和核苷酸序列之间形成的复合物 HCV分离株被鉴定。

4. 发明授权

US06656689B2 Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms 失效
公开(公告)号：US06656689B2
公开(公告)日：2003-12-02
申请号：US09863086
申请日：2001-05-22
申请人： Rudi Rossau , Hugo Van Heuverswyn
发明人： Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q168
CPC分类号： C12Q1/6888 , C12Q1/689
摘要： The invention relates to a probe consisting of at least about 15 nucleotides from the spacer region between rRNA genes of a non-viral organism, particularly prokaryotic organism and more particularly bacteria, and preferably from about 15 nucleotides to about the maximum number of nucleotides of the spacer region and more preferably from about 15 to about 100 nucleotides to be used for the detection of non-viral microorganisms.

5. 发明授权

US5846704A Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US5846704A
公开(公告)日：1998-12-08
申请号：US256568
申请日：1994-07-18
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12N15/09 , C07H21/04 , C12N15/40 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C12N9/34
CPC分类号： C12Q1/707 , C12Q1/6834
摘要： A method of genotyping of HCV isolates using probes targeting sequences from the 5- untranslated region of HCV.
摘要翻译： PCT No.PCT / EP93 / 03325 Sec。 371日期：1994年7月18日 102（e）1994年7月18日PCT 1993年11月26日PCT公布。公开号WO94 / 12670 日期1994年6月9日使用来自HCV的5-非翻译区的序列的探针对HCV分离株进行基因分型的方法。

6. 发明授权

US07258982B2 Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US07258982B2
公开(公告)日：2007-08-21
申请号：US10822711
申请日：2004-04-13
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/707 , C12Q1/6834 , C12Q2563/131 , C12Q2545/101 , C12Q2525/101 , C12Q2531/113
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position −291 to nucleotide at position −66 of the 5′ untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes, detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针与上述定义的探针互补，检测可能形成在所述探针与H的核苷酸序列之间的复合物 CV分离鉴定。

7. 发明授权

US06811978B2 Detection and identification of pseudomonas species using the 16S-23S rRNA spacer 失效
标题翻译：使用16S-23S rRNA间隔区检测和鉴定假单胞菌
公开(公告)号：US06811978B2
公开(公告)日：2004-11-02
申请号：US09931486
申请日：2001-08-17
申请人： Geert Jannes , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Jannes , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q168
CPC分类号： C12Q1/689 , C12Q1/6888 , C12Q2600/16
摘要： The present invention relates to 16S-23S rRNA spacer sequences from Pseudomonas species and their use in a method for detection and/or identification of Pseudomonas species. The invention further it relates to a method for detection and identification of at least one Pseudomonas species, or for the simultaneous detection of several Pseudomonas species in a sample, involving the steps of: (i) optionally releasing, isolating and/or concentrating the polynucleic acids present in the sample; (ii) optionally amplifying the 16S-23S rRNA spacer region, or a part thereof, with at least one primer pair; (iii) detecting the presence of a 16S-23S rRNA spacer sequence; and (iv) identifying the Pseudomonas species present in the sample from the nucleic acid(s) detected in the sample.

8. 发明授权

US6051696A Process for typing of HCV isolates 失效
标题翻译： HCV分离株的分型方法
公开(公告)号：US6051696A
公开(公告)日：2000-04-18
申请号：US44665
申请日：1998-03-19
申请人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
发明人： Geert Maertens , Lieven Stuyver , Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12N15/09 , C07H21/04 , C12N15/40 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C07H21/02 , C12N15/00
CPC分类号： C12Q1/707 , C12Q1/6834
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of:contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position -291 to nucleotide at position -66 of the 5' untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, br with said probe being complementary to the above-defined probes,detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，所述编号的位置以编码HCV多聚蛋白的开放阅读框的第一个ATG密码子开始，所述探针与上述定义的探针互补，检测可能形成在所述探针与H的核苷酸序列之间的复合物 CV分离鉴定。

9. 发明授权

US5721097A Hybridization probes for the detection of branhamella catarrhalis strains 失效
标题翻译：用于检测卡他氏菌菌株的杂交探针
公开(公告)号：US5721097A
公开(公告)日：1998-02-24
申请号：US299810
申请日：1994-09-01
申请人： Rudi Rossau , Hugo Van Heuverswyn
发明人： Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689
摘要： Methods of detection of the Gram-negative bacterium, Branhamella catarrhalis are disclosed. These methods use nucleic acid hybridization probes derived from the bacterium's ribosomal RNA genes.
摘要翻译：公开了检测革兰氏阴性细菌布拉汉氏菌的方法。这些方法使用衍生自细菌核糖体RNA基因的核酸杂交探针。

10. 发明授权

US5536638A Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae 失效
标题翻译：衍生自16S和23S rRNA基因之间的间隔区的杂交探针用于检测淋病奈瑟氏球菌
公开(公告)号：US5536638A
公开(公告)日：1996-07-16
申请号：US412614
申请日：1995-03-29
申请人： Rudi Rossau , Hugo Van Heuverswyn
发明人： Rudi Rossau , Hugo Van Heuverswyn
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6888 , C12Q1/689
摘要： The invention relates to a probe consisting of at least about 15 nucleotides from the spacer region between rRNA genes of a non-viral organism, particularly prokaryotic organism and more particularly bacteria, and preferably from about 15 nucleotides to about the maximum number of nucleotides of the spacer region and more preferably from about 15 to about 100 nucleotides to be used for the detection of non-viral microorganisms.
摘要翻译：本发明涉及由非病毒生物体的rRNA基因之间的间隔区至少约15个核苷酸组成的探针，特别是原核生物，更特别是细菌，优选约15个核苷酸至约最大数目的核苷酸间隔区，更优选约15至约100个核苷酸用于检测非病毒微生物。

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