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1. 发明申请

US20140314831A1 RECOMBINANT POLYPEPTIDES FOR MEMBRANE FUSION AND USES THEREOF 审中-公开
标题翻译：用于膜融合的重组多聚体及其用途
公开(公告)号：US20140314831A1
公开(公告)日：2014-10-23
申请号：US13877101
申请日：2011-09-29
申请人： Roy Duncan , John Lewis , Roberto Justo De Antueno , Rae-Lynn Nesbitt , Eileen Kathryn Clancy
发明人： Roy Duncan , John Lewis , Roberto Justo De Antueno , Rae-Lynn Nesbitt , Eileen Kathryn Clancy
IPC分类号： C07K14/46 , C12N15/113
CPC分类号： C07K14/46 , A61K9/1271 , C07K2319/00 , C07K2319/03 , C07K2319/033 , C07K2319/33 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.
摘要翻译：公开了一种促进膜融合的重组多肽。该重组多肽具有与p14融合相关小跨膜（FAST）蛋白的胞外域具有至少80％的序列同一性并具有功能性的肉豆蔻酰化基序，来自FAST蛋白的跨膜结构域和至少80％序列的序列的序列与p15 FAST蛋白的endodomain一致。可以将靶向配体加入重组多肽进行选择性融合。重组多肽可以包含在脂质体等的膜中，以促进生物活性化合物（例如siRNA）的递送，或者重组多肽可以与脂质载体混合并加入到培养的细胞中以诱导细胞细胞融合和异核形成。

2. 发明授权

US10227386B2 Recombinant polypeptides for membrane fusion and uses thereof 有权
公开(公告)号：US10227386B2
公开(公告)日：2019-03-12
申请号：US13877101
申请日：2011-09-29
申请人： Roy Duncan , Eileen Kathryn Clancy , John Lewis , Roberto Justo De Antueno , Rae-Lynn Nesbitt
发明人： Roy Duncan , Eileen Kathryn Clancy , John Lewis , Roberto Justo De Antueno , Rae-Lynn Nesbitt
IPC分类号： C07K14/46 , C07K14/01 , A61K9/127 , C12N15/113 , C12N15/11
摘要： Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.

3. 发明申请

US20120322156A1 MEMBRANE FUSION PROTEINS DERIVED FROM REOVIRUS 审中-公开
标题翻译：从REOVIRUS衍生的膜蛋白融合蛋白
公开(公告)号：US20120322156A1
公开(公告)日：2012-12-20
申请号：US13594628
申请日：2012-08-24
申请人： Roy Duncan
发明人： Roy Duncan
IPC分类号： C12N15/06 , C09K3/00 , C07K19/00
CPC分类号： C07K14/005 , C12N2720/12022
摘要： In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
摘要翻译：根据本发明，已经鉴定了一系列膜融合蛋白和编码该蛋白的多核苷酸。蛋白质和核苷酸来源于家禽病毒科。从poikilothermic宿主分离的呼肠孤病毒中分离出两种膜融合蛋白：从蟒蛇分离的爬行动物呼肠孤病毒（RRV）的p14蛋白和从鲑鱼分离的来自水痘病毒（AQV）的p16蛋白。编码这些蛋白质的基因已被克隆并测序。这些蛋白质的氨基酸序列分析表明，缺乏其他膜融合蛋白中发现的典型融合肽基序。这些蛋白质在细胞中的表达导致细胞 - 细胞融合。

4. 发明申请

US20110144313A1 MEMBRANE FUSION PROTEINS DERIVED FROM REOVIRUS 有权
标题翻译：从REOVIRUS衍生的膜蛋白融合蛋白
公开(公告)号：US20110144313A1
公开(公告)日：2011-06-16
申请号：US12940016
申请日：2010-11-04
申请人： Roy Duncan
发明人： Roy Duncan
IPC分类号： C07K16/10 , C07K14/14 , C07H21/00 , C12N5/10 , C12N1/00
CPC分类号： C07K14/005 , C12N2720/12022
摘要： In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
摘要翻译：根据本发明，已经鉴定了一系列膜融合蛋白和编码该蛋白的多核苷酸。蛋白质和核苷酸来源于家禽病毒科。从poikilothermic宿主分离的呼肠孤病毒中分离出两种膜融合蛋白：从蟒蛇分离的爬行动物呼肠孤病毒（RRV）的p14蛋白和从鲑鱼分离的来自水痘病毒（AQV）的p16蛋白。编码这些蛋白质的基因已被克隆并测序。这些蛋白质的氨基酸序列分析表明，缺乏其他膜融合蛋白中发现的典型融合肽基序。这些蛋白质在细胞中的表达导致细胞 - 细胞融合。

5. 发明申请

US20100294340A1 Solar Module with a Frame for Mounting a Solar panel 审中-公开
标题翻译：带太阳能电池板的太阳能电池组件
公开(公告)号：US20100294340A1
公开(公告)日：2010-11-25
申请号：US12665517
申请日：2008-06-12
申请人： Daniel W. Cunningham , Kai H.W. Duponte , Neil V. Placer , Andy E. Parr , Roy Duncan , Seigfried Ebner
发明人： Daniel W. Cunningham , Kai H.W. Duponte , Neil V. Placer , Andy E. Parr , Roy Duncan , Seigfried Ebner
IPC分类号： H01L31/048 , F16M13/00
CPC分类号： H02S20/00 , F24S25/20 , F24S25/30 , F24S25/60 , F24S40/44 , F24S80/40 , F24S2025/801 , F24S2025/806 , Y02E10/47 , Y02E10/50
摘要： This invention relates to a frame for mounting a solar panel where a tubular frame member has a generally triangular cross section. The frame member includes a riser element, a span element and a truss element. 5 The frame meets the IEC 61215, Second edition standard for wind and snow loadings without significantly increasing the weight of the solar module compared to conventional frames with an open channel. This invention also relates to an array of solar modules mounted on a structure as well as a method of mounting the frame with a connection channel for slidably accepting an anchor.
摘要翻译：本发明涉及一种用于安装太阳能电池板的框架，其中管状框架构件具有大致三角形的横截面。框架构件包括提升板元件，跨距元件和桁架元件。 5与具有开放通道的传统框架相比，该框架符合IEC 61215，第二版风雪载荷标准，而不会显着增加太阳能模块的重量。本发明还涉及一种安装在结构上的太阳能模块的阵列，以及一种用于可滑动地接纳锚的用于安装框架的方法。

6. 发明申请

US20130036077A1 NEURAL NET FOR USE IN DRILLING SIMULATION 有权
标题翻译：用于钻井模拟的神经网络
公开(公告)号：US20130036077A1
公开(公告)日：2013-02-07
申请号：US13645562
申请日：2012-10-05
申请人： David P. Moran , Mark P. Frenzel , Roy Duncan
发明人： David P. Moran , Mark P. Frenzel , Roy Duncan
IPC分类号： G06G7/48 , G06N3/08
CPC分类号： E21B7/00 , E21B44/00 , E21B2041/0028 , G05B13/027 , G05B17/02
摘要： A method of optimizing a drilling tool assembly including inputting well data into an optimization system, the optimization system having an experience data set and an artificial neural network. The method further including comparing the well data to the experience data set and developing an initial drilling tool assembly based on the comparing the well data to the experience data, wherein the drilling tool assembly is developed using the artificial neural network. Additionally, the method including simulating the initial drilling tool assembly in the optimization system and creating result data in the optimization system based on the simulating.
摘要翻译：一种优化钻具组合的方法，包括将井数据输入到优化系统中，所述优化系统具有体验数据集和人造神经网络。该方法还包括将井数据与经验数据集进行比较，并且基于将井数据与经验数据进行比较来开发初始钻井工具组件，其中使用人造神经网络来开发钻井工具组件。另外，该方法包括模拟优化系统中的初始钻孔组件，并基于模拟创建优化系统中的结果数据。

7. 发明申请

US20080262810A1 NEURAL NET FOR USE IN DRILLING SIMULATION 有权
标题翻译：用于钻井模拟的神经网络
公开(公告)号：US20080262810A1
公开(公告)日：2008-10-23
申请号：US12105108
申请日：2008-04-17
申请人： David P. Moran , Mark P. Frenzel , Roy Duncan
发明人： David P. Moran , Mark P. Frenzel , Roy Duncan
IPC分类号： G06G7/48 , G06F15/18
CPC分类号： E21B7/00 , E21B44/00 , E21B2041/0028 , G05B13/027 , G05B17/02
摘要： A method of optimizing a drilling tool assembly including inputting well data into an optimization system, the optimization system having an experience data set and an artificial neural network. The method further including comparing the well data to the experience data set and developing an initial drilling tool assembly based on the comparing the well data to the experience data, wherein the drilling tool assembly is developed using the artificial neural network. Additionally, the method including simulating the initial drilling tool assembly in the optimization system and creating result data in the optimization system based on the simulating.
摘要翻译：一种优化钻具组合的方法，包括将井数据输入到优化系统中，所述优化系统具有体验数据集和人造神经网络。该方法还包括将井数据与经验数据集进行比较，并且基于将井数据与经验数据进行比较来开发初始钻井工具组件，其中使用人造神经网络来开发钻井工具组件。另外，该方法包括模拟优化系统中的初始钻孔组件，并基于模拟创建优化系统中的结果数据。

8. 发明授权

US08285531B2 Neural net for use in drilling simulation 有权
标题翻译：用于钻井模拟的神经网络
公开(公告)号：US08285531B2
公开(公告)日：2012-10-09
申请号：US12105108
申请日：2008-04-17
申请人： David P. Moran , Mark P. Frenzel , Roy Duncan
发明人： David P. Moran , Mark P. Frenzel , Roy Duncan
IPC分类号： G06G7/48
CPC分类号： E21B7/00 , E21B44/00 , E21B2041/0028 , G05B13/027 , G05B17/02
摘要： A method of optimizing a drilling tool assembly including inputting well data into an optimization system, the optimization system having an experience data set and an artificial neural network. The method further including comparing the well data to the experience data set and developing an initial drilling tool assembly based on the comparing the well data to the experience data, wherein the drilling tool assembly is developed using the artificial neural network. Additionally, the method including simulating the initial drilling tool assembly in the optimization system and creating result data in the optimization system based on the simulating.
摘要翻译：一种优化钻具组合的方法，包括将井数据输入到优化系统中，所述优化系统具有体验数据集和人造神经网络。该方法还包括将井数据与经验数据集进行比较，并且基于将井数据与经验数据进行比较来开发初始钻井工具组件，其中使用人造神经网络来开发钻井工具组件。另外，该方法包括模拟优化系统中的初始钻孔组件，并基于模拟创建优化系统中的结果数据。

9. 发明授权

US08252901B2 Membrane fusion proteins derived from reovirus 有权
标题翻译：从呼肠弧病毒衍生的膜融合蛋白
公开(公告)号：US08252901B2
公开(公告)日：2012-08-28
申请号：US12940016
申请日：2010-11-04
申请人： Roy Duncan
发明人： Roy Duncan
IPC分类号： C07K14/00 , C12N1/21
CPC分类号： C07K14/005 , C12N2720/12022
摘要： In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
摘要翻译：根据本发明，已经鉴定了一系列膜融合蛋白和编码该蛋白的多核苷酸。蛋白质和核苷酸来源于家禽病毒科。从poikilothermic宿主分离的呼肠孤病毒中分离出两种膜融合蛋白：从蟒蛇分离的爬行动物呼肠孤病毒（RRV）的p14蛋白和从鲑鱼分离的来自水痘病毒（AQV）的p16蛋白。编码这些蛋白质的基因已被克隆并测序。这些蛋白质的氨基酸序列分析表明，缺乏其他膜融合蛋白中发现的典型融合肽基序。这些蛋白质在细胞中的表达导致细胞 - 细胞融合。

10. 发明授权

US07851595B2 Membrane fusion proteins derived from reovirus 有权
标题翻译：从呼肠弧病毒衍生的膜融合蛋白
公开(公告)号：US07851595B2
公开(公告)日：2010-12-14
申请号：US11952714
申请日：2007-12-07
申请人： Roy Duncan
发明人： Roy Duncan
IPC分类号： C07K14/00 , C12N1/21
CPC分类号： C07K14/005 , C12N2720/12022
摘要： In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
摘要翻译：根据本发明，已经鉴定了一系列膜融合蛋白和编码该蛋白的多核苷酸。蛋白质和核苷酸来源于家禽病毒科。从poikilothermic宿主分离的呼肠孤病毒中分离出两种膜融合蛋白：从蟒蛇分离的爬行动物呼肠孤病毒（RRV）的p14蛋白和从鲑鱼分离的来自水痘病毒（AQV）的p16蛋白。编码这些蛋白质的基因已被克隆并测序。这些蛋白质的氨基酸序列分析表明，缺乏其他膜融合蛋白中发现的典型融合肽基序。这些蛋白质在细胞中的表达导致细胞 - 细胞融合。

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