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1. 发明申请

US20080268515A1 Method and apparatus for production and refinement of microbial consortia for the generation of selective therapeutic chemical agents 审中-公开
标题翻译：用于生成和细化微生物菌群以产生选择性治疗化学试剂的方法和装置
公开(公告)号：US20080268515A1
公开(公告)日：2008-10-30
申请号：US12156240
申请日：2008-05-29
申请人： Roy Cullimore , Charles R. Pellegrino , Lori Johnston , Mark Newman
发明人： Roy Cullimore , Charles R. Pellegrino , Lori Johnston , Mark Newman
IPC分类号： C12N11/00 , C12M1/00
CPC分类号： C12M35/02 , C12M23/34 , C12M25/08 , C12N1/12 , C12N1/14 , C12N1/20 , C12P1/04 , C12P39/00
摘要： A culturing fluid of defined bacterial consortia is placed within a cultivation apparatus to generate growths of either a bioconcretious or biocolloidal form within, or attached to surfaces exposed to, the culturing fluid. Such growths involve the interactive activities between all of the bacterial consortia to generate growths and economically attractive chemical daughter and end products within the fluid environment bounded by the cultivation apparatus. The cultivation apparatus allows the culturing fluid to flow along passageways that have alternating constricted and expanded zones in a manner that creates the growth of bioconcretious or biocolloidal structures within which the bacterial consortia interact to allow maintenance of these growth structures and stimulate the production of the desired chemical products of significance. The bacterial consortia generate either biocolloids or bioconcretions within an electrically charged field that is generated by the interaction of the consortia with dissimilar metal or carbon surfaces of the passageways. The grown interacting bacterial consortia and their culturing fluids can be used as sources of chemicals such as therapeutic agents that are anti-microbial, probiotic, anti-biotic, or anti-cancer agents.
摘要翻译：将定义的细菌联合体的培养液放置在培养装置内以在培养液中暴露于或附着于表面的生物共生或生物胶体形式生长。这种增长涉及所有细菌联盟之间的互动活动，以在由培养装置限定的流体环境内产生生长和经济吸引力的化学子和终产物。培养装置允许培养流体沿着具有交替的收缩和扩张区的通道流动，其方式是产生生物相容性或生物胶体结构的生长，其中细菌共同体相互作用以允许维持这些生长结构并刺激所需的化学产品意义重大。细菌联合体在电荷场中产生生物胶体或生物结合物，这是由联盟与通道的不同金属或碳表面的相互作用产生的。生长的相互作用的细菌联合体及其培养液可用作诸如抗微生物，益生菌，抗生物或抗癌剂的治疗剂的化学物质来源。

2. 发明申请

US20060172406A1 Method and apparatus for production and refinement of microbial consortia and method of use of microbial consortia as therapeutic agent 审中-公开
标题翻译：用于微生物菌群生产和细化的方法和装置以及使用微生物联盟作为治疗剂的方法
公开(公告)号：US20060172406A1
公开(公告)日：2006-08-03
申请号：US10812436
申请日：2004-03-30
申请人： Charles Pellegrino , Lori Johnston , Roy Cullimore , Mark Newman
发明人： Charles Pellegrino , Lori Johnston , Roy Cullimore , Mark Newman
IPC分类号： C12N1/20 , C12M3/00
CPC分类号： C12N1/14 , C12M25/08 , C12N1/12 , C12N1/20
摘要： A method of producing a rusticle consortia includes the steps of placing one or more samples obtained from a rusticle on a growth substrate, placing the growth substrate with the samples thereon into a tank filled with an aqueous solution, and controlling an environment of the aqueous solution to promote growth of the rusticle on the growth substrate. The growth substrate may comprise an anodically charged metal such as a mild steel plate that has been embrittled or unlike metals such as Fe and Cu. The aqueous solution is preferably water containing an oxygen and nutrients sufficient to promote growth of the rusticles. A charge may be applied to a location near the growth substrate to form a concentration of particles given off by the rusticle. In preferred embodiments, the grown rusticles are used as therapeutic agents such as anti-microbial, anti-biotic, or anti-cancer agents.
摘要翻译：一种生锈花生菌的方法包括以下步骤：将一个或多个从花岗岩获得的样品放置在生长衬底上，将其上的样品放置在填充有水溶液的罐中，并控制水溶液的环境促进生长基质上的锈斑生长。生长衬底可以包括阳极充电的金属，例如已经脆化的不锈钢或与金属如Fe和Cu不同的低碳钢板。水溶液优选为含有足够促进生锈的氧和营养物质的水。可以将电荷施加到生长衬底附近的位置以形成由细根发出的颗粒的浓度。在优选的实施方案中，生长的大麻作为治疗剂，例如抗微生物，抗生物或抗癌剂。

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