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1. 发明授权

US08546389B2 Viral polymerase inhibitors 失效
标题翻译：病毒聚合酶抑制剂
公开(公告)号：US08546389B2
公开(公告)日：2013-10-01
申请号：US13278021
申请日：2011-10-20
申请人： Rosliana Halim , Michael Harding , Richard Hufton , Craig James Morton , Saba Jahangiri , Brett Raymond Pool , Tyrone Pieter Jeynes , Alistair George Draffan , Barbara Frey , Michael John Lilly
发明人： Rosliana Halim , Michael Harding , Richard Hufton , Craig James Morton , Saba Jahangiri , Brett Raymond Pool , Tyrone Pieter Jeynes , Alistair George Draffan , Barbara Frey , Michael John Lilly
IPC分类号： A61K31/5377 , A61K31/416 , A61K31/41 , A61K31/4178 , A61K31/4523 , A61K31/4427 , A61K31/497 , A61K31/427 , A61K31/422 , A61K31/501 , A61K31/4245 , C07D413/04 , C07D231/56 , C07D257/04 , C07D233/54 , C07D211/00 , C07D401/02 , C07D417/02 , C07D261/06 , C07D403/02 , C07D413/02 , C07D271/08
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04
摘要： The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C virus (HCV) infections:
摘要翻译：本发明涉及式（I）的病毒聚合酶抑制剂，其盐，N-氧化物，溶剂合物，水合物，外消旋物，对映体或异构体，其制备方法及其在治疗黄病毒病毒感染如丙型肝炎病毒（HCV）感染：

2. 发明申请

US20120142686A1 VIRAL POLYMERASE INHIBITORS 失效
标题翻译：病毒聚合酶抑制剂
公开(公告)号：US20120142686A1
公开(公告)日：2012-06-07
申请号：US13278021
申请日：2011-10-20
申请人： Rosliana Halim , Michael Harding , Richard Hufton , Craig James Morton , Saba Jahangiri , Brett Raymond Pool , Tyrone Pieter Jeynes , Alistair George Draffan , Barbara Frey , Michael John Lilly
发明人： Rosliana Halim , Michael Harding , Richard Hufton , Craig James Morton , Saba Jahangiri , Brett Raymond Pool , Tyrone Pieter Jeynes , Alistair George Draffan , Barbara Frey , Michael John Lilly
IPC分类号： A61K31/416 , C07D403/12 , C07D401/12 , C07D413/12 , C07D405/12 , C07D417/02 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/497 , A61K31/427 , A61K31/4178 , A61P31/14 , C12N9/99 , C12N5/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04
摘要： The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C virus (HCV) infections:
摘要翻译：本发明涉及式（I）的病毒聚合酶抑制剂，其盐，N-氧化物，溶剂合物，水合物，外消旋物，对映体或异构体，其制备方法及其在治疗黄病毒病毒感染如丙型肝炎病毒（HCV）感染：

3. 发明申请

US20100035836A1 BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS 有权
标题翻译：双相核苷酸和核苷酸作为治疗药物
公开(公告)号：US20100035836A1
公开(公告)日：2010-02-11
申请号：US12496311
申请日：2009-07-01
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A61K31/70 , C07H19/04
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译：本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。

4. 发明申请

US20130018013A1 BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS 有权
标题翻译：双相核苷酸和核苷酸作为治疗药物
公开(公告)号：US20130018013A1
公开(公告)日：2013-01-17
申请号：US13607472
申请日：2012-09-07
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A61K31/706 , A61P31/14 , C07H19/23
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译：本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。

5. 发明授权

US08119607B2 Bicyclic nucleosides and nucleotides as therapeutic agents 有权
标题翻译：双环核苷和核苷酸作为治疗剂
公开(公告)号：US08119607B2
公开(公告)日：2012-02-21
申请号：US12496311
申请日：2009-07-01
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译：本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。

6. 发明授权

US08501699B2 Bicyclic nucleosides and nucleotides as therapeutic agents 有权
标题翻译：双环核苷和核苷酸作为治疗剂
公开(公告)号：US08501699B2
公开(公告)日：2013-08-06
申请号：US13607472
申请日：2012-09-07
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Hangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Hangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译：本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。

7. 发明申请

US20050221962A1 Free wheel clutch mechanism for bicycle drive train 有权
标题翻译：自行车传动系的自由轮离合器机构
公开(公告)号：US20050221962A1
公开(公告)日：2005-10-06
申请号：US11137095
申请日：2005-05-24
申请人： Patrick Warner , Michael Harding , Mu-Chuan Wu , Andy Baker
发明人： Patrick Warner , Michael Harding , Mu-Chuan Wu , Andy Baker
IPC分类号： A63B21/00 , A63B21/22 , A63B22/00 , A63B22/08 , B62M1/10 , F16D7/02 , F16D41/24 , A63B22/06 , A63B69/16
CPC分类号： B62M1/10 , A63B21/157 , A63B21/225 , A63B22/0605 , A63B2022/0658 , A63B2225/09 , F16D7/025 , F16D41/24
摘要： An exercise bicycle including a frame having a seat and handlebars, a high-inertia flywheel having a hub at a center of rotation, the flywheel being rotatably supported on the frame at the hub, and a drive train including a drive sprocket, a crank arm attached to and extending from the drive sprocket, and a pedal attached to the crank arm, the drive train being rotatably supported by the frame. The drive train also includes a slave sprocket fixed to the flywheel at the hub, with the drive and slave sprockets connected in a direct-drive relationship, the drive train driveable in a forward and rearward directions to cause the flywheel to rotate. A clutch mechanism is positioned in engagement with the slave sprocket and the hub to create a frictional engagement between the sprocket and the hub, and to establish a break-free force threshold. When the drive train is actuated in the forward direction, the slave sprocket and the hub move together, and when the drive train is actuated in the rearward direction under the influence of a force greater than the break-free force threshold, the clutch mechanism slips between the slave sprocket and the hub, allowing the slave sprocket and the flywheel to move independently of one another. The clutch mechanism including a spring tensioner whereby the break-free force may be adjusted.
摘要翻译：一种运动自行车，包括具有座椅和车把的框架，具有在旋转中心的轮毂的高惯量飞轮，所述飞轮可旋转地支撑在轮毂上的框架上，以及传动系，其包括驱动链轮，曲柄臂附接到驱动链轮并从驱动链轮延伸，以及附接到曲柄臂的踏板，传动系由框架可旋转地支撑。传动系统还包括固定在轮毂上的飞轮的从动链轮，其中驱动链轮和从动链轮以直接驱动关系连接，传动系可在前后方向上驱动以使飞轮旋转。离合器机构被定位成与从动链轮和轮毂接合以在链轮和轮毂之间形成摩擦接合，并且建立无破坏力的阈值。当传动系向前方驱动时，从动链轮和轮毂一起移动，当传动系在大于无断裂力阈值的力的影响下沿向后方向致动时，离合器机构滑动在从动链轮和轮毂之间，允许从动链轮和飞轮彼此独立地移动。离合器机构包括弹簧张紧器，从而可以调节破碎力。

8. 发明申请

US20070143465A1 Connection Tapping 审中-公开
标题翻译：连接攻丝
公开(公告)号：US20070143465A1
公开(公告)日：2007-06-21
申请号：US11567696
申请日：2006-12-06
申请人： Roberta Gonzalez , Michael Harding , Jack Bishop
发明人： Roberta Gonzalez , Michael Harding , Jack Bishop
IPC分类号： G06F15/173
CPC分类号： H04L43/50 , H04L41/0816 , H04L41/22
摘要： There are disclosed systems and methods for managing network devices and/or physical layer devices involving a server computer, a client computer coupled with the server computer, and a connector device coupled with the server computer, and a plurality of network devices and/or physical layer devices coupled with the connector device. A management application executing on the server may provide a graphical user interface allowing for the selection and arrangement of the network devices and/or physical layer devices into a use case. The management application may provide the graphical user interface in conjunction with a client application that executes on the client computer. Taps and monitors may be added to the arrangement and the use case.
摘要翻译：公开了用于管理涉及服务器计算机的网络设备和/或物理层设备的系统和方法，与服务器计算机耦合的客户端计算机以及与服务器计算机耦合的连接器设备，以及多个网络设备和/或物理层与连接器装置耦合的层装置。在服务器上执行的管理应用可以提供图形用户界面，允许将网络设备和/或物理层设备选择和布置到用例中。管理应用程序可以与在客户端计算机上执行的客户端应用程序一起提供图形用户界面。抽头和监视器可以被添加到安排和使用案例中。

9. 发明申请

US20070083885A1 On-line process for bidding on advertising spots 审中-公开
标题翻译：在线广告投标流程
公开(公告)号：US20070083885A1
公开(公告)日：2007-04-12
申请号：US11528553
申请日：2006-09-28
申请人： Michael Harding
发明人： Michael Harding
IPC分类号： H04N7/10 , H04N7/025
CPC分类号： G06Q30/08 , G06Q30/02
摘要： A method for buying and/or selling advertising spots electronically is provided. Buyers (agencies) may enter requests describing a desired advertising spot, and the requests may be correlated and/or filtered against available inventory posted by sellers (stations). A station may be notified of a request to and may respond by offering to sell an advertising spot corresponding to the request. In various implementations, agencies may accept, decline, or counter-offer the offer, or an application may automatically process an agency response to the offer. The method may be practiced in scatter markets and/or up-front advertising markets.
摘要翻译：提供了以电子方式购买和/或销售广告点的方法。买方（代理机构）可以输入描述所需广告点的请求，并且请求可以与卖家（站）发布的可用库存相关和/或过滤。可以向车站通知请求，并可以通过提供出售对应于该请求的广告点进行响应。在各种实施中，代理商可以接受，拒绝或反向提供报价，或者应用可以自动处理代理商对报价的响应。该方法可以在分散市场和/或前期广告市场中实践。

10. 发明申请

US20070004564A9 FREE WHEEL CLUTCH MECHANISM FOR BICYCLE DRIVE TRAIN 失效
标题翻译：自行车离合器自行车驱动机构
公开(公告)号：US20070004564A9
公开(公告)日：2007-01-04
申请号：US09803630
申请日：2001-03-09
申请人： Patrick Warner , Michael Harding , Mu-Chuan Wu , Andy Baker
发明人： Patrick Warner , Michael Harding , Mu-Chuan Wu , Andy Baker
IPC分类号： A63B22/06 , A63B69/16
CPC分类号： B62M1/10 , A63B21/157 , A63B21/225 , A63B22/0605 , A63B2022/0658 , A63B2225/09 , F16D7/025 , F16D41/24
摘要： An exercise bicycle including a frame having a seat and handlebars, a high-inertia flywheel having a hub at a center of rotation, the flywheel being rotatably supported on the frame at the hub, and a drive train including a drive sprocket, a crank arm attached to and extending from the drive sprocket, and a pedal attached to the crank arm, the drive train being rotatably supported by the frame. The drive train also includes a slave sprocket fixed to the flywheel at the hub, with the drive and slave sprockets connected in a direct-drive relationship, the drive train driveable in a forward and rearward directions to cause the flywheel to rotate. A clutch mechanism is positioned in engagement with the slave sprocket and the hub to create a frictional engagement between the sprocket and the hub, and to establish a break-free force threshold. When the drive train is actuated in the forward direction, the slave sprocket and the hub move together, and when the drive train is actuated in the rearward direction under the influence of a force greater than the break-free force threshold, the clutch mechanism slips between the slave sprocket and the hub, allowing the slave sprocket and the flywheel to move independently of one another. The clutch mechanism including a spring tensioner whereby the break-free force may be adjusted.
摘要翻译：一种运动自行车，包括具有座椅和车把的框架，具有在旋转中心的轮毂的高惯量飞轮，所述飞轮可旋转地支撑在轮毂上的框架上，以及传动系，其包括驱动链轮，曲柄臂附接到驱动链轮并从驱动链轮延伸，以及附接到曲柄臂的踏板，传动系由框架可旋转地支撑。传动系统还包括固定在轮毂上的飞轮的从动链轮，其中驱动链轮和从动链轮以直接驱动关系连接，传动系可在前后方向上驱动以使飞轮旋转。离合器机构被定位成与从动链轮和轮毂接合以在链轮和轮毂之间形成摩擦接合，并且建立无破坏力的阈值。当传动系向前方驱动时，从动链轮和轮毂一起移动，当传动系在大于无断裂力阈值的力的影响下沿向后方向致动时，离合器机构滑动在从动链轮和轮毂之间，允许从动链轮和飞轮彼此独立地移动。离合器机构包括弹簧张紧器，从而可以调节破碎力。

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