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1. 发明授权

US07235634B2 2786, a novel human aminopeptidase 失效
标题翻译： 2786，一种新型人氨基肽酶
公开(公告)号：US07235634B2
公开(公告)日：2007-06-26
申请号：US10767308
申请日：2004-01-29
申请人： Rosana Kapeller-Libermann , David White , Kyle J. MacBeth
发明人： Rosana Kapeller-Libermann , David White , Kyle J. MacBeth
IPC分类号： C07K14/00
CPC分类号： C12N9/48
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的人类氨基肽酶。本发明还涉及编码氨基肽酶的多核苷酸。本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

2. 发明授权

US06383780B1 2786, a novel human aminopeptidase 有权
标题翻译： 2786，一种新型人氨基肽酶
公开(公告)号：US06383780B1
公开(公告)日：2002-05-07
申请号：US09443795
申请日：1999-11-19
申请人： Rosana Kapeller-Libermann , David White , Kyle J. MacBeth
发明人： Rosana Kapeller-Libermann , David White , Kyle J. MacBeth
IPC分类号： C12P2106
CPC分类号： C12N9/48
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的人类氨基肽酶。本发明还涉及编码氨基肽酶的多核苷酸。本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

3. 发明授权

US07485308B2 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor 有权
标题翻译： 26199,33530,3949,47148,50226,58764,612113,32144,32235,23565,13305,14911,86216,25206和8843分子及其用途
公开(公告)号：US07485308B2
公开(公告)日：2009-02-03
申请号：US11493347
申请日：2006-07-26
申请人： Rachel E. Meyers , Kyle J. MacBeth , Rory A. J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
发明人： Rachel E. Meyers , Kyle J. MacBeth , Rory A. J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
IPC分类号： A61K39/00 , C12P21/06
CPC分类号： C12N9/001 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/0006 , C12N9/10 , C12N9/1048 , C12N9/1096 , C12N9/12 , C12N9/1205 , C12N9/16 , C12N9/48 , C12N9/80 , C12N2799/021 , C12Q1/32 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N2500/10 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。还提供了利用本发明组合物的诊断和治疗方法。

4. 发明授权

US06369210B1 22012, human carboxypeptidase 失效
标题翻译： 22012，人羧肽酶
公开(公告)号：US06369210B1
公开(公告)日：2002-04-09
申请号：US09345469
申请日：1999-06-30
申请人： Rosana Kapeller-Libermann , Kyle J. MacBeth , Mark Williamson
发明人： Rosana Kapeller-Libermann , Kyle J. MacBeth , Mark Williamson
IPC分类号： C07H2104
CPC分类号： C12N9/48 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a newly identified human carboxypeptidase. The invention also relates to polynucleotides encoding the carboxypeptidase. The invention further relates to methods using the carboxypeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in carboxypeptidase-related disorders. The invention further relates to drug-screening methods using the carboxypeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the carboxypeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the carboxypeptidase polypeptides and polynucleotides.
摘要翻译：本发明涉及一种新鉴定的人类羧肽酶。本发明还涉及编码羧肽酶的多核苷酸。本发明还涉及使用羧肽酶多肽和多核苷酸作为羧肽酶相关病症诊断和治疗的靶标的方法。本发明还涉及使用羧肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于羧肽酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生羧肽酶多肽和多核苷酸的方法。

5. 发明申请

US20110182879A1 NOVEL HUMAN TRANSFERASE FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：新人类转移家族成员及其用途
公开(公告)号：US20110182879A1
公开(公告)日：2011-07-28
申请号：US12828319
申请日：2010-07-01
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/435 , C07K16/18 , C12P21/02 , G01N33/50 , G01N33/53 , A61K38/02 , A61P43/00
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

6. 发明申请

US20100150901A1 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor 审中-公开
标题翻译： 26199,33530,3949,47148,50226,58764,612113,32144,32235,23565,13305,14911,86216,25206和8843分子及其用途
公开(公告)号：US20100150901A1
公开(公告)日：2010-06-17
申请号：US12288677
申请日：2008-10-22
申请人： Rachel E. Meyers , Kyle J. MacBeth , Rory A.J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
发明人： Rachel E. Meyers , Kyle J. MacBeth , Rory A.J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
IPC分类号： A61K39/395 , C07H21/02 , C12N5/10 , C07K16/00 , C12P21/00 , G01N33/53 , C07H21/04 , C12Q1/68 , A61K38/00 , A61K38/16 , C07K14/00 , A61K31/7105 , A61K31/713 , A61K31/711 , A61P35/00
CPC分类号： C12N9/001 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/0006 , C12N9/10 , C12N9/1048 , C12N9/1096 , C12N9/12 , C12N9/1205 , C12N9/16 , C12N9/48 , C12N9/80 , C12N2799/021 , C12Q1/32 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N2500/10 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。还提供了利用本发明组合物的诊断和治疗方法。

7. 发明申请

US20090263860A1 Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor 失效
标题翻译：小分子13237,18480,2245,16228,7677,26320,46169,36166,16836,46867,21617,55562,39228,62088,4675,23155,26657,42755,32229,22325,46863和32252分子及其用途
公开(公告)号：US20090263860A1
公开(公告)日：2009-10-22
申请号：US11980299
申请日：2007-10-30
申请人： Rachel E. Meyers , Mark J. Williamson , Rosana Kapeller-Libermann , Kyle J. MacBeth , John Joseph Hunter , Laura A. Rudolph-Owen , Rajasekhar Bandaru , Fong-Ying Tsai
发明人： Rachel E. Meyers , Mark J. Williamson , Rosana Kapeller-Libermann , Kyle J. MacBeth , John Joseph Hunter , Laura A. Rudolph-Owen , Rajasekhar Bandaru , Fong-Ying Tsai
IPC分类号： C12P21/02 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863 和32252个核酸分子。本发明还提供反义核酸分子，重组表达载体，其含有13237,18480,2245,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216575,42755,32229 ，22325,46863和32252核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中13237,18480,2362,46169,3677,26320,46869,38166,16836,46867,21617,26173,26169，已经引入或破坏了55562,39228,62088,4675,23155,21657,42755,32229,22325,46863或32252基因。本发明还进一步提供分离的13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863或32252蛋白质，融合蛋白，抗原肽和抗-13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216547,42755,32229,22325,46863 或32252抗体。还提供了利用本发明组合物的诊断和治疗方法。

8. 发明授权

US07301016B2 Human transferase family members and uses thereof 失效
标题翻译：人转移酶家族成员及其用途
公开(公告)号：US07301016B2
公开(公告)日：2007-11-27
申请号：US10184648
申请日：2002-06-27
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： C07H1/00 , C07H5/00 , C07H19/00 , C07H21/00 , C07H21/02 , C08B37/00 , C12Q1/68 , C12P21/06 , C12P19/34 , C12N1/12 , C12N1/20 , C12N15/00 , C12N15/06
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员。本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或中断了本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

9. 发明申请

US20080248477A1 Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor 审中-公开
标题翻译：新型ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白和核酸分子及其用途
公开(公告)号：US20080248477A1
公开(公告)日：2008-10-09
申请号：US12001395
申请日：2007-12-11
申请人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
发明人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/00 , C07K16/00 , C12P19/34 , G01N33/53
CPC分类号： C12N9/0022 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/525 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K14/723 , C07K2319/00 , Y02A50/411
摘要： Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST多肽，蛋白质和核酸分子。除了分离的全长ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白之外，本发明还提供了分离的ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST融合蛋白，抗原肽和抗ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST抗体。本发明还提供意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的非宿主细胞其中引入或破坏意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST基因的转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

US20110020798A1 Novel italy, LOR-2, strife, trash, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor 审中-公开
标题翻译：新意大利，LOR-2，冲突，垃圾，BDSF，LRSG和STMST蛋白质和核酸分子及其用途
公开(公告)号：US20110020798A1
公开(公告)日：2011-01-27
申请号：US12653955
申请日：2009-12-18
申请人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
发明人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
IPC分类号： C12Q1/68 , G01N33/566 , C12N5/10 , C12P21/02 , C07K16/18 , C07H21/00 , C07K14/47 , C12N15/63
CPC分类号： C12N9/0022 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/525 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K14/723 , C07K2319/00 , Y02A50/411
摘要： Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST多肽，蛋白质和核酸分子。除了分离的全长ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白之外，本发明还提供了分离的ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST融合蛋白，抗原肽和抗ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST抗体。本发明还提供意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的非宿主细胞其中引入或破坏意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST基因的转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

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