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1. 发明申请

US20120045828A1 Apparatus for Magnetic Separation of Cells 有权
标题翻译：细胞磁分离装置
公开(公告)号：US20120045828A1
公开(公告)日：2012-02-23
申请号：US13284482
申请日：2011-10-28
申请人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
发明人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
IPC分类号： C12N5/09 , C12M3/00
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/26
摘要： Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
摘要翻译：这里描述了一种自动化的机器人装置，其以非常高的纯度分离循环肿瘤细胞（CTC）或其他生物结构。该设备使用强大的磁棒覆盖在可拆卸的塑料袖子。这些棒穿过血液样品，捕获例如用与磁性响应颗粒例如超顺磁珠连接的抗体标记的癌细胞。在完成捕获方案后，磁棒经历几轮洗涤，从而除去所有污染的血细胞。通过从袖子中取出磁棒将捕获的靶细胞释放到最终的捕获溶液中。此外，由该装置俘获的细胞在捕获后培养时显示出不降低的活力。以适合于遗传分析的状态捕获细胞。还公开了用于单细胞分析的方法。机器人允许设备以高吞吐量运行。

2. 发明授权

US09267943B2 Apparatus for magnetic separation of cells 有权
标题翻译：细胞磁分离装置
公开(公告)号：US09267943B2
公开(公告)日：2016-02-23
申请号：US13284482
申请日：2011-10-28
申请人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
发明人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
IPC分类号： G01N33/543 , B03C1/01 , B03C1/28
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/26
摘要： Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
摘要翻译：这里描述了一种自动化的机器人装置，其以非常高的纯度分离循环肿瘤细胞（CTC）或其他生物结构。该设备使用强大的磁棒覆盖在可拆卸的塑料袖子。这些棒穿过血液样品，捕获例如用与磁性响应颗粒例如超顺磁珠连接的抗体标记的癌细胞。在完成捕获方案后，磁棒经历几轮洗涤，从而除去所有污染的血细胞。通过从袖子中取出磁棒将捕获的靶细胞释放到最终的捕获溶液中。此外，由该装置俘获的细胞在捕获后培养时显示出不降低的活力。以适合于遗传分析的状态捕获细胞。还公开了用于单细胞分析的方法。机器人允许设备以高吞吐量运行。

3. 发明授权

US08071395B2 Methods and apparatus for magnetic separation of cells 有权
标题翻译：细胞磁分离的方法和装置
公开(公告)号：US08071395B2
公开(公告)日：2011-12-06
申请号：US12333213
申请日：2008-12-11
申请人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
发明人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
IPC分类号： G01N33/551
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/26
摘要： Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
摘要翻译：这里描述了一种自动化的机器人装置，其以非常高的纯度分离循环肿瘤细胞（CTC）或其他生物结构。该设备使用强大的磁棒覆盖在可拆卸的塑料袖子。这些棒穿过血液样品，捕获例如用与磁性响应颗粒例如超顺磁珠连接的抗体标记的癌细胞。在完成捕获方案后，磁棒经历几轮洗涤，从而除去所有污染的血细胞。通过从袖子中取出磁棒将捕获的靶细胞释放到最终的捕获溶液中。此外，由该装置俘获的细胞在捕获后培养时显示出不降低的活力。以适合于遗传分析的状态捕获细胞。还公开了用于单细胞分析的方法。机器人允许设备以高吞吐量运行。

4. 发明申请

US20090220979A1 Methods and Apparatus for Magnetic Separation of Cells 有权
标题翻译：细胞磁分离的方法和装置
公开(公告)号：US20090220979A1
公开(公告)日：2009-09-03
申请号：US12333213
申请日：2008-12-11
申请人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
发明人： Ronald W. Davis , Stefanie S. Jeffrey , Michael N. Mindrinos , R. Fabian Pease , Ashley Ann Powell , AmirAli Hajhossein Talasaz
IPC分类号： C12N13/00 , C12M1/42 , C12Q1/68 , C12N5/06
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/26
摘要： Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
摘要翻译：这里描述了一种自动化的机器人装置，其以非常高的纯度分离循环肿瘤细胞（CTC）或其他生物结构。该设备使用强大的磁棒覆盖在可拆卸的塑料袖子。这些棒穿过血液样品，捕获例如用与磁性响应颗粒例如超顺磁珠连接的抗体标记的癌细胞。在完成捕获方案后，磁棒经历几轮洗涤，从而除去所有污染的血细胞。通过从袖子中取出磁棒将捕获的靶细胞释放到最终的捕获溶液中。此外，由该装置俘获的细胞在捕获后培养时显示出不降低的活力。以适合于遗传分析的状态捕获细胞。还公开了用于单细胞分析的方法。机器人允许设备以高吞吐量运行。

5. 发明授权

US07558419B1 System and method for detecting integrated circuit pattern defects 有权
标题翻译：检测集成电路图案缺陷的系统和方法
公开(公告)号：US07558419B1
公开(公告)日：2009-07-07
申请号：US10917060
申请日：2004-08-12
申请人： Jun Ye , Yu Cao , R. Fabian Pease
发明人： Jun Ye , Yu Cao , R. Fabian Pease
IPC分类号： G06K9/00
CPC分类号： G06T7/001 , G03F1/84 , G06T2207/30148
摘要： There are many inventions described and illustrated herein. In one aspect, the present invention is directed to a technique of, and system for inspecting integrated circuits, including, for example, patterns projected, provided or formed on a wafer using photomasks, or patterns on the photomask itself. The inspection system and technique of this aspect includes first identifying, determining and/or detecting areas and/or patterns that are potentially defective by removing, filtering and/or eliminating from a set of potential defects any and/or all typical, regular or normal patterns. The identification, determination and/or detection of potential defects may be performed relatively quickly by a rapidly executing algorithm. In this way, a first or “coarse” analysis is performed rapidly and some, many, all or substantially all of the regular, normal or typical patterns are eliminated from further analysis. Thereafter, a second more detailed analysis is performed. This second analysis focuses on the set of potential defects that were identified, determined and/or detected during the first analysis of the photomask or wafer (i.e., the “coarse” analysis). The second analysis may be considerably a more detailed or a “fine” analysis relative to the first or “coarse” analysis. Indeed, in one embodiment, the second analysis may implement a more computational intensive process, without sacrificing throughput, since only a small portion of the photomask or wafer is inspected in the second analysis. In this way, the detailed analysis of the defect candidates may identify (i) all or substantially all of the actual defects and/or (ii) only the actual defects from the potential defects identified during the first analysis.
摘要翻译：这里描述和说明了许多发明。在一个方面，本发明涉及用于检查集成电路的技术和系统，包括例如使用光掩模投影，提供或形成在晶片上的图案或光掩模本身上的图案。该方面的检查系统和技术包括首先识别，确定和/或检测潜在缺陷的区域和/或图案，该区域和/或图案通过去除，过滤和/或从一组潜在的缺陷中消除任何和/或所有典型的，规则的或正常的模式。可能通过快速执行的算法相对较快地执行潜在缺陷的识别，确定和/或检测。以这种方式，快速执行第一个或“粗略”分析，并从进一步的分析中消除一些，许多，全部或基本上所有常规，正常或典型的模式。此后，进行第二更详细的分析。该第二分析集中在在光掩模或晶片的第一次分析期间（即，“粗略”分析））中识别，确定和/或检测到的潜在缺陷集合。第二次分析可能相对于第一次或“粗略”分析可能是更详细或“精细”的分析。实际上，在一个实施例中，第二分析可以实现更加计算密集的过程，而不会牺牲吞吐量，因为在第二次分析中只检查了一小部分光掩模或晶片。以这种方式，缺陷候选人的详细分析可以识别（i）所有或基本上所有的实际缺陷和/或（ii）仅在第一次分析期间识别的潜在缺陷的实际缺陷。

6. 发明授权

US06239273B1 Printing molecular library arrays 有权
标题翻译：印刷分子库阵列
公开(公告)号：US06239273B1
公开(公告)日：2001-05-29
申请号：US09427850
申请日：1999-10-26
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： C07M2100
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00432 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B41M3/00 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
摘要翻译：一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。该方法和装置还依赖于基于标准的基于DMT的化学，以及气相脱保护剂如固体TCA等。

7. 发明授权

US5831070A Printing oligonucleotide arrays using deprotection agents solely in the vapor phase 失效
标题翻译：使用去保护剂仅在气相中印刷寡核苷酸阵列
公开(公告)号：US5831070A
公开(公告)日：1998-11-03
申请号：US635272
申请日：1996-04-19
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： B01J19/00 , B41M3/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , G03F7/00 , C07H21/02 , C07K5/00 , C07K16/00
CPC分类号： C07H21/00 , B01J19/0046 , G03F7/00 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00722 , B41M3/00 , C40B40/06 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
摘要翻译：一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。该方法和装置还依赖于基于标准的基于DMT的化学和气相脱保护剂如固体TCA等。

8. 发明授权

US06667394B2 Printing oligonucleotide arrays 失效
公开(公告)号：US06667394B2
公开(公告)日：2003-12-23
申请号：US09841405
申请日：2001-04-24
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： C07H2100
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00432 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B41M3/00 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.

9. 发明授权

US5932966A Electron sources utilizing patterned negative electron affinity photocathodes 失效
标题翻译：利用图案化负电子亲和光电阴极的电子源
公开(公告)号：US5932966A
公开(公告)日：1999-08-03
申请号：US987397
申请日：1997-12-09
申请人： James E. Schneider , Kenneth A. Costello , Mark A. McCord , R. Fabian Pease , Aaron W. Baum
发明人： James E. Schneider , Kenneth A. Costello , Mark A. McCord , R. Fabian Pease , Aaron W. Baum
IPC分类号： H01J40/06 , G03F7/20 , H01J3/02 , H01J27/04 , H01J37/073 , H01J37/075 , H01J40/16
CPC分类号： G03F7/70375 , H01J27/04 , H01J3/021 , H01J37/073 , H01J37/075 , H01J40/16 , H01J2201/3423 , H01J2237/06333 , H01J2237/31779
摘要： An electron source includes a negative electron affinity photocathode on a light-transmissive substrate and a light beam generator for directing a light beam through the substrate at the photocathode for exciting electrons into the conduction band. The photocathode has at least one active area for emission of electrons with dimensions of less than about two micrometers. The electron source further includes electron optics for forming the electrons into an electron beam and a vacuum enclosure for maintaining the photocathode at high vacuum. The photocathode is patterned to define emission areas. A patterned mask may be located on the emission surface of the active layer, may be buried within the active layer or may be located between the active layer and the substrate.
摘要翻译：电子源包括透光性基板上的负电子亲合性光电阴极和光束发生器，用于将光束引导到光电阴极处的基板，用于将电子激发到导带中。光电阴极具有用于发射尺寸小于约两微米的电子的至少一个有源面积。电子源还包括用于将电子形成电子束的电子光学器件和用于将光电阴极保持在高真空的真空外壳。图案化光电阴极以限定发射区域。图案化掩模可以位于有源层的发射表面上，可以被掩埋在有源层内或者可以位于有源层和衬底之间。

10. 发明授权

US5599695A Printing molecular library arrays using deprotection agents solely in the vapor phase 失效
标题翻译：使用去保护剂仅在气相中印刷分子库阵列
公开(公告)号：US5599695A
公开(公告)日：1997-02-04
申请号：US395604
申请日：1995-02-27
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： B01J19/00 , B41M3/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , G03F7/00 , C12P19/34 , C07H21/02 , C07K5/00 , G01N33/543
CPC分类号： C07H21/00 , B01J19/0046 , G03F7/00 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00722 , B41M3/00 , C40B40/06 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
摘要翻译：一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。该方法和装置还依赖于基于标准的基于DMT的化学，以及气相脱保护剂如固体TCA等。

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