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1. 发明授权

US5753173A Method of manufacturing a blood oxygenation system 失效
标题翻译：血液氧化系统的制造方法
公开(公告)号：US5753173A
公开(公告)日：1998-05-19
申请号：US725015
申请日：1996-10-02
申请人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
发明人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36 , B01D63/02 , B29C45/04 , B29C37/02 , D21F1/60 , B32B31/70
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , A61M1/3627 , A61M1/3632 , A61M1/101 , A61M1/3621 , A61M2209/082 , B01D2313/38 , B01D2313/50 , Y10S128/13
摘要： A novel integral cardiotomy/venous blood reservoir, blood oxygenator and heat exchanging device, method of making a blood oxygenating and heat exchanging device and an extracorporeal circulatory support circuit. The reservoir includes a novel blood defoaming and filtering chamber closely receiving filtering and defoaming media. The blood oxygenating and heat exchanging device includes thermal formed housing portions, and a heat exchanging barrier, blood oxygenating medium and/or filtering medium, which are sealed by potting compound at one time. The oxygenating medium comprises a hollow fiber type medium, with its ends left open to be sealingly mounted in a gas path by a novel mounting bracket.
摘要翻译：一种新颖的整体式心切开/静脉血库，血氧饱和器和热交换装置，制备血氧和热交换装置的方法以及体外循环支持电路。水库包括一个新颖的血液消泡和过滤室，紧密接收过滤和消泡介质。血液氧化和热交换装置包括热成形的壳体部分，以及一次由灌封化合物密封的热交换屏障，血氧饱和介质和/或过滤介质。氧合介质包括中空纤维型介质，其端部敞开以通过新的安装支架密封地安装在气体路径中。

2. 发明授权

US5514335A Blood oxygenation system and reservoir and method of manufacture 失效
标题翻译：血液氧化系统和储层及其制造方法
公开(公告)号：US5514335A
公开(公告)日：1996-05-07
申请号：US142809
申请日：1993-10-25
申请人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
发明人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36 , B01D63/02 , A61M1/14 , A61M1/34
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , A61M1/3627 , A61M1/3632 , A61M1/101 , A61M1/3621 , A61M2209/082 , B01D2313/38 , B01D2313/50 , Y10S128/13
摘要： A novel integral cardiotomy/venous blood reservoir, blood oxygenator and heat exchanging device, method of making a blood oxygenating and heat exchanging device and an extracorporeal circulatory support circuit. The reservoir includes a novel blood defoaming and filtering chamber closely receiving filtering and defoaming media. The blood oxygenating and heat exchanging device includes thermal formed housing portions, and a heat exchanging barrier, blood oxygenating medium and/or filtering medium, which are sealed by potting compound at one time. The oxygenating medium comprises a hollow fiber type medium, with its ends left open to be sealingly mounted in a gas path by a novel mounting bracket.
摘要翻译：一种新颖的整体式心切开/静脉血库，血氧饱和器和热交换装置，制备血氧和热交换装置的方法以及体外循环支持电路。水库包括一个新颖的血液消泡和过滤室，紧密接收过滤和消泡介质。血液氧化和热交换装置包括热成形的壳体部分，以及一次由灌封化合物密封的热交换屏障，血氧饱和介质和/或过滤介质。氧合介质包括中空纤维型介质，其端部敞开以通过新的安装支架密封地安装在气体路径中。

3. 发明授权

US5580522A Blood oxygenation system and reservoir and method of manufacture 失效
公开(公告)号：US5580522A
公开(公告)日：1996-12-03
申请号：US429359
申请日：1995-04-26
申请人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
发明人： Ronald J. Leonard , Erin J. Lindsay , David B. Maurer , Daniel W. Viitala
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36 , B01D63/02 , A61M1/03
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , A61M1/3627 , A61M1/3632 , A61M1/101 , A61M1/3621 , A61M2209/082 , B01D2313/38 , B01D2313/50 , Y10S128/13
摘要： A novel integral cardiotomy/venous blood reservoir, blood oxygenator and heat exchanging device, method of making a blood oxygenating and heat exchanging device and an extracorporeal circulatory support circuit. The reservoir includes a novel blood defoaming and filtering chamber closely receiving filtering and defoaming media. The blood oxygenating and heat exchanging device includes thermal formed housing portions, and a heat exchanging barrier, blood oxygenating medium and/or filtering medium, which are sealed by potting compound at one time. The oxygenating medium comprises a hollow fiber type medium, with its ends left open to be sealingly mounted in a gas path by a novel mounting bracket.

4. 发明授权

US5255734A Combination mount and fluid path for heat exchanger 失效
标题翻译：热交换器的组合安装和流体路径
公开(公告)号：US5255734A
公开(公告)日：1993-10-26
申请号：US888840
申请日：1992-05-27
申请人： Ronald J. Leonard , David B. Maurer , Erin J. Lindsay
发明人： Ronald J. Leonard , David B. Maurer , Erin J. Lindsay
IPC分类号： A61M1/32 , A61M1/36 , A61M5/44 , F28F9/007 , F28F27/00
CPC分类号： F28F9/007 , A61M5/44 , A61M1/36 , A61M2205/3606 , A61M2205/366 , A61M2209/082
摘要： A mounting assembly for holding a heat exchanger particularly of the type used in administering cardioplegia during heart surgery. The mounting assembly both mounts the heat exchanger and provides heatexchanging fluid (e.g., water) to the heat exchanger. The mounting assembly also includes a valve and sealing mechanism which are simultaneously operated to ensure that the valve is not opened until after the heat exchanger is properly sealed. The sealing mechanism includes an expandable seal that is designed to hold the heat exchanger on the mounting assembly.

5. 发明授权

US5958338A Mounting apparatus for blood handling systems 失效
标题翻译：血液处理系统的安装装置
公开(公告)号：US5958338A
公开(公告)日：1999-09-28
申请号：US962360
申请日：1997-10-31
申请人： Erin J. Lindsay , Ronald J. Leonard
发明人： Erin J. Lindsay , Ronald J. Leonard
IPC分类号： A61M1/16 , A61M1/36 , A61M1/14 , A61M37/00 , B64D47/00 , F16D31/00
CPC分类号： A61M1/3627 , A61M1/1698 , A61M2209/082
摘要： A blood handling system has a first blood handling apparatus mounted on a second blood handling apparatus with a mounting apparatus. The mounting apparatus has two primary components: a retention sleeve attached to a stem that protrudes from the lower portion of the first blood handling apparatus; and a slotted plate that is attached to a stem on the second blood handling apparatus. The retention sleeve has a track for receiving the slotted plate and a flexible tab, with a protruding tooth, that securely engages the slotted plate in a locked position. If it becomes necessary to disconnect the first blood handling apparatus from the second blood handling apparatus during surgery, the tab may be easily moved into an unlocked position, allowing the disk to slide freely out of the track so that the units can be easily separated from each other.
摘要翻译：血液处理系统具有安装在具有安装装置的第二血液处理装置上的第一血液处理装置。安装装置具有两个主要部件：附接到从第一血液处理装置的下部突出的杆的保持套筒; 以及附接到第二血液处理装置上的杆的开槽板。保持套筒具有用于接收开槽板的轨道和具有突出齿的柔性突片，其在锁定位置牢固地接合开槽板。如果需要在手术期间将第一血液处理设备与第二血液处理设备断开连接，则该突片可以容易地移动到解锁位置，从而允许盘自由地滑出轨道，使得单元可以容易地从彼此。

6. 发明授权

US5762868A Blood oxygenator and heat exchanger 失效
标题翻译：血液充氧器和换热器
公开(公告)号：US5762868A
公开(公告)日：1998-06-09
申请号：US565438
申请日：1995-11-30
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M1/36 , B01D63/02 , A61M1/34
CPC分类号： B01D63/026 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D63/02 , B01D2313/38 , Y10T428/2927
摘要： An integral blood oxygenator and heat exchanger device for oxygenating and heating or cooling a patient's blood during heart bypass surgery. The device preferably includes a pleated blood filter disposed within a gap formed between the opposite ends of the blood oxygenating medium. A blood inlet manifold closely receives a tubular heat exchanging barrier and directs blood flow around the barrier to a blood outlet slot. The blood oxygenating medium covers the blood outlet slot so that blood must flow through the blood oxygenating medium before reaching the blood filter. A vent port and bypass port may be provided in the gap formed by the opposite ends of the blood oxygenating medium upstream of the blood filter.
摘要翻译：用于在心脏旁路手术期间对患者血液进行氧化和加热或冷却的整体式血氧机和热交换器装置。该装置优选地包括设置在形成在血液充氧介质的相对端之间的间隙内的褶式血液过滤器。血液入口歧管紧密地接收管状热交换屏障，并将血液围绕屏障引导到血液出口狭槽。血液充氧介质覆盖血液出口狭缝，使血液在到达血液过滤器之前必须流经血液充氧介质。可以在由血液过滤器上游的血液充氧介质的相对端形成的间隙中设置排气口和旁通口。

7. 发明授权

US5747138A Multilayer hollow-fiber body and method of making 失效
标题翻译：多层中空纤维体及其制造方法
公开(公告)号：US5747138A
公开(公告)日：1998-05-05
申请号：US822523
申请日：1997-04-16
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/18 , A61M1/16 , B01D63/02 , B32B5/12
CPC分类号： B01D63/026 , A61M1/1625 , B01D63/02 , B01D63/021 , A61M1/1698 , B01D2313/025 , Y10T428/24124 , Y10T428/24215 , Y10T428/24231
摘要： A multilayer hollow fiber body useful, for example, in a blood oxygenator. The multilayer hollow fiber body comprises a single hollow fiber mat arranged in the form of a body comprising a plurality of hollow fiber plies. The mat comprises a plurality of generally parallel hollow fibers disposed at regular intervals, and a plurality of connecting fibers holding the connecting fibers. The mat is repeatedly folded over on itself along fold lines, each of which is at an oblique angle to the hollow fibers, to form a multilayer hollow fiber body in which the hollow fibers of any ply of the multilayer hollow fiber body are disposed so as to cross the hollow fibers of an adjacent successive ply of the multilayer hollow fiber body. Also disclosed is a method of making the multilayer hollow fiber body.
摘要翻译：可用于例如在血液充氧器中的多层中空纤维体。多层中空纤维体包括以包括多个中空纤维层的主体的形式布置的单个中空纤维垫。垫包括以规则间隔布置的多个大致平行的中空纤维，以及多个连接纤维，其保持连接纤维。该折叠线沿着与中空纤维成倾斜角的折叠线重复折叠，形成多层中空纤维体，多层中空纤维体的任何层的中空纤维被设置为以交叉多层中空纤维体的相邻连续层的中空纤维。还公开了制造多层中空纤维体的方法。

8. 发明授权

US4863600A Hollow fiber bundle having transverse binding means and method of making same 失效
标题翻译：具有横向结合装置的中空纤维束及其制造方法
公开(公告)号：US4863600A
公开(公告)日：1989-09-05
申请号：US945141
申请日：1986-12-22
申请人： Ronald J. Leonard , Kenneth M. Johnson
发明人： Ronald J. Leonard , Kenneth M. Johnson
IPC分类号： B01D63/00 , B01D63/02 , B65H81/00
CPC分类号： B01D63/025 , B01D63/02 , B01D63/021 , B65H81/00
摘要： A mass transfer device (60) includes a hollow fiber bundle (10) comprising a generally cylindrical core (14) having opposed ends, a plurality of layers of hollow fiber (12) that have been wound around the core, and binding means (48a, 48b, 48c), such as double-sided pressure-sensitive tape that have been wound around the layers of hollow fiber in a plurality of longitudinally spaced locations along the core and intermediate the opposite ends of the core for providing longitudinally spaced support means for the hollow fiber bundle. The hollow fiber bundle is enclosed in a housing (62) having an inner wall (80) which defines a generally circular opening for receiving the hollow fiber bundle except that the inner wall adjust a fluid outlet manifold (74) includes an expansion volume (82) for the hollow fibers that are adjacent that fluid outlet manifold. A screen (88) is provided adjacent the fluid outlet manifold to prevent the fibers from migrating too far into the outlet and to provide a controlled expansion.
摘要翻译：传质装置（60）包括中空纤维束（10），该中空纤维束（10）包括具有相对端的大致圆柱形的芯（14），已经缠绕在芯上的多层中空纤维（12）和装订装置（48a ，48b，48c），例如双层压敏胶带，其沿着芯部缠绕在多个纵向间隔开的中空纤维层周围并且在芯的相对端之间中间，以提供纵向间隔开的支撑装置中空纤维束。中空纤维束被封装在具有内壁（80）的壳体（62）中，内壁（80）限定用于接收中空纤维束的大致圆形的开口，除了内壁调节流体出口歧管（74）包括膨胀容积（82 ）用于与该流体出口歧管相邻的中空纤维。设置在流体出口歧管附近的屏幕（88），以防止纤维迁移到远离出口并提供受控的膨胀。

9. 发明授权

US5382407A Membrane blood oxygenator 失效
标题翻译：膜血液充氧器
公开(公告)号：US5382407A
公开(公告)日：1995-01-17
申请号：US957415
申请日：1992-10-05
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M39/22
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , A61M39/228
摘要： A membrane oxygenator is disclosed. The oxygenator has a housing, gas and blood inlets and outlets, and a transfer membrane mechanism for transferring oxygen to blood. The oxygenator has a device for increasing its efficiency. The device maintains the total pressure of the oxygenating gas at each point within gas flow paths near yet below the total pressure of the blood opposite the transfer membrane mechanism generally throughout the oxygenator. The mechanism restricts the flow of oxygenating gas exiting through a oxygenating gas outlet with approximately the pressure of blood exiting through a blood outlet by providing a pressurization fluid with approximately the pressure of the blood exiting through the blood outlet. In a preferred embodiment, the oxygenating gas outlet is situated within the hollow portion of the housing.
摘要翻译：公开了膜氧合器。氧合器具有壳体，气体和血液入口和出口，以及用于将氧气输送到血液的转移膜机构。氧合器具有提高其效率的装置。该设备保持气体流动路径内的每个点处的氧合气体的总压力接近但低于与整个整个氧合器中的转移膜机构相反的血液总压力。该机构通过提供近似于通过出血口离开的血液的压力的加压流体来限制离开氧合气体出口的充氧气体的流量，其中血液离开血液出口的压力。在优选实施例中，氧合气出口位于壳体的中空部分内。

10. 发明授权

US5152964A Membrane blood oxygenator 失效
标题翻译：膜血液充氧器
公开(公告)号：US5152964A
公开(公告)日：1992-10-06
申请号：US657338
申请日：1991-02-15
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M39/22
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , A61M39/228 , Y10S128/03 , Y10S261/28
摘要： A membrane blood oxygenator having a mechanism for automatically maintaining the total pressure of the oxygenating gas near yet below that of the blood across the membrane is described. This includes a valve for restricting the flow of oxygenating gas exiting the oxygenator with the pressure of the blood exiting the oxygenator. A tubing communicates the pressure of the exiting blood to the valve to activate the valve.
摘要翻译：描述了具有用于自动维持氧合气体的总压力接近血液穿过膜的机构的膜血液充氧器。这包括用于限制离开充氧器的充氧气体的流动与离开氧合器的血液压力的阀。管道将离开的血液的压力传递到阀门以启动阀门。

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