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1. 发明授权

US06175757B1 Luminal mapping 失效
标题翻译： Luminal映射
公开(公告)号：US06175757B1
公开(公告)日：2001-01-16
申请号：US09017573
申请日：1998-02-02
申请人： Ronald Dean Watkins , Charles Lucian Dumoulin , Robert David Darrow , Christine Elise Dumoulin
发明人： Ronald Dean Watkins , Charles Lucian Dumoulin , Robert David Darrow , Christine Elise Dumoulin
IPC分类号： A61B812
CPC分类号： A61B8/12 , A61B5/055 , A61B5/06 , A61B5/062 , A61B8/4245 , A61B8/4461 , Y10S128/916
摘要： An invasive probe for mapping the walls of a lumen employs a real-time tracking means and a wall distance measurement means. As the probe is advanced within the lumen, the real-time tracking means provides three-dimensional coordinates of the probe's position and orientation. Concurrent with probe localization, the distance between the probe and the lumen walls is measured. Both the probe position and the wall distance measurement are sent to a data acquisition system which in turn provides a graphic or numeric display to the operator. Probe tracking can be performed with radio-frequency, magnetic resonance, ultrasonic techniques or the like. If desired, lumen wall distance measurements can be performed with magnetic resonance or ultrasound methods. Lumen wall distance measurements can also be performed with mechanical devices such as balloons and/or expanding structures.
摘要翻译：用于映射管腔壁的入侵探针采用实时跟踪装置和壁距测量装置。当探头在管腔内前进时，实时跟踪装置提供探头位置和方位的三维坐标。与探头定位同时测量探头与腔壁之间的距离。探头位置和墙壁距离测量都发送到数据采集系统，该系统又向操作员提供图形或数字显示。可以使用射频，磁共振，超声波技术等进行探测跟踪。如果需要，可以用磁共振或超声波方法进行管腔壁距离测量。腔壁距离测量也可以用诸如球囊和/或膨胀结构的机械装置进行。

2. 发明授权

US6129667A Luminal diagnostics employing spectral analysis 失效
标题翻译：光谱诊断采用光谱分析
公开(公告)号：US6129667A
公开(公告)日：2000-10-10
申请号：US017565
申请日：1998-02-02
申请人： Charles Lucian Dumoulin , Robert David Darrow , Ronald Dean Watkins
发明人： Charles Lucian Dumoulin , Robert David Darrow , Ronald Dean Watkins
IPC分类号： A61B5/00 , A61B5/055 , A61B5/06 , A61B6/12 , A61B8/08
CPC分类号： A61B5/06 , A61B1/00183 , A61B5/0084 , A61B5/02007 , A61B8/0841 , A61B5/0075 , A61B5/055
摘要： An invasive probe for determining the morphological characteristics of walls of a lumen employs a real-time tracking means and an optical spectral measurement means. As the probe is advanced within the lumen, the real-time tracking means provides three-dimensional coordinates of the probe's position and orientation. Concurrent with probe localization, measurement of the spectral properties of the lumen wall are made by detecting the reflectance and/or absorption of light at the lumen wall. Both the probe position and the spectral measurement are sent to a data acquisition system which in turn provides an graphic or numeric display to the operator. Probe tracking can be performed with radio-frequency, magnetic resonance, ultrasonic techniques or the like. If desired, spectral measurements can be made in the visible, ultra-violet or infra-red spectral bands to provide optimized detection of chemical species of interest.
摘要翻译：用于确定管腔壁的形态特征的入侵探针采用实时跟踪装置和光谱测量装置。当探头在管腔内前进时，实时跟踪装置提供探头位置和方位的三维坐标。与探针定位同时，通过检测管腔壁上的光的反射和/或吸收来测量管腔壁的光谱特性。探头位置和光谱测量都被发送到数据采集系统，数据采集系统又向操作者提供图形或数字显示。可以使用射频，磁共振，超声波技术等进行探测跟踪。如果需要，可以在可见光，紫外线或红外光谱带中进行光谱测量，以提供感兴趣的化学物质的优化检测。

3. 发明授权

US06492814B1 Self localizing receive coils for MR 有权
标题翻译：自动定位MR接收线圈
公开(公告)号：US06492814B1
公开(公告)日：2002-12-10
申请号：US09683404
申请日：2001-12-21
申请人： Ronald Dean Watkins , Charles Lucian Dumoulin , Robert David Darrow
发明人： Ronald Dean Watkins , Charles Lucian Dumoulin , Robert David Darrow
IPC分类号： G01V300
CPC分类号： G01R33/341
摘要： A self-localizing receive coil system for use with a Magnetic Resonance Imaging (MRI) system comprises at least one surface coil assembly for placement adjacent to a region of interest to be imaged and a plurality of tracking devices attached to the surface coil assembly for use in indicating location and orientation of the surface coil assembly during imaging.
摘要翻译：用于与磁共振成像（MRI）系统一起使用的自定位接收线圈系统包括至少一个表面线圈组件，用于邻近要成像的感兴趣区域放置，以及附接到表面线圈组件以用于的多个跟踪装置在成像期间指示表面线圈组件的位置和取向。

4. 发明授权

US5730134A System to monitor temperature near an invasive device during magnetic resonance procedures 失效
标题翻译：在磁共振程序期间监测侵入性装置附近的温度的系统
公开(公告)号：US5730134A
公开(公告)日：1998-03-24
申请号：US714840
申请日：1996-09-09
申请人： Charles Lucian Dumoulin , Ronald Dean Watkins , Robert David Darrow , Steven Peter Souza
发明人： Charles Lucian Dumoulin , Ronald Dean Watkins , Robert David Darrow , Steven Peter Souza
IPC分类号： G01K7/00 , A61B5/00 , A61B5/01 , A61B5/055 , G01R33/28 , G01R33/48
CPC分类号： A61B5/01 , A61B5/055 , G01R33/287 , G01R33/4804
摘要： A temperature monitoring system employs a temperature detection means incorporated into an invasive device intended to be placed within a body during a magnetic resonance procedure. The temperature monitoring system is used to monitor temperature rises in tissue arising from the creation of electric fields within the tissue. These electric fields are created by the application of RF pulses during the course of a magnetic resonance procedure which induce electrical current in the invasive device. It the detected temperature rise exceeds a selected threshold, the temperature monitoring system can cause the magnetic resonance imaging system to either reduce RF power or terminate the procedure. An optical coupling may be used between the imaging or tracking RF coil and the MR receiver to eliminate heating induced by the application of RF pulses during the procedure.
摘要翻译：温度监测系统采用将温度检测装置并入到旨在在磁共振程序期间放置在体内的侵入性装置中。温度监测系统用于监测组织内产生的电场产生的组织温度升高。这些电场是通过在磁共振过程中施加RF脉冲而产生的，其在侵入性装置中引起电流。检测到的温度上升超过选定的阈值，温度监测系统可以使磁共振成像系统降低RF功率或终止程序。可以在成像或跟踪RF线圈和MR接收器之间使用光耦合器来消除在该过程期间由RF脉冲施加引起的加热。

5. 发明授权

US06470204B1 Intracavity probe for MR image guided biopsy and delivery of therapy 失效
标题翻译：用于MR图像引导活检和输送治疗的腔内探针
公开(公告)号：US06470204B1
公开(公告)日：2002-10-22
申请号：US09609899
申请日：2000-07-03
申请人： Egidijus Edward Uzgiris , Kenneth William Rohling , Ronald Dean Watkins , Robert David Darrow , Charles Lucian Dumoulin , Randy Otto John Giaquinto , Michael Edward Moran
发明人： Egidijus Edward Uzgiris , Kenneth William Rohling , Ronald Dean Watkins , Robert David Darrow , Charles Lucian Dumoulin , Randy Otto John Giaquinto , Michael Edward Moran
IPC分类号： A61B505
CPC分类号： A61B5/4381 , A61B5/055
摘要： An insertable intracavity probe for use in Magnetic Resonance Imaging (MRI) and therapy of a region of interest proximal to a cavity, the probe having a substantially rigid probe shell for insertion into the cavity. The probe shell is adapted to incorporate at least one device for imaging the region of interest. A guide track is incorporated in the probe shell and is adapted to guide at least one biopsy or therapy device to the region of interest during imaging. Intracavity regions include cervical, rectal, and other regions associated with internal cavities of a patient.
摘要翻译：用于磁共振成像（MRI）的可插入腔内探针和对腔近侧感兴趣区域的治疗，所述探针具有用于插入腔的基本上刚性的探针壳。探针外壳适于引入至少一个用于对感兴趣区域进行成像的装置。引导轨道结合在探针壳体中，并且适于在成像期间将至少一个活组织检查或治疗装置引导到感兴趣区域。腔内区域包括与患者的内腔相关的颈部，直肠和其它区域。

6. 发明授权

US5882305A Optical coupling for invasive devices 失效
标题翻译：用于入侵设备的光耦合器
公开(公告)号：US5882305A
公开(公告)日：1999-03-16
申请号：US954150
申请日：1997-10-20
申请人： Charles Lucian Dumoulin , Ronald Dean Watkins , Robert David Darrow , Steven Peter Souza
发明人： Charles Lucian Dumoulin , Ronald Dean Watkins , Robert David Darrow , Steven Peter Souza
IPC分类号： G01K7/00 , A61B5/00 , A61B5/01 , A61B5/055 , G01R33/28 , G01R33/48
CPC分类号： A61B5/01 , A61B5/055 , G01R33/287 , G01R33/4804
摘要： An optical coupling is incorporated into an invasive device used in magnetic resonance (MR) imaging. The coupling is incorporated into the invasive device between an imaging or tracking RF coil, and the MR receiver. The optical coupling has a first transducer circuit coupled to the RF which converts between optical and electrical signals. An optical fiber is coupled to the first transducer circuit and extends out of the invasive device to medical imaging equipment. Near this equipment, a second transducer circuit converts optical signals to electrical, and electrical signals to optical, just opposite that of the first transducer circuit. The present invention thereby replaces long lead wires which can cause heating during MR imaging, and may distort an MR image.
摘要翻译：光耦合器被并入用于磁共振（MR）成像的侵入性装置中。耦合结合到成像或跟踪RF线圈与MR接收器之间的侵入性装置中。光耦合器具有耦合到RF的第一传感器电路，其在光信号和电信号之间进行转换。光纤耦合到第一换能器电路，并且从侵入性装置延伸到医疗成像设备。在该设备附近，第二传感器电路将光信号转换成电，并将电信号转换成与第一换能器电路相反的光信号。因此，本发明代替在MR成像期间可能引起加热的长引线，并且可能使MR图像失真。

7. 发明授权

US5807253A Patient electrical isolation system 失效
标题翻译：病人电气隔离系统
公开(公告)号：US5807253A
公开(公告)日：1998-09-15
申请号：US944631
申请日：1997-10-06
申请人： Charles Lucian Dumoulin , Kenneth William Rohling , Ronald Dean Watkins , Randy Otto John Giaquinto
发明人： Charles Lucian Dumoulin , Kenneth William Rohling , Ronald Dean Watkins , Randy Otto John Giaquinto
IPC分类号： G01B7/00 , A61B5/055 , A61B5/06 , A61M25/00 , A61B1/00
CPC分类号： A61B5/06 , A61B5/055 , Y10S128/908
摘要： A patient isolation device is used as a safety device to provide electrical insulation between medical electronic equipment and portions of the equipment which come in contact with the patient. In one implementation of the patient isolation device, an RF coil is incorporated in a catheter connected to medical electronic equipment which tracks the position of the catheter. Typically, there is also medical imaging electronics to provide internal images of the subject along with an indication of the location of the catheter. Typically, the signal from the RF coil is provided to a preamplifier to amplify the signal. The isolation device is placed between the RF coil and the preamplifier such that MR response signals may pass through to the preamplifiers but in the event of a short or electrical malfunction the line voltage will not pass backward into the RF coil causing damage to the patient.
摘要翻译：患者隔离装置用作安全装置，以在医疗电子设备与与患者接触的设备的部分之间提供电绝缘。在患者隔离装置的一个实施方式中，将RF线圈并入连接到跟踪导管位置的医疗电子设备的导管中。通常，还提供医疗成像电子装置以提供对象的内部图像以及导管位置的指示。通常，来自RF线圈的信号被提供给前置放大器以放大信号。隔离装置被放置在RF线圈和前置放大器之间，使得MR响应信号可以通过前置放大器，但是在短路或电气故障的情况下，线路电压将不会向后进入RF线圈，从而导致患者的损坏。

8. 发明授权

US06611702B2 Apparatus for use in neonatal magnetic resonance imaging 有权
公开(公告)号：US06611702B2
公开(公告)日：2003-08-26
申请号：US09681687
申请日：2001-05-21
申请人： Kenneth William Rohling , Ronald Dean Watkins , Charles Lucian Dumoulin , Joseph Edward Piel, Jr. , Charles John Rossi, Jr. , Randy Otto John Giaquinto
发明人： Kenneth William Rohling , Ronald Dean Watkins , Charles Lucian Dumoulin , Joseph Edward Piel, Jr. , Charles John Rossi, Jr. , Randy Otto John Giaquinto
IPC分类号： A61B5055
CPC分类号： G01R33/30 , A61B5/0555 , G01R33/34076
摘要： An incubator arrangement and radiofrequency (RF) coil are provided for use in a Magnetic Resonance Imaging (MRI) system. The incubator arrangement comprises an enclosure adapted to support a subject in a magnet of the MRI system during imaging and a radiofrequency coil disposed within the enclosure. The RF coil is adapted to provide visual and physical access to the subject, and further adapted to obtain a selected signal to noise ratio.

9. 发明授权

US5715822A Magnetic resonance devices suitable for both tracking and imaging 失效
标题翻译：磁共振装置适用于跟踪和成像
公开(公告)号：US5715822A
公开(公告)日：1998-02-10
申请号：US535695
申请日：1995-09-28
申请人： Ronald Dean Watkins , Charles Lucian Dumoulin
发明人： Ronald Dean Watkins , Charles Lucian Dumoulin
IPC分类号： A61B5/05 , A61B5/055 , G01R33/28 , G01R33/34 , G06Q50/00 , G06T1/00
CPC分类号： G01R33/287 , G01R33/34084
摘要： A novel RF coil attached to an invasive device, such as a catheter, is used to detect magnetic resonance (MR) signals for monitoring the position of the device within a subject and for the acquisition of high-resolution magnetic resonance images of the tissue surrounding the device. The novel coil is sensitive to a small volume of MR active tissue during tracking procedures, but is sensitive to a larger volume during imaging procedures. During tracking, the MR signals are detected in the presence of magnetic field gradients and thus have frequencies which are substantially proportional to the location of the coil along the direction of the applied gradient. Signals are detected responsive to applied magnetic gradients to determine the position of the coil in several dimensions. The position of the novel coil, and hence the device, as determined by the tracking system is superimposed upon independently acquired medical diagnostic images. Magnetic Resonance images of the tissue surrounding the novel coil can be obtained by detecting the MR response signals from the novel coil using gradient-recalled, spin-echo or other MR imaging sequences.
摘要翻译：附接到诸如导管的侵入性装置的新型RF线圈用于检测用于监测受试者内的装置的位置的磁共振（MR）信号，并且用于获取周围组织的高分辨率磁共振图像装置。新型线圈在跟踪过程中对少量MR活性组织敏感，但在成像过程中对较大体积敏感。在跟踪期间，在存在磁场梯度的情况下检测MR信号，因此具有与沿施加的梯度方向的线圈位置基本成比例的频率。响应于所施加的磁梯度来检测信号以确定线圈在几个维度中的位置。由跟踪系统确定的新颖线圈的位置以及因此的装置叠加在独立获取的医学诊断图像上。通过使用梯度回归，自旋回波或其他MR成像序列检测来自新颖线圈的MR响应信号，可以获得围绕新线圈的组织的磁共振图像。

10. 发明授权

US07725157B2 System and method for interventional procedures using MRI 失效
标题翻译：使用MRI进行介入手术的系统和方法
公开(公告)号：US07725157B2
公开(公告)日：2010-05-25
申请号：US11383608
申请日：2006-05-16
申请人： Charles Lucian Dumoulin , Richard Philip Mallozzi , Robert David Darrow , Harvey Ellis Cline , Renee Ann Guhde
发明人： Charles Lucian Dumoulin , Richard Philip Mallozzi , Robert David Darrow , Harvey Ellis Cline , Renee Ann Guhde
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0402 , A61B5/042 , A61B5/06 , A61B5/743 , A61B6/503 , A61B6/504 , A61B8/0891 , A61B34/20 , A61B2034/2051 , A61B2090/364 , A61B2090/374 , G01R33/287
摘要： An imaging and interventional system and methods are provided. The system comprises an imaging device for acquiring volumetric image data for an anatomical region of interest, a catheter for acquiring electrophysiological (EP) measurements of the anatomical region of interest, the catheter having at least one tracking coil for detecting signals indicative of a position of the catheter, and, a processor coupled to the catheter for receiving the EP measurements and signals indicative of the position of the catheter. The position of the catheter and EP measurements are combined and superimposed on a resultant image. The method comprises acquiring volumetric image data for an anatomical region of interest, acquiring position data for a catheter inserted in the region of interest, obtaining electrophysiological (EP) measurements for the region of interest and combining the image data, position data and EP measurements into a resultant image for use in the interventional procedure.
摘要翻译：提供了成像和介入系统和方法。该系统包括用于获取感兴趣解剖区域的体积图像数据的成像装置，用于获取感兴趣解剖区域的电生理学（EP）测量值的导管，所述导管具有至少一个跟踪线圈，用于检测指示位置的信号导管，以及耦合到导管的处理器，用于接收EP测量值和指示导管位置的信号。将导管的位置和EP测量结合并叠加在合成的图像上。该方法包括获取感兴趣的解剖区域的体积图像数据，获取插入在感兴趣区域中的导管的位置数据，获得感兴趣区域的电生理（EP）测量值，并将图像数据，位置数据和EP测量结合到用于介入程序的结果图像。

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