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1. 发明申请

US20070154898A1 Dark quenchers for donor-acceptor energy transfer 有权
标题翻译：供体 - 受体能量转移的暗猝灭剂
公开(公告)号：US20070154898A1
公开(公告)日：2007-07-05
申请号：US11437991
申请日：2006-05-19
申请人： Ronald Cook , Matt Lyttle , Daren Dick
发明人： Ronald Cook , Matt Lyttle , Daren Dick
IPC分类号： C12Q1/68 , C12Q1/37 , C12P19/34
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
摘要翻译：本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。

2. 发明申请

US20060194218A1 Inducible fluorescence assay 有权
公开(公告)号：US20060194218A1
公开(公告)日：2006-08-31
申请号：US11177998
申请日：2005-07-08
申请人： Ronald Cook , Eliana Armstrong , Hans Johansson
发明人： Ronald Cook , Eliana Armstrong , Hans Johansson
IPC分类号： C12Q1/68 , C12P21/06 , C07H21/04 , G01N33/543
CPC分类号： C12Q1/26 , C09B11/08 , C12Q1/6818 , C12Q1/6897 , G01N33/542 , G01N2333/90209 , Y10S436/903 , Y10T436/13
摘要： In one aspect, the invention provides fluorescent probes and assays. The probes include a fluorophore-quencher pair that undergoes a switch from dark to fluorescent in response to a reaction of the quencher. The switch of the probe from dark to fluorescent is typically mediated by an enzyme that acts directly or indirectly on the quencher, interfering with its ability to quench fluorescence emission from the fluorophore. In another aspect, the invention provides a reporter gene assay system and methods of using this system. The assay system includes a fluorophore-quencher probe and an enzyme that acts directly or indirectly on the quencher, increasing the fluorescent emission of the fluorophore. In still other aspects, the invention provides nucleic acid constructs and cells expressing the peptide products of these constructs. In assays of the invention, the presence of a target substance is detected by the switching of fluorescence mediated by the change in oxidation state of the quencher. The assay systems are of use in numerous assay formats, e.g., confirming the expression of the enzyme that acts on the quencher, and/or detecting a species conjugated to the enzyme.

3. 发明授权

US4605391A Apparatus for flanging can ends 失效
标题翻译：用于折边的装置可以结束
公开(公告)号：US4605391A
公开(公告)日：1986-08-12
申请号：US716839
申请日：1985-03-28
申请人： Ronald Cook
发明人： Ronald Cook
IPC分类号： B31B17/00
CPC分类号： B31F1/0038 , B31B2201/25 , B31B2201/2604 , B31B2217/082 , B31B2217/108
摘要： An apparatus for flanging the upper and lower ends of a continuous stream of fiberboard cans includes a central rotating turret with a pair of flanges which rotate with the turret and are oriented to grasp each can in its top and bottom opening and press it against a pair of stationary curvilinear rails to spin the can as the rails flange the upper and lower ends of the can. An inlet turret and outlet turret sequentially space the cans and feed them into the rotating turret and flanges.
摘要翻译：用于对连续的纤维板罐的上端和下端进行折边的装置包括具有一对凸缘的中心旋转转台，所述一对凸缘与转台一起旋转并且被定位成在其顶部和底部开口中抓住每个罐并将其按压的固定曲线轨道，以便将罐体的上端和下端作为导轨法兰旋转。进口转塔和出口转台依次对罐进行间隔并将其送入转动的转台和法兰。

4. 发明授权

US07442669B2 Oxidation catalysts comprising metal exchanged hexaaluminate wherein the metal is Sr, Pd, La, and/or Mn 失效
标题翻译：包含金属交换六铝酸盐的氧化催化剂，其中金属是Sr，Pd，La和/或Mn
公开(公告)号：US07442669B2
公开(公告)日：2008-10-28
申请号：US10382132
申请日：2003-03-05
申请人： David Wickham , Ronald Cook
发明人： David Wickham , Ronald Cook
IPC分类号： C01F7/02
CPC分类号： C01G55/002 , B01J21/04 , B01J23/002 , B01J23/34 , B01J35/1009 , B01J37/30 , B01J2523/00 , C01F7/021 , C01F17/0025 , C01G45/006 , C01P2002/50 , C01P2006/13 , F23C13/08 , B01J2523/24 , B01J2523/3706 , B01J2523/72 , B01J2523/31 , B01J2523/824
摘要： The present invention provides metal-exchanged hexaaluminate catalysts that exhibit good catalytic activity and/or stability at high temperatures for extended periods with retention of activity as combustion catalysts, and more generally as oxidation catalysts, that make them eminently suitable for use in methane combustion, particularly for use in natural gas fired gas turbines. The hexaaluminate catalysts of this invention are of particular interest for methane combustion processes for minimization of the generation of undesired levels (less than about 10 ppm) of NOx species. Metal exchanged hexaaluminate oxidation catalysts are also useful for oxidation of volatile organic compounds (VOC), particularly hydrocarbons. Metal exchanged hexaaluminate oxidation catalysts are further useful for partial oxidation, particularly at high temperatures, of reduced species, particularly hydrocarbons (alkanes and alkenes).
摘要翻译：本发明提供了金属交换的六铝酸盐催化剂，其在高温下长时间显示出良好的催化活性和/或稳定性，同时保留作为燃烧催化剂的活性，更一般地，其作为氧化催化剂，使其非常适合用于甲烷燃烧，特别适用于天然气燃气轮机。本发明的六铝酸盐催化剂对于最小化NOx物质的不期望水平（小于约10ppm）的产生的甲烷燃烧过程是特别有意义的。金属交换的六铝酸盐氧化催化剂也可用于挥发性有机化合物（VOC），特别是烃的氧化。金属交换的六铝酸盐氧化催化剂还可用于部分氧化，特别是在高温下的还原物质，特别是烃（烷烃和烯烃）。

5. 发明申请

US20060035262A1 Dark quenchers for donor-acceptor energy transfer 审中-公开
公开(公告)号：US20060035262A1
公开(公告)日：2006-02-16
申请号：US11226852
申请日：2005-09-13
申请人： Ronald Cook , Matt Lyttle , Daren Dick
发明人： Ronald Cook , Matt Lyttle , Daren Dick
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

6. 发明授权

US4587925A Continuous adhesive applicator 失效
标题翻译：连续涂胶器
公开(公告)号：US4587925A
公开(公告)日：1986-05-13
申请号：US664251
申请日：1984-10-24
申请人： Ronald Cook
发明人： Ronald Cook
IPC分类号： B05C1/02
CPC分类号： B05C1/027 , B05C1/022
摘要： A continuous adhesive applicator for applying adhesive, sealant, or the like to cans as they travel along an automated processing line. The apparatus moves the cans through the station area while holding the cans in a selected orientation, rotates the cans as they move through the station, and applies adhesive or the like to a selected portion of each can as it moves through the station. Restraining means, which are cycled for repetitive movement through the station along the path of travel of the line of cans, capture the cans and move them through the station while holding them in the selected orientation.
摘要翻译：一种连续的粘合剂涂布器，用于当它们沿着自动化处理线行进时，将粘合剂，密封剂等用于罐头。该装置将罐移动通过车站区域，同时将罐头保持在选定的方向，当罐子移动通过车站时旋转罐，并且当罐子移动通过车站时，将胶粘剂等施加到每个罐的选定部分。沿着罐头行进路线重复移动通过车站的限制装置捕获罐并将它们移动通过车站，同时将它们保持在所选择的方向。

7. 发明申请

US20070059752A1 Fluorescence energy transfer probes with stabilized conformations 审中-公开
公开(公告)号：US20070059752A1
公开(公告)日：2007-03-15
申请号：US11520152
申请日：2006-09-13
申请人： Ronald Cook
发明人： Ronald Cook
IPC分类号： C12Q1/68 , C07J17/00 , C07H21/04 , C12P19/34
CPC分类号： C07H21/04 , C07H21/00 , C07H21/02 , C07J51/00 , C12Q1/6816 , C12Q1/6818 , C12Q2525/125 , C12Q2525/191 , C12Q2565/1015
摘要： The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.

8. 发明申请

US20050176851A1 RELEASABLE CORROSION INHIBITOR COMPOSITIONS 失效
标题翻译：可释放的腐蚀抑制剂组合物
公开(公告)号：US20050176851A1
公开(公告)日：2005-08-11
申请号：US10412737
申请日：2003-04-11
申请人： Ronald Cook
发明人： Ronald Cook
IPC分类号： B32B5/16 , B32B15/04 , C08K9/10 , C09K3/00
CPC分类号： C08K9/04 , B01J2/30 , B82Y30/00 , C01P2004/64 , C08K3/22 , C08K3/346 , C09C1/24 , C09C1/407 , C09D5/082 , C09D163/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2998 , Y10T428/31678 , C08L2666/54
摘要： A new class of releasable corrosion inhibiting materials for protective coatings, methods of making the same, methods of using the same, and coatings containing the same are provided. The materials comprise one or more corrosion inhibitors that are chemically anchored to the surface of a particle having an aluminum oxyhydroxide surface through a carboxylate bond. The carboxylate/aluminum-oxyhydroxide-surface bond breaks under corrosion-causing conditions (for example the presence of high levels of hydroxide ions generated by the cathodic oxygen reduction reaction on metals such as iron and aluminum) thereby allowing the corrosion inhibitors to detach from the particle surface when corrosion is present.
摘要翻译：提供了一类用于保护涂层的可释放的防腐蚀材料，其制备方法，使用方法和含有它们的涂层。这些材料包括一种或多种腐蚀抑制剂，其通过羧酸盐键化学锚定到具有羟基氧化铝表面的颗粒的表面。羧酸盐/羟基氧化铝 - 表面键在腐蚀条件下（例如，通过阴极氧还原反应产生的高水平氢氧根离子存在于金属和铝等金属上），从而使腐蚀抑制剂从存在腐蚀时的颗粒表面。

9. 发明授权

US06623032B2 Belt force sensor 失效
公开(公告)号：US06623032B2
公开(公告)日：2003-09-23
申请号：US09767973
申请日：2001-01-23
申请人： Brian Michael Curtis , Jeffrey A. Clark , Maria T. Kremer , Harald Lichtinger , Michael Allan Dingman , Ronald Cook
发明人： Brian Michael Curtis , Jeffrey A. Clark , Maria T. Kremer , Harald Lichtinger , Michael Allan Dingman , Ronald Cook
IPC分类号： B60R2132
CPC分类号： B60R21/01556 , B60N2002/2815 , B60R21/0155 , B60R22/00 , B60R22/105 , B60R22/12 , B60R2022/4841 , G06Q20/042
摘要： An occupant restraint assembly and for a motor vehicle operates to sense the tension forces on a seat belt to detect the presence of a human occupant or a child restraint seat. A sensor attached to the seat belt measures tension forces. The sensor is mounted in line with the seat belt. A strain gauge senses tension on the seat belt. An additional embodiment of the sensor includes three prongs attached to a common beam that allow the sensor to be slipped onto the seat belt without modification to the seat belt. A middle prong includes the strain gauge to sense movement relative to outside prongs. The seat belt threads over the outside prongs and under the middle prong such that tension on the seat belt forces the middle prong transversely to tension exerted on the seat belt.

10. 发明授权

US4413587A Can or tube adhesive applicator 失效
标题翻译：罐头或管子贴胶机
公开(公告)号：US4413587A
公开(公告)日：1983-11-08
申请号：US302067
申请日：1981-09-14
申请人： Ronald Cook
发明人： Ronald Cook
IPC分类号： B05C1/02 , B05C7/06 , B05C9/04
CPC分类号： B05C1/022 , B05C7/06 , B05C9/045
摘要： An apparatus to apply uniform amounts of adhesive to containers at a high rate of speed. Containers are selected at a variable interval. The containers are positioned against dual spiral timing screws (one timing screw above the other). Turning the timing screws a constant (but adjustable) number of degrees with respect to each other while they rotate at the same speed will either advance a container in a level position or they may be advanced while tilted, forward or backward depending upon the relative position of the upper and lower timing screw. While the container is advancing, it is also being turned so that the upper surfaces of the container may be positioned against a rotating cylinder to which a layer of adhesive is continuously applied. In this manner adhesive may be applied around the entire circumference of a container on the top, inside edge, outside edge or both edges.
摘要翻译：以高速率将均匀量的粘合剂施加到容器的装置。以可变间隔选择容器。容器定位在双螺旋定时螺钉（一个定时螺钉之上）。将定时螺钉相对于彼此旋转的恒定（但可调节）数量以相同的速度旋转将使容器在水平位置前进，或者它们可以在倾斜，向前或向后倾斜时取决于相对位置的上下定时螺丝。当容器前进时，它也被转动，使得容器的上表面可以抵靠旋转的圆柱体定位，粘合剂层被连续地施加到旋转的圆柱体上。以这种方式，可以在顶部，内部边缘，外部边缘或两个边缘上的容器的整个圆周周围施加粘合剂。

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