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1. 发明授权

US07920971B2 Quantification schemes for quantifying nucleic acids 有权
标题翻译：定量核酸定量方案
公开(公告)号：US07920971B2
公开(公告)日：2011-04-05
申请号：US10571958
申请日：2004-09-24
申请人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
发明人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
IPC分类号： G01N33/48
CPC分类号： C12Q1/6851 , C12Q2537/165
摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
摘要翻译：方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少目标的特征值，根据预定义或选择的量化方案量化目标的原始量。

2. 发明申请

US20060292571A1 Quantification schemes for quantifying nucleic acids 失效
标题翻译：定量核酸定量方案
公开(公告)号：US20060292571A1
公开(公告)日：2006-12-28
申请号：US10571958
申请日：2004-09-14
申请人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
发明人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： C12Q1/6851 , C12Q2537/165
摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
摘要翻译：方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少所述目标的特征值，根据预定义或选择的量化方案量化原始目标量。

3. 发明授权

US08026068B2 Use of silica material in an amplification reaction 有权
标题翻译：在扩增反应中使用二氧化硅材料
公开(公告)号：US08026068B2
公开(公告)日：2011-09-27
申请号：US10337190
申请日：2003-01-06
申请人： Judith Pinsl-Ober , Peter Wenzig , Ralf Schoenbrunner , Patrick O'Donnell , Erich Kyger , Khushbeer Malhotra , Kurt Weindel , Knut Bartl
发明人： Judith Pinsl-Ober , Peter Wenzig , Ralf Schoenbrunner , Patrick O'Donnell , Erich Kyger , Khushbeer Malhotra , Kurt Weindel , Knut Bartl
IPC分类号： C12P19/34
CPC分类号： C12N15/1006 , C12Q1/6806 , C12Q2547/101 , C12Q2531/113
摘要： This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is preferably carried out as an automated process preferably in a high throughput format. The method is preferably used in diagnostics.
摘要翻译：本发明涉及使用具有未修饰的二氧化硅表面的材料分离靶核酸的方法，并且在具有未改性的二氧化硅表面的材料存在下随后扩增靶核酸。该方法优选以高通量格式作为自动化方法进行。该方法优选用于诊断。

4. 发明申请

US20070212680A1 Safety approach for diagnostic systems 审中-公开
标题翻译：诊断系统的安全方法
公开(公告)号：US20070212680A1
公开(公告)日：2007-09-13
申请号：US11701842
申请日：2007-02-01
申请人： Juergen Friedrichs , Judith Pinsl-Ober
发明人： Juergen Friedrichs , Judith Pinsl-Ober
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G01N33/5005 , G16H10/40 , G16H50/80
摘要： The present invention provides a diagnostic safety method, a diagnostic device, a computer program and a diagnostic system for analyzing a plurality of samples with regard to the presence of contaminations. More particular, the present invention provides a diagnostic safety method, a diagnostic device, a computer program and a diagnostic system for analyzing a plurality of samples based on redundant diagnostic results.
摘要翻译：本发明提供了诊断安全方法，诊断装置，计算机程序和用于分析关于污染物存在的多个样品的诊断系统。更具体地，本发明提供了一种用于基于冗余诊断结果分析多个样本的诊断安全方法，诊断装置，计算机程序和诊断系统。

5. 发明授权

US5424212A Analysis system for the automatic analysis of body fluids 失效
标题翻译：用于体液自动分析的分析系统
公开(公告)号：US5424212A
公开(公告)日：1995-06-13
申请号：US197457
申请日：1994-02-16
申请人： Judith Pinsl-Ober , Herbert Buschek , Klaus Erler
发明人： Judith Pinsl-Ober , Herbert Buschek , Klaus Erler
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N21/13 , G01N33/48
CPC分类号： G01N35/00663 , G01N35/00712 , G01N35/025 , G01N2035/00435 , G01N2035/00534 , G01N2035/00564 , G01N2035/00673 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/115831
摘要： Analysis system for the automatic analysis of body fluids for a plurality of different analytes (parameters). An analytical apparatus incorporates reaction vessels (8) which are transported on the apparatus to various handling stations (10 to 16). The system also includes liquid reagents, which are held in readiness on the apparatus in reagent vessels (9), their volume sufficing for a large number of analyses. In order to achieve a high degree of analytical accuracy with reduced probability of operating errors and without significant increasing of the overall system costs, a calibrator is stored ready for use in liquid form in a calibrator station (17) of the analytical apparatus, the calibration is initiated and carried out fully automatically (i.e. without human intervention) for the various parameters independently of one another. For the initiation of the calibration for a parameter, in at least one system-immanent calibration-influencing variable is determined and combined logically with a control value defined specifically for the respective parameter and the decision on the initiation of the calibration is taken automatically in accordance with the logic combination.
摘要翻译：用于多种不同分析物（参数）的体液自动分析的分析系统。分析装置包括在装置上运送到各种处理站（10至16）的反应容器（8）。该系统还包括液体试剂，其在试剂容器（9）中的装置上保持准备，其容量足以进行大量分析。为了实现高度的分析精度，降低了操作错误的可能性，并且没有显着提高整个系统成本，校准器被储存成准备在液体形式中用于分析仪器的校准器站（17），校准对于各个参数彼此独立地启动和完全自动执行（即无需人为干预）。为了启动参数的校准，在至少一个系统内在的校准影响变量中被确定并且与逻辑上与专门针对相应参数定义的控制值进行组合，并且根据校准自动地进行关于校准开始的决定与逻辑组合。

6. 发明授权

US5350458A Method for cleaning a diagnostic analyzer 失效
标题翻译：清洁诊断分析仪的方法
公开(公告)号：US5350458A
公开(公告)日：1994-09-27
申请号：US19826
申请日：1993-02-19
申请人： Judith Pinsl-Ober , Roland Schenk
发明人： Judith Pinsl-Ober , Roland Schenk
IPC分类号： C11D1/00 , C11D1/12 , C11D1/14 , C11D3/20 , G01N35/10 , B01F17/00 , B01F17/30 , B08B3/08 , B08B9/02
CPC分类号： C11D1/004 , C11D1/123 , C11D1/143 , C11D3/2082 , C11D3/2086 , G01N35/1004 , Y10S516/04
摘要： The invention provides a cleaning solution and a method of using the cleaning solution for cleaning diagnostic analyzers. The solution contains a rapidly wetting surfactant and an inorganic or organic acid. The invention provides rapid and effective cleaning of proteins from all types of materials used for components of automatic analyzers.
摘要翻译：本发明提供一种清洁溶液和使用该清洁溶液来清洁诊断分析仪的方法。该溶液含有快速润湿的表面活性剂和无机或有机酸。本发明提供了快速有效地清洗用于自动分析仪组件的所有类型的材料。

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