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1. 发明授权

US08241269B2 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US08241269B2
公开(公告)日：2012-08-14
申请号：US12853787
申请日：2010-08-10
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/22
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.
摘要翻译：用于将流体透皮递送至患者的流体递送装置。该装置包括可应用于患者皮肤的信封。该包络线包括至少一个与至少一个不可渗透层相连的扩散层，使得至少一个室被限定在其间。其他实施方案也包括内部扩散层，因此也具有另外的室。在一种布置中，粘合剂边界层允许该装置可移除地固定到患者身上并且抑制流体径向迁移超出该装置的周边。在另一种布置中，优选地，提供抗微生物层以抑制微生物的生长。

2. 发明授权

US07854732B2 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US07854732B2
公开(公告)日：2010-12-21
申请号：US12343397
申请日：2008-12-23
申请人： Roger Massengale , Alan Dine , Kevin M. Forrest , Bill Porter , Donald M. Earhart
发明人： Roger Massengale , Alan Dine , Kevin M. Forrest , Bill Porter , Donald M. Earhart
IPC分类号： A61K9/22 , A61F13/00
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device is provided for transdermal delivery of fluid medications to patients. The device can comprise a thin envelope which is applied to a patient's skin. The envelope can comprise at least one diffusion layer coupled to at least one impermeable layer such that at least one chamber can exist therebetween. Other embodiments can include internal diffusion layers, and thus can possess additional chambers, as well. The impermeable layer can comprise a top surface of the device. A valve positioned in the impermeable layer can facilitate filling the device with fluid, as well as connection of the device to external fluid sources such as an intravenous bag, pump, or other external fluid delivery system. The diffusion layer can comprise a coiled wire member to control the rate of fluid flow from the device to the patient's skin.
摘要翻译：提供流体递送装置用于向患者透皮递送流体药物。该装置可以包括施加到患者皮肤的薄的信封。信封可以包括耦合到至少一个不可渗透层的至少一个扩散层，使得其间可以存在至少一个室。其他实施例可以包括内部扩散层，并且因此也可以具有附加的室。不透水层可以包括该装置的顶表面。定位在不渗透层中的阀可以有助于用流体填充装置，以及将装置连接到诸如静脉内袋，泵或其它外部流体输送系统的外部流体源。扩散层可以包括螺旋线构件，以控制从装置到患者皮肤的流体流速。

3. 发明授权

US07470266B2 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US07470266B2
公开(公告)日：2008-12-30
申请号：US10663362
申请日：2003-09-16
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/22
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device is provided for transdermal delivery of fluid medications to patients. The device comprises a thin envelope which is applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least one chamber exists therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. The impermeable layer comprises a top surface of the device. A valve positioned in the impermeable layer facilitates filling the device with fluid, as well as connection of the device to external fluid sources such as an intravenous bag, pump, or other external fluid delivery system. The diffusion layer may comprise a semi-permeable membrane which controls the rate of fluid flow from the device to the patient's skin.
摘要翻译：提供流体递送装置用于向患者透皮递送流体药物。该装置包括施加到患者皮肤上的薄膜。该包络线包括至少一个与至少一个不可渗透层耦合的扩散层，使得至少一个室存在于其间。其他实施方案也包括内部扩散层，因此也具有另外的室。不透水层包括该装置的顶表面。定位在不渗透层中的阀有助于用流体填充装置，以及将装置连接到诸如静脉内袋，泵或其它外部流体输送系统的外部流体源。扩散层可以包括半透膜，其控制从装置到患者皮肤的流体流速。

4. 发明授权

US07771413B2 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US07771413B2
公开(公告)日：2010-08-10
申请号：US10942735
申请日：2004-09-16
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/22
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.
摘要翻译：用于将流体透皮递送至患者的流体递送装置。该装置包括可应用于患者皮肤的信封。该包络线包括至少一个与至少一个不可渗透层相连的扩散层，使得至少一个室被限定在其间。其他实施方案也包括内部扩散层，因此也具有另外的室。在一种布置中，粘合剂边界层允许该装置可移除地固定到患者身上并且抑制流体径向迁移超出该装置的周边。在另一种布置中，优选地，提供抗微生物层以抑制微生物的生长。

5. 发明申请

US20090105667A1 FLUID MEDICATION DELIVERY DEVICE 有权
标题翻译：流体药物递送装置
公开(公告)号：US20090105667A1
公开(公告)日：2009-04-23
申请号：US12343397
申请日：2008-12-23
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61M5/00
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device is provided for transdermal delivery of fluid medications to patients. The device can comprise a thin envelope which is applied to a patient's skin. The envelope can comprise at least one diffusion layer coupled to at least one impermeable layer such that at least one chamber can exist therebetween. Other embodiments can include internal diffusion layers, and thus can possess additional chambers, as well. The impermeable layer can comprise a top surface of the device. A valve positioned in the impermeable layer can facilitate filling the device with fluid, as well as connection of the device to external fluid sources such as an intravenous bag, pump, or other external fluid delivery system. The diffusion layer can comprise a coiled wire member to control the rate of fluid flow from the device to the patient's skin.
摘要翻译：提供流体递送装置用于向患者透皮递送流体药物。该装置可以包括施加到患者皮肤的薄的信封。信封可以包括耦合到至少一个不可渗透层的至少一个扩散层，使得其间可以存在至少一个室。其他实施例可以包括内部扩散层，并且因此也可以具有附加的室。不透水层可以包括该装置的顶表面。定位在不渗透层中的阀可以有助于用流体填充装置，以及将装置连接到诸如静脉内袋，泵或其它外部流体输送系统的外部流体源。扩散层可以包括螺旋线构件，以控制从装置到患者皮肤的流体流速。

6. 发明授权

US08323266B2 Fluid medication delivery device 有权
公开(公告)号：US08323266B2
公开(公告)日：2012-12-04
申请号：US12853774
申请日：2010-08-10
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/00
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.

7. 发明申请

US20050106225A1 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US20050106225A1
公开(公告)日：2005-05-19
申请号：US10942735
申请日：2004-09-16
申请人： Roger Massengale , Kevin Forrest , Bill Porter , Donald Earhart , Alan Dine
发明人： Roger Massengale , Kevin Forrest , Bill Porter , Donald Earhart , Alan Dine
IPC分类号： A61F13/00 , A61K9/22 , A61K9/70 , A61K31/00 , A61L15/00 , A61L15/22 , A61L15/42 , A61M35/00 , A61L15/16
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.
摘要翻译：用于将流体透皮递送至患者的流体递送装置。该装置包括可应用于患者皮肤的信封。该包络线包括至少一个与至少一个不可渗透层相连的扩散层，使得至少一个室被限定在其间。其他实施方案也包括内部扩散层，因此也具有另外的室。在一种布置中，粘合剂边界层允许该装置可移除地固定到患者身上并且抑制流体径向迁移超出该装置的周边。在另一种布置中，优选地，提供抗微生物层以抑制微生物的生长。

8. 发明申请

US20050058711A1 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US20050058711A1
公开(公告)日：2005-03-17
申请号：US10663362
申请日：2003-09-16
申请人： Roger Massengale , Kevin Forrest , Bill Porter , Donald Earhart , Alan Dine
发明人： Roger Massengale , Kevin Forrest , Bill Porter , Donald Earhart , Alan Dine
IPC分类号： A61F13/00 , A61K9/22 , A61K9/70 , A61K31/00 , A61L15/00 , A61L15/22 , A61L15/42 , A61M35/00 , A61K9/24
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device is provided for transdermal delivery of fluid medications to patients. The device comprises a thin envelope which is applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least one chamber exists therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. The impermeable layer comprises a top surface of the device. A valve positioned in the impermeable layer facilitates filling the device with fluid, as well as connection of the device to external fluid sources such as an intravenous bag, pump, or other external fluid delivery system. The diffusion layer may comprise a semi-permeable membrane which controls the rate of fluid flow from the device to the patient's skin.
摘要翻译：提供流体递送装置用于向患者透皮递送流体药物。该装置包括施加到患者皮肤上的薄膜。该包络线包括至少一个与至少一个不可渗透层耦合的扩散层，使得至少一个室存在于其间。其他实施方案也包括内部扩散层，因此也具有另外的室。不透水层包括该装置的顶表面。定位在不渗透层中的阀有助于用流体填充装置，以及将装置连接到诸如静脉内袋，泵或其它外部流体输送系统的外部流体源。扩散层可以包括半透膜，其控制从装置到患者皮肤的流体流速。

9. 发明授权

US09289232B2 Soft tissue tunneling device 有权
标题翻译：软组织隧道装置
公开(公告)号：US09289232B2
公开(公告)日：2016-03-22
申请号：US11744667
申请日：2007-05-04
申请人： Roger Massengale , Mark Siminuk , Alan Dine , Doug Carroll
发明人： Roger Massengale , Mark Siminuk , Alan Dine , Doug Carroll
IPC分类号： A61B17/00 , A61B17/34 , A61M25/01
CPC分类号： A61B17/3415 , A61M25/0194 , A61M2025/0197
摘要： A tissue tunneling device is configured to be delivered within the body. The tunneling device includes a shaft with a blunt distal end to prevent coring or other damage to tissue during the delivery of the tunneling device. In some arrangements, the shaft includes one or more lumen, through which medication or another fluid may be administered. An anesthetic or other pain relieving medication may be delivered through the lumen to lessen the discomfort of delivering the tunneling device to the desired anatomical site. The shaft may also include a retractable needle for facilitating the advancement of the tunneling device through skin or other tissue. The shaft may also be provided with an outer sheath, which may be left within the anatomy after the tunneling device has been removed. The shaft may be malleable for custom-shaping the tunneling device prior to and/or during delivery.
摘要翻译：组织穿隧装置构造成在体内递送。隧道装置包括具有钝的远端的轴，以在隧道装置的输送期间防止对组织的取芯或其它损坏。在一些布置中，轴包括一个或多个内腔，通过该内腔可以施用药物或另一种流体。可以通过内腔输送麻醉剂或其它缓解疼痛的药物，以减少将隧道装置递送到期望的解剖部位的不适。轴还可以包括可伸缩的针，用于促进隧穿装置通过皮肤或其它组织的推进。轴还可以设置有外护套，其可以在移除隧道装置之后留在解剖结构内。在传送之前和/或传送期间，轴可以是可延展的用于定形成形隧道装置。

10. 发明申请

US20080086161A1 SOFT TISSUE TUNNELING DEVICE 有权
标题翻译：软组织隧道装置
公开(公告)号：US20080086161A1
公开(公告)日：2008-04-10
申请号：US11744667
申请日：2007-05-04
申请人： Roger Massengale , Mark Siminuk , Alan Dine , Doug Carroll
发明人： Roger Massengale , Mark Siminuk , Alan Dine , Doug Carroll
IPC分类号： A61B1/32
CPC分类号： A61B17/3415 , A61M25/0194 , A61M2025/0197
摘要： A tissue tunneling device is configured to be delivered within the body. The tunneling device includes a shaft with a blunt distal end to prevent coring or other damage to tissue during the delivery of the tunneling device. In some arrangements, the shaft includes one or more lumen, through which medication or another fluid may be administered. An anesthetic or other pain relieving medication may be delivered through the lumen to lessen the discomfort of delivering the tunneling device to the desired anatomical site. The shaft may also include a retractable needle for facilitating the advancement of the tunneling device through skin or other tissue. The shaft may also be provided with an outer sheath, which may be left within the anatomy after the tunneling device has been removed. The shaft may be malleable for custom-shaping the tunneling device prior to and/or during delivery.
摘要翻译：组织穿隧装置构造成在体内递送。隧道装置包括具有钝的远端的轴，以在隧道装置的输送期间防止对组织的取芯或其它损坏。在一些布置中，轴包括一个或多个内腔，通过该内腔可以施用药物或另一种流体。可以通过内腔输送麻醉剂或其它缓解疼痛的药物，以减少将隧道装置递送到期望的解剖部位的不适。轴还可以包括可伸缩的针，用于促进隧穿装置通过皮肤或其它组织的推进。轴还可以设置有外护套，其可以在移除隧道装置之后留在解剖结构内。在传送之前和/或传送期间，轴可以是可延展的用于定形成形隧道装置。

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