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1. 发明授权

US07195926B1 Antibodies to a cathepsin C homolog 失效
标题翻译：组织蛋白酶C同系物的抗体
公开(公告)号：US07195926B1
公开(公告)日：2007-03-27
申请号：US09520941
申请日：2000-03-08
申请人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
发明人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , C12P21/04 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , A61K2039/505 , G01N33/5055 , G01N33/573 , G01N33/6893 , G01N2800/102 , G01N2800/104 , G01N2800/108 , G01N2800/26 , G01N2800/323
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码在THP-1细胞中表达的新的组织蛋白酶C同系物（RCP）的核苷酸和氨基酸序列。本发明还提供编码RCP的核苷酸序列的反义分子，用于产生纯化的RCP的表达载体，能够特异性结合RCP的抗体，用于检测编码RCP的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达RCP的细胞，用于基于编码RCP的核酸分子激活单核细胞/巨噬细胞的诊断测试，以及使用该蛋白质产生能够特异性结合蛋白质的抗体和使用蛋白质筛选抑制剂。

2. 发明授权

US6066488A Cathepsin C homolog 失效
标题翻译：组织蛋白酶C同源物
公开(公告)号：US6066488A
公开(公告)日：2000-05-23
申请号：US871314
申请日：1997-06-09
申请人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
发明人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
IPC分类号： G01N33/50 , C07K14/60 , C12N9/48 , C12N15/09 , C12N15/57 , C12Q1/34 , C12Q1/68 , G01N33/53 , G01N33/566 , C12N9/50 , C12N9/64 , C12N15/00
CPC分类号： C12N9/48
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码在THP-1细胞中表达的新的组织蛋白酶C同系物（RCP）的核苷酸和氨基酸序列。本发明还提供编码RCP的核苷酸序列的反义分子，用于产生纯化的RCP的表达载体，能够特异性结合RCP的抗体，用于检测编码RCP的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达RCP的细胞，用于基于编码RCP的核酸分子激活单核细胞/巨噬细胞的诊断测试，以及使用该蛋白质产生能够特异性结合蛋白质的抗体和使用蛋白质筛选抑制剂。

3. 发明授权

US6033848A Human ice homolog 失效
标题翻译：人类冰同源物
公开(公告)号：US6033848A
公开(公告)日：2000-03-07
申请号：US522813
申请日：1995-08-01
申请人： Scott Michael Braxton , Dinh Diep , Jeffrey J. Seilhamer
发明人： Scott Michael Braxton , Dinh Diep , Jeffrey J. Seilhamer
IPC分类号： C12N9/64 , C12Q1/68 , C07H21/04 , C12N9/00 , C12P21/02
CPC分类号： C12N9/6475 , A61K2039/505 , C07K2319/02
摘要： The present invention provides a polynucleotide (icel) which identifies and encodes a human ice homolog (ICEL) expressed in lung cells and tissues. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified ICEL peptide, antibodies capable of binding to ICEL, inhibitors which bind to ICEL and pharmaceutical compositions based on ICEL specific antibodies or inhibitors. The invention specifically provides for diagnostic assays which identify a disorder or disease with altered icel expression which allows identification and monitoring of hospital patients. These assays utilize icel encoding or controlling nucleic acid sequences, fragments or oligomers thereof, or antibodies specific for the peptide.
摘要翻译：本发明提供鉴定和编码在肺细胞和组织中表达的人类冰同源物（ICEL）的多核苷酸（icel）。本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。本发明还提供用于产生纯化的ICEL肽，能够结合ICEL的抗体，与ICEL结合的抑制剂和基于ICEL特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。本发明特别提供了鉴定具有改变的icel表达的障碍或疾病的诊断测定，其允许鉴定和监测医院患者。这些测定法利用编码或控制其核酸序列，其片段或寡聚体，或对该肽具有特异性的抗体。

4. 发明授权

US5929210A Serpin derived from human hypothalmus 失效
标题翻译： Serpin衍生自人类下丘脑
公开(公告)号：US5929210A
公开(公告)日：1999-07-27
申请号：US997040
申请日：1997-12-23
申请人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
发明人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译：本发明提供鉴定和编码在人下丘脑中表达的新型serpin（CAPE）的核苷酸和氨基酸序列。本发明还提供编码CAPE的核苷酸序列的反义分子，用于产生纯化的CAPE的表达载体，能够特异性结合CAPE的抗体，用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达Cape的细胞，含有生物活性CAPE的药物组合物，基于CAPE编码核酸分子的诊断试验，以及包含施用生物活性CAPE的治疗方法。

5. 发明授权

US6001632A Human protein disulfide isomerase 失效
标题翻译：人蛋白二硫键异构酶
公开(公告)号：US6001632A
公开(公告)日：1999-12-14
申请号：US181318
申请日：1998-10-27
申请人： Scott Michael Braxton , Lynn E. Murry
发明人： Scott Michael Braxton , Lynn E. Murry
IPC分类号： A61K38/00 , C12N9/90 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/90 , A61K38/00
摘要： The present invention provides a polynucleotide (pdih) the partial sequence for which was initially isolated from a lung cDNA library and which identifies and encodes a novel human protein disulfide isomerase (PDIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PDIH. The invention also provides for the use of purified PDIH and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the abnormal expression of PDIH. Additionally, the invention provides for the use of antisense molecules to pdih or inhibitors of PDIH in pharmaceutical compositions for treatment of diseases. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of pdih, or anti-PDIH antibodies which specifically bind to the polypeptide, PDIH.
摘要翻译：本发明提供了一种多核苷酸（pdih），其部分序列最初从肺cDNA文库中分离，并鉴定并编码新的人蛋白质二硫键异构酶（PDIH）。本发明提供了包含编码PDIH的核酸序列的基因工程表达载体和宿主细胞。本发明还提供纯化的PDIH及其激动剂在商业生产重组蛋白质和用于治疗与PDIH异常表达相关的疾病的药物组合物中的用途。另外，本发明提供了用于治疗疾病的药物组合物中的pdih反义分子或PDIH抑制剂的用途。本发明还描述了使用包含其多肽，其片段或其互补物的诊断组合物的诊断测定法，其与pIIh的基因组序列或转录物或与PDIH特异性结合的抗PDIH抗体杂交。

6. 发明授权

US5869637A Human Kallikrein 失效
标题翻译：人激肽释放酶
公开(公告)号：US5869637A
公开(公告)日：1999-02-09
申请号：US681151
申请日：1996-07-22
申请人： Janice Au-Young , Olga Bandman , Scott Michael Braxton , Surya K. Goli
发明人： Janice Au-Young , Olga Bandman , Scott Michael Braxton , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K38/48 , A61P7/02 , A61P9/04 , A61P9/12 , A61P29/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/12 , C12N15/57 , C12P21/02 , C12P21/08 , C07H21/02 , C07H21/04 , C12N15/63
CPC分类号： C12N9/6445 , A61K38/00 , C07K2319/00
摘要： The present provides a polynucleotide which identifies and encodes a novel human kallikrein (HKLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HKLP. The invention also provides for the use of substantially purified HKLP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HKLP. Additionally, the invention provides for the use of antisense molecules to HKLP in pharmaceutical compositions for treatment of diseases associated with the expression of HKLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HKLP or anti-HKLP antibodies which specifically bind to HKLP.
摘要翻译：本发明提供鉴定和编码新型人激肽释放酶（HKLP）的多核苷酸。本发明提供了包含编码HKLP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与HKLP表达相关的疾病的药物组合物中使用基本上纯化的HKLP及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与HKLP表达相关的疾病的药物组合物中HKLP的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码HKLP或特异性结合HKLP的抗HKLP抗体的多核苷酸的基因组序列或转录物杂交。

7. 发明授权

US5808001A Human ice homolog antibodies and compositions thereof 失效
标题翻译：人类冰同源抗体及其组合物
公开(公告)号：US5808001A
公开(公告)日：1998-09-15
申请号：US900491
申请日：1997-07-25
申请人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
发明人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/00 , C12N15/57 , C12P21/08 , C12Q1/68 , C12R1/91 , C07K16/00
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。本发明还提供编码ICEY的核苷酸序列的反义分子，用于产生纯化的ICEY的表达载体，能够特异性结合ICEY的抗体，用于检测ICEY编码核苷酸序列的杂交探针或寡核苷酸，遗传工程化宿主用于表达ICEY的细胞，用于基于编码ICEY编码核酸分子的单核细胞/巨噬细胞活化的诊断试验，以及使用该蛋白质产生能够特异性结合该蛋白质的抗体并使用蛋白质筛选抑制剂。

8. 发明授权

US5840562A DNA encoding human cysteine protease 失效
标题翻译：编码人半胱氨酸蛋白酶的DNA
公开(公告)号：US5840562A
公开(公告)日：1998-11-24
申请号：US928613
申请日：1997-09-12
申请人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
发明人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
IPC分类号： C12N9/64 , C12N9/48 , C07H21/04
CPC分类号： C12N9/6472
摘要： The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
摘要翻译：本发明提供了鉴定和编码在肾上腺和人脐静脉内皮的细胞中表达的新型半胱氨酸蛋白酶（NCP）的多核苷酸（ncp）。本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。本发明进一步提供用于产生纯化的NCP肽，能够结合NCP的抗体，结合NCP的抑制剂和基于NCP特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。本发明特别提供了基于改变的ncp表达并允许鉴定这种病症的诊断测定法。这些测定使用从ncp编码或控制核酸序列或针对NCP特异的抗体设计的探针。

9. 发明授权

US5804376A Pancreas-derived serpin 失效
公开(公告)号：US5804376A
公开(公告)日：1998-09-08
申请号：US434881
申请日：1995-05-02
申请人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
发明人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
IPC分类号： G01N33/566 , A61K31/70 , A61K38/00 , A61K48/00 , A61P1/00 , C07K14/81 , C07K16/38 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/15 , C12Q1/68 , G01N33/573 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.

10. 发明授权

US5700924A Serpin derived from human hypothalamus 失效
标题翻译： Serpin衍生自人类下丘脑
公开(公告)号：US5700924A
公开(公告)日：1997-12-23
申请号：US487823
申请日：1995-06-07
申请人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
发明人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53 , C12N15/85 , C07H21/04 , C12N15/63 , C12P19/34
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译：本发明提供鉴定和编码在人下丘脑中表达的新型serpin（CAPE）的核苷酸和氨基酸序列。本发明还提供编码CAPE的核苷酸序列的反义分子，用于产生纯化的CAPE的表达载体，能够特异性结合CAPE的抗体，用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达Cape的细胞，含有生物活性CAPE的药物组合物，基于CAPE编码核酸分子的诊断试验，以及包含施用生物活性CAPE的治疗方法。

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