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1. 发明授权

US5808001A Human ice homolog antibodies and compositions thereof 失效
标题翻译：人类冰同源抗体及其组合物
公开(公告)号：US5808001A
公开(公告)日：1998-09-15
申请号：US900491
申请日：1997-07-25
申请人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
发明人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/00 , C12N15/57 , C12P21/08 , C12Q1/68 , C12R1/91 , C07K16/00
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。本发明还提供编码ICEY的核苷酸序列的反义分子，用于产生纯化的ICEY的表达载体，能够特异性结合ICEY的抗体，用于检测ICEY编码核苷酸序列的杂交探针或寡核苷酸，遗传工程化宿主用于表达ICEY的细胞，用于基于编码ICEY编码核酸分子的单核细胞/巨噬细胞活化的诊断试验，以及使用该蛋白质产生能够特异性结合该蛋白质的抗体并使用蛋白质筛选抑制剂。

2. 发明授权

US5840562A DNA encoding human cysteine protease 失效
标题翻译：编码人半胱氨酸蛋白酶的DNA
公开(公告)号：US5840562A
公开(公告)日：1998-11-24
申请号：US928613
申请日：1997-09-12
申请人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
发明人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
IPC分类号： C12N9/64 , C12N9/48 , C07H21/04
CPC分类号： C12N9/6472
摘要： The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
摘要翻译：本发明提供了鉴定和编码在肾上腺和人脐静脉内皮的细胞中表达的新型半胱氨酸蛋白酶（NCP）的多核苷酸（ncp）。本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。本发明进一步提供用于产生纯化的NCP肽，能够结合NCP的抗体，结合NCP的抑制剂和基于NCP特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。本发明特别提供了基于改变的ncp表达并允许鉴定这种病症的诊断测定法。这些测定使用从ncp编码或控制核酸序列或针对NCP特异的抗体设计的探针。

3. 发明授权

US5654146A Human ice homolog 失效
标题翻译：人类冰同源物
公开(公告)号：US5654146A
公开(公告)日：1997-08-05
申请号：US443865
申请日：1995-05-31
申请人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
发明人： Scott Michael Braxton , Angelo M. Delegeane , Dinh Diep
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/00 , C12N15/57 , C12P21/08 , C12Q1/68 , C12R1/91 , C12N9/00 , C12N15/12 , G01N33/573
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for expression vectors for the production of purified ICEY, hybridization probes for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for ICEY or for polynucleotides encoding ICEY, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。本发明还提供用于产生纯化的ICEY的表达载体，用于检测编码ICEY的核苷酸序列的杂交探针，用于表达ICEY的遗传工程化宿主细胞，用于ICEY的ICEY诊断试验或用于编码ICEY的多核苷酸的用途该蛋白质产生能够特异性结合蛋白质的抗体并使用蛋白质筛选抑制剂。

4. 发明授权

US6007997A Human cysteine protease 失效
标题翻译：人半胱氨酸蛋白酶
公开(公告)号：US6007997A
公开(公告)日：1999-12-28
申请号：US193524
申请日：1998-11-17
申请人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
发明人： Dinh Diep , Scott Michael Braxton , Angelo M. Delegeane
IPC分类号： C12N9/64 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： C12N9/6472
摘要： The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
摘要翻译：本发明提供了鉴定和编码在肾上腺和人脐静脉内皮的细胞中表达的新型半胱氨酸蛋白酶（NCP）的多核苷酸（ncp）。本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。本发明进一步提供用于产生纯化的NCP肽，能够结合NCP的抗体，结合NCP的抑制剂和基于NCP特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。本发明特别提供了基于改变的ncp表达并允许鉴定这种病症的诊断测定法。这些测定使用从ncp编码或控制核酸序列或针对NCP特异的抗体设计的探针。

5. 发明授权

US5738991A Method of detecting elastase IV 失效
标题翻译：检测弹性蛋白酶IV的方法
公开(公告)号：US5738991A
公开(公告)日：1998-04-14
申请号：US568031
申请日：1995-12-06
申请人： Scott Michael Braxton , Dinh Diep , Angelo M. Delegeane
发明人： Scott Michael Braxton , Dinh Diep , Angelo M. Delegeane
IPC分类号： A61K38/00 , C12N9/64 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C12N9/6424 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.
摘要翻译：本发明提供了鉴定和编码在胰腺组织中表达的大鼠弹性蛋白酶IV（HEIV）的人同源物的核苷酸和氨基酸序列。本发明还提供编码用于检测编码HEIV的核苷酸序列的HEIV，杂交探针或寡核苷酸的核苷酸序列的反义分子，以及基于编码HEIV的核酸分子的诊断测试。本发明还提供用于表达HEIV，生物活性HEIV，能够特异性结合HEIV的抗体的基因工程宿主细胞，以及包含能够结合HEIV以改变其活性的化合物，例如抗体或抑制剂的治疗方法。

6. 发明授权

US5929210A Serpin derived from human hypothalmus 失效
标题翻译： Serpin衍生自人类下丘脑
公开(公告)号：US5929210A
公开(公告)日：1999-07-27
申请号：US997040
申请日：1997-12-23
申请人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
发明人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译：本发明提供鉴定和编码在人下丘脑中表达的新型serpin（CAPE）的核苷酸和氨基酸序列。本发明还提供编码CAPE的核苷酸序列的反义分子，用于产生纯化的CAPE的表达载体，能够特异性结合CAPE的抗体，用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达Cape的细胞，含有生物活性CAPE的药物组合物，基于CAPE编码核酸分子的诊断试验，以及包含施用生物活性CAPE的治疗方法。

7. 发明授权

US5804376A Pancreas-derived serpin 失效
公开(公告)号：US5804376A
公开(公告)日：1998-09-08
申请号：US434881
申请日：1995-05-02
申请人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
发明人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
IPC分类号： G01N33/566 , A61K31/70 , A61K38/00 , A61K48/00 , A61P1/00 , C07K14/81 , C07K16/38 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/15 , C12Q1/68 , G01N33/573 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.

8. 发明授权

US5700924A Serpin derived from human hypothalamus 失效
标题翻译： Serpin衍生自人类下丘脑
公开(公告)号：US5700924A
公开(公告)日：1997-12-23
申请号：US487823
申请日：1995-06-07
申请人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
发明人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53 , C12N15/85 , C07H21/04 , C12N15/63 , C12P19/34
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译：本发明提供鉴定和编码在人下丘脑中表达的新型serpin（CAPE）的核苷酸和氨基酸序列。本发明还提供编码CAPE的核苷酸序列的反义分子，用于产生纯化的CAPE的表达载体，能够特异性结合CAPE的抗体，用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达Cape的细胞，含有生物活性CAPE的药物组合物，基于CAPE编码核酸分子的诊断试验，以及包含施用生物活性CAPE的治疗方法。

9. 发明授权

US6013448A Pancreas-derived serpin 失效
标题翻译：胰腺来源的丝氨酸蛋白酶抑制剂
公开(公告)号：US6013448A
公开(公告)日：2000-01-11
申请号：US977771
申请日：1997-11-25
申请人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
发明人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
IPC分类号： G01N33/566 , A61K31/70 , A61K38/00 , A61K48/00 , A61P1/00 , C07K14/81 , C07K16/38 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/15 , C12Q1/68 , G01N33/573 , C07H21/02
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.
摘要翻译：本发明提供鉴定和编码在人胰腺中表达的新型胰腺来源的丝氨酸蛋白酶抑制剂（PDS）的核苷酸和氨基酸序列。本发明还提供编码PDS的核苷酸序列的反义分子，用于产生纯化的PDS的表达载体，能够特异性结合PDS的抗体，用于检测PDS-编码核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达PDS的细胞，基于PDS编码核酸分子的诊断试验和含有能够特异性结合丝氨酸蛋白酶的PDS的药物组合物。

10. 发明授权

US5955284A Assay method to detect serpin derived from human hypothalamus 失效
标题翻译：检测来自人类下丘脑的丝氨酸蛋白酶的测定方法
公开(公告)号：US5955284A
公开(公告)日：1999-09-21
申请号：US203237
申请日：1998-12-01
申请人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
发明人： Scott Michael Braxton , Dinh Diep , Susan G. Stuart
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译：本发明提供鉴定和编码在人下丘脑中表达的新型serpin（CAPE）的核苷酸和氨基酸序列。本发明还提供编码CAPE的核苷酸序列的反义分子，用于产生纯化的CAPE的表达载体，能够特异性结合CAPE的抗体，用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达Cape的细胞，含有生物活性CAPE的药物组合物，基于CAPE编码核酸分子的诊断试验，以及包含施用生物活性CAPE的治疗方法。

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