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1. 发明申请

US20060058817A1 Delivery devices and methods for heart valve repair 失效
公开(公告)号：US20060058817A1
公开(公告)日：2006-03-16
申请号：US10901555
申请日：2004-07-27
申请人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
发明人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
IPC分类号： A61B17/10
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0496 , A61B2017/2905 , A61F2/2445 , A61F2/2451 , A61F2/2466 , A61M2025/0096
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

2. 发明申请

US20060025750A1 Delivery devices and methods for heart valve repair 有权
公开(公告)号：US20060025750A1
公开(公告)日：2006-02-02
申请号：US10901455
申请日：2004-07-27
申请人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
发明人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
IPC分类号： A61M31/00
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0437 , A61B2017/0464 , A61B2017/0496 , A61B2017/07221 , A61B2017/2905 , A61F2/2445 , A61M2025/0096
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

3. 发明申请

US20050107810A1 Devices and methods for heart valve repair 审中-公开
标题翻译：心脏瓣膜修复的装置和方法
公开(公告)号：US20050107810A1
公开(公告)日：2005-05-19
申请号：US10776682
申请日：2004-02-10
申请人： Rodolfo Morales , Niel Starksen
发明人： Rodolfo Morales , Niel Starksen
IPC分类号： A61B17/00 , A61B17/34 , A61F2/24 , A61B17/10
CPC分类号： A61B17/0487 , A61B1/00082 , A61B1/00096 , A61B1/04 , A61B8/12 , A61B17/00234 , A61B17/0401 , A61B17/0644 , A61B17/0684 , A61B17/083 , A61B17/10 , A61B17/1285 , A61B17/3421 , A61B17/3423 , A61B2017/00243 , A61B2017/0488 , A61B2017/0496 , A61B2017/06023 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/2445 , A61F2/2451
摘要： Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.
摘要翻译：方法和装置提供心脏瓣膜环的收缩以治疗心脏瓣膜反流和其他状况。实施例通常包括用于将收紧或紧固装置附接到心脏瓣膜环的装置以减小环的周长，从而减少瓣膜反流。紧固装置可以包括多个系绳夹，多个未卷绕的压接夹，稳定装置，可视化装置等。在一个实施例中，多个系留夹紧件被周向地固定到阀环上，并且联接夹子的系链被收紧以减小环空的至少一部分的圆周。方法和装置可以用于开心手术，微创手术，基于导管的手术，和/或跳动心脏或停止的心脏的程序。

4. 发明申请

US20060129188A1 Remodeling a cardiac annulus 有权
标题翻译：重塑心脏环
公开(公告)号：US20060129188A1
公开(公告)日：2006-06-15
申请号：US11255400
申请日：2005-10-20
申请人： Niel Starksen , John To , Rodolfo Morales
发明人： Niel Starksen , John To , Rodolfo Morales
IPC分类号： A61B17/04
CPC分类号： A61B17/064 , A61B17/00234 , A61B17/0401 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61F2/2445
摘要： Described herein are methods of remodeling the base of a ventricle. In particular, methods of remodeling a valve annulus by forming a new fibrous annulus are described. These methods may result in a remodeled annulus that corrects valve leaflet function without substantially inhibiting the mobility of the leaflet. The methods of remodeling the base of the ventricle include the steps of securing a plurality of anchors to the valve annulus beneath one or more leaflets of the valve, constricting the valve annulus by cinching a tether connecting the anchors, and securing the anchors in the cinched conformation to allow the growth of fibrous tissue. The annulus may be cinched (e.g., while visualizing the annulus) so that the mobility of the valve leaflets is not significantly restricted. The remodeled annulus is typically constricted to shorten the diameter of the annulus to correct for valve dysfunction (e.g., regurgitation).
摘要翻译：本文描述了重建心室基部的方法。特别地，描述了通过形成新的纤维环重新形成瓣膜环的方法。这些方法可能导致改造的瓣环，其校正瓣膜小叶功能而基本上不抑制小叶的移动性。重建心室基部的方法包括以下步骤：将多个锚固件固定在阀的一个或多个小叶下方的瓣膜环上，通过收紧连接锚固件的系绳来收缩瓣膜环，并将锚固件固定在带状物允许纤维组织生长的构象。环可以被束缚（例如，同时可视化环），使得瓣膜小叶的移动性没有被显着限制。改造的环通常被收缩以缩短环的直径以纠正瓣膜功能障碍（例如，反流）。

5. 发明申请

US20050065550A1 Delivery devices and methods for heart valve repair 有权
公开(公告)号：US20050065550A1
公开(公告)日：2005-03-24
申请号：US10901019
申请日：2004-07-27
申请人： Niel Starksen , John To , Rodolfo Morales
发明人： Niel Starksen , John To , Rodolfo Morales
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/08 , A61F2/24
CPC分类号： A61B17/064 , A61B17/00234 , A61B17/0401 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0437 , A61B2017/0464 , A61B2017/07221 , A61F2/2445 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

6. 发明申请

US20050216078A1 Delivery devices and methods for heart valve repair 审中-公开
标题翻译：心脏瓣膜修复的输送装置和方法
公开(公告)号：US20050216078A1
公开(公告)日：2005-09-29
申请号：US11137833
申请日：2005-05-24
申请人： Niel Starksen , John To , Rodolfo Morales
发明人： Niel Starksen , John To , Rodolfo Morales
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/08 , A61F2/24
CPC分类号： A61B17/064 , A61B17/00234 , A61B17/0401 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61F2/2451 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常包括将锚定器输送装置通过患者的脉管系统推进到心脏中的一个位置处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个耦合的锚固件从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

7. 发明申请

US20050107811A1 Delivery devices and methods for heart valve repair 审中-公开
公开(公告)号：US20050107811A1
公开(公告)日：2005-05-19
申请号：US10900980
申请日：2004-07-27
申请人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
发明人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/12 , A61F2/24 , A61M20060101
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

8. 发明申请

US20060025787A1 Devices and methods for heart valve repair 审中-公开
公开(公告)号：US20060025787A1
公开(公告)日：2006-02-02
申请号：US11237461
申请日：2005-09-27
申请人： Rodolfo Morales , Niel Starksen
发明人： Rodolfo Morales , Niel Starksen
IPC分类号： A61B17/08
CPC分类号： A61B17/0487 , A61B1/00082 , A61B1/00096 , A61B1/04 , A61B8/12 , A61B17/00234 , A61B17/0401 , A61B17/0644 , A61B17/0684 , A61B17/083 , A61B17/10 , A61B17/1285 , A61B17/3421 , A61B17/3423 , A61B2017/00243 , A61B2017/0488 , A61B2017/0496 , A61B2017/06023 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/2445 , A61F2/2451
摘要： Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.

9. 发明申请

US20060025784A1 Delivery devices and methods for heart valve repair 有权
公开(公告)号：US20060025784A1
公开(公告)日：2006-02-02
申请号：US10901444
申请日：2004-07-27
申请人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
发明人： Niel Starksen , John To , Mariel Fabro , Michael Wei , Rodolfo Morales
IPC分类号： A61B17/08
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

10. 发明申请

US20050119523A1 Cardiac visualization devices and methods 有权
标题翻译：心脏可视化装置和方法
公开(公告)号：US20050119523A1
公开(公告)日：2005-06-02
申请号：US10927784
申请日：2004-08-27
申请人： Niel Starksen , Nick Pliam , Rodolfo Morales , John To
发明人： Niel Starksen , Nick Pliam , Rodolfo Morales , John To
IPC分类号： A61B17/00 , A61B17/128 , A61B18/14
CPC分类号： A61B17/00234 , A61B17/1285 , A61B18/1492 , A61B2017/00243
摘要： Devices and methods for facilitating transvascular, minimally invasive and other “less invasive” surgical procedures generally include a sheath with an expandable balloon at the distal end, an inflation lumen for expanding the balloon, and a device passage lumen for allowing passage of one or more surgical instruments. The sheath is configured to house at least one visualization device such that an optical element of the device is positioned to view the surgical site. In some embodiments, instruments may be passed through the sheath, with the distal balloon partially or fully circumscribing or encircling the instruments. Any suitable instrument(s) may be passed through sheaths of the invention, such as a surgical clip applier for repairing a heart valve, an ablation member for treating atrial fibrillation, one or more pacemaker leads, a coronary sinus access device or the like.
摘要翻译：用于促进经血管，微创和其它“侵入性较小”外科手术的装置和方法通常包括在远端具有可膨胀气囊的护套，用于扩张气囊的充气腔，以及允许一个或多个手术器械。鞘被配置为容纳至少一个可视化装置，使得装置的光学元件被定位成观察手术部位。在一些实施例中，器械可以穿过护套，其中远端气囊部分或完全限定或环绕器械。任何合适的仪器可以通过本发明的护套，例如用于修复心脏瓣膜的手术夹具施放器，用于治疗房颤的消融构件，一个或多个起搏器引线，冠状窦入口装置等。

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