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1. 发明授权

US08950728B2 Devices and methods for occluding a flexible tube 有权
标题翻译：用于封闭柔性管的装置和方法
公开(公告)号：US08950728B2
公开(公告)日：2015-02-10
申请号：US12714056
申请日：2010-02-26
申请人： Rodney S. Kenley , Dean Kamen , Keith D. Violette , Kevin L. Grant , Larry B. Gray , Richard J. Lanigan , Jason A. Demers
发明人： Rodney S. Kenley , Dean Kamen , Keith D. Violette , Kevin L. Grant , Larry B. Gray , Richard J. Lanigan , Jason A. Demers
IPC分类号： F16K7/06 , A61M39/28
CPC分类号： A61M39/281 , F16K7/06 , F16K7/063
摘要： A device and method to constrict or occlude the lumen of a flexible tube may include an occluder under the influence of an elastic force, such as a spring force, that can compress a portion of the wall of the flexible tube. The occluder can be under the influence of the elastic force, but prevented from occluding the tube by a stop. The stop can be connected to a tube gripping feature, so that a pulling force on the tube near the gripping feature can disengage the stop from the occluder, releasing the occluder to compress the tube. In some embodiments, the pulling force applied to the tube causes movement of the gripping feature by taking up slack in a portion of the tube held in the device. In other embodiments, the pulling force applied to the tube causes the tube to stretch elastically near the gripping feature, causing the gripping feature to move, and disengaging the stop from the occluder.
摘要翻译：用于收缩或闭塞柔性管的内腔的装置和方法可以包括在弹性力（例如弹簧力）的影响下的阻塞器，其能够压缩柔性管的壁的一部分。闭塞器可能受到弹力的影响，但阻止了阻塞管堵塞。止动件可以连接到管夹持特征，使得靠近抓握特征处的管上的拉力可以使止动件从闭塞器脱离，释放封堵器以压缩管。在一些实施例中，施加到管的拉力通过在保持在装置中的管的一部分中卷起松弛而引起夹持特征的移动。在其他实施例中，施加到管的拉力导致管在夹持特征附近弹性伸展，导致夹持特征移动，并使止动件从闭塞器脱离。

2. 发明申请

US20100234809A1 Devices and Methods For Occluding a Flexible Tube 有权
标题翻译：用于封闭柔性管的装置和方法
公开(公告)号：US20100234809A1
公开(公告)日：2010-09-16
申请号：US12714056
申请日：2010-02-26
申请人： Rodney S. Kenley , Dean Kamen , Keith D. Violette , Kevin L. Grant , Larry B. Gray , Richard J. Lanigan , Jason A. Demers
发明人： Rodney S. Kenley , Dean Kamen , Keith D. Violette , Kevin L. Grant , Larry B. Gray , Richard J. Lanigan , Jason A. Demers
IPC分类号： A61M39/00
CPC分类号： A61M39/281 , F16K7/06 , F16K7/063
摘要： A device and method to constrict or occlude the lumen of a flexible tube may include an occluder under the influence of an elastic force, such as a spring force, that can compress a portion of the wall of the flexible tube. The occluder can be under the influence of the elastic force, but prevented from occluding the tube by a stop. The stop can be connected to a tube gripping feature, so that a pulling force on the tube near the gripping feature can disengage the stop from the occluder, releasing the occluder to compress the tube. In some embodiments, the pulling force applied to the tube causes movement of the gripping feature by taking up slack in a portion of the tube held in the device. In other embodiments, the pulling force applied to the tube causes the tube to stretch elastically near the gripping feature, causing the gripping feature to move, and disengaging the stop from the occluder.
摘要翻译：用于收缩或闭塞柔性管的内腔的装置和方法可以包括在弹性力（例如弹簧力）的影响下的阻塞器，其能够压缩柔性管的壁的一部分。闭塞器可能受到弹力的影响，但阻止了阻塞管堵塞。止动件可以连接到管夹持特征，使得靠近抓握特征处的管上的拉力可以使止动件从闭塞器脱离，释放封堵器以压缩管。在一些实施例中，施加到管的拉力通过在保持在装置中的管的一部分中卷起松弛而引起夹持特征的移动。在其他实施例中，施加到管的拉力导致管在夹持特征附近弹性伸展，导致夹持特征移动，并使止动件从闭塞器脱离。

3. 发明授权

US6146523A User interface and method for control of medical instruments, such as dialysis machines 有权
标题翻译：用于医疗器械控制的用户界面和方法，如透析机
公开(公告)号：US6146523A
公开(公告)日：2000-11-14
申请号：US128185
申请日：1998-08-03
申请人： Rodney S. Kenley , Dawn Matthews , Douglas L. Wilkerson , Joel DeJesus , Tom L. Brose , Andrew Gebhardt , Lori A. Plummer , Frederick H. Peter, Jr. , Russel L. Sage , Dennis M. Treu , Michael Edward Wiklund , William R. Dolan , Shawn O. Barrett
发明人： Rodney S. Kenley , Dawn Matthews , Douglas L. Wilkerson , Joel DeJesus , Tom L. Brose , Andrew Gebhardt , Lori A. Plummer , Frederick H. Peter, Jr. , Russel L. Sage , Dennis M. Treu , Michael Edward Wiklund , William R. Dolan , Shawn O. Barrett
IPC分类号： A61M1/14 , A61M1/16 , B01D61/30 , B01D61/32
CPC分类号： A61M1/14 , G06F19/3406 , G06F19/3481 , A61M2205/17 , A61M2205/502 , A61M2205/505 , A61M2205/52 , Y10S248/919
摘要： A user interface for a medical instrument such as a dialysis machine is described which uses both a touch screen and at least one hard key off of the touch screen to effectuate a change in a parameter associated with the operation of the machine or the treatment session. The user interface is connected to a central computer control system having a host microprocessor and a backup safety microprocessor. The hard key is directly wired to the safety microprocessor. After the user selects a new parametric value on the touch screen, the user presses a hard key. The host and safety microprocessors implement a verification routine to insure that the entered parameter is appropriate for the patient's treatment and the display on the touch screen. If the verification procedure ends in a positive result, the user is prompted to presses a second hard key to confirm the change, causing an additional verification check to be preformed. If the additional verification check is successful, the parametric value is entered into a memory (such as a hard disk) storing instructions for operation of the medical instrument.
摘要翻译：描述了诸如透析机的医疗器械的用户界面，其使用触摸屏和来自触摸屏的至少一个硬键来实现与机器或治疗会话的操作相关联的参数的改变。用户接口连接到具有主机微处理器和备用安全微处理器的中央计算机控制系统。硬键直接连接到安全微处理器。在用户在触摸屏上选择新的参数值之后，用户按下硬键。主机和安全微处理器实施验证程序，以确保输入的参数适合于患者的治疗和触摸屏上的显示。如果验证过程以肯定结果结束，则提示用户按下第二个硬键以确认更改，从而进行附加的验证检查。如果额外的验证检查成功，则将参数值输入到存储用于医疗仪器操作的指令的存储器（例如硬盘）中。

5. 发明授权

US6044691A Blood tubing set integrity tests for extracorporeal circuits 有权
标题翻译：血管设置体外循环的完整性测试
公开(公告)号：US6044691A
公开(公告)日：2000-04-04
申请号：US140483
申请日：1998-08-26
申请人： Rodney S. Kenley , Seema A. Kapadia , Christine F. Schroeder , Thomas M. Feldsien , Michael Duch , Dennis M. Treu , Frederick H. Peter, Jr.
发明人： Rodney S. Kenley , Seema A. Kapadia , Christine F. Schroeder , Thomas M. Feldsien , Michael Duch , Dennis M. Treu , Frederick H. Peter, Jr.
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , A61M1/36 , G01M3/26 , B01D61/30
CPC分类号： A61M1/3621 , A61M1/1684 , A61M1/16 , A61M2205/14 , A61M2205/15
摘要： Several tests are described for verifying the integrity of the extracorporeal circuit of a medical instrument, such as a dialysis machine. One test verifies the condition of the blood tubing set. Another test verifies that the clamps in the arterial and venous lines adequately occlude the arterial and venous lines. Another test confirms that the arterial and venous lines are properly installed on their respective ports for receiving the lines after the treatment session has ended. In this last test, a fluid such as heated water is then introduced into one of the arterial or venous lines and sent out of the line through its respective port, where it is detected with suitable fluid detection equipment such as a thermistor. The heated fluid and thermistor verify that the arterial line is connected to its arterial port and the venous line is connected to its venous port and that there is an unobstructed fluid path in the blood tubing set. If the lines are installed on the wrong port, the user is prompted to correctly install the arterial and venous lines on their respective ports.
摘要翻译：描述了用于验证诸如透析机的医疗器械的体外电路的完整性的若干测试。一个测试验证血管套管的状况。另一项测试证实，动脉和静脉线中的夹具充分阻塞动脉和静脉线。另一项测试证实，在治疗结束后，动脉和静脉线适当地安装在各自的端口上用于接收线路。在最后一次测试中，然后将诸如加热水的流体引入动脉或静脉血管中的一个，并通过其相应的端口从管线中排出，在那里用合适的流体检测设备如热敏电阻检测。加热的流体和热敏电阻验证动脉管线是否连接到其动脉端口，并且静脉管线连接到其静脉端口，并且在血管组中存在无阻碍的流体路径。如果线路安装在错误的端口上，则提示用户在其各自的端口上正确安装动脉和静脉线。

6. 发明授权

US5932103A Withdrawal of priming fluid from extracorporeal circuit of hemodialysis machines or the like 失效
标题翻译：从血液透析机的体外循环中抽出引发液等
公开(公告)号：US5932103A
公开(公告)日：1999-08-03
申请号：US938111
申请日：1997-09-26
申请人： Rodney S. Kenley , Christine F. Schroeder
发明人： Rodney S. Kenley , Christine F. Schroeder
IPC分类号： A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , B01D61/02 , B01D61/04 , B01D61/12 , B01D65/02 , B01D65/10 , C02F1/44 , B01D61/24 , A61M1/14 , B01D61/28 , B01D61/32
CPC分类号： B01D61/025 , A61L2/04 , A61L2/18 , A61M1/165 , A61M1/1668 , A61M1/3431 , A61M1/3434 , A61M1/3643 , A61M1/3647 , A61M1/3649 , A61M1/365 , B01D61/04 , B01D61/12 , B01D65/022 , B01D65/10 , C02F1/441 , A61M1/16 , A61M1/1692 , A61M2205/17 , A61M2205/505 , B01D2311/04 , B01D2321/04
摘要： A method for withdrawing priming fluid from the extracorporeal circuit of a dialysis machine is described which substantially prevents return of the priming fluid back to the patient. In accordance with the method, priming fluid is drawn from the extracorporeal circuit through the dialyzer membrane and into the dialysate circuit. Blood is introduced into the extracorporeal circuit as the priming fluid is withdrawn through the dialyzer. Withdrawal of the priming fluid may be accomplished by pumping the blood pump in the forward direction at a first rate and operating a pump in the dialysate circuit at a second rate. Valves in the dialysate circuit are operated such that the pump in the dialysate circuit draws priming fluid across the dialyzer membrane into the dialysate circuit, and thereby prevents the priming fluid from being returned to the patient. In a preferred embodiment, the fluid volumes of the arterial and venous portions of the extracorporeal circuit, and the fluid volume of the blood side of the dialyzer, are known in advance. With this information, it is possible to operate the blood and dialysate pumps such that the blood progresses into the arterial and venous lines at different rates such that blood reaches the dialyzer via both lines at about the same time, while at the same time the priming fluid is withdrawn through the dialyzer. Thus, in this embodiment, blood fills the extracorporeal circuit after priming with only a small amount of priming fluid remaining in the blood compartment of the dialyzer being returned to the patient.
摘要翻译：描述了一种用于从透析机的体外回路抽出引发液的方法，其基本上防止引发流体返回到患者体内。根据该方法，将引发流体从体外循环通过透析器膜吸入透析液回路中。当引流液通过透析器取出时，将血液引入体外循环。起动流体的抽出可以通过以第一速率以正向方向泵送血泵并以第二速率操作透析液回路中的泵来实现。操作透析液回路中的阀，使得透析液回路中的泵将启动流体穿过透析器膜吸入透析液回路中，从而防止引发液体返回到患者体内。在优选实施例中，体外循环的动脉和静脉部分的流体体积以及透析器的血液侧的流体体积是预先已知的。利用该信息，可以操作血液和透析泵，使得血液以不同的速率进入动脉和静脉线，使得血液在同一时间经由两条线路到达透析器，同时启动流体通过透析器取出。因此，在本实施例中，仅在少量的剩余在透析器的血液室中的引发液体返回给患者之后，血液填充体外循环。

7. 发明授权

US5714060A Disinfection of arterial and venous line connectors hemodialysis machine 失效
标题翻译：动脉和静脉血液透析机的消毒
公开(公告)号：US5714060A
公开(公告)日：1998-02-03
申请号：US707509
申请日：1996-09-04
申请人： Rodney S. Kenley , Dennis M. Treu , Frederick H. Peter, Jr. , Thomas M. Feldsein , Kenneth E. Pawlak , Wayne F. Adolf
发明人： Rodney S. Kenley , Dennis M. Treu , Frederick H. Peter, Jr. , Thomas M. Feldsein , Kenneth E. Pawlak , Wayne F. Adolf
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04 , B01D35/00
CPC分类号： B01D65/102 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1649 , A61M1/165 , A61M1/1656 , A61M1/166 , A61M1/1662 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1682 , A61M1/1684 , A61M1/1686 , A61M1/1688 , A61M1/169 , A61M1/1692 , A61M1/1694 , A61M1/288 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3468 , A61M1/3626 , A61M1/3627 , A61M1/3629 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , B01D61/02 , B01D61/025 , B01D61/04 , B01D61/12 , B01D61/32 , B01D65/022 , B01D65/104 , C02F1/441 , F16K17/0453 , A61M1/1658 , A61M2205/12 , A61M2205/15 , A61M2205/17 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , A61M2205/6072 , A61M2205/705 , A61M2205/707 , A61M2205/7554 , A61M2205/7581 , A61M2206/11 , A61M39/16 , B01D2311/04 , B01D2321/04 , B01D2321/16 , B01D2321/32 , Y10S210/929 , Y10S215/03 , Y10T137/7722 , Y10T137/7794 , Y10T137/7796 , Y10T137/7799
摘要： A hemodialysis machine has ports of a disinfection manifold for receiving the arterial and venous line connectors terminating the arterial and venous lines. The ports are in fluid communication with a hydraulic system that circulates disinfection fluid through the machine including the extracorporeal circuit. The ports are constructed so as to provide a gap extending circumferentially around the arterial and venous line connectors. When the disinfection fluid circulates through the ports of the disinfection manifold, the fluid circulates around the external surfaces of the connectors as well as through the internal fluid passages, thereby insuring a complete disinfection of the connectors.
摘要翻译：血液透析机具有消毒歧管的端口，用于接收端接动脉和静脉线的动脉和静脉管路连接器。端口与液压系统流体连通，该液压系统使消毒液体循环通过包括体外回路的机器。端口被构造成提供围绕动脉和静脉线连接器周向延伸的间隙。当消毒液循环通过消毒歧管的端口时，流体围绕连接器的外表面以及通过内部流体通道循环，从而确保连接器的完全消毒。

8. 发明授权

US5658456A Batch dialysate chemical vessel with machine-readable indicator 失效
标题翻译：具有机器可读指示剂的批次透析液
公开(公告)号：US5658456A
公开(公告)日：1997-08-19
申请号：US559148
申请日：1995-11-17
申请人： Rodney S. Kenley , Dawn Matthews , Douglas L. Wilkerson , Dennis M. Treu , Donald C. Walker
发明人： Rodney S. Kenley , Dawn Matthews , Douglas L. Wilkerson , Dennis M. Treu , Donald C. Walker
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04 , B01D21/20 , B01D61/00
CPC分类号： B01D65/102 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1649 , A61M1/165 , A61M1/1656 , A61M1/166 , A61M1/1662 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1682 , A61M1/1684 , A61M1/1686 , A61M1/1688 , A61M1/169 , A61M1/1692 , A61M1/1694 , A61M1/288 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3468 , A61M1/3626 , A61M1/3627 , A61M1/3629 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , B01D61/02 , B01D61/025 , B01D61/04 , B01D61/12 , B01D61/32 , B01D65/022 , B01D65/104 , C02F1/441 , F16K17/0453 , A61M1/1658 , A61M2205/12 , A61M2205/15 , A61M2205/17 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , A61M2205/6072 , A61M2205/705 , A61M2205/707 , A61M2205/7554 , A61M2205/7581 , A61M2206/11 , A61M39/16 , B01D2311/04 , B01D2321/04 , B01D2321/16 , B01D2321/32 , Y10S210/929 , Y10S215/03 , Y10T137/7722 , Y10T137/7794 , Y10T137/7796 , Y10T137/7799
摘要： A vessel storing a batch of chemicals for delivery into a dialysate preparation tank includes a machine readable indicator, permitting automatic identification of the contents of the vessel prior to operating the vessel and introduction of chemicals into a tank where the dialysate solution is mixed. Various types of machine-readable indicators may be used, such as, for example, "touch" memory buttons, bar codes, or magnetic strips. Suitable reading devices for the machine-readable indicators are provided for reading the contents of the bottle.
摘要翻译：存储用于输送到透析液制备罐中的一批化学品的容器包括机器可读指示器，其允许在操作容器之前自动识别容器的内容物并将化学品引入混合透析液的罐中。可以使用各种类型的机器可读指示器，例如“触摸”存储器按钮，条形码或磁条。提供用于机读指示器的合适的读取装置用于读取瓶子的内容物。

9. 发明申请

US20130248450A1 RECIRCULATING FLUID FILTRATION SYSTEM 有权
标题翻译：循环流体过滤系统
公开(公告)号：US20130248450A1
公开(公告)日：2013-09-26
申请号：US13619010
申请日：2012-09-14
申请人： Rodney S. Kenley , Ryan K. LaRocque , Andrew A. Schnellinger
发明人： Rodney S. Kenley , Ryan K. LaRocque , Andrew A. Schnellinger
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/16 , A61M1/3472 , A61M1/3486 , A61M1/3601 , A61M1/3624 , A61M1/3633 , A61M1/3679 , A61M2202/0413 , A61M2202/0415 , A61M2202/049 , A61M2202/203 , A61M2202/206 , B01D24/48 , B01D37/04 , B01D37/046
摘要： A fluid filtration system comprising a cross-flow filter is arranged to permit a first pump to recirculate part of the retentate of the filter to the inlet of the cross-flow filter and a second pump to return part of the permeate to the inlet of the cross-flow filter. A third pump is configured supply source fluid to the inlet of the filter. The flow path between the second pump and the cross-flow filter inlet may include an adsorption filter that may selectively remove contaminants, toxins, or pathogens in the permeate. A controller may control the first, second and third pumps to provide predetermined flow ratios among the fluid flow paths of the system in order to achieve a desired filtration level. This system may be applicable to the removal of harmful substances from blood, by first separating the plasma from the blood and then removing harmful substances from the plasma.
摘要翻译：包括交叉流过滤器的流体过滤系统被布置成允许第一泵将过滤器的滞留物的一部分再循环到交叉流过滤器的入口，并且第二泵将部分渗透物返回到交叉流过滤器。第三个泵被配置为将过滤器的入口供给源流体。第二泵和横流过滤器入口之间的流动路径可以包括可以选择性地去除渗透物中的污染物，毒素或病原体的吸附过滤器。控制器可以控制第一，第二和第三泵以在系统的流体流动路径之间提供预定的流量比，以便实现期望的过滤水平。该系统可以通过首先从血液中分离血浆，然后从血浆中除去有害物质，从而适用于从血液中除去有害物质。

10. 发明申请

US20130126430A1 Systems, Apparatus, and Methods for a Water Purification System 审中-公开
标题翻译：水净化系统，仪器和方法
公开(公告)号：US20130126430A1
公开(公告)日：2013-05-23
申请号：US13618267
申请日：2012-09-14
申请人： Rodney S. Kenley , Ryan K. LaRocque, JR. , Andrew A. Schnellinger , Marc A. Nisbet , Paul R. Ambler
发明人： Rodney S. Kenley , Ryan K. LaRocque, JR. , Andrew A. Schnellinger , Marc A. Nisbet , Paul R. Ambler
IPC分类号： C02F1/44
CPC分类号： C02F1/441 , B01D61/00 , B01D61/025 , B01D61/04 , B01D61/12 , B01D65/02 , B01D2311/02 , B01D2311/04 , B01D2311/06 , B01D2311/10 , B01D2311/12 , B01D2311/14 , B01D2311/16 , B01D2311/243 , B01D2311/25 , B01D2311/2619 , B01D2311/2626 , B01D2313/19 , B01D2315/10 , B01D2321/16 , B01D2321/40 , C02F1/001 , C02F1/008 , C02F1/28 , C02F1/283 , C02F1/32 , C02F9/00 , C02F2101/12 , C02F2101/36 , C02F2101/38 , C02F2209/003 , C02F2209/02 , C02F2209/03 , C02F2209/05 , C02F2209/40 , C02F2301/04 , C02F2301/046 , C02F2301/06 , F04B41/06
摘要： A water purification system comprising a cross-flow filter is arranged to permit recirculation of the retentate or reject water from the retentate outlet of the filter to the inlet of the filter. A first pump is configured to pump source water into the feed water path of the filter, and to raise the fluid pressure in the feed water path and recirculation path. A second pump is configured to recirculate water from the retentate outlet of the filter to the inlet of the filter at a flow rate substantially higher than the flow rate of water generated by the first pump. A drain path connected to the recirculation path or feed water path may include a flow restrictor to permit removal of highly concentrated reject water while maintaining a minimum fluid pressure within the recirculation flowpath.
摘要翻译：包括交叉流过滤器的水净化系统被布置成允许滞留物或排出水从过滤器的滞留物出口再循环到过滤器的入口。第一泵构造成将源水泵送到过滤器的给水路径中，并且提高给水路径和再循环路径中的流体压力。第二泵被构造成以基本上高于由第一泵产生的水的流量的流速将水从过滤器的滞留物出口再循环到过滤器的入口。连接到再循环路径或给水路径的排出路径可以包括限流器，以允许去除高浓度的废水，同时保持再循环流动路径内的最小流体压力。

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