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1. 发明授权

US06784288B2 Polynucleotide and polypeptide sequences of monkey cathepsin S 有权
标题翻译：猴组织蛋白酶S的多核苷酸和多肽序列
公开(公告)号：US06784288B2
公开(公告)日：2004-08-31
申请号：US10010577
申请日：2001-11-08
申请人： Robin Thurmond , Lars Karlsson , Sherry Baker
发明人： Robin Thurmond , Lars Karlsson , Sherry Baker
IPC分类号： C12N1557
CPC分类号： C12N9/6472
摘要： DNAs encoding monkey cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码猴组织蛋白酶S的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

2. 发明授权

US06780985B2 Polynucleotide and polypeptide sequences of Canine Cathepsin S 有权
标题翻译：犬组织蛋白酶S的多核苷酸和多肽序列
公开(公告)号：US06780985B2
公开(公告)日：2004-08-24
申请号：US10010580
申请日：2001-11-08
申请人： Robin Thurmond , Lars Karlsson , Sherry Baker
发明人： Robin Thurmond , Lars Karlsson , Sherry Baker
IPC分类号： C12N1557
CPC分类号： C12N9/6472
摘要： DNAs encoding canine Cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码犬组织蛋白酶S的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

3. 发明申请

US20080102476A1 Analyzing Histamine H4 Receptor-Mediated Effects In Whole Blood 审中-公开
标题翻译：分析组胺H4受体介导的全血中的作用
公开(公告)号：US20080102476A1
公开(公告)日：2008-05-01
申请号：US10572985
申请日：2004-09-24
申请人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
发明人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
IPC分类号： G01N33/53
CPC分类号： G01N33/566 , G01N2500/04
摘要： Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.
摘要翻译：描述了用于分析全血以检测组胺H 4受体介导的作用的测定方法，例如嗜酸性粒细胞形状变化，细胞骨架变化，粘附分子上调或钙通量。这些方法在临床和诊断应用中是有用的。

4. 发明申请

US20070117785A1 Substituted pyrazoles and methods of treatment with substituted pyrazoles 审中-公开
标题翻译：取代的吡唑和用取代的吡唑处理的方法
公开(公告)号：US20070117785A1
公开(公告)日：2007-05-24
申请号：US11542838
申请日：2006-10-04
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/416
CPC分类号： A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
摘要翻译：描述了取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如自身免疫性疾病或过敏性疾病（包括由组织蛋白酶S介导的特应性过敏性病症）的方法。

5. 发明申请

US20070105841A1 Method for treating allergies using substituted pyrazoles 审中-公开
标题翻译：使用取代的吡唑治疗过敏症的方法
公开(公告)号：US20070105841A1
公开(公告)日：2007-05-10
申请号：US11590900
申请日：2006-10-31
申请人： J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
发明人： J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
IPC分类号： A61K31/551 , A61K31/53 , A61K31/501 , A61K31/496
CPC分类号： A61K31/496 , A61K31/501 , A61K31/53 , A61K31/551
摘要： A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译：一种使用取代的吡唑治疗过敏性疾病（包括特应性过敏症状）的方法。

6. 发明授权

US07026132B2 Method of monitoring the effect of Cathepsin S inhibitors 失效
标题翻译：监测组织蛋白酶S抑制剂作用的方法
公开(公告)号：US07026132B2
公开(公告)日：2006-04-11
申请号：US09938941
申请日：2001-08-24
申请人： Robin Thurmond , Siquan Sun , Lars Karlsson
发明人： Robin Thurmond , Siquan Sun , Lars Karlsson
IPC分类号： G01N33/53
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/8139 , G01N2333/96466 , Y10S435/962 , Y10S436/811 , Y10S436/813 , Y10S436/825 , Y10T436/25125 , Y10T436/25375
摘要： The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed subjects.
摘要翻译：本发明涉及一种通过测定剂量血液中不变链（Ii）的中间降解产物（特别是p10Ii片段）的积累来监测组织蛋白酶S抑制剂的体内施用效果的方法。

7. 发明申请

US20050085487A1 Heterocyclic compounds 审中-公开
标题翻译：杂环化合物
公开(公告)号：US20050085487A1
公开(公告)日：2005-04-21
申请号：US10961247
申请日：2004-10-08
申请人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译：杂环化合物及其制备方法和使用方法。

8. 发明申请

US20050101587A9 Method for treating allergies using substituted pyrazoles 审中-公开
标题翻译：使用取代的吡唑治疗过敏症的方法
公开(公告)号：US20050101587A9
公开(公告)日：2005-05-12
申请号：US09947117
申请日：2001-09-05
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
IPC分类号： A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
CPC分类号： A61K31/541 , A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/55
摘要： A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译：一种使用取代的吡唑治疗过敏性疾病（包括特应性过敏症状）的方法。

9. 发明授权

US06458552B1 Metalloprotease peptide substrates and methods 有权
标题翻译：金属蛋白酶肽底物和方法
公开(公告)号：US06458552B1
公开(公告)日：2002-10-01
申请号：US09588417
申请日：2000-06-06
申请人： Anne Fourie , Lars Karlsson , Robin Thurmond
发明人： Anne Fourie , Lars Karlsson , Robin Thurmond
IPC分类号： C12Q137
CPC分类号： C07K7/06 , C07K7/08 , C07K14/7056 , C07K14/8146 , C07K16/40 , C12N9/6489 , G01N33/573
摘要： The present invention describes peptide substrates of the metalloproteases, ADAM8, ADAM15 and MDC-L. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases. The invention further describes CD23 processing activity for these enzymes that may have important therapeutic implications for the use of inhibitors of these enzymes in allergic diseases such as asthma.
摘要翻译：本发明描述了金属蛋白酶ADAM8，ADAM15和MDC-L的肽底物。本发明还描述了使用这些肽发现调节这些蛋白酶的药剂的方法。本发明进一步描述了这些酶的CD23加工活性，其对于在过敏性疾病如哮喘中使用这些酶的抑制剂可能具有重要的治疗意义。

10. 发明申请

US20140104110A1 Method for Real-time, Automatic, Wideband, High Accuracy RF Direction Finding 有权
标题翻译：实时，自动，宽带，高精度RF方向寻找方法
公开(公告)号：US20140104110A1
公开(公告)日：2014-04-17
申请号：US13653476
申请日：2012-10-17
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： G01S3/02
CPC分类号： G01S3/74
摘要： This system and method provides a direction finding system that enables modern RF DF systems to analyze short duration signals in the entire instantaneous bandwidth. By providing a method to process wideband data, the invention drastically improves throughput and probability of intercept (POI). The invention is unique in that it does not require separate narrowband channels for analysis, and can simultaneously calculate azimuth and elevation estimates for every frequency in the bandwidth of an incident signal. It is also well-suited for fixed point, FPGA implementations making it a perfect match for modern state-of-the-art processing systems. The system and method capitalizes on the ability of Fourier Frequency Transform operations to accurately resolve incident wave phase at discrete frequencies. The system then uses the phase information from the individual elements in the array to arrive at an emitter azimuth angle. The azimuth angle is nearly simultaneously used in concert with lookup tables of all possible elevation angles to compare the arrival time delay between the array elements to determine emitter elevation angle.
摘要翻译：该系统和方法提供了一种方向发现系统，其使得现代RF DF系统能够在整个瞬时带宽中分析短持续时间信号。通过提供处理宽带数据的方法，本发明大大提高了吞吐量和拦截概率（POI）。本发明是独特的，因为它不需要单独的窄带信道用于分析，并且可以同时计算入射信号带宽中每个频率的方位角和高程估计。它也非常适合固定点，FPGA实现使其成为现代最先进的处理系统的完美匹配。该系统和方法利用傅里叶频率变换操作精确地解决离散频率入射波相位的能力。然后，系统使用来自阵列中的各个元件的相位信息来达到发射器方位角。方位角几乎同时用于所有可能仰角的查找表，以比较阵列元件之间的到达时间延迟，以确定发射器仰角。

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