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1. 发明授权

US07103404B2 Detection of tachyarrhythmia termination 有权
标题翻译：检测快速性心律失常终止
公开(公告)号：US07103404B2
公开(公告)日：2006-09-05
申请号：US10375457
申请日：2003-02-27
申请人： Robert W. Stadler , Eduardo N. Warman , James H. Ericksen , Reece W. Holbrook
发明人： Robert W. Stadler , Eduardo N. Warman , James H. Ericksen , Reece W. Holbrook
IPC分类号： A61B5/0452 , A61N1/37
CPC分类号： A61N1/3622
摘要： Determining termination of an identified tachyarrhythmia episode may involve analysis of a relative decrease in tachyarrhythmia rate, a normalization of electrogram morphology criteria, or both. An implanted medical device may obtain a tachyarrhythmia rate and a morphology of a cardiac waveform. The device may compare the tachyarrhythmia rate to a threshold tachyarrhythmia rate and the morphology to a template morphology, and classify the heart beat as indicating termination of the tachyarrhythmia episode when the tachyarrhythmia rate is less than the threshold tachyarrhythmia rate, the morphology categorizes as normal, or both. For arrhythmias with no therapy delivered, observation of arrhythmia behavior at the point of termination may lead to improved classification. In addition, observation of a relative decrease in tachyarrhythmia rate immediately after therapy application can lead to application of slower but more specific criteria for redetection. Also, delivery of cardioversion shocks can be aborted upon tachyarrhythmia termination.
摘要翻译：确定确定的快速性心律失常发作的终止可能涉及快速心律失常率相对降低的分析，电描记图形态学标准的归一化或两者。植入的医疗装置可以获得心律失常速率和心脏波形的形态。该装置可以将快速性心律失常率与阈值快速性心律失常率和形态学比较为模板形态，并且当心律失常发生率低于阈值快速性心律失常率时，将心跳分类为指示快速性心律失常发作的终止，形态分类为正常，或两者。对于没有治疗的心律失常，在终止时观察心律失常行为可能导致分类改善。另外，在治疗后立即观察到快速性心律失常发生率的相对降低可导致应用较慢但更具体的重新检测标准。此外，快速性心律失常终止时，心脏复律冲击的输送可以中止。

2. 发明授权

US09179860B2 Determining a location of a member 有权
标题翻译：确定会员的位置
公开(公告)号：US09179860B2
公开(公告)日：2015-11-10
申请号：US12423466
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05 , A61B5/06 , A61B5/0432 , A61B5/044 , A61B5/042 , A61B5/053 , A61B19/00 , A61B5/0428 , A61B8/06 , A61B8/00 , A61B17/00 , A61B17/22
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

3. 发明授权

US08831701B2 Uni-polar and bi-polar switchable tracking system between 有权
标题翻译：单极和双极可切换跟踪系统之间
公开(公告)号：US08831701B2
公开(公告)日：2014-09-09
申请号：US12423521
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04 , A61B5/06 , A61B5/0428
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

4. 发明授权

US08777874B2 Acoustic based cough detection 有权
标题翻译：声学咳嗽检测
公开(公告)号：US08777874B2
公开(公告)日：2014-07-15
申请号：US13114838
申请日：2011-05-24
申请人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
发明人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
IPC分类号： A61B7/00
CPC分类号： A61B5/0823 , A61B5/0205 , A61B5/11 , A61B5/686 , A61B2562/0204 , A61B2562/0219 , A61N1/3621 , A61N1/3627
摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.
摘要翻译：本公开涉及使用声信号检测咳嗽和咳嗽发作。在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。在一些示例中，可植入医疗装置还执行咳嗽严重度评估。在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

5. 发明授权

US08660640B2 Determining a size of a representation of a tracked member 失效
标题翻译：确定被跟踪成员的表示的大小
公开(公告)号：US08660640B2
公开(公告)日：2014-02-25
申请号：US12423454
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

6. 发明授权

US08532734B2 Method and apparatus for mapping a structure 有权
标题翻译：用于映射结构的方法和装置
公开(公告)号：US08532734B2
公开(公告)日：2013-09-10
申请号：US12421332
申请日：2009-04-09
申请人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
发明人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
IPC分类号： A61B5/04
CPC分类号： G06T19/003 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B5/066 , A61B5/068 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/102 , A61B2034/105 , A61B2034/2051 , A61B2034/2068 , A61B2034/2072 , A61B2090/061 , A61B2090/063 , A61B2090/371 , A61B2090/376 , A61B2090/378
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

7. 发明申请

US20120232606A1 USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 审中-公开
公开(公告)号：US20120232606A1
公开(公告)日：2012-09-13
申请号：US13357659
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

8. 发明授权

US08214018B2 Determining a flow characteristic of a material in a structure 失效
标题翻译：确定结构中材料的流动特性
公开(公告)号：US08214018B2
公开(公告)日：2012-07-03
申请号：US12422681
申请日：2009-04-13
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

9. 发明申请

US20100023081A1 Comprehensive System for Detection of Coronary Syndrome, Cardiac Ischemia and Myocardial Infarction 审中-公开
标题翻译：冠状动脉综合征，心脏缺血和心肌梗死综合检测系统
公开(公告)号：US20100023081A1
公开(公告)日：2010-01-28
申请号：US12181247
申请日：2008-07-28
申请人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
发明人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/02405 , A61B5/08 , A61B5/11 , A61B5/14532 , A61B5/14539 , A61B5/7275 , A61B7/00 , A61N1/3627 , A61N1/36514
摘要： Heart-monitoring systems, apparatus, and methods adapted to detect CS, CI and/or MI. In one embodiment, a system comprising at least two first-tier sensors capable of measuring and converting into signals at least two aspects related to cardiac function, at least one second-tier sensor that is also a first-tier sensor, at least one signal processor capable of transmitting a first-tier and second-tier trigger signal when coronary syndrome, cardiac ischemia or myocardial infarction has been detected, at least one communication device capable of communicating, at least one control element adapted to produce a first-tier and second-tier trigger signal when at least one first-tier sensor exceeds its threshold signal level, to exclude the signal from the first-tier sensor that exceeded its threshold and lower at least one threshold of the at least one first-tier sensor is provided.
摘要翻译：适用于检测CS，CI和/或MI的心脏监测系统，装置和方法。在一个实施例中，一种系统包括至少两个第一层传感器，能够测量和转换成与心脏功能相关的至少两个方面的信号，至少一个第二层传感器，其也是第一层传感器，至少一个信号处理器能够在冠状动脉综合征，心脏缺血或心肌梗塞已经被检测时发送第一层和第二层触发信号，至少一个能够通信的通信设备，至少一个适于产生第一层和第二层的控制元件当至少一个第一层传感器超过其阈值信号电平时，将第一层传感器的信号排除超过其阈值并降低至少一个第一层传感器的至少一个阈值。

10. 发明授权

US07647107B2 Addressing recurrent atrial fibrillation 失效
标题翻译：解决复发性房颤
公开(公告)号：US07647107B2
公开(公告)日：2010-01-12
申请号：US11532741
申请日：2006-09-18
申请人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
发明人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：在AF事件终止后将超速起搏应用于一个或两个心房的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过速起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

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