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1. 发明授权

US08273032B2 Physiological parameter monitoring with minimization of motion artifacts 有权
标题翻译：最小化运动假象的生理参数监测
公开(公告)号：US08273032B2
公开(公告)日：2012-09-25
申请号：US12182847
申请日：2008-07-30
申请人： James Kevin Carney , Can Cinbis
发明人： James Kevin Carney , Can Cinbis
IPC分类号： A61B5/02
CPC分类号： A61B5/02427 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B5/7207 , A61B5/7214 , A61B2562/0233 , A61B2562/043
摘要： An implanted system includes at least two optical sensors implanted proximate to an artery of a patient such that one optical sensor is upstream of another optical sensor. Arterial pulses of the patient may be detected based on electrical signals from at least one of the optical sensors. In addition, electrical signals from the optical sensors may be used to minimize the effects of motion artifacts on the detection of arterial pulses. For example, a detected pulse may be determined to be a spurious pulse if the optical sensors indicate the occurrence of the pulse within a predetermined range of time. As another example, a first optical sensor signal may be shifted in time relative to a second optical sensor signal, and the signals may be correlated. An arterial pulse may be detected at a time at which a peak or trough amplitude value of the correlated signal is observed.
摘要翻译：植入系统包括在患者的动脉附近植入的至少两个光学传感器，使得一个光学传感器在另一个光学传感器的上游。可以基于来自至少一个光学传感器的电信号来检测患者的动脉。此外，可以使用来自光学传感器的电信号来最小化运动假象对动脉脉冲检测的影响。例如，如果光学传感器指示在预定的时间范围内出现脉冲，则检测到的脉冲可以被确定为杂散脉冲。作为另一示例，第一光学传感器信号可以相对于第二光学传感器信号在时间上移位，并且信号可以相关。可以在观察到相关信号的峰值或谷值振幅值的时间检测到动脉脉冲。

2. 发明授权

US06908439B2 Catheter with dual temperature detection for vulnerable plaque determination 有权
标题翻译：导管采用双重温度检测方法进行易损斑块测定
公开(公告)号：US06908439B2
公开(公告)日：2005-06-21
申请号：US10692251
申请日：2003-10-23
申请人： James Kevin Carney
发明人： James Kevin Carney
IPC分类号： A61B5/00
CPC分类号： A61B5/01
摘要： A method and system for determining vulnerable plaque in a cardiovascular lumen is disclosed. A guide member is inserted into the cardiovascular lumen. Temperature is sensed from a first position and a second position along the inserted guide member. Vulnerable plaque is determined based on the sensed temperature from the first position and the second position.
摘要翻译：公开了一种用于确定心血管内腔中脆弱斑块的方法和系统。引导构件插入心血管内腔。沿着插入的引导构件从第一位置和第二位置感测温度。基于来自第一位置和第二位置的感测温度来确定易损斑块。

3. 发明申请

US20100022861A1 IMPLANTABLE OPTICAL HEMODYNAMIC SENSOR INCLUDING AN EXTENSION MEMBER 审中-公开
标题翻译：可伸缩的光学血液动力学传感器，包括延伸部件
公开(公告)号：US20100022861A1
公开(公告)日：2010-01-28
申请号：US12180991
申请日：2008-07-28
申请人： Can Cinbis , Richard James O'Brien , James Kevin Carney
发明人： Can Cinbis , Richard James O'Brien , James Kevin Carney
IPC分类号： A61B5/1459 , A61B5/026 , A61B5/00
CPC分类号： A61N1/3704 , A61B5/0031 , A61B5/0084 , A61B5/0086 , A61B5/02154 , A61B5/0261 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/36571 , A61N1/375 , A61N1/3962
摘要： An implantable medical device includes an optical hemodynamic sensor comprising at least one optical emitter and at least one detector. In some examples, the at least one optical emitter may be optically coupled to at least one light transmission member that extends from a housing of the medical device. In addition, in some examples, the at least one detector may be optically coupled to at least one light transmission member that extends from the housing of the medical device. In other examples, an optical emitter and/or detector of a hemodynamic sensor may be carried by an elongated member that extends from a housing of the IMD. The elongated member may electrically couple the optical emitter and/or detector to a controller or other components within the IMD housing.
摘要翻译：可植入医疗装置包括光学血液动力学传感器，其包括至少一个光发射器和至少一个检测器。在一些示例中，至少一个光发射器可以光耦合到从医疗装置的壳体延伸的至少一个光透射构件。此外，在一些示例中，至少一个检测器可以光耦合到从医疗装置的壳体延伸的至少一个光传输构件。在其他示例中，血液动力学传感器的光学发射器和/或检测器可以由从IMD的壳体延伸的细长构件承载。细长构件可以将光学发射器和/或检测器电耦合到IMD壳体内的控制器或其它部件。

4. 发明申请

US20100022856A1 IMPLANTABLE OPTICAL HEMODYNAMIC SENSOR INCLUDING LIGHT TRANSMISSION MEMBER 审中-公开
标题翻译：可入射光学血液动力传感器，包括光传输部件
公开(公告)号：US20100022856A1
公开(公告)日：2010-01-28
申请号：US12181025
申请日：2008-07-28
申请人： Can Cinbis , Richard James O'Brien , James Kevin Carney , William T. Donofrio
发明人： Can Cinbis , Richard James O'Brien , James Kevin Carney , William T. Donofrio
IPC分类号： A61B5/1455
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/02028 , A61B5/0402 , A61B5/14535 , A61B5/14552 , A61B5/1459 , A61N1/36557 , A61N1/36571
摘要： An implantable medical device (IMD) includes an optical hemodynamic sensor comprising at least one optical emitter and at least one detector. In some examples, the at least one optical emitter may be optically coupled to at least one light transmission member that extends from a housing of the IMD. In addition, in some examples, the at least one detector may be optically coupled to at least one light transmission member that extends from the housing of the IMD. In other examples, an optical emitter and/or detector of a hemodynamic sensor may be carried by an extension member that extends from a housing of the IMD. The elongated member may electrically couple the optical emitter and/or detector to a controller or other components within the IMD housing.
摘要翻译：可植入医疗装置（IMD）包括光学血液动力学传感器，其包括至少一个光发射器和至少一个检测器。在一些示例中，所述至少一个光发射器可以光耦合到从IMD的壳体延伸的至少一个光传输构件。此外，在一些示例中，至少一个检测器可以光耦合到从IMD的壳体延伸的至少一个光传输部件。在其他示例中，血液动力学传感器的光学发射器和/或检测器可以由从IMD的壳体延伸的延伸构件承载。细长构件可以将光学发射器和/或检测器电耦合到IMD壳体内的控制器或其它部件。

5. 发明申请

US20100030088A1 PHYSIOLOGICAL PARAMETER MONITORING WITH MINIMIZATION OF MOTION ARTIFACTS 有权
标题翻译：生物学参数监测与运动文学的最小化
公开(公告)号：US20100030088A1
公开(公告)日：2010-02-04
申请号：US12182847
申请日：2008-07-30
申请人： James Kevin Carney , Can Cinbis
发明人： James Kevin Carney , Can Cinbis
IPC分类号： A61B5/02
CPC分类号： A61B5/02427 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B5/7207 , A61B5/7214 , A61B2562/0233 , A61B2562/043
摘要： An implanted system includes at least two optical sensors implanted proximate to an artery of a patient such that one optical sensor is upstream of another optical sensor. Arterial pulses of the patient may be detected based on electrical signals from at least one of the optical sensors. In addition, electrical signals from the optical sensors may be used to minimize the effects of motion artifacts on the detection of arterial pulses. For example, a detected pulse may be determined to be a spurious pulse if the optical sensors indicate the occurrence of the pulse within a predetermined range of time. As another example, a first optical sensor signal may be shifted in time relative to a second optical sensor signal, and the signals may be correlated. An arterial pulse may be detected at a time at which a peak or trough amplitude value of the correlated signal is observed.
摘要翻译：植入系统包括在患者的动脉附近植入的至少两个光学传感器，使得一个光学传感器在另一个光学传感器的上游。可以基于来自至少一个光学传感器的电信号来检测患者的动脉。此外，可以使用来自光学传感器的电信号来最小化运动假象对动脉脉冲检测的影响。例如，如果光学传感器指示在预定的时间范围内出现脉冲，则检测到的脉冲可以被确定为杂散脉冲。作为另一示例，第一光学传感器信号可以相对于第二光学传感器信号在时间上移位，并且信号可以相关。可以在观察到相关信号的峰值或谷值振幅值的时间检测到动脉脉冲。

6. 发明申请

US20100023081A1 Comprehensive System for Detection of Coronary Syndrome, Cardiac Ischemia and Myocardial Infarction 审中-公开
标题翻译：冠状动脉综合征，心脏缺血和心肌梗死综合检测系统
公开(公告)号：US20100023081A1
公开(公告)日：2010-01-28
申请号：US12181247
申请日：2008-07-28
申请人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
发明人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/02405 , A61B5/08 , A61B5/11 , A61B5/14532 , A61B5/14539 , A61B5/7275 , A61B7/00 , A61N1/3627 , A61N1/36514
摘要： Heart-monitoring systems, apparatus, and methods adapted to detect CS, CI and/or MI. In one embodiment, a system comprising at least two first-tier sensors capable of measuring and converting into signals at least two aspects related to cardiac function, at least one second-tier sensor that is also a first-tier sensor, at least one signal processor capable of transmitting a first-tier and second-tier trigger signal when coronary syndrome, cardiac ischemia or myocardial infarction has been detected, at least one communication device capable of communicating, at least one control element adapted to produce a first-tier and second-tier trigger signal when at least one first-tier sensor exceeds its threshold signal level, to exclude the signal from the first-tier sensor that exceeded its threshold and lower at least one threshold of the at least one first-tier sensor is provided.
摘要翻译：适用于检测CS，CI和/或MI的心脏监测系统，装置和方法。在一个实施例中，一种系统包括至少两个第一层传感器，能够测量和转换成与心脏功能相关的至少两个方面的信号，至少一个第二层传感器，其也是第一层传感器，至少一个信号处理器能够在冠状动脉综合征，心脏缺血或心肌梗塞已经被检测时发送第一层和第二层触发信号，至少一个能够通信的通信设备，至少一个适于产生第一层和第二层的控制元件当至少一个第一层传感器超过其阈值信号电平时，将第一层传感器的信号排除超过其阈值并降低至少一个第一层传感器的至少一个阈值。

7. 发明授权

US07473230B2 Instrumented catheter with distance compensation to sense vulnerable plaque 有权
标题翻译：仪器导管用距离补偿来感测易损斑块
公开(公告)号：US07473230B2
公开(公告)日：2009-01-06
申请号：US11676604
申请日：2007-02-20
申请人： James Kevin Carney , David L. Thompson , Mark Brister
发明人： James Kevin Carney , David L. Thompson , Mark Brister
IPC分类号： A61B5/00
CPC分类号： A61B5/01 , A61B5/02007 , A61B5/1076
摘要： A method and apparatus for determining vulnerable plaque in a cardiovascular lumen is disclosed. In one embodiment, a guide member comprising a temperature sensor and a distance sensor are inserted into the cardiovascular lumen. The temperature of the cardiovascular wall is measured with the temperature sensor, and the distance from the temperature sensor to the cardiovascular wall is determined. The cardiovascular wall temperature is adjusted based on the distance determination, and the vulnerable plaque is determined based on the adjusted wall temperature measurement.
摘要翻译：公开了一种用于确定心血管内腔中脆弱斑块的方法和装置。在一个实施例中，将包括温度传感器和距离传感器的引导构件插入心血管内腔。用温度传感器测量心血管壁的温度，并确定从温度传感器到心血管壁的距离。基于距离测定调节心血管壁温度，并根据调整后的壁温测定值确定易损斑块。

8. 发明授权

US07195599B2 Instrumented catheter with distance compensation to sense vulnerable plaque 有权
标题翻译：仪器导管用距离补偿来感测易损斑块
公开(公告)号：US07195599B2
公开(公告)日：2007-03-27
申请号：US10692145
申请日：2003-10-22
申请人： James Kevin Carney , David L. Thompson , Mark Brister
发明人： James Kevin Carney , David L. Thompson , Mark Brister
IPC分类号： A61B5/00
CPC分类号： A61B5/01 , A61B5/02007 , A61B5/1076
摘要： A method and apparatus for determining vulnerable plaque in a cardiovascular lumen is disclosed. In one embodiment, a guide member comprising a temperature sensor and a distance sensor are inserted into the cardiovascular lumen. The temperature of the cardiovascular wall is measured with the temperature sensor, and the distance from the temperature sensor to the cardiovascular wall is determined. The cardiovascular wall temperature is adjusted based on the distance determination, and the vulnerable plaque is determined based on the adjusted wall temperature measurement.
摘要翻译：公开了一种用于确定心血管内腔中脆弱斑块的方法和装置。在一个实施例中，将包括温度传感器和距离传感器的引导构件插入心血管内腔。用温度传感器测量心血管壁的温度，并确定从温度传感器到心血管壁的距离。基于距离测定调节心血管壁温度，并根据调整后的壁温测定值确定易损斑块。

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