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1. 发明授权

US5081044A Detection of hydrogen peroxide with optical indicator chalcogen compounds 失效
标题翻译：用光学指标硫属化合物检测过氧化氢
公开(公告)号：US5081044A
公开(公告)日：1992-01-14
申请号：US590226
申请日：1990-09-28
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C12Q1/28 , G01N33/00
CPC分类号： G01N33/0036 , C12Q1/28 , C12Q2326/00 , Y10T436/206664
摘要： Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and a method for using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.
摘要翻译：对氧化剂（例如过氧化氢）有响应的光学指示剂硫属化合物（硒化物或硫化物）以及使用这些指示剂的方法。氧化后，得到的中间体自发消除硫族元素残余物，产生提供光信号如荧光的信号化合物。优选的荧光指示剂化合物是3-硫族原-3,4-二氢香豆素衍生物和3-硫族原-3,4-二氢-2-喹诺酮衍生物。这种指示剂化合物在通过过氧化氢氧化时提供高度荧光的产物，并且可用于响应于待测分析物产生过氧化氢的分析系统。

2. 发明授权

US4996332A Optical indicator coumarins and methods for their preparation and use 失效
标题翻译：光学指示剂香豆素及其制备和使用方法
公开(公告)号：US4996332A
公开(公告)日：1991-02-26
申请号：US205732
申请日：1988-06-13
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C07D215/54 , C07D311/20 , C12Q1/28
CPC分类号： C07D311/20 , C07D215/54 , C12Q1/28
摘要： Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.
摘要翻译：对氧化剂（例如过氧化氢）有响应的光学指示剂硫属化合物（硒化物或硫化物）以及制备和使用这些指示剂的方法。氧化后，得到的中间体自发消除硫族元素残余物，产生提供光信号如荧光的信号化合物。优选的荧光指示剂化合物是3-硫族原-3,4-二氢香豆素衍生物和3-硫族原-3,4-二氢-2-喹诺酮衍生物。这种指示剂化合物在通过过氧化氢氧化时提供高度荧光的产物，并且可用于响应于待测分析物产生过氧化氢的分析系统。

3. 发明授权

US4794079A Determination of hydrogen peroxide using fluorogenic dihydroquinolone and dihydrocoumarin indicators 失效
标题翻译：使用荧光二氢喹诺酮和二氢香豆素指标测定过氧化氢
公开(公告)号：US4794079A
公开(公告)日：1988-12-27
申请号：US781747
申请日：1985-09-30
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C07D215/38 , C07D215/54 , C07D407/12 , C07D491/06 , C07F9/60 , C12Q1/28
CPC分类号： C07D407/12 , C07D215/38 , C07D215/54 , C07D491/06 , C07F9/60 , C12Q1/28 , C12Q2326/00
摘要： Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.0 or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.
摘要翻译：响应于过氧化氢的存在的荧光指示剂化合物和测试样品中测定过氧化氢的方法和测试组合物。优选的指示剂化合物是3,4-二氢香豆素衍生物和3,4-二氢-2-喹诺酮衍生物，特别是在7-位具有二烷基氨基的那些。这些特别优选的化合物具有下式：其中R 1是氢，氰基或-COOR 6，-CONHR 6或-CON（R 6）2，其中R 6是氢，烷基，链烯基或芳基; R3和R4是低级烷基; 并且Y为= 0或= N-R5，其中R5为氢或低级烷基。指示剂化合物在过氧化物存在下在过氧化物活性物质的氧化下产生高度荧光的产物，并且可用于在测试样品中测定的对分析物产生过氧化氢的分析系统中。

4. 发明授权

US4778893A Optical indicator 3,4-dihydro-2-quinolones 失效
标题翻译：光学指示剂3,4-二氢-2-喹诺酮
公开(公告)号：US4778893A
公开(公告)日：1988-10-18
申请号：US540
申请日：1987-01-05
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C07D215/54 , C07D311/20 , C12Q1/28 , C07D215/20 , C07D311/02
CPC分类号： C12Q1/28 , C07D215/54 , C07D311/20 , C12Q2326/00 , Y10S436/815
摘要： Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.
摘要翻译：对氧化剂（例如过氧化氢）有响应的光学指示剂硫属化合物（硒化物或硫化物）以及制备和使用这些指示剂的方法。氧化后，得到的中间体自发消除硫族元素残余物，产生提供光信号如荧光的信号化合物。优选的荧光指示剂化合物是3-硫族原-3,4-二氢香豆素衍生物和3-硫族原-3,4-二氢-2-喹诺酮衍生物。这种指示剂化合物在通过过氧化氢氧化时提供高度荧光的产物，并且可用于响应于待测分析物产生过氧化氢的分析系统。

5. 发明授权

US4558130A Fluorogenic dihydroquinolone and dihydrocoumarin indicators for hydrogen peroxide 失效
标题翻译：荧光二氢喹诺酮和二氢香豆素指示剂用于过氧化氢
公开(公告)号：US4558130A
公开(公告)日：1985-12-10
申请号：US594242
申请日：1984-03-27
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C07D215/22 , C07D215/20 , C07D215/38 , C07D215/54 , C07D311/20 , C07D407/12 , C07D471/16 , C07D491/06 , C07D491/16 , C07F9/60 , C12Q1/28 , G01N21/76 , G01N21/78 , G01N33/50 , G01N33/52 , C09B23/04
CPC分类号： C07D407/12 , C07D215/38 , C07D215/54 , C07D491/06 , C07F9/60 , C12Q1/28 , C12Q2326/00
摘要： Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.O or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.
摘要翻译：响应于过氧化氢的存在的荧光指示剂化合物和测试样品中测定过氧化氢的方法和测试组合物。优选的指示剂化合物是3,4-二氢香豆素衍生物和3,4-二氢-2-喹诺酮衍生物，特别是在7-位具有二烷基氨基的那些。这些特别优选的化合物具有下式：其中R 1是氢，氰基或-COOR 6，-CONHR 6或-CON（R 6）2，其中R 6是氢，烷基，链烯基或芳基; R3和R4是低级烷基; Y为= O或= N-R5，其中R5为氢或低级烷基。指示剂化合物在过氧化物存在下在过氧化物活性物质的氧化下产生高度荧光的产物，并且可用于在测试样品中测定的对分析物产生过氧化氢的分析系统中。

6. 发明授权

US5187105A Process for determining thiols using chromogenic benzoisothiazolone derivatives 失效
标题翻译：使用显色苯并异噻唑啉酮衍生物测定硫醇的方法
公开(公告)号：US5187105A
公开(公告)日：1993-02-16
申请号：US659897
申请日：1991-02-25
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： C07D275/04 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22 , G01N31/221 , Y10T436/18 , Y10T436/182
摘要： A process for measuring the presence or appearance of thiols in aqueous system, the process involving contacting the aqueous system with a chromogenic thiol indicating benzoisothiazolone derivative and then observing chromophoric changes due to thiol mediated reduction of the benzoisothiazolone derivative wherein the changes are proportional to the amount or rate of appearance of the thiols in the aqueous system.
摘要翻译：一种测定水性体系中硫醇的存在或外观的方法，该方法包括使含水系统与显色苯并异噻唑酮衍生物的显色硫醇接触，然后观察由于硫醇介导的苯并异噻唑酮衍生物的还原产生的发色变化，其中变化与量或水溶液体系中硫醇的出现速率。

7. 发明授权

US06872573B2 Fluorescent creatinine assay 失效
标题翻译：荧光肌酐测定
公开(公告)号：US06872573B2
公开(公告)日：2005-03-29
申请号：US10335718
申请日：2003-01-02
申请人： James P. Albarella , Robert P. Hatch
发明人： James P. Albarella , Robert P. Hatch
IPC分类号： C07C20060101 , C12Q1/28 , G01N33/00 , G01N33/58 , G01N33/70
CPC分类号： G01N33/582 , C12Q1/28 , G01N33/70 , Y10S436/80 , Y10T436/147777 , Y10T436/171538 , Y10T436/206664
摘要： A method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copperII/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH).
摘要翻译：使用在铜/肌酸酐复合物存在下氧化时产生荧光反应的指示剂来检测体液中肌酐的方法。优选的指示剂是4-（1-甲基肼基）-7-硝基苯并恶二唑（MNBDH）。

8. 发明授权

US5250695A Use of specific counteranions to modify the solubility of tetrazolium salts 失效
标题翻译：使用特定的沉淀物来改变四唑盐的溶解度
公开(公告)号：US5250695A
公开(公告)日：1993-10-05
申请号：US898317
申请日：1992-06-15
申请人： Joel M. Blatt , Robert P. Hatch
发明人： Joel M. Blatt , Robert P. Hatch
IPC分类号： C07C309/04 , C07C309/30 , C07D257/04 , C07D405/04 , C07D417/04 , C07D417/14 , C07F9/11 , C07F9/12 , C07F9/38 , G01N33/52 , G01N33/66
CPC分类号： C07D257/04 , C07D417/04 , C07D417/14 , C07F9/11 , C07F9/12
摘要： Disclosed are sulfonate and phosphonate salts of tetrazolium compounds whose enhanced solubility in various solvents renders them particularly suitable for use as redox indicators in dry reagent, diagnostic test systems.

9. 发明授权

US5723619A Method for the synthesis of deoxypyridinoline 失效
标题翻译：合成脱氧吡啶啉的方法
公开(公告)号：US5723619A
公开(公告)日：1998-03-03
申请号：US782214
申请日：1997-01-13
申请人： Robert P. Hatch
发明人： Robert P. Hatch
IPC分类号： C07D213/65 , B01J27/10 , C07B61/00 , C07D213/66 , C07D213/127 , C07D213/16 , C07D213/20
CPC分类号： C07D213/66
摘要： Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a N.alpha.-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.
摘要翻译：公开了化学合成脱氧吡啶啉（DPD）的方法。合成涉及由Nα保护的赖氨酸和5,6-环氧-2-N保护的O-保护的（2S）-2-氨基己酸酯开始制备受保护的3-羟基吡啶鎓，随后进行脱保护，得到所需的DPD。

10. 发明授权

US5468641A Device for validating urobilinogen test devices 失效
标题翻译：用于验证尿胆素原测试装置的装置
公开(公告)号：US5468641A
公开(公告)日：1995-11-21
申请号：US238003
申请日：1994-05-03
申请人： Robert P. Hatch , Marilyn J. Radtke
发明人： Robert P. Hatch , Marilyn J. Radtke
IPC分类号： G01N33/50 , G01N33/52 , G01N33/72 , G01N33/48
CPC分类号： G01N33/72 , Y10T436/146666
摘要： The present invention involves the use of certain indole sulfonates in a test control method for the Ehrlich reagent used in diagnostic tests for urobilinogen. The indole sulfonates exhibit unique solubility characteristics which facilitate their application to dry carrier matrixes with subsequent rehydration during their use in the test control method.
摘要翻译：本发明涉及在用于尿胆素原的诊断试验中的Ehrlich试剂的测试对照方法中使用某些吲哚磺酸盐。吲哚磺酸盐表现出独特的溶解度特征，其便于其在干燥载体基质中的应用，随后在测试控制方法中使用期间进行再水合。

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