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1. 发明授权

US09229007B2 Fluorescence detection of cysteine and homocysteine 有权
标题翻译：荧光检测半胱氨酸和高半胱氨酸
公开(公告)号：US09229007B2
公开(公告)日：2016-01-05
申请号：US14236791
申请日：2012-08-02
申请人： Robert Strongin , Xiaofeng Yang
发明人： Robert Strongin , Xiaofeng Yang
IPC分类号： G01N33/68 , G01N33/50 , G01N33/00 , C07D277/66
CPC分类号： G01N33/6815 , C07D277/66 , G01N21/6428 , G01N33/68 , G01N2021/6439 , Y10T436/17 , Y10T436/173845
摘要： Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.
摘要翻译：公开了用于选择性检测具有硫醇基和氨基的化合物（例如半胱氨酸和/或同型半胱氨酸）的探针的实施方案，以及用于用探针检测中性培养基中的化合物的方法和试剂盒。所述探针具有根据通式的结构，其中R 1 -R 4独立地是氢羟基，卤素，硫醇，硫醚，低级脂族或低级烷氧基，x是0-4的整数，每个R 5独立地是卤素，羟基，硫醇，硫醚，低级脂族或低级烷氧基。所公开的探针的实施方案能够与半胱氨酸和/或同型半胱氨酸进行缩合/环化反应。半胱氨酸和/或同型半胱氨酸可以通过在特征波长处确定探针的荧光发射来选择性地检测和鉴定。

2. 发明申请

US20140206095A1 FLUORESCENCE DETECTION OF CYSTEINE AND HOMOCYSTEINE 有权
标题翻译： CYSTEINE和HOMOCYSTEINE的荧光检测
公开(公告)号：US20140206095A1
公开(公告)日：2014-07-24
申请号：US14236791
申请日：2012-08-02
申请人： Robert Strongin , Xiaofeng Yang
发明人： Robert Strongin , Xiaofeng Yang
IPC分类号： G01N33/68
CPC分类号： G01N33/6815 , C07D277/66 , G01N21/6428 , G01N33/68 , G01N2021/6439 , Y10T436/17 , Y10T436/173845
摘要： Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.
摘要翻译：公开了用于选择性检测具有硫醇基和氨基的化合物（例如半胱氨酸和/或同型半胱氨酸）的探针的实施方案，以及用于用探针检测中性培养基中的化合物的方法和试剂盒。所述探针具有根据通式的结构，其中R 1 -R 4独立地是氢羟基，卤素，硫醇，硫醚，低级脂族或低级烷氧基，x是0-4的整数，每个R 5独立地是卤素，羟基，硫醇，硫醚，低级脂族或低级烷氧基。所公开的探针的实施方案能够与半胱氨酸和/或同型半胱氨酸进行缩合/环化反应。半胱氨酸和/或同型半胱氨酸可以通过在特征波长处确定探针的荧光发射来选择性地检测和鉴定。

3. 发明授权

US08252780B2 Organometallic complexes as therapeutic agents 有权
标题翻译：有机金属配合物作为治疗剂
公开(公告)号：US08252780B2
公开(公告)日：2012-08-28
申请号：US12516878
申请日：2007-11-30
申请人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
发明人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
IPC分类号： A61K31/555 , A61K31/295 , A61P35/00 , C07D271/04 , C07D209/34 , C07D333/36 , C07F15/02
CPC分类号： C07F15/025 , C07F3/003 , C07F13/005 , C07F15/008
摘要： This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
摘要翻译：本发明包括基于三氟甲磺酸盐的金属络合物。包括金属螯合类似物及其制备和使用方法。这些类似物具有治疗活性，包括抗癌活性。

4. 发明申请

US20100273763A1 ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS 有权
标题翻译：作为治疗药物的有机复合物
公开(公告)号：US20100273763A1
公开(公告)日：2010-10-28
申请号：US12516878
申请日：2007-11-30
申请人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
发明人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
IPC分类号： A61K31/555 , A61K31/295 , C07D271/04 , C07D209/34 , C07D333/36 , C07F15/02 , A61P35/00
CPC分类号： C07F15/025 , C07F3/003 , C07F13/005 , C07F15/008
摘要： This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
摘要翻译：本发明包括基于三氟甲磺酸盐的金属络合物。包括金属螯合类似物及其制备和使用方法。这些类似物具有治疗活性，包括抗癌活性。

5. 发明申请

US20140371193A1 ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗药物的有机复合物
公开(公告)号：US20140371193A1
公开(公告)日：2014-12-18
申请号：US14477482
申请日：2014-09-04
申请人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
发明人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
IPC分类号： C07F15/02 , C07F3/00 , C07F13/00 , C07F15/00
CPC分类号： C07F15/025 , C07F3/003 , C07F13/005 , C07F15/008
摘要： This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
摘要翻译：本发明包括基于三氟甲磺酸盐的金属络合物。包括金属螯合类似物及其制备和使用方法。这些类似物具有治疗活性，包括抗癌活性。

6. 发明授权

US08933129B2 Compounds and methods for modulating activity of calcium release channels 有权
标题翻译：用于调节钙释放通道活性的化合物和方法
公开(公告)号：US08933129B2
公开(公告)日：2015-01-13
申请号：US13264055
申请日：2010-04-15
申请人： Jonathan Abramson , Robert Strongin
发明人： Jonathan Abramson , Robert Strongin
IPC分类号： A61K31/136 , A61K31/085 , A61K31/138 , C07C215/28 , C07D417/06 , A61K31/554 , C07D417/14
CPC分类号： C07D417/06 , A61K31/554 , C07D417/14
摘要： The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1′, R2, R2′, R3, R3′, and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.
摘要翻译：本发明提供式I和II的化合物及其药学上可接受的盐，水合物，复合物，酯和前药，其中R1，R1'，R2，R2'，R3，R3'和X如本文所定义。本教导还提供了制备式I和II化合物的方法，以及治疗RyR相关病症，病症和疾病的方法，包括向有需要的受试者施用治疗有效量的式I或II化合物。此外，本教导涉及降低兰诺定受体的开放概率的方法，以及通过将式I或II的化合物与式I或II的化合物与（例如，细胞质的细胞质）兰诺定受体。

7. 发明申请

US20130023511A1 ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗药物的有机复合物
公开(公告)号：US20130023511A1
公开(公告)日：2013-01-24
申请号：US13555401
申请日：2012-07-23
申请人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
发明人： Laurent Brard , Rakesh Singh , Satyan Kalkunte , Robert Strongin , Onur Alpturk
IPC分类号： C07F15/02 , A61K31/36 , A61P35/00 , A61K31/4035 , C07F15/00 , C07F5/00 , A61K31/136 , A61K31/4245
CPC分类号： C07F15/025 , C07F3/003 , C07F13/005 , C07F15/008
摘要： This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
摘要翻译：本发明包括基于三氟甲磺酸盐的金属络合物。包括金属螯合类似物及其制备和使用方法。这些类似物具有治疗活性，包括抗癌活性。

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