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1. 发明授权

US5912934A Underwater inspection system for nuclear power facilities 失效
标题翻译：核电设施水下检验系统
公开(公告)号：US5912934A
公开(公告)日：1999-06-15
申请号：US892625
申请日：1997-07-14
申请人： Robert S. Acks , Arthur E. Vigil , John L. Buchanan
发明人： Robert S. Acks , Arthur E. Vigil , John L. Buchanan
IPC分类号： G21C17/08 , G21C19/02 , G21C17/00
CPC分类号： G21C19/02 , G21C17/08 , G21Y2002/204 , G21Y2004/401
摘要： A nuclear fuel identification system for use in nuclear power plants has an imaging system having a video camera and an array of illuminators surrounding the video camera and positioned to shine onto a nuclear fuel cell. The illuminators are sequentially activated to provide a series of images each having a different shadow pattern. These images are then digitized and stored until a complete set of the images are available. At that time, the images are superimposed and optimized for improved contrast. By viewing the distinct shadow patterns on the nuclear fuel cell, the identifying markings are readily visible. In addition to the shadow imaging system, a variety of laser devices are used to accomplish similar image generating functions. Such laser devices include a laser scanner, a distance laser device, an interferometer, a holographic interferometer, and a bi-refringent crystal prism.
摘要翻译：用于核电站的核燃料识别系统具有成像系统，该成像系统具有摄像机和围绕摄像机的照明器阵列并定位成照射到核燃料电池上。依次启动照明器以提供一系列具有不同阴影图案的图像。然后将这些图像数字化并存储，直到完整的图像集合可用。那时，图像被叠加和优化，以提高对比度。通过观察核燃料电池上的不同阴影图案，识别标记是容易可见的。除了阴影成像系统之外，还使用各种激光装置来实现类似的图像生成功能。这种激光装置包括激光扫描器，距离激光装置，干涉仪，全息干涉仪和双重反射晶体棱镜。

2. 发明授权

US07115617B2 Amino-substituted pyrimidinyl derivatives and methods of use 有权
公开(公告)号：US07115617B2
公开(公告)日：2006-10-03
申请号：US10225819
申请日：2002-08-21
申请人： John L. Buchanan , Stuart Chaffee , Jean-Christophe Harmange , Perry M. Novak , Xiaotian Zhu
发明人： John L. Buchanan , Stuart Chaffee , Jean-Christophe Harmange , Perry M. Novak , Xiaotian Zhu
IPC分类号： C07D413/12 , A61K31/422 , C07D239/48
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.

3. 发明授权

US07442698B2 Substituted heterocyclic compounds and methods of use 失效
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：US07442698B2
公开(公告)日：2008-10-28
申请号：US10891636
申请日：2004-07-13
申请人： John L. Buchanan , Daniel Elbaum , Matthew W. Martin , David C. McGowan , Perry M. Novak , Joseph J. Nunes
发明人： John L. Buchanan , Daniel Elbaum , Matthew W. Martin , David C. McGowan , Perry M. Novak , Joseph J. Nunes
IPC分类号： C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C04B35/632 , C07D213/75 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.
摘要翻译：本发明涉及具有通式I的嘧啶或吡啶氨基甲酸酯化合物及其药学上可接受的盐或衍生物。还包括治疗各种疾病和病症的方法，包括炎症，T细胞活化和增殖的抑制，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹，癌症，结肠癌，胸腺瘤，仅举几例哺乳动物，所述方法包括给予治疗有效量的如上所述的式I化合物或其盐或衍生物形式。

4. 发明授权

US07074789B2 Kinase inhibitors 失效
标题翻译：激酶抑制剂
公开(公告)号：US07074789B2
公开(公告)日：2006-07-11
申请号：US10699518
申请日：2003-10-31
申请人： David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
发明人： David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
IPC分类号： C07D403/12 , C07D403/14 , A61K31/4155 , A61P35/04
CPC分类号： C07D401/04 , C07D251/18 , C07D251/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.
摘要翻译：本发明涉及结合ATP或GTP和/或催化磷酸转移的酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备磷酸转移酶抑制剂化合物的方法，抑制磷酸转移酶活性的方法，以及治疗疾病或疾病症状的方法。

5. 发明授权

US09334269B2 Carboxamides as inhibitors of voltage-gated sodium channels 有权
标题翻译：载体作为电压门控钠通道的抑制剂
公开(公告)号：US09334269B2
公开(公告)日：2016-05-10
申请号：US13575912
申请日：2011-02-16
申请人： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Bingfan Du , Hanh Nho Nguyen , Xiao Mei Zheng
发明人： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Bingfan Du , Hanh Nho Nguyen , Xiao Mei Zheng
IPC分类号： C07D471/10 , C07D401/04 , C07D403/04 , C07D251/48 , C07D213/74 , C07D239/48
CPC分类号： C07D471/10 , C07D213/74 , C07D239/48 , C07D251/48 , C07D401/04 , C07D403/04
摘要： The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译：本发明提供了作为电压门控钠通道（Nav），特别是Nav 1.7的抑制剂的化合物，因此可用于治疗通过抑制这些通道，特别是慢性疼痛障碍可治疗的疾病。还提供含有这些化合物的药物组合物和制备这些化合物的方法。

6. 发明申请

US20130131035A1 CARBOXAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS 有权
标题翻译：碳酰胺作为电压门控通道的抑制剂
公开(公告)号：US20130131035A1
公开(公告)日：2013-05-23
申请号：US13575912
申请日：2011-02-16
申请人： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Bingfan Du , Hanh Nho Nguyen , Xiao Mei Zheng
发明人： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Bingfan Du , Hanh Nho Nguyen , Xiao Mei Zheng
IPC分类号： C07D471/10 , C07D401/04 , C07D403/04 , C07D251/48
CPC分类号： C07D471/10 , C07D213/74 , C07D239/48 , C07D251/48 , C07D401/04 , C07D403/04
摘要： The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译：本发明提供了作为电压门控钠通道（Nav），特别是Nav 1.7的抑制剂的化合物，因此可用于治疗通过抑制这些通道，特别是慢性疼痛障碍可治疗的疾病。还提供含有这些化合物的药物组合物和制备这些化合物的方法。

7. 发明授权

US08178557B2 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US08178557B2
公开(公告)日：2012-05-15
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/04
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

8. 发明授权

US07763624B2 Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors 有权
标题翻译：取代的吡唑并[3,4-d]嘧啶作为ACK-1和LCK抑制剂
公开(公告)号：US07763624B2
公开(公告)日：2010-07-27
申请号：US11506381
申请日：2006-08-18
申请人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
发明人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/496 , A61P35/00 , C07D231/56 , A61K31/416
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。

9. 发明申请

US20090176774A1 Compounds and methods of use 有权
公开(公告)号：US20090176774A1
公开(公告)日：2009-07-09
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

10. 发明授权

US06939874B2 Substituted pyrimidinyl derivatives and methods of use 失效
标题翻译：取代的嘧啶基衍生物和使用方法
公开(公告)号：US06939874B2
公开(公告)日：2005-09-06
申请号：US10225783
申请日：2002-08-21
申请人： Jean-Christophe Harmange , John L. Buchanan , Stuart Chaffee , Perry M. Novak , Simon Van Der Plas , Xiaotian Zhu
发明人： Jean-Christophe Harmange , John L. Buchanan , Stuart Chaffee , Perry M. Novak , Simon Van Der Plas , Xiaotian Zhu
IPC分类号： A61K31/506 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4709
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
摘要翻译：本发明包括其化合物，类似物，前药和药学上可接受的盐，药物组合物，用途和预防和治疗癌症的方法。

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