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1. 发明申请

US20060204991A1 Nucleic acid affinity columns 审中-公开
标题翻译：核酸亲和柱
公开(公告)号：US20060204991A1
公开(公告)日：2006-09-14
申请号：US11360146
申请日：2006-02-22
申请人： Robert Lipshutz , MacDonald Morris , Mark Chee , Thomas Gingeras
发明人： Robert Lipshutz , MacDonald Morris , Mark Chee , Thomas Gingeras
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6809 , C12Q1/6837 , C40B40/06 , C12Q2565/107 , C12Q2525/155
摘要： This invention provides nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample Methods of producing such affinity matrices are also provided In general the methods involve the steps of a) providing a nucleic acid amplification template array comprising a surface to which are attached at least 50 oligonucleotides having different nucleic acid sequences, and wherein each different oligonucleotide is localized in a predetermined region of said surface, the density of said oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and all of said different oligonucleotides have an identical terminal 3′ nucleic acid sequence and an identical terminal 5′ nucleic acid sequence b) amplifying said multiplicity of oligonucleotides to provide a pool of amplified nucleic acids, and c) attaching the pool of nucleic acids to a solid support
摘要翻译：本发明提供了携带大量不同核酸亲和配体的核酸亲和基质，允许从样品中同时选择和除去大量预选择的核酸。还提供了产生这种亲和基质的方法一般来说，该方法涉及步骤a）提供核酸扩增模板阵列，其包含与至少50个具有不同核酸序列的寡核苷酸连接的表面，并且其中每个不同的寡核苷酸定位在所述表面的预定区域中，所述寡核苷酸的密度较大每1cm 2超过约60个不同的寡核苷酸，并且所有所述不同的寡核苷酸具有相同的末端3'核酸序列和相同的末端5'核酸序列b）扩增所述多重寡核苷酸以提供一组扩增的核酸，以及c）附着核酸池酸固体支持物

2. 发明申请

US20050118633A1 Nucleic acid affinity columns 审中-公开
标题翻译：核酸亲和柱
公开(公告)号：US20050118633A1
公开(公告)日：2005-06-02
申请号：US10984127
申请日：2004-11-08
申请人： Robert Lipshutz , MacDonald Morris , Mark Chee , Thomas Gingeras
发明人： Robert Lipshutz , MacDonald Morris , Mark Chee , Thomas Gingeras
IPC分类号： C12Q1/68 , C40B40/06 , C12P19/34
CPC分类号： C12Q1/6806 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6809 , C12Q1/6837 , C40B40/06 , C12Q2565/107 , C12Q2525/155
摘要： This invention provides nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample. Methods of producing such affinity matrices are also provided.
摘要翻译：本发明提供了携带大量不同核酸亲和配体的核酸亲和基质，允许同时从样品中选择和除去大量预选核酸。还提供了生产这种亲和基质的方法。

3. 发明申请

US20070054286A1 Arrays of nucleic acid probes for analyzing biotransformation genes 失效
标题翻译：用于分析生物转化基因的核酸探针阵列
公开(公告)号：US20070054286A1
公开(公告)日：2007-03-08
申请号：US11401482
申请日：2006-04-11
申请人： Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
发明人： Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6874 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , C40B40/06 , C40B60/14
摘要： The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.
摘要翻译：本发明提供了固定化探针的阵列，以及采用该阵列的方法，用于检测生物转化基因如细胞色素P450中的突变。例如，一个这样的阵列包括四个探针组。第一探针组包含多个探针，每个探针包含与来自生物转化基因的参考序列的亚序列完全互补的至少三个核苷酸的片段，该片段包含与参考文献中的相应核苷酸互补的至少一个询问位置序列。第二，第三和第四探针组各自包括在第一探针组中的每个探针的相应探针。第二，第三和第四探针组中的探针与包含来自第一探针组的相应探针或包含至少一个询问位置的至少三个核苷酸的亚序列的序列相同，除了至少一个询问位置由来自四个探针组的四个相应探针中的每一个中的不同核苷酸占据。

4. 发明申请

US20060229824A1 Arrays of nucleic acid probes for analyzing biotransformation genes 审中-公开
标题翻译：用于分析生物转化基因的核酸探针阵列
公开(公告)号：US20060229824A1
公开(公告)日：2006-10-12
申请号：US11367800
申请日：2006-03-03
申请人： Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
发明人： Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
IPC分类号： G06F19/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6874 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , C40B40/06 , C40B60/14
摘要： The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.
摘要翻译：本发明提供了固定化探针的阵列，以及采用该阵列的方法，用于检测生物转化基因如细胞色素P450中的突变。例如，一个这样的阵列包括四个探针组。第一探针组包含多个探针，每个探针包含与来自生物转化基因的参考序列的亚序列完全互补的至少三个核苷酸的片段，该片段包含与参考文献中的相应核苷酸互补的至少一个询问位置序列。第二，第三和第四探针组各自包括在第一探针组中的每个探针的相应探针。第二，第三和第四探针组中的探针与包含来自第一探针组的相应探针或包含至少一个询问位置的至少三个核苷酸的亚序列的序列相同，除了至少一个询问位置由来自四个探针组的四个相应探针中的每一个中的不同核苷酸占据。

5. 发明授权

US08224665B2 Estimating healthcare outcomes for individuals 有权
标题翻译：估计个人的医疗结果
公开(公告)号：US08224665B2
公开(公告)日：2012-07-17
申请号：US12146727
申请日：2008-06-26
申请人： MacDonald Morris
发明人： MacDonald Morris
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q40/08 , G06F19/00 , G06F19/325 , G06F19/328 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H50/50
摘要： A method and apparatus for predicting a health benefit for an individual is provided. Outcomes from a first simulation on a set of simulated individuals reflecting a population are stored and used to determine a first risk function and corresponding cost values. Outcomes from a second simulation on a set of simulated individuals reflecting having a healthcare intervention are stored and used to determine a second risk function reflecting the intervention and corresponding cost values of the intervention. A benefit function is derived from the difference of the first and second risk functions. A cost function that describes the cost of the intervention is derived from the respective cost values. The derived benefit function and cost function are used to predict the corresponding benefit and cost of the healthcare intervention for a given individual. Individuals can be ranked by degree of expected benefit.
摘要翻译：提供了一种用于预测个体的健康益处的方法和装置。存储一组反映人口的模拟个体的第一次模拟的结果，并用于确定第一风险函数和相应的成本值。存储用于反映具有医疗保健干预的一组模拟个体的第二模拟的结果并用于确定反映干预的干预和相应成本值的第二风险函数。利益函数来源于第一和第二风险函数的差异。描述干预成本的成本函数是从各自的成本值得出的。衍生的福利函数和成本函数用于预测给定个人的医疗干预的相应收益和成本。个人可以按预期收益程度排列。

6. 发明申请

US20100317018A1 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION 有权
公开(公告)号：US20100317018A1
公开(公告)日：2010-12-16
申请号：US12855178
申请日：2010-08-12
申请人： Jay WOHLGEMUTH , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
发明人： Jay WOHLGEMUTH , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q1/6888 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , Y10T436/143333
摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

7. 发明申请

US20060160099A1 Substrate preparation process 审中-公开
公开(公告)号：US20060160099A1
公开(公告)日：2006-07-20
申请号：US11015257
申请日：2004-12-16
申请人： Martin Goldberg , Martin Diggelman , Earl Hubbell , Glenn McGall , Nam Ngo , MacDonald Morris , Mel Yamamoto , Jennifer Tan , Richard Rava
发明人： Martin Goldberg , Martin Diggelman , Earl Hubbell , Glenn McGall , Nam Ngo , MacDonald Morris , Mel Yamamoto , Jennifer Tan , Richard Rava
IPC分类号： C12Q1/68 , C12M1/34 , B05D3/02
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.

8. 发明授权

US08930225B2 Estimating healthcare outcomes for individuals 有权
标题翻译：估计个人的医疗结果
公开(公告)号：US08930225B2
公开(公告)日：2015-01-06
申请号：US13448055
申请日：2012-04-16
申请人： MacDonald Morris
发明人： MacDonald Morris
IPC分类号： G06Q50/22 , G06Q50/24 , G06F19/00 , G06Q10/10 , G06Q40/08
CPC分类号： G06Q40/08 , G06F19/00 , G06F19/325 , G06F19/328 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H50/50
摘要： A method and apparatus for predicting a health benefit for an individual is provided. Outcomes from a first simulation on a set of simulated individuals reflecting a population are stored and used to determine a first risk function and corresponding cost values. Outcomes from a second simulation on a set of simulated individuals reflecting having a healthcare intervention are stored and used to determine a second risk function reflecting the intervention and corresponding cost values of the intervention. A benefit function is derived from the difference of the first and second risk functions. A cost function that describes the cost of the intervention is derived from the respective cost values. The derived benefit function and cost function are used to predict the corresponding benefit and cost of the healthcare intervention for a given individual. Individuals can be ranked by degree of expected benefit.
摘要翻译：提供了一种用于预测个体的健康益处的方法和装置。存储一组反映人口的模拟个体的第一次模拟的结果，并用于确定第一风险函数和相应的成本值。存储用于反映具有医疗保健干预的一组模拟个体的第二模拟的结果并用于确定反映干预的干预和相应成本值的第二风险函数。利益函数来源于第一和第二风险函数的差异。描述干预成本的成本函数是从各自的成本值得出的。衍生的福利函数和成本函数用于预测给定个人的医疗干预的相应收益和成本。个人可以按预期收益程度排列。

9. 发明申请

US20120245953A1 ESTIMATING HEALTHCARE OUTCOMES FOR INDIVIDUALS 有权
标题翻译：估计个人健康成就
公开(公告)号：US20120245953A1
公开(公告)日：2012-09-27
申请号：US13448055
申请日：2012-04-16
申请人： MacDonald Morris
发明人： MacDonald Morris
IPC分类号： G06Q50/22
CPC分类号： G06Q40/08 , G06F19/00 , G06F19/325 , G06F19/328 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H50/50
摘要： A method and apparatus for predicting a health benefit for an individual is provided. Outcomes from a first simulation on a set of simulated individuals reflecting a population are stored and used to determine a first risk function and corresponding cost values. Outcomes from a second simulation on a set of simulated individuals reflecting having a healthcare intervention are stored and used to determine a second risk function reflecting the intervention and corresponding cost values of the intervention. A benefit function is derived from the difference of the first and second risk functions. A cost function that describes the cost of the intervention is derived from the respective cost values. The derived benefit function and cost function are used to predict the corresponding benefit and cost of the healthcare intervention for a given individual. Individuals can be ranked by degree of expected benefit.
摘要翻译：提供了一种用于预测个体的健康益处的方法和装置。存储一组反映人口的模拟个体的第一次模拟的结果，并用于确定第一风险函数和相应的成本值。存储用于反映具有医疗干预的一组模拟个体的第二模拟的结果并用于确定反映干预的干预和对应成本值的第二风险函数。利益函数来源于第一和第二风险函数的差异。描述干预成本的成本函数是从各自的成本值得出的。衍生的福利函数和成本函数用于预测给定个人的医疗干预的相应收益和成本。个人可以按预期收益程度排列。

10. 发明授权

US08067578B2 Substrate preparation process 失效
标题翻译：基材制备工艺
公开(公告)号：US08067578B2
公开(公告)日：2011-11-29
申请号：US12634475
申请日：2009-12-09
申请人： Martin J Goldberg , Martin Diggelman , Earl A. Hubbell , Glenn H. McGall , Nam Quoc Ngo , MacDonald Morris , Melvin Yamamoto , Jennifer Tan , Richard P. Rava
发明人： Martin J Goldberg , Martin Diggelman , Earl A. Hubbell , Glenn H. McGall , Nam Quoc Ngo , MacDonald Morris , Melvin Yamamoto , Jennifer Tan , Richard P. Rava
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , Y02P20/55 , Y10S436/809
摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.
摘要翻译：本发明提供了用于大规模制备聚合物序列阵列的新方法，其中每个阵列包括具有已知单体序列的多个不同的位置不同的聚合物序列。本发明的方法将高通量处理步骤与高分辨率光刻技术结合在聚合物阵列的制造中。

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