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1. 发明授权

US09399196B2 Composite polyamide membrane derived from monomer including amine-reactive and phosphorous-containing functional groups 有权
标题翻译：衍生自包括胺反应性和含磷官能团的单体的复合聚酰胺膜
公开(公告)号：US09399196B2
公开(公告)日：2016-07-26
申请号：US14125202
申请日：2012-07-17
申请人： Chunming Zhang , Aman A. Desai , Steven D. Jons , Mou Paul , Steven Rosenberg , Abhishek Roy , XiaoHua S. Qiu
发明人： Chunming Zhang , Aman A. Desai , Steven D. Jons , Mou Paul , Steven Rosenberg , Abhishek Roy , XiaoHua S. Qiu
IPC分类号： B01D71/56 , B01D69/12
CPC分类号： B01D71/56 , B01D69/125
摘要： A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a monomer comprising at least one phosphorous-containing functional group or salt thereof and an at least one amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer.
摘要翻译：一种制备复合聚酰胺膜的方法，包括以下步骤：将多官能胺单体和多官能酰基卤单体施用到多孔载体的表面并使单体界面聚合以形成薄膜聚酰胺层，其中该方法包括至少一种的步骤：i）在包含至少一个含磷官能团或其盐和至少一个胺反应性官能团的单体存在下进行界面聚合; 和/或ii）将这样的单体施加到薄膜聚酰胺层上。

2. 发明申请

US20130287946A1 COMPOSITE POLYAMIDE MEMBRANE 审中-公开
标题翻译：复合聚酰胺膜
公开(公告)号：US20130287946A1
公开(公告)日：2013-10-31
申请号：US13990133
申请日：2012-01-20
申请人： Steven D. Jons , Joseph D. Koob , Mou Paul , XiaoHua Sam Qiu , Steven Rosenberg , Abhishek Roy
发明人： Steven D. Jons , Joseph D. Koob , Mou Paul , XiaoHua Sam Qiu , Steven Rosenberg , Abhishek Roy
IPC分类号： B01D69/12
CPC分类号： B01D69/125 , B01D67/0093 , B01D71/56 , B01D2323/36
摘要： A method for making a composite polyamide membrane including the steps of applying a polyfunctional amine monomer and polyfunctional acid halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of an additional monomer comprising an aromatic moiety at least one carboxylic acid functional group or salt thereof and a single amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer. Many additional embodiments are described including applications for such membranes.
摘要翻译：一种制备复合聚酰胺膜的方法，包括以下步骤：向多孔载体的表面施加多官能胺单体和多官能酰卤单体，并使所述单体界面聚合以形成薄膜聚酰胺层，其中所述方法包括至少一种的步骤：i）在包含芳族部分至少一个羧酸官能团或其盐和单个胺反应性官能团的另外的单体的存在下进行界面聚合; 和/或ii）将这样的单体施加到薄膜聚酰胺层上。描述了许多另外的实施例，包括这种膜的应用。

3. 发明申请

US20130287945A1 COMPOSITE POLYAMIDE MEMBRANE 有权
标题翻译：复合聚酰胺膜
公开(公告)号：US20130287945A1
公开(公告)日：2013-10-31
申请号：US13990139
申请日：2012-01-20
申请人： Abhishek Roy , Steven D. Jons , Joseph D. Koob , Mou Paul , XiaoHua Sam Qiu , Steven Rosenberg
发明人： Abhishek Roy , Steven D. Jons , Joseph D. Koob , Mou Paul , XiaoHua Sam Qiu , Steven Rosenberg
IPC分类号： B01D69/10
CPC分类号： B01D69/10 , B01D67/0093 , B01D69/125 , B01D71/56 , B01D2323/36
摘要： A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a C2-C20 aliphatic monomer comprising at least one carboxylic acid functional group or salt thereof, and a single amine-reactive functional group; and ii) applying a C2-C20 aliphatic monomer comprising at least one carboxylic acid functional group or salt thereof, and a single amine-reactive functional group to the thin film polyamide layer. Many additional embodiments are described including applications for such membranes.
摘要翻译：一种制备复合聚酰胺膜的方法，包括以下步骤：将多官能胺单体和多官能酰基卤单体施用到多孔载体的表面并使单体界面聚合以形成薄膜聚酰胺层，其中该方法包括至少一种的步骤：i）在包含至少一个羧酸官能团或其盐的C 2 -C 20脂族单体和单个胺反应性官能团的存在下进行界面聚合; 和ii）将包含至少一种羧酸官能团或其盐的C 2 -C 20脂族单体和单胺反应性官能团施加到薄膜聚酰胺层上。描述了许多另外的实施例，包括这种膜的应用。

4. 发明申请

US20110306518A1 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION 审中-公开
标题翻译：用于诊断和监测移植物排斥的方法和组合物
公开(公告)号：US20110306518A1
公开(公告)日：2011-12-15
申请号：US13215139
申请日：2011-08-22
申请人： Jay WOHLGEMUTH , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
发明人： Jay WOHLGEMUTH , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q1/6888 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , Y10T436/143333
摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
摘要翻译：描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

5. 发明授权

US07993832B2 Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders 有权
标题翻译：用于诊断和监测移植排斥和免疫疾病状态的方法和组合物
公开(公告)号：US07993832B2
公开(公告)日：2011-08-09
申请号：US11893236
申请日：2007-08-14
申请人： Steven Rosenberg , Kirk Fry , Bin Wu , Russell L. Dedrick
发明人： Steven Rosenberg , Kirk Fry , Bin Wu , Russell L. Dedrick
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , G01N2800/24 , G01N2800/245 , G01N2800/52
摘要： The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.
摘要翻译：本发明提供了使用剪接变体及其试剂来诊断和监测移植物和免疫疾病状态的方法，所述方法包括诊断，监测和预测移植排斥或不排斥反应，类固醇反应性以及免疫疾病的发作或发作。

6. 发明授权

US07892745B2 Methods and compositions for diagnosing and monitoring transplant rejection 有权
公开(公告)号：US07892745B2
公开(公告)日：2011-02-22
申请号：US12584615
申请日：2009-09-08
申请人： Jay Wohlgemuth , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
发明人： Jay Wohlgemuth , Kirk Fry , Robert Woodward , Ngoc Ly , James Prentice , MacDonald Morris , Steven Rosenberg
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q1/6888 , C12Q2600/112 , C12Q2600/158 , G01N33/564 , Y10T436/143333
摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

7. 发明授权

US07342575B1 Electronic writing systems and methods 有权
标题翻译：电子书写系统和方法
公开(公告)号：US07342575B1
公开(公告)日：2008-03-11
申请号：US10818599
申请日：2004-04-06
申请人： Peter G. Hartwell , Steven Rosenberg , Steven L Naberhuis
发明人： Peter G. Hartwell , Steven Rosenberg , Steven L Naberhuis
IPC分类号： G09G5/00
CPC分类号： G06F3/038 , G06F3/0317 , G06F3/03545
摘要： Electronic writing systems and methods are described. In one aspect, an electronic writing system includes an elongated housing, an inertial sensor, an optical sensor, and a tracking module. The elongated housing has an optical input. The inertial sensor is attached to the housing and is operable to generate data indicative of movement of the housing relative to an inertial reference frame. The optical sensor is attached to the housing and is operable to generate data from light received through the optical input. The tracking module is operable to compute relative displacement data from inertial movement data corresponding to data generated by the inertial sensor. The tracking module also is operable to detect at least one calibrated position from calibration data encoded in optical data generated from light received by the optical sensor.
摘要翻译：描述了电子书写系统和方法。在一个方面，电子书写系统包括细长壳体，惯性传感器，光学传感器和跟踪模块。细长壳体具有光学输入。惯性传感器附接到壳体并且可操作以产生指示壳体相对于惯性参考系的运动的数据。光学传感器附接到壳体并且可操作以从通过光学输入接收的光产生数据。跟踪模块可操作以从对应于由惯性传感器产生的数据的惯性运动数据计算相对位移数据。跟踪模块还可操作以从由光学传感器接收的光产生的光学数据中编码的校准数据中检测至少一个校准位置。

8. 发明申请

US20080050341A1 Adoptive Immunotherapy with Enhanced T Lymphocyte Survival 有权
标题翻译：采用增强型T淋巴细胞存活的免疫治疗
公开(公告)号：US20080050341A1
公开(公告)日：2008-02-28
申请号：US11576621
申请日：2005-10-07
申请人： Richard Morgan , Steven Rosenberg , Cary Hsu
发明人： Richard Morgan , Steven Rosenberg , Cary Hsu
IPC分类号： A61K48/00 , A61P35/00 , C12N5/10
CPC分类号： C12N5/0636 , A61K2039/5156 , A61K2039/5158 , A61K2039/55527
摘要： The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.
摘要翻译：本发明提供包含T淋巴细胞或其群体的组合物，例如表达至少一种编码细胞因子的重组多核苷酸的组合物，其在免疫应答的收缩阶段增强T淋巴细胞存活。本发明进一步提供分离的T淋巴细胞或其群体，其表达至少一种编码细胞因子的重组多核苷酸，其中所述多核苷酸包含编码细胞因子的非天然编码序列。还提供了这种组合物和T淋巴细胞或其群体用于治疗或预防医学病症例如癌症的用途。本文进一步提供了具有增强的T细胞存活的T淋巴细胞的制备方法。

9. 发明申请

US20060263813A1 Methods of monitoring functional status of transplants using gene panels 审中-公开
标题翻译：使用基因组监测移植功能状态的方法
公开(公告)号：US20060263813A1
公开(公告)日：2006-11-23
申请号：US11433191
申请日：2006-05-11
申请人： Steven Rosenberg , Preeti Lal , Kirk Fry , Tod Klingler , Dirk Walther , Robert Woodward
发明人： Steven Rosenberg , Preeti Lal , Kirk Fry , Tod Klingler , Dirk Walther , Robert Woodward
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158
摘要： Methods useful in monitoring the functional status of a transplant in a patient by detecting the expression levels of gene panels are described herein. Algorithms for analysis of the expression for monitoring the functional status of transplants are also described.
摘要翻译：本文描述了通过检测基因片段的表达水平来监测患者中移植物的功能状态的方法。还描述了用于分析用于监测移植物的功能状态的表达的算法。

10. 发明授权

US07094752B2 Peptide ligands of the urokinase receptor 失效
标题翻译：尿激酶受体的肽配体
公开(公告)号：US07094752B2
公开(公告)日：2006-08-22
申请号：US10821544
申请日：2004-04-09
申请人： Steven Rosenberg , Michael V. Doyle , Harold A. Chapman
发明人： Steven Rosenberg , Michael V. Doyle , Harold A. Chapman
IPC分类号： A61K38/04 , C07K7/04
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The invention has applications in design of therapeutics for treating disorders characterized by upregulation of uPA and uPAR, and cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostical applications to such disorders.
摘要翻译：描述了能够结合uPAR并抑制整联蛋白和玻连蛋白结合的新型肽。还提供了编码新肽的核酸序列。描述了筛选模拟本发明的肽的拮抗功能的小分子，其他肽或拟肽的方法。本发明在用于治疗以uPA和uPAR上调为特征的疾病以及癌症和慢性炎症，细胞迁移或uPAR：整联蛋白结合相互作用以及诊断应用于此类疾病的治疗剂的设计中具有应用。

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