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1. 发明申请

US20090162835A9 Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries 有权
标题翻译：构建文库的新方法，其包括肽，多肽或蛋白质不同家族的显示和/或表达成员以及新文库
公开(公告)号：US20090162835A9
公开(公告)日：2009-06-25
申请号：US10045674
申请日：2001-10-25
申请人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
发明人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K16/005 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C12N15/10 , C12N15/1037 , C12N15/1093 , C12N15/66 , C40B40/02 , C40B40/08
摘要： Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
摘要翻译：用于构建共同显示和/或表达肽，多肽或蛋白质不同家族成员的文库的方法和使用这些方法产生的文库。筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

2. 发明申请

US20060166252A1 Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins 有权
标题翻译：构建遗传包装库的新方法，其共同显示多肽，多肽或蛋白质家族的成员
公开(公告)号：US20060166252A1
公开(公告)日：2006-07-27
申请号：US11365556
申请日：2006-02-28
申请人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet
发明人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet
IPC分类号： C40B40/08 , C40B40/10
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/1037 , C12N15/66 , C40B40/02
摘要： Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
摘要翻译：可用于构建共同显示肽，多肽或蛋白质不同家族成员的文库和使用这些方法产生的文库的方法。筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

3. 发明申请

US20060036076A1 Metalloproteinase-binding proteins 有权
公开(公告)号：US20060036076A1
公开(公告)日：2006-02-16
申请号：US10993543
申请日：2004-11-19
申请人： Daniel Dransfield , Kristin Rookey , Robert Ladner
发明人： Daniel Dransfield , Kristin Rookey , Robert Ladner
IPC分类号： C07K14/725 , C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/005 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders.

4. 发明申请

US20070217997A1 Metalloproteinase binding proteins 有权
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：US20070217997A1
公开(公告)日：2007-09-20
申请号：US11648423
申请日：2006-12-29
申请人： Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
发明人： Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
IPC分类号： A61K51/00 , G01N33/574 , A61K39/395 , C07K16/30
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译：描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。

5. 发明申请

US20060234302A1 Libraries and methods for isolating antibodies 失效
公开(公告)号：US20060234302A1
公开(公告)日：2006-10-19
申请号：US11346403
申请日：2006-02-01
申请人： Rene Hoet , Sonia Schoonbroodt , Robert Ladner
发明人： Rene Hoet , Sonia Schoonbroodt , Robert Ladner
IPC分类号： C40B30/04
CPC分类号： C07K16/005 , C07K16/00 , C07K16/18 , C07K16/2896 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C40B30/04
摘要： The disclosure features methods for identifying antibodies that bind to a carbohydrate moiety. Libraries coding for antibodies that bind to a carbohydrate moiety are provided. The libraries can be provided by modifying a pre-existing nucleic acid library. Antibodies that bind to a carbohydrate moiety are described.

6. 发明申请

US20080064637A1 Prevention and reduction of blood loss 审中-公开
标题翻译：预防和减少失血
公开(公告)号：US20080064637A1
公开(公告)日：2008-03-13
申请号：US11796272
申请日：2007-04-27
申请人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams
发明人： Robert Ladner , Arthur Ley , Shirish Hirani , Anthony Williams
IPC分类号： A61K38/16 , A61P9/10
CPC分类号： A61K38/57 , A61K9/0019 , A61K38/55 , C12N9/6445
摘要： Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
摘要翻译：描述了用于预防或减少患者中缺血和/或全身炎症反应的方法，例如进行心胸外科手术的患者中的围手术期失血和/或全身炎症反应。冠状动脉旁路移植术等外科手术，特别是当此类手术涉及体外循环，如体外循环时。

7. 发明申请

US20070020252A1 Modified protease inhibitors 审中-公开
标题翻译：改性蛋白酶抑制剂
公开(公告)号：US20070020252A1
公开(公告)日：2007-01-25
申请号：US10570186
申请日：2004-08-30
申请人： Robert Ladner , Aaron Sato , Arthur Ley , Michelle Amaral , Mary Bossard , Michael Roberts , Yan Zhang
发明人： Robert Ladner , Aaron Sato , Arthur Ley , Michelle Amaral , Mary Bossard , Michael Roberts , Yan Zhang
IPC分类号： A61K38/54 , C12N9/99
CPC分类号： C07K14/8114 , A61K38/00 , A61K47/60 , A61K49/0002
摘要： DX-890 inhibits elastase. DX-890 can be attached a single polyethylene glycol moiety. The polyethylene glycol is at least 18 kDa in molecular weight and is attached to the polypeptide by a single covalent bond to the N-terminus of the polypeptide.
摘要翻译： DX-890可抑制弹性蛋白酶。 DX-890可以连接单个聚乙二醇部分。聚乙二醇的分子量至少为18kDa，并且通过与多肽的N末端的单一共价键连接到多肽上。

8. 发明申请

US20060257937A1 Focused libraries of genetic packages 审中-公开
公开(公告)号：US20060257937A1
公开(公告)日：2006-11-16
申请号：US11416460
申请日：2006-05-01
申请人： Robert Ladner
发明人： Robert Ladner
IPC分类号： C40B30/06 , C40B40/10 , G01N33/53
CPC分类号： C12N15/1037 , C07K16/00 , C07K16/005 , C07K2317/565 , C40B40/02 , C40B40/08 , C40B40/10
摘要： Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.

9. 发明申请

US20060051764A1 Thymidylate synthase polymorphisms for use in screening for cancer susceptibility 审中-公开
标题翻译：用于筛选癌症易感性的胸苷酸合酶多态性
公开(公告)号：US20060051764A1
公开(公告)日：2006-03-09
申请号：US10532201
申请日：2003-10-21
申请人： Michael Mandola , Jan Stoehlmacher , Heinz-Josef Lenz , Robert Ladner
发明人： Michael Mandola , Jan Stoehlmacher , Heinz-Josef Lenz , Robert Ladner
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention discloses a novel single nucleotide polymorphism (SNP) in the isolated 5′ tandem repeats of the thymidylate synthase (TS) gene and methods for its use. The novel SNP, located in the 12th nucleotide of a 28 bp third tandem repeat (3R) of the TS gene, substitutes a C for a G, and is the variant form of the repeat. Subjects with the wild-type form of 3R have greater transcription of the TS gene than subjects with the variant form. The invention also reveals that a six base pair deletion in the 3′ region of TS (−6 bp/1494) indicates mRNA instability and thus reduced production of TS. In diseased tissue, such as cancer, reduced production of TS is beneficial because it prevents the cancerous cells from growing and spreading. Analysis of either polymorphism or both together allows for prediction of a subject's response to chemotherapeutic and anti-cardiovascular disease treatments because both diseases are related to TS levels in a subject.
摘要翻译：本发明公开了在胸苷酸合酶（TS）基因的分离的5'串联重复中的新型单核苷酸多态性（SNP）及其使用方法。位于TS基因的28bp第三串联重复（3R）的第12个核苷酸的新型SNP代替C代表G，并且是重复的变体形式。具有野生型形式的3R的受试者比具有变体形式的受试者具有更高的TS基因转录。本发明还揭示了在TS（-6bp / 1494）的3'区域中的6个碱基对缺失表示mRNA不稳定性，从而降低TS的产生。在患病组织如癌症中，减少TS的产生是有益的，因为它可防止癌细胞生长和扩散。多态性或两者的分析可以预测受试者对化学治疗和抗心血管疾病治疗的反应，因为这两种疾病都与受试者的TS水平相关。

10. 发明申请

US20060111296A1 Plasmin-inhibitory therapies 审中-公开
标题翻译：纤溶酶抑制疗法
公开(公告)号：US20060111296A1
公开(公告)日：2006-05-25
申请号：US11287121
申请日：2005-11-22
申请人： Laetitia Devy , Arthur Ley , Robert Ladner
发明人： Laetitia Devy , Arthur Ley , Robert Ladner
IPC分类号： A61K38/38
CPC分类号： A61K38/57 , A61K38/38
摘要： The disclosure features a method of treating cancers, angiogenesis-related disorders and lymphangiogenesis-related disorders with plasmin inhibitors. An exemplary method includes: administering, to a subject, a plasmin inhibitor, such as a protein that includes a Kunitz domain that inhibits plasmin.
摘要翻译：该公开内容特征在于用纤溶酶抑制剂治疗癌症，血管发生相关疾病和淋巴管生成相关疾病的方法。一种示例性方法包括：向受试者施用纤溶酶抑制剂，例如包含抑制纤溶酶的Kunitz结构域的蛋白质。

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