专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060036076A1 Metalloproteinase-binding proteins 有权
公开(公告)号：US20060036076A1
公开(公告)日：2006-02-16
申请号：US10993543
申请日：2004-11-19
申请人： Daniel Dransfield , Kristin Rookey , Robert Ladner
发明人： Daniel Dransfield , Kristin Rookey , Robert Ladner
IPC分类号： C07K14/725 , C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/005 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders.

2. 发明申请

US20060166252A1 Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins 有权
标题翻译：构建遗传包装库的新方法，其共同显示多肽，多肽或蛋白质家族的成员
公开(公告)号：US20060166252A1
公开(公告)日：2006-07-27
申请号：US11365556
申请日：2006-02-28
申请人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet
发明人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet
IPC分类号： C40B40/08 , C40B40/10
CPC分类号： C12N15/1093 , C12N15/10 , C12N15/1037 , C12N15/66 , C40B40/02
摘要： Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
摘要翻译：可用于构建共同显示肽，多肽或蛋白质不同家族成员的文库和使用这些方法产生的文库的方法。筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

3. 发明申请

US20090162835A9 Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries 有权
标题翻译：构建文库的新方法，其包括肽，多肽或蛋白质不同家族的显示和/或表达成员以及新文库
公开(公告)号：US20090162835A9
公开(公告)日：2009-06-25
申请号：US10045674
申请日：2001-10-25
申请人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
发明人： Robert Ladner , Edward Cohen , Horacio Nastri , Kristin Rookey , Rene Hoet , Hendricus Mattheus Hoogenboom
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K16/005 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C12N15/10 , C12N15/1037 , C12N15/1093 , C12N15/66 , C40B40/02 , C40B40/08
摘要： Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
摘要翻译：用于构建共同显示和/或表达肽，多肽或蛋白质不同家族成员的文库的方法和使用这些方法产生的文库。筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

4. 发明授权

US08557743B2 Display library process 有权
标题翻译：显示库过程
公开(公告)号：US08557743B2
公开(公告)日：2013-10-15
申请号：US10656350
申请日：2003-09-05
申请人： Robert C. Ladner , Shannon Hogan , Kristin Rookey
发明人： Robert C. Ladner , Shannon Hogan , Kristin Rookey
IPC分类号： C12Q1/70
CPC分类号： C12N15/1037 , B03C1/01 , B03C1/288 , C40B30/04 , G01N33/56983 , G01N2500/10
摘要： Disclosed are methods of selecting phage encoding a target binding protein. The methods can include forming a mixture comprising a plurality of diverse display phage, a target, and a support, and forming phage immobilized to the support, each of which comprises a phage which binds the target and the target immobilized to the support. Phage that do not bind to the target are separated. Host cells are contacted with the phage immobilized to the support via binding to the target so that the host cells are infected by the phage immobilized to the support. Replicate phage are produced from the infected cells in the presence of the target immobilized to the support, thereby forming replicate phage immobilized to the support via binding to the support. Replicate phage that do not bind to the target are separated. Host cells are contacted with the replicate phage immobilized to the support.
摘要翻译：公开了选择编码靶结合蛋白的噬菌体的方法。所述方法可以包括形成包含多个不同显示噬菌体，靶和支持物的混合物，以及形成固定在载体上的噬菌体，每个噬菌体包含结合目标物的噬菌体和固定在载体上的靶标。不绑定目标的噬菌体被分离。宿主细胞通过与靶标结合而与固定在载体上的噬菌体接触，使得宿主细胞被固定在载体上的噬菌体感染。在固定在载体上的靶存在下，从被感染的细胞产生复制噬菌体，从而通过结合载体形成固定在载体上的复制噬菌体。复制不绑定到目标的噬菌体被分离。宿主细胞与固定在载体上的复制噬菌体接触。

5. 发明授权

US07514534B2 Metalloproteinase-binding proteins 有权
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：US07514534B2
公开(公告)日：2009-04-07
申请号：US10993543
申请日：2004-11-19
申请人： Daniel T. Dransfield , Kristin Rookey , Robert C. Ladner
发明人： Daniel T. Dransfield , Kristin Rookey , Robert C. Ladner
IPC分类号： C07K14/725 , C07K16/46 , A61K39/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/005 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders.
摘要翻译：公开了与基质金属蛋白酶如MMP-26相互作用的抗体。示例性抗体抑制MMP-26活性。这些抗体可以用于例如治疗或预防转移性疾病，过度增殖性疾病，特征在于过度的细胞外基质降解的疾病和炎症性疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式