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1. 发明授权

US4669467A Mode mixer for a laser catheter 失效
标题翻译：用于激光导管的模式混合器
公开(公告)号：US4669467A
公开(公告)日：1987-06-02
申请号：US715122
申请日：1985-03-22
申请人： Robert L. Willett , Robert M. Cothren, Jr. , Carter Kittrell , Michael S. Feld
发明人： Robert L. Willett , Robert M. Cothren, Jr. , Carter Kittrell , Michael S. Feld
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20 , A61B18/24 , G02B6/42 , A61B17/36
CPC分类号： A61B18/20 , A61B18/245 , G02B6/4296 , A61B2017/00061 , A61B2017/22038 , A61B2017/22039 , A61B2017/22048 , A61B2018/00636 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A mode mixer is described for mixing themodes of optical fibers in a laser catheter adapted to be inserted in arteries for treatment of arterial tissue or obstructions. The mode mixer creates microbends in the fibers by physically deforming the fibers, such as by mechanically pressing the fibers against a rigid member to adjust the spot size of light exiting the fibers.
摘要翻译：描述了用于在适于插入动脉中用于治疗动脉组织或障碍物的激光导管中混合光纤的方案的模式混合器。模式混合器通过使纤维物理变形而在纤维中产生微弯曲，例如通过将纤维机械地压靠在刚性部件上以调节离开纤维的光的光点尺寸。

2. 发明授权

US4718417A Visible fluorescence spectral diagnostic for laser angiosurgery 失效
标题翻译：可见荧光光谱诊断激光照射
公开(公告)号：US4718417A
公开(公告)日：1988-01-12
申请号：US715131
申请日：1985-03-22
申请人： Carter Kittrell , Robert L. Willett , Cynthia de los Santos-Pacheco , Leo T. Kenny , Michael S. Feld
发明人： Carter Kittrell , Robert L. Willett , Cynthia de los Santos-Pacheco , Leo T. Kenny , Michael S. Feld
IPC分类号： A61B1/005 , A61B5/00 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/20 , A61B18/24 , A61B19/00 , A61N5/06 , G02B6/42 , G01N21/64
CPC分类号： A61B1/00183 , A61B1/0056 , A61B18/20 , A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61N5/0601 , G02B6/4296 , A61B2017/00057 , A61B2017/00061 , A61B2017/22038 , A61B2017/22051 , A61B2017/22059 , A61B2017/22061 , A61B2018/00636 , A61B2018/1861 , A61B90/39 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A method of diagnosis of the type of tissue in an artery, including distinguishing artery wall from atheromateous plaque is described, in which a catheter with one or more optical fibers is enclosed at a distal end by an optical shield transparent to light radiation and wherein the proximal end of the catheter and optical fibers are coupled to a source of optical radiation. The catheter is inserted into an artery until the optical shield is brought into contact with a suspected arterial lesion or other tissue to be diagnosed.An optical fiber is selected and light coupled from the source at a wavelength of about 480 nm enters the proximal end of the optical fiber and is transmitted by the selected optical fiber to the distal end out the optical shield and impineges on the suspected lesion. The scattered and fluorescence light is returned to the proximal end of the selected optical fiber, and is coupled to a spectral analyzer wherein the fluorescence or scattered light excited by said light is analyzed to determine if the material contacted by the optical shield and, in particular, the portion irradiated by the incident light from the selected optical fiber is healthy arterial tissue or plaque or other material. This determination is made by observing at the proximal end of the selected fiber the fluorescence excited by the light to analyze the spectral profile in the range of 520-610 nm, where peaks occur. A determination is made from the ratios of fluorescence peak heights at 550 nm and 600 nm and the valley at 580 nm, or by analyzing other fluorescence wavelengths, whether the tissue being analyzed is artery wall, plaque, blood, or other tissue.
摘要翻译：描述了一种诊断动脉组织类型的方法，包括区分动脉壁与动脉粥样硬化斑块，其中具有一个或多个光纤的导管在远端被通过光辐射透明的光屏蔽封闭，并且其中导管的近端和光纤耦合到光辐射源。将导管插入动脉中，直到光学屏蔽与疑似动脉损伤或待诊断的其他组织接触。选择光纤并且从大约480nm的波长的光耦合光入射到光纤的近端，并且被所选择的光纤传输到远端出光屏蔽并且刺激到可疑病变。散射的和荧光的光返回到所选择的光纤的近端，并耦合到光谱分析仪，其中分析由所述光激发的荧光或散射光，以确定与光学屏蔽接触的材料，特别是来自所选择的光纤的入射光照射的部分是健康动脉组织或斑块或其它材料。通过在所选择的光纤的近端观察由光激发的荧光来分析520-610nm范围内发生峰的光谱分布，进行该测定。通过在550nm和600nm的荧光峰高与580nm的谷的比例，或通过分析其他荧光波长来确定被分析的组织是动脉壁，斑块，血液或其他组织。

3. 发明授权

US08066945B2 Detection apparatus for biological materials and methods of making and using the same 有权
标题翻译：用于生物材料的检测装置及其制造和使用方法
公开(公告)号：US08066945B2
公开(公告)日：2011-11-29
申请号：US13020446
申请日：2011-02-03
申请人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
发明人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
IPC分类号： G01N27/00 , G01N33/53 , G01N33/551
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00317 , B01J2219/00443 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/0075 , C40B60/04 , C40B60/10 , Y10T29/49117 , Y10T29/49155 , Y10T29/49826 , Y10T436/11
摘要： Apparatus comprising a surface site comprising a substantially inorganic surface having a chemical composition selected from the group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site is interposed; a distal site end on the surface site and distanced from the interlayers, the surface being provided on the distal site end; the surface site and the interlayers being interposed between first and second supports; first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; the conductors being capable of applying an external voltage potential across the polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising a third conductor in electrical communication with the surface site, the third conductor positioned for electrical communication with a source of an external bias voltage. Techniques for making apparatus.
摘要翻译：包括表面位置的装置包括具有选自金属，半导体，绝缘体及其混合物的化学组成的基本无机表面，所述表面位于多肽结合区域内并且对多肽具有选择性结合亲和力; 多个中间层，其间插入表面部位; 位于表面部位的远侧位置端部并且远离中间层，所述表面设置在远端位置端部; 表面部位和夹层介于第一和第二支撑之间; 第一和第二导体，其设置在第一和第二支撑件上，并且具有位于多肽接合区域内的相应的第一和第二远端导体末端; 导体能够跨越多肽接合区域施加外部电压电位。装置，可选地包括这样的第一和第二支撑件和导体; 并且包括与表面部位电连通的第三导体，所述第三导体定位成与外部偏置电压源电连通。制造设备的技术。

4. 发明申请

US20110212553A1 Interfering excitations in FQHE fluids 有权
标题翻译：在FQHE液体中干扰激发
公开(公告)号：US20110212553A1
公开(公告)日：2011-09-01
申请号：US13068307
申请日：2011-05-06
申请人： Kirk William Baldwin , Loren N. Pfeiffer , Kenneth William West , Robert L. Willett
发明人： Kirk William Baldwin , Loren N. Pfeiffer , Kenneth William West , Robert L. Willett
IPC分类号： H01L43/06
CPC分类号： H01L43/065 , G06N99/002
摘要： An apparatus includes a substrate with a planar surface, a multilayer of semiconductor layers located on the planar surface, a plurality of electrodes located over the multilayer, and a dielectric layer located between the electrodes and the multilayer. The multilayer includes a 2D quantum well. A first set of the electrodes is located to substantially surround a lateral area of the 2D quantum well. A second set of the electrodes is controllable to vary a lateral width of a non-depleted channel between the substantially surrounded lateral area of the 2D quantum well and another area of the 2D quantum well. A third set of the electrodes is controllable to vary an area of a non-depleted portion of the lateral area.
摘要翻译：一种装置包括具有平坦表面的基底，位于平坦表面上的多层半导体层，位于多层上方的多个电极以及位于电极和多层之间的电介质层。多层包括2D量子阱。第一组电极被定位成基本上围绕2D量子阱的横向区域。第二组电极是可控制的，以改变2D量子阱的基本上包围的横向区域和2D量子阱的另一区域之间的非耗尽通道的横向宽度。第三组电极是可控的以改变横向区域的非耗尽部分的面积。

5. 发明授权

US07341692B2 Detection apparatus for biological materials and methods of making and using the same 有权
标题翻译：用于生物材料的检测装置及其制造和使用方法
公开(公告)号：US07341692B2
公开(公告)日：2008-03-11
申请号：US11119519
申请日：2005-04-30
申请人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
发明人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
IPC分类号： G01N27/00 , G01N33/53 , G01N33/551 , G01N33/552 , G01N33/553
CPC分类号： G01N33/553 , G01N33/5438 , G01N33/551
摘要： Apparatus comprising a surface site layer having a distal site end, wherein the distal site end includes a substantially inorganic surface having a chemical composition selected from a group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site layer is interposed, wherein the distal site end is distanced from the interlayers, first and second supports, wherein the surface site layer and the interlayers are interposed between the first and second supports; and first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; wherein the conductors are capable of applying an external voltage potential across the polypeptide bonding region.
摘要翻译：包括具有远端部位端的表面部位层的装置，其中所述远端部位端包括具有选自金属，半导体，绝缘体及其混合物的化学组成的基本无机表面，所述表面位于多肽结合区域内并且对多肽具有选择性结合亲和力; 多个中间层，其间插入有表面位置层，其中所述远端位置端与所述夹层间隔开，所述第一和第二支撑件，其中所述表面位置层和所述夹层介于所述第一和第二支撑件之间; 以及第一和第二导体，其设置在第一和第二支撑件上，并且具有位于多肽接合区域内的相应的第一和第二远端导体末端; 其中导体能够跨越多肽接合区域施加外部电压电位。

6. 发明申请

US20130140523A1 Quantum Well Device With Lateral Electrodes 有权
标题翻译：具有横向电极的量子阱装置
公开(公告)号：US20130140523A1
公开(公告)日：2013-06-06
申请号：US13349056
申请日：2012-01-12
申请人： Robert L. Willett
发明人： Robert L. Willett
IPC分类号： H01L29/15
CPC分类号： H01L43/14 , G06N99/002 , H01L43/04 , H01L43/065
摘要： An apparatus includes a substrate, a sequence of crystalline semiconductor layers on a planar surface of the substrate, and first and second sets of electrodes over the sequence. The sequence has a 2D quantum well therein. The first set of electrodes border opposite sides of a lateral region of the sequence and are controllable to vary a width of a non-depleted portion of the quantum well along the top surface. The second set of electrodes border channels between the lateral region and first and second adjacent lateral areas of the sequence and are controllable to vary widths of non-depleted segments of the quantum well in the channels. The electrodes are such that straight lines connecting the lateral areas via the channels either pass between one of the electrodes and the substrate or are misaligned to an effective [1 10] lattice direction of the sequence.
摘要翻译：一种设备包括衬底，在衬底的平面表面上的一系列晶体半导体层，以及该序列上的第一组和第二组电极。该序列在其中具有2D量子阱。第一组电极与序列的横向区域的相对侧边界，并且可控制以沿着顶表面改变量子阱的非耗尽部分的宽度。第二组电极在横向区域和序列的第一和第二相邻横向区域之间边界通道，并且可控制以改变通道中量子阱的非耗尽区段的宽度。这些电极使得经由通道连接横向区域的直线可以通过电极之间的一个电极和衬底，或者不对准序列的有效[110]晶格方向。

7. 发明申请

US20120107176A1 Detection Apparatus for Biological Materials and Methods of Making and Using the Same 有权
标题翻译：生物材料检测装置及其使用方法
公开(公告)号：US20120107176A1
公开(公告)日：2012-05-03
申请号：US13284868
申请日：2011-10-28
申请人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
发明人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
IPC分类号： G01N27/00 , H05K3/10 , H01R43/00
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00317 , B01J2219/00443 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/0075 , C40B60/04 , C40B60/10 , Y10T29/49117 , Y10T29/49155 , Y10T29/49826 , Y10T436/11
摘要： Apparatus comprising surface site comprising substantially inorganic surface having chemical composition selected from group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within polypeptide bonding region and having selective bonding affinity for polypeptide; plurality of interlayers between which surface site is interposed; distal site end on surface site and distanced from interlayers, the surface being provided on distal site end; surface site and interlayers being interposed between first and second supports; first and second conductors provided on first and second supports and having respective first and second distal conductor ends positioned within polypeptide bonding region; conductors being capable of applying external voltage potential across polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising third conductor in electrical communication with surface site, the third conductor positioned for electrical communication with source of an external bias voltage. Techniques for making apparatus.
摘要翻译：包括表面位置的装置包括具有选自金属，半导体，绝缘体及其混合物的化学组成的基本上无机表面，所述表面位于多肽结合区域内并且对多肽具有选择性结合亲和力; 介于其间的多个中间层; 表面部位的远端位置远离中间层，表面位于远端位置; 表面部位和夹层介于第一和第二支撑件之间; 第一和第二导体，其设置在第一和第二支撑上，并且具有位于多肽接合区域内的相应的第一和第二远端导体末端; 导体能够跨越多肽接合区域施加外部电压电位。装置，可选地包括这样的第一和第二支撑件和导体; 并且包括与表面部位电连通的第三导体，所述第三导体定位成与外部偏置电压源电连通。制造设备的技术。

8. 发明授权

US08377702B2 Detection apparatus for biological materials and methods of making and using the same 有权
标题翻译：用于生物材料的检测装置及其制造和使用方法
公开(公告)号：US08377702B2
公开(公告)日：2013-02-19
申请号：US13252169
申请日：2011-10-03
申请人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
发明人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00317 , B01J2219/00443 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/0075 , C40B60/04 , C40B60/10 , Y10T29/49117 , Y10T29/49155 , Y10T29/49826 , Y10T436/11
摘要： Method that includes providing plurality of test sites each having first and second layers respectively including inorganic first and second surface sites forming parts of interior of a well, the surface sites having positions and thicknesses being configured for locating thereon portions of unidentified amino acid-containing molecules; exposing each of a first plurality of the test sites to a fluid containing a different one of plurality of pre-identified amino acid-containing molecules and determining bonding signatures onto each of first plurality of test sites; exposing each of second plurality of test sites to another fluid containing unidentified amino acid-containing molecule and determining bonding signatures onto second plurality of test sites; and comparing bonding signatures to determine or exclude identity of unidentified amino acid-containing molecule.
摘要翻译：包括提供多个测试位置的方法，每个测试位置各自具有分别包括形成井内部的部分的无机第一和第二表面位置的第一和第二层，所述表面位置具有配置用于在其上定位未识别含氨基酸的分子的部分 ; 将第一多个测试位点中的每一个暴露于含有多个预先识别的含氨基酸分子中的不同一个的流体，并将结合签名确定到第一多个测试位点中的每一个上; 将第二多个测试位点中的每一个暴露于含有不确定含氨基酸的分子的另一种流体，并将结合签名确定到第二多个测试位点上; 并比较结合特征以确定或排除未鉴定的含氨基酸分子的同一性。

9. 发明申请

US20110123401A1 Detection Apparatus for Biological Materials and Methods of Making and Using the Same 有权
标题翻译：生物材料检测装置及其使用方法
公开(公告)号：US20110123401A1
公开(公告)日：2011-05-26
申请号：US13020446
申请日：2011-02-03
申请人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
发明人： Robert L. Willett , Kirk W. Baldwin , Loren N. Pfeiffer
IPC分类号： G01N30/00 , B23P17/04
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00317 , B01J2219/00443 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/0075 , C40B60/04 , C40B60/10 , Y10T29/49117 , Y10T29/49155 , Y10T29/49826 , Y10T436/11
摘要： Apparatus comprising a surface site comprising a substantially inorganic surface having a chemical composition selected from the group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site is interposed; a distal site end on the surface site and distanced from the interlayers, the surface being provided on the distal site end; the surface site and the interlayers being interposed between first and second supports; first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; the conductors being capable of applying an external voltage potential across the polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising a third conductor in electrical communication with the surface site, the third conductor positioned for electrical communication with a source of an external bias voltage. Techniques for making apparatus.
摘要翻译：包括表面位置的装置包括具有选自金属，半导体，绝缘体及其混合物的化学组成的基本无机表面，所述表面位于多肽结合区域内并且对多肽具有选择性结合亲和力; 多个中间层，其间插入表面部位; 位于表面部位的远侧位置端部并且远离中间层，所述表面设置在远端位置端部; 表面部位和夹层介于第一和第二支撑之间; 第一和第二导体，其设置在第一和第二支撑件上，并且具有位于多肽接合区域内的相应的第一和第二远端导体末端; 导体能够跨越多肽接合区域施加外部电压电位。装置，可选地包括这样的第一和第二支撑件和导体; 并且包括与表面部位电连通的第三导体，所述第三导体定位成与外部偏置电压源电连通。制造设备的技术。

10. 发明授权

US08987703B2 Quantum well device with lateral electrodes 有权
标题翻译：量子阱器件与侧面电极
公开(公告)号：US08987703B2
公开(公告)日：2015-03-24
申请号：US13349056
申请日：2012-01-12
申请人： Robert L. Willett
发明人： Robert L. Willett
IPC分类号： H01L43/06 , H01L43/14
CPC分类号： H01L43/14 , G06N99/002 , H01L43/04 , H01L43/065
摘要： An apparatus includes a substrate, a sequence of crystalline semiconductor layers on a planar surface of the substrate, and first and second sets of electrodes over the sequence. The sequence has a 2D quantum well therein. The first set of electrodes border opposite sides of a lateral region of the sequence and are controllable to vary a width of a non-depleted portion of the quantum well along the top surface. The second set of electrodes border channels between the lateral region and first and second adjacent lateral areas of the sequence and are controllable to vary widths of non-depleted segments of the quantum well in the channels. The electrodes are such that straight lines connecting the lateral areas via the channels either pass between one of the electrodes and the substrate or are misaligned to an effective [1 1 0] lattice direction of the sequence.
摘要翻译：一种设备包括衬底，在衬底的平面表面上的一系列晶体半导体层，以及该序列上的第一组和第二组电极。该序列在其中具有2D量子阱。第一组电极与序列的横向区域的相对侧边界，并且可控制以沿着顶表面改变量子阱的非耗尽部分的宽度。第二组电极在横向区域和序列的第一和第二相邻横向区域之间边界通道，并且可控制以改变通道中量子阱的非耗尽区段的宽度。这些电极使得经由通道连接横向区域的直线可以在一个电极和衬底之间通过，或者不对准序列的有效[110]晶格方向。

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