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1. 发明授权

US07691838B2 Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics 失效
标题翻译：使用HSP90抑制剂与抗虚型药物组合治疗疾病的方法
公开(公告)号：US07691838B2
公开(公告)日：2010-04-06
申请号：US10856742
申请日：2004-05-27
申请人： Robert Johnson, Jr. , Yiqing Zhou , Thomas Müller
发明人： Robert Johnson, Jr. , Yiqing Zhou , Thomas Müller
IPC分类号： A01N43/00 , A61K31/33 , A01N43/02 , A61K31/335 , A01N43/42 , A61K31/44 , A01N43/78 , A61K31/425
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗有丝分裂剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一个步骤中一种抗有丝分裂剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用受试者的HSP90抑制剂治疗并随后用剂量的抗有丝分裂剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一种抗有丝分裂的剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

2. 发明申请

US20090171606A1 SEMICONDUCTOR MANUFACTURE PERFORMANCE ANALYSIS 审中-公开
标题翻译：半导体制造性能分析
公开(公告)号：US20090171606A1
公开(公告)日：2009-07-02
申请号：US11968132
申请日：2007-12-31
申请人： Takahiro Murata , Kedar Dongre , Yiqing Zhou , Mark Armstrong
发明人： Takahiro Murata , Kedar Dongre , Yiqing Zhou , Mark Armstrong
IPC分类号： G06F19/00 , G01R31/26
CPC分类号： G01R31/2894 , G01R31/2601 , G05B2219/31318 , G05B2219/37224 , H01L22/14
摘要： A software architecture, design and implementation that enables efficient transistor performance analysis across multiple levels of parameter granularity with interactive drill-down, drill-across capability, for use during semiconductor technology development. The software may include several features, such as highly modular, robust architecture to enable analysis across the multiple granularity of transistor performance data, i.e., per die, material group, and aggregate, GUI-based template configuration to specify the analysis across the multiple levels in a uniform set of operations, subsystems to execute the template specified with the GUI, integration of pass-fail analysis analytics, interactive drill-down on particular data points of user interest in automatically generated charts, and drill-across capability allowing linking of data points highlighted on a single chart to those that are correlated in all other charts. Other embodiments are described.
摘要翻译：一种软件架构，设计和实现，可通过交互式深入钻取功能实现多级参数粒度的高效晶体管性能分析，以便在半导体技术开发过程中使用。该软件可以包括几个特征，例如高度模块化，稳健的架构，以实现跨晶体管性能数据的多个粒度分析，即每个芯片，材料组和聚合，基于GUI的模板配置，以指定跨多层次的分析在统一的操作集合中，执行使用GUI指定的模板的子系统，整合失败分析分析，对用户对自动生成的图表感兴趣的特定数据点的交互式深度挖掘以及允许连接数据的钻取功能在单个图表上突出显示的点与在所有其他图表中相关的点。描述其他实施例。

3. 发明授权

US07062410B2 Transistor performance analysis system 失效
标题翻译：晶体管性能分析系统
公开(公告)号：US07062410B2
公开(公告)日：2006-06-13
申请号：US10874395
申请日：2004-06-23
申请人： Charles H. Winstead , Yiqing Zhou , Carrie Auyeung
发明人： Charles H. Winstead , Yiqing Zhou , Carrie Auyeung
IPC分类号： G06F11/30 , G06F17/50
CPC分类号： G01R31/2837 , G01R31/2601
摘要： A system for conducting transistor performance analysis is disclosed, in which automatic graph plotting is interactively enhanced with human judgment. The system includes executing transistor performance analysis software, which receives templates specifying parameters, graph charting options, and algorithms, as well as a database of transistor values, as its inputs. The software produces an output document with linked graphs and a summary report. The software extracts, filters and applies statistical regression to large quantities of data. The software also applies statistical filtering to the data and automatically plots hundreds of charts and graphs based on the data. Graphs are color-coded to highlight relationships that suffer from unusually high noise in the data. Users can manually adjust lines on the graphs, which are automatically reflected in dependent graphs and the summary report. Changes to program methodology can be achieved by changing the template rather than by modifying the software.
摘要翻译：公开了一种用于进行晶体管性能分析的系统，其中通过人的判断来交互地增强自动图形绘图。该系统包括执行晶体管性能分析软件，其接收指定参数的模板，图表图表选项和算法，以及晶体管值的数据库作为其输入。该软件生成带有链接图形和汇总报告的输出文档。该软件提取，过滤和应用统计回归大量的数据。该软件还对数据应用统计过滤，并根据数据自动绘制数百个图表。图形进行了颜色编码，以突出显示数据中异常高噪声的关系。用户可以手动调整图形上的线，这些线自动反映在从属图形和摘要报告中。可以通过更改模板而不是修改软件来实现对程序方法的更改。

4. 发明授权

US08451957B2 System and method for time synchronization of OFDM-based communications 有权
标题翻译：基于OFDM的通信时间同步的系统和方法
公开(公告)号：US08451957B2
公开(公告)日：2013-05-28
申请号：US12421536
申请日：2009-04-09
申请人： Pan Zhengang , Tao Li , Yiqing Zhou , Man Wai Kwan
发明人： Pan Zhengang , Tao Li , Yiqing Zhou , Man Wai Kwan
IPC分类号： H04L27/06
CPC分类号： H04L27/2671 , H04L27/2663 , H04L27/2678 , H04L27/2688
摘要： Systems and methods for time synchronization of orthogonal frequency-division multiplexing (OFDM)-based communications are disclosed. A cyclic prefix (CP) correlation-based timing synchronization method is disclosed for early path (e.g. first-received path) detection for OFDM-based communication. Systems and methods are disclosed for performing double peak value detection in an OFDM-based system for reliably detecting an early (e.g., first-received) path in a received OFDM symbol for use in timing synchronization. In the double peak value detection method, a first peak value detection is performed to detect the path with the largest power, and a second peak value detection is then performed to detect a desired early (e.g., first-received) path. A compensation linear curve is used to facilitate the second peak value detection.
摘要翻译：公开了用于基于正交频分复用（OFDM）的通信的时间同步的系统和方法。针对基于OFDM的通信的早期路径（例如，第一接收路径）检测公开了一种基于循环前缀（CP）相关的定时同步方法。公开了用于在基于OFDM的系统中执行双峰值检测的系统和方法，用于可靠地检测用于定时同步的接收的OFDM符号中的早期（例如，第一接收）路径。在双峰值检测方法中，执行第一峰值检测以检测具有最大功率的路径，然后执行第二峰值检测以检测期望的早（例如，第一接收）路径。使用补偿线性曲线来促进第二峰值检测。

5. 发明申请

US20060252740A1 Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor 审中-公开
标题翻译：使用17-AAG或17-AG或与蛋白酶体抑制剂组合的前药治疗多发性骨髓瘤的方法
公开(公告)号：US20060252740A1
公开(公告)日：2006-11-09
申请号：US11412299
申请日：2006-04-26
申请人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
发明人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
IPC分类号： A61K31/395
CPC分类号： C07D225/06 , A61K31/395 , A61K45/06 , A61K2300/00
摘要： A method for treating multiple myeloma in a subject by administering to the subject 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a pro drug of either 17-AAG or 17-AG, in combination with a proteasome inhibitor.
摘要翻译：一种通过向受试者施用17-烯丙基氨基-17-脱甲氧基 - 格尔德霉素或17-氨基格尔德霉素或17-AAG或17-AG的原药与蛋白酶体抑制剂组合来治疗受试者中的多发性骨髓瘤的方法。

6. 发明申请

US20050288899A1 Transistor performance analysis system 失效
标题翻译：晶体管性能分析系统
公开(公告)号：US20050288899A1
公开(公告)日：2005-12-29
申请号：US10874395
申请日：2004-06-23
申请人： Charles Winstead , Yiqing Zhou , Carrie Auyeung
发明人： Charles Winstead , Yiqing Zhou , Carrie Auyeung
IPC分类号： G06F11/30
CPC分类号： G01R31/2837 , G01R31/2601
摘要： A system for conducting transistor performance analysis is disclosed, in which automatic graph plotting is interactively enhanced with human judgment. The system includes executing transistor performance analysis software, which receives templates specifying parameters, graph charting options, and algorithms, as well as a database of transistor values, as its inputs. The software produces an output document with linked graphs and a summary report. The software extracts, filters and applies statistical regression to large quantities of data. The software also applies statistical filtering to the data and automatically plots hundreds of charts and graphs based on the data. Graphs are color-coded to highlight relationships that suffer from unusually high noise in the data. Users can manually adjust lines on the graphs, which are automatically reflected in dependent graphs and the summary report. Changes to program methodology can be achieved by changing the template rather than by modifying the software.
摘要翻译：公开了一种用于进行晶体管性能分析的系统，其中通过人的判断来交互地增强自动图形绘图。该系统包括执行晶体管性能分析软件，其接收指定参数的模板，图表图表选项和算法，以及晶体管值的数据库作为其输入。该软件生成带有链接图形和汇总报告的输出文档。该软件提取，过滤和应用统计回归大量的数据。该软件还对数据应用统计过滤，并根据数据自动绘制数百个图表。图形进行了颜色编码，以突出显示数据中异常高噪声的关系。用户可以手动调整图形上的线，这些线自动反映在从属图形和摘要报告中。可以通过更改模板而不是修改软件来实现对程序方法的更改。

7. 发明申请

US20050054589A1 Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics 审中-公开
标题翻译：使用HSP90抑制剂与抗生素联合治疗疾病的方法
公开(公告)号：US20050054589A1
公开(公告)日：2005-03-10
申请号：US10857605
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/70 , A61K31/704
CPC分类号： A61K31/704 , A61K31/33 , A61K31/395 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antibiotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antibiotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antibiotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antibiotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗生素，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用抗生素的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，随后用一定剂量的抗生素治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种抗生素剂量治疗受试者，随后用一定剂量的HSP90抑制剂治疗。

8. 发明申请

US20050020534A1 Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites 审中-公开
标题翻译：使用HSP90抑制剂与抗代谢药联合治疗疾病的方法
公开(公告)号：US20050020534A1
公开(公告)日：2005-01-27
申请号：US10856342
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/395 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/525 , A61K31/7072 , A61K45/06
CPC分类号： A61K31/513 , A61K31/395 , A61K31/522 , A61K31/525 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimetabolite, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimetabolite in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimetabolite. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimetabolite and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗代谢物，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用抗代谢药剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，并随后用一种抗代谢药物剂量治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用抗体代谢物剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

9. 发明授权

US08737546B2 Channel estimation techniques for OFDM 有权
标题翻译： OFDM的信道估计技术
公开(公告)号：US08737546B2
公开(公告)日：2014-05-27
申请号：US12428670
申请日：2009-04-23
申请人： Pan Zhengang , Man Wai Kwan , Yiqing Zhou , Tao Li
发明人： Pan Zhengang , Man Wai Kwan , Yiqing Zhou , Tao Li
IPC分类号： H04B1/10
CPC分类号： H04L25/0232 , H04L25/022 , H04L25/025 , H04L27/2647
摘要： An Orthogonal Frequency Division Multiplexing (OFDM) receiver comprises: a channel estimator receiving a signal that includes a plurality of symbols, each of the symbols including a plurality of pilots and a plurality of data subcarriers, wherein each symbol further includes at least one pilot subcarrier, the estimator using a first channel response estimate of the at least one pilot subcarrier in a first symbol to select a first weight matrix from a plurality of pre-generated weight matrices, and generating channel estimation information for data subcarriers in the first symbol using the selected first weight matrix.
摘要翻译：正交频分复用（OFDM）接收机包括：信道估计器，其接收包括多个符号的信号，每个符号包括多个导频和多个数据子载波，其中每个符号还包括至少一个导频子载波所述估计器使用第一符号中的所述至少一个导频子载波的第一信道响应估计来从多个预先生成的加权矩阵中选择第一权重矩阵，并且使用所述第一符号中的数据子载波生成信道估计信息，选择第一加权矩阵。

10. 发明申请

US20100272194A1 Channel Estimation Techniques for OFDM 有权
标题翻译： OFDM的信道估计技术
公开(公告)号：US20100272194A1
公开(公告)日：2010-10-28
申请号：US12428670
申请日：2009-04-23
申请人： Pan Zhengang , Man W. Kwan , Yiqing Zhou , Tao Li
发明人： Pan Zhengang , Man W. Kwan , Yiqing Zhou , Tao Li
IPC分类号： H04K1/10
CPC分类号： H04L25/0232 , H04L25/022 , H04L25/025 , H04L27/2647
摘要： An Orthogonal Frequency Division Multiplexing (OFDM) receiver comprises: a channel estimator receiving a signal that includes a plurality of symbols, each of the symbols including a plurality of pilots and a plurality of data subcarriers, wherein each symbol further includes at least one pilot subcarrier, the estimator using a first channel response estimate of the at least one pilot subcarrier in a first symbol to select a first weight matrix from a plurality of pre-generated weight matrices, and generating channel estimation information for data subcarriers in the first symbol using the selected first weight matrix.
摘要翻译：正交频分复用（OFDM）接收机包括：信道估计器，其接收包括多个符号的信号，每个符号包括多个导频和多个数据子载波，其中每个符号还包括至少一个导频子载波所述估计器使用第一符号中的所述至少一个导频子载波的第一信道响应估计来从多个预先生成的加权矩阵中选择第一权重矩阵，并且使用所述第一符号中的数据子载波生成信道估计信息，选择第一加权矩阵。

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