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1. 发明授权

US06307456B1 Light industrial circuit breaker terminal cover 失效
标题翻译：轻工业断路器端子盖
公开(公告)号：US06307456B1
公开(公告)日：2001-10-23
申请号：US09459173
申请日：1999-12-10
申请人： Robert J. Caggiano , Michael R. Wood , Richard E. Saunders , David D. MacDonald
发明人： Robert J. Caggiano , Michael R. Wood , Richard E. Saunders , David D. MacDonald
IPC分类号： H01H1304
CPC分类号： H01H9/0264
摘要： An electrically-insulative terminal cover is arranged on the line end of a light industrial-rated circuit breaker to allow a close-fit arrangement between a plurality of such circuit breakers within a common enclosure. The terminal cover is in the form of a top piece and a perpendicular side piece. The top piece comprises a pair of notches for receiving a pair of electrical conductors connecting with a corresponding pair of circuit breaker electrical terminals. The side piece includes a pair of elongated notches adapted for receiving sides of a pair of adjacent circuit breakers. A center side piece between the elongated notches can be press-fit within a combined slot defined by slots in sides of a pair of abutting side walls of adjacent circuit breakers. The top piece provides electric isolation to a top of the electrical terminals while the side piece provides electric isolation to a front of the electrical terminals.
摘要翻译：电气绝缘端子盖布置在轻工业级断路器的线路端，以允许在公共外壳内的多个这样的断路器之间紧密配合。端子盖是顶部件和垂直侧部件的形式。顶部件包括一对凹口，用于接收与相应的一对断路器电端子连接的一对电导体。侧件包括一对适于接收一对相邻断路器的侧面的细长凹口。细长凹口之间的中心侧片可以压配合在由相邻断路器的一对邻接侧壁的侧面中的槽限定的组合槽内。顶部件提供电绝缘到电气端子的顶部，而侧部件提供电气隔离到电气端子的前部。

2. 发明申请

US20110190329A1 NON-AMIDIC LINKERS WITH BRANCHED TERMINI AS CGRP RECEPTOR ANTAGONISTS 有权
标题翻译：具有分支终端作为CGRP受体拮抗剂的非氨基连接子
公开(公告)号：US20110190329A1
公开(公告)日：2011-08-04
申请号：US13059361
申请日：2009-08-11
申请人： Michael R. Wood , June J. Kim , Harold G. Selnick , Shawn J. Stachel
发明人： Michael R. Wood , June J. Kim , Harold G. Selnick , Shawn J. Stachel
IPC分类号： A61K31/437 , C07D471/10 , C07D471/20 , C07D235/02 , A61K31/4184 , A61P29/00 , A61P25/06 , A61P9/12 , A61P25/08
CPC分类号： C07D471/04 , C07D235/02 , C07D471/20
摘要： The present invention is directed to novel non-amidic linkers with branched termini derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及具有支链末端衍生物的新型非酰胺接头，其为CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如偏头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

3. 发明申请

US20110120955A1 METHODS FOR REMOVING FATS, OIL AND GREASE AND RECOVERING TALLOW FROM WASTEWATER 审中-公开
标题翻译：去除脂肪，油和油脂并从废水中回收的方法
公开(公告)号：US20110120955A1
公开(公告)日：2011-05-26
申请号：US13055986
申请日：2008-07-31
申请人： Michael R. Wood
发明人： Michael R. Wood
IPC分类号： B01D17/05 , C02F1/56 , B01D17/00 , B01D21/01
CPC分类号： B03D1/02 , C02F1/24 , C02F1/56 , C02F2101/32 , C02F2103/22 , C02F2103/32 , C11B13/00 , Y02W30/74
摘要： A method for recovering tallow from food or animal processing wastewater includes adding a flocculant to the wastewater to agglomerate suspended fats, oil and grease particles in the wastewater, separating solid waste materials from the wastewater and processing the solid waste materials to recover tallow. The flocculant includes polyacrylamide or an acrylamide copolymer. A process for separating fats, oil and grease from food or animal processing wastewater is also provided.
摘要翻译：从食品或动物加工废水中回收牛脂的方法包括向废水中加入絮凝剂，将废水中的悬浮脂肪，油和脂肪颗粒聚集在一起，将固体废物与废水分离，加工固体废物以回收牛油。絮凝剂包括聚丙烯酰胺或丙烯酰胺共聚物。还提供了从食品或动物处理废水中分离脂肪，油和油脂的方法。

4. 发明授权

US07816380B2 1-hydroxycycloalkanecarboxamide derivatives 有权
标题翻译： 1-羟基环烷烃甲酰胺衍生物
公开(公告)号：US07816380B2
公开(公告)日：2010-10-19
申请号：US11920306
申请日：2006-05-30
申请人： Scott D. Kuduk , Michael R. Wood
发明人： Scott D. Kuduk , Michael R. Wood
IPC分类号： A61K31/24 , C07D419/00 , C07D413/00
CPC分类号： C07D213/61 , C07D401/10 , C07D413/10
摘要： α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R1 and R2 attached to the same carbon atom together represent oxo; R4 is H or methyl; R5 is Cl or I2; R6 is selected from —CO2—C1-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7 and R8 are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
摘要翻译：式（I）的α-羟基环烷甲酰胺衍生物或其药学上可接受的盐，其中式（a）是单键或双键; R 1，R 2和R 3各自独立地选自H，卤素和OH; 或连接在同一碳原子上的R1和R2一起代表氧代; R4是H或甲基; R5是Cl或I2; R 6选自-CO 2 -C 1-4烷基，-O-C 1-4烷基，-O-C 1-4卤代烷基，2-甲基四唑-5-基，5-甲基-1,2,4-恶二唑-3-基，3 - 甲基-1,2,4-恶二唑-5-基，5-卤代甲基-1,2,4-恶二唑-3-基，3-卤代甲基-1,2,4-恶二唑-5-基，四唑-5 - 5-氯甲基-1,2,3-三唑基和5-甲基-1,2,3-三唑基; R 7和R 8各自独立地为Cl或I 2; 和n为0或1是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。

5. 发明申请

US20090212784A1 Electrical lighting tester for vehicle-towed trailers 审中-公开
标题翻译：汽车牵引拖车电气照明测试仪
公开(公告)号：US20090212784A1
公开(公告)日：2009-08-27
申请号：US12317198
申请日：2008-12-22
申请人： Joseph E. Kilian , Michael R. Wood
发明人： Joseph E. Kilian , Michael R. Wood
IPC分类号： G01R31/00
CPC分类号： G01R31/44 , G01R31/006
摘要： A compact, portable electrical tester to test the functionality of the lights of a lighting system of vehicle-towed commercial and utility trailers. By virtue of the presently-disclosed lighting tester, the lights of a trailer can be remotely tested by a single test taker without the presence of a tow vehicle or tow vehicle operator. Housed within the chassis of the lighting tester are a 120-volt AC/12-volt DC power supply and a set of DC test circuits. The DC test circuits are connected between the power supply and different ones of the lights of the trailer to be tested. In the preferred embodiment, each DC test circuit includes a light selection toggle switch that is connected in electrical series with a DC circuit breaker toggle switch. A particular light selection toggle switch is selectively actuated to a closed switch position so that DC power will be supplied from the power supply to illuminate a particular light or group of lights under test. A particular series connected circuit breaker toggle switch is selectively actuated to a closed circuit position to close the DC test circuit in which it is connected. Each of the light selection and circuit breaker toggle switches is accessible to be manually actuated at the front of the chassis.
摘要翻译：一种紧凑的便携式电气测试仪，用于测试车辆牵引的商业和实用拖车照明系统的灯的功能。凭借目前公开的照明测试仪，拖车的灯可以由单个测试者进行远程测试，而不需要拖车或牵引车辆操作员。在照明测试仪的底盘内装有一个120伏的交流/ 12伏直流电源和一组直流测试电路。直流测试电路连接在电源和待测试拖车的不同灯之间。在优选实施例中，每个DC测试电路包括与DC断路器拨动开关电连接的光选择拨动开关。特定的光选择拨动开关被选择性地致动到闭合的开关位置，使得将从电源供应DC电力以照亮被测试的特定光或一组灯。特定的串联连接的断路器拨动开关被选择性地启动到闭合电路位置以关闭其连接的DC测试电路。每个灯选择和断路器拨动开关可以在机箱前部手动启动。

6. 发明申请

US20090062349A1 1-Hydroxycycloalkanecarboxamide derivatives 有权
标题翻译： 1-羟基环烷甲酰胺衍生物
公开(公告)号：US20090062349A1
公开(公告)日：2009-03-05
申请号：US11920306
申请日：2006-05-30
申请人： Scott D. Kuduk , Michael R. Wood
发明人： Scott D. Kuduk , Michael R. Wood
IPC分类号： C07D401/10 , C07D413/10 , A61K31/44 , A61K31/4439 , A61P29/00
CPC分类号： C07D213/61 , C07D401/10 , C07D413/10
摘要： α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R1 and R2 attached to the same carbon atom together represent oxo; R4 is H or methyl; R5 is Cl or I2; R6 is selected from —CO2—C3-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7 and R8 are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
摘要翻译：式（I）的α-羟基环烷甲酰胺衍生物或其药学上可接受的盐，其中式（a）是单键或双键; R 1，R 2和R 3各自独立地选自H，卤素和OH; 或连接在同一碳原子上的R1和R2一起代表氧代; R4是H或甲基; R5是Cl或I2; R6选自-CO 2 -C 3-4烷基，-O-C 1-4烷基，-O-C 1-4卤代烷基，2-甲基四唑-5-基，5-甲基-1,2,4-恶二唑-3-基，3 - 甲基-1,2,4-恶二唑-5-基，5-卤代甲基-1,2,4-恶二唑-3-基，3-卤代甲基-1,2,4-恶二唑-5-基，四唑-5 - 5-氯甲基-1,2,3-三唑基和5-甲基-1,2,3-三唑基; R 7和R 8各自独立地为Cl或I 2; 和n为0或1是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。

7. 发明申请

US20130197027A1 HETEROCYCLYL-AZABICYCLO[3.2.1]OCTANE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：异噻唑啉酮[3.2.1] OCTANE ANALOGS作为选择性M1激动剂及其制备方法和使用方法
公开(公告)号：US20130197027A1
公开(公告)日：2013-08-01
申请号：US13583852
申请日：2011-03-10
申请人： Craig Lindsley , P. Jeffrey Conn , Colleen M. Niswender , Michael R. Wood , Brian Chauder , Evan P. Lebois
发明人： Craig Lindsley , P. Jeffrey Conn , Colleen M. Niswender , Michael R. Wood , Brian Chauder , Evan P. Lebois
IPC分类号： C07D451/02
CPC分类号： C07D451/02 , C07D451/04
摘要： In one aspect, the invention relates to compounds which are useful as allosteric or bitopic agonists of the M1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及可用作M1毒蕈碱受体的变构或苦味激动剂的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物例如治疗神经变性疾病（包括阿尔茨海默病）的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

8. 发明授权

US08372859B2 CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups 有权
标题翻译： CGRP受体拮抗剂与叔酰胺，磺酰胺，氨基甲酸酯和尿素端基
公开(公告)号：US08372859B2
公开(公告)日：2013-02-12
申请号：US12594993
申请日：2008-04-07
申请人： Michael R. Wood , June Kim , Melody McWherter , Harold G. Selnick , Kathy Schirripa
发明人： Michael R. Wood , June Kim , Melody McWherter , Harold G. Selnick , Kathy Schirripa
IPC分类号： A61K31/44 , A01N43/50
CPC分类号： C07D235/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Compounds of formula I: (wherein variables A, m, n, J, Re, Rf, R4, Ea, Eb, Ec, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式I化合物（其中变量A，m，n，J，Re，Rf，R4，Ea，Eb，Ec，RPG和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防CGRP涉及的疾病，如偏头痛; 和包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

9. 发明授权

US07790754B2 Alpha-hydroxy amides as bradykinin antagonists or inverse agonists 有权
标题翻译： α-羟基酰胺作为缓激肽拮抗剂或反向激动剂
公开(公告)号：US07790754B2
公开(公告)日：2010-09-07
申请号：US10583675
申请日：2004-12-17
申请人： Michael R. Wood , Neville J. Anthony , Mark G. Bock , Scott D. Kuduk
发明人： Michael R. Wood , Neville J. Anthony , Mark G. Bock , Scott D. Kuduk
IPC分类号： A61K31/4439 , C07D413/10
CPC分类号： C07D239/26 , C07C235/06 , C07C235/08 , C07C235/12 , C07C235/26 , C07C235/34 , C07C235/40 , C07C2601/02 , C07C2601/04 , C07C2601/18 , C07D209/12 , C07D213/56 , C07D213/61 , C07D257/04 , C07D271/06 , C07D275/06 , C07D401/10 , C07D413/10
摘要： α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3) (CH2)nNRbSO2Rd. (4) (CH2)nNRbCO2Ra. (5) (CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or (b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6) (CH2)kCO2Ra. and (7) (CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl.
摘要翻译：通式（I）的α-羟基酰胺衍生物是可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状的缓激肽B1拮抗剂或反向激动剂。 R2a选自（1）选自Ra的基团。（2）（CH2）nNRbC（O）Ra。（3）（CH2）nNRbSO2Rd。（4）（CH2）nNRbCO2Ra。（5）（CH2）k-杂环，其任选被1至3个独立地选自卤素，硝基，氰基，硫代C 1-4烷基和C 1-3卤代烷基的基团取代，其中所述杂环是（a）5元杂芳族环，其具有选自NO和S的环杂原子，并且任选地具有至多3个另外的环氮原子，其中所述环任选地被苯并稠合; 或（b）含有1至3个环氮原子的6-元杂环和其N-氧化物。其中所述环任选地被苯并稠合。（6）（CH2）kCO2Ra。和（7）（CH 2）C（O）NR b R c。 R2b是OH或选自R2a的基团; 或R 2a和R 2b与它们所连接的碳原子一起形成任选被1至4个独立地选自卤素的基团取代的3至7元碳环。 ORa。 C 1-4烷基和C 1-4卤代烷基。

10. 发明授权

US07625901B2 Substituted monocyclic CGRP receptor antagonists 有权
标题翻译：取代的单环CGRP受体拮抗剂
公开(公告)号：US07625901B2
公开(公告)日：2009-12-01
申请号：US12214460
申请日：2008-06-19
申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
发明人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
IPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D519/00 , C07D471/20 , A61K31/499 , A61K31/4965 , A61K31/438 , A61K31/4439 , A61K31/4188 , A61P25/06
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式I化合物（其中变量A1，A2，A3，A4，m，n，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y如本文所述） CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

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