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1. 发明授权

US5283260A Method for reducing insulin resistance in mammals 失效
标题翻译：减少哺乳动物胰岛素抵抗的方法
公开(公告)号：US5283260A
公开(公告)日：1994-02-01
申请号：US43720
申请日：1993-04-08
申请人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
发明人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvylphenyl al anine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酰基苯胺，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

2. 发明授权

US5256697A Method of administering pyruvate and methods of synthesizing pyruvate precursors 失效
标题翻译：丙酮酸的施用方法和丙酮酸前体的合成方法
公开(公告)号：US5256697A
公开(公告)日：1993-10-26
申请号：US868891
申请日：1992-04-16
申请人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
发明人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72 , A61K31/16
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酸 - 苯丙氨酸，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

3. 发明授权

US09552584B1 Electronic Wallet Ready to Pay Timer 有权
标题翻译：电子钱包准备支付定时器
公开(公告)号：US09552584B1
公开(公告)日：2017-01-24
申请号：US13096748
申请日：2011-04-28
申请人： Christopher J. Bierbaum , Allison A. DiMartino , Robert H. Miller , Elizabeth Roche , Jason Whitney , Kevin Zhu
发明人： Christopher J. Bierbaum , Allison A. DiMartino , Robert H. Miller , Elizabeth Roche , Jason Whitney , Kevin Zhu
IPC分类号： G06F17/00 , G06Q30/02
CPC分类号： G06Q30/02 , G06Q20/127 , G06Q20/20 , G06Q20/32 , G06Q20/363
摘要： A mobile device having a time controlled electronic wallet is disclosed. The mobile device comprises a processor and an electronic wallet application that executes on the processor. The electronic wallet application enters a ready-to-pay mode, initiates a ready-to-pay timer when entering the ready-to-pay mode, transmits the confidential information when in the ready-to-pay mode based on receiving contactless communication, and leaves the ready-to-pay mode when the ready-to-pay timer expires.
摘要翻译：公开了一种具有时间控制的电子钱包的移动设备。移动设备包括处理器和在处理器上执行的电子钱包应用程序。电子钱包应用程序进入即付模式，在进入即付模式时启动即时付费定时器，基于接收非接触式通信在待就付模式下发送机密信息，并且当准备付费定时器到期时，离开即时付费模式。

4. 发明授权

US09193951B2 Differentiation method for production of glial cell populations 有权
标题翻译：分化方法生产胶质细胞群体
公开(公告)号：US09193951B2
公开(公告)日：2015-11-24
申请号：US13280543
申请日：2011-10-25
申请人： Paul J. Tesar , Robert H. Miller , Fadi J. Najm
发明人： Paul J. Tesar , Robert H. Miller , Fadi J. Najm
IPC分类号： C12N5/0793 , C12N5/079 , C12N5/0797 , A61P25/00 , A61K35/12 , A61K35/30
CPC分类号： C12N5/0622 , A61K35/30 , C12N2501/01 , C12N2501/105 , C12N2501/115 , C12N2501/13 , C12N2501/135 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/727 , C12N2506/02
摘要： The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
摘要翻译：本发明提供从多能细胞产生少突胶质细胞祖细胞的方法，以及用于在相对纯的培养物中长时间维持这些少突胶质细胞祖细胞的方法。本发明还提供了将这些少突胶质细胞祖细胞进一步分化成各种胶质细胞的方法。

5. 发明申请

US20120100615A1 CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS 有权
标题翻译：细胞因子将分化的SOMATIC细胞转化为细胞
公开(公告)号：US20120100615A1
公开(公告)日：2012-04-26
申请号：US13280562
申请日：2011-10-25
申请人： Paul J. Tesar , Robert H. Miller , Fadi J. Najm
发明人： Paul J. Tesar , Robert H. Miller , Fadi J. Najm
IPC分类号： C12N15/86 , C12N5/10 , C12N15/85
CPC分类号： C12N5/0696 , C12N5/0622 , C12N2501/115 , C12N2501/135 , C12N2501/41 , C12N2501/60 , C12N2506/1307
摘要： The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
摘要翻译：本发明涉及将分化的体细胞（例如由胚胎中胚层产生的分化细胞）重新编程成胶质细胞。从该重编程产生的胶质细胞在功能上等同于由外胚层起源产生的神经胶质细胞。

6. 发明授权

US06643569B2 Method and system for detecting a failure or performance degradation in a dynamic system such as a flight vehicle 失效
标题翻译：用于检测诸如飞行器的动态系统中的故障或性能下降的方法和系统
公开(公告)号：US06643569B2
公开(公告)日：2003-11-04
申请号：US10109028
申请日：2002-03-28
申请人： Robert H. Miller , William B. Ribbens
发明人： Robert H. Miller , William B. Ribbens
IPC分类号： G06F700
CPC分类号： G05B23/0245 , G06Q10/04 , G06Q50/30
摘要： A method and system for detecting a failure or performance degradation in a dynamic system having sensors for measuring state variables and providing corresponding output signals in response to one or more system input signals are provided. The method includes calculating estimated gains of a filter and selecting an appropriate linear model for processing the output signals based on the input signals. The step of calculating utilizes one or more models of the dynamic system to obtain estimated signals. The method further includes calculating output error residuals based on the output signals and the estimated signals. The method also includes detecting one or more hypothesized failures or performance degradations of a component or subsystem of the dynamic system based on the error residuals. The step of calculating the estimated values is performed optimally with respect to one or more of: noise, uncertainty of parameters of the models and un-modeled dynamics of the dynamic system which may be a flight vehicle or financial market or modeled financial system.
摘要翻译：提供了一种用于检测具有用于测量状态变量的传感器并响应于一个或多个系统输入信号提供相应的输出信号的动态系统的故障或性能下降的方法和系统。该方法包括计算滤波器的估计增益并且基于输入信号选择用于处理输出信号的适当线性模型。计算步骤利用动态系统的一个或多个模型来获得估计的信号。该方法还包括基于输出信号和估计信号来计算输出误差残差。该方法还包括基于误差残差来检测动态系统的组件或子系统的一个或多个假设故障或性能下降。计算估计值的步骤相对于噪声，模型的参数的不确定性和动态系统的未建模动态（可以是飞行车辆或金融市场或建模的金融系统）中的一个或多个来最佳地执行。

7. 发明授权

US5472980A Parental administration of pyruyate precursors 失效
标题翻译：亲本管理丙酮酸前体
公开(公告)号：US5472980A
公开(公告)日：1995-12-05
申请号：US285683
申请日：1994-08-04
申请人： Robert H. Miller
发明人： Robert H. Miller
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酸 - 苯丙氨酸，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

8. 发明授权

US5238738A Polymeric minus filter 失效
标题翻译：聚合物过滤器
公开(公告)号：US5238738A
公开(公告)日：1993-08-24
申请号：US784367
申请日：1991-10-29
申请人： Robert H. Miller
发明人： Robert H. Miller
IPC分类号： G02B5/28 , G02C7/10
CPC分类号： G02B5/287 , Y10S428/913 , Y10T428/261 , Y10T428/31507 , Y10T428/31533 , Y10T428/31663 , Y10T428/31692 , Y10T428/31913 , Y10T428/31931 , Y10T428/31935
摘要： A polymeric minus filter for an incident electromagnetic spectral band comprises at least one polymeric interference stack tuned to a predetermined design wavelength centered around .lambda..sub.0, wherein .lambda..sub.0 is in the range of 300 nm to 2000 nm, said filter comprises an optically transparent substrate and having deposited thereon at ambient temperatures (20.degree. to 23.degree. C.) a multiplicity of pairs of polymeric thin interference layers plus one final polymeric layer having index of refraction n.sub.2, each pair of interference layers having a total optical thickness equal to 1/2 wavelength of .lambda..sub.0, the members of each pair having refractive indices n.sub.1 and n.sub.2, respectively, wherein the layer having refractive index n.sub.2 is directly superimposed upon said substrate having refractive index n.sub.s and wherein n.sub.s is approximately equal to n.sub.1, and wherein n.sub.2

9. 发明授权

US07593869B2 Method and system for electronically executing sale transactions across a plurality of networked terminals 失效
标题翻译：用于跨多个网络终端电子执行销售交易的方法和系统
公开(公告)号：US07593869B2
公开(公告)日：2009-09-22
申请号：US10853510
申请日：2004-05-26
申请人： Kenneth Nahan , Sherri Nahan , John D. Graham , Ahmet K. Corapcioglu , Robert H. Miller , Alexander Lipman , Andrei Osipou
发明人： Kenneth Nahan , Sherri Nahan , John D. Graham , Ahmet K. Corapcioglu , Robert H. Miller , Alexander Lipman , Andrei Osipou
IPC分类号： G06Q30/00
CPC分类号： G06Q10/087 , G06Q10/02 , G06Q30/06 , G06Q30/0601 , G06Q30/0625 , G06Q30/0633 , G06Q30/0635 , G06Q30/0643 , Y10S707/99945 , Y10S707/99948
摘要： The present invention includes a system and method of electronically executing transactions with a preprogrammed main computer having data and image storage and retrieval equipment. A plurality of electronic images of works of art which are for sale are created by at least one listing dealer and stored on the storage equipment associated with the main computer. Data is input about each stored image and input data is associated with each corresponding stored image. A plurality of preprogrammed intelligent terminals each having data storage and retrieval equipment, at least one display screen and at least one input device, located at least one listing dealer location and at least one buying dealer location communicate with the main computer. Search criteria are input through the intelligent terminals for selecting at least one of the stored electronic images for review. Selected images and corresponding data are communicated to the intelligent terminals and at least a portion of the selected electronic images are displayed. A reservation on at least one of the displayed electronic images can be made to prevent the completion of a sale transaction involving the artwork corresponding to the selected reserved electronic image. An indication of the reserve status of the work is displayed in conjunction with the display of the reserved work on any of the intelligent terminals. A buy order can be input on the intelligent terminals to transact a purchase of the artwork corresponding to the electronic image subject to the buy order. Instructions to complete the purchase are automatically generated and communicated to the intelligent terminals corresponding to the appropriate listing dealer and the appropriate buying dealer.
摘要翻译：本发明包括一种用具有数据和图像存储和检索设备的预编程主计算机电子地执行交易的系统和方法。用于销售的艺术作品的多个电子图像由至少一个列表经销商创建并存储在与主计算机相关联的存储设备上。输入关于每个存储的图像的数据，并且输入数据与每个对应的存储图像相关联。多个预编程智能终端各自具有数据存储和检索设备，至少一个显示屏幕和至少一个输入设备，位于至少一个列表经销商位置和至少一个购买经销商位置与主计算机通信。通过智能终端输入搜索标准，用于选择所存储的电子图像中的至少一个用于复查。所选择的图像和对应的数据被传送到智能终端，并且显示所选择的电子图像的至少一部分。可以对所显示的电子图像中的至少一个进行预约，以防止涉及与所选择的保留电子图像相对应的作品的销售交易的完成。与任何智能终端的预留工作的显示一起显示工作的保留状态的指示。可以在智能终端上输入购买订单，以交易购买对应于购买订单的电子图像的图稿。自动生成完成购买的说明，并将其传送给与相应的上市经销商和适当的购买经销商对应的智能终端。

10. 发明授权

US07251313B1 Method and system for returning a call based on information in a voicemail message 有权
标题翻译：基于语音邮件消息中的信息返回呼叫的方法和系统
公开(公告)号：US07251313B1
公开(公告)日：2007-07-31
申请号：US10823363
申请日：2004-04-12
申请人： Robert H. Miller , Elizabeth Roche , Balaji S. Thenthiruperai
发明人： Robert H. Miller , Elizabeth Roche , Balaji S. Thenthiruperai
IPC分类号： H04M1/64
CPC分类号： H04M3/53333
摘要： A method for returning a phone call based on information contained in a voicemail message. The method comprises receiving the voicemail message and applying service logic to analyze the voicemail message to extract a spoken phone number included in the voicemail message. The method further comprises associating the extracted phone number with the voicemail message and, in conjunction with retrieving the voicemail message, providing a recipient of the voicemail message with an option to dial the extracted phone number.
摘要翻译：一种基于包含在语音邮件消息中的信息返回电话的方法。该方法包括接收语音邮件消息并应用服务逻辑来分析语音邮件消息以提取语音邮件消息中包括的语音电话号码。该方法还包括将所提取的电话号码与语音邮件消息相关联，并且与检索语音邮件消息相结合，向语音邮件消息的接收者提供拨打所提取的电话号码的选项。

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