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1. 发明授权

US5283260A Method for reducing insulin resistance in mammals 失效
标题翻译：减少哺乳动物胰岛素抵抗的方法
公开(公告)号：US5283260A
公开(公告)日：1994-02-01
申请号：US43720
申请日：1993-04-08
申请人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
发明人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvylphenyl al anine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酰基苯胺，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

2. 发明授权

US5256697A Method of administering pyruvate and methods of synthesizing pyruvate precursors 失效
标题翻译：丙酮酸的施用方法和丙酮酸前体的合成方法
公开(公告)号：US5256697A
公开(公告)日：1993-10-26
申请号：US868891
申请日：1992-04-16
申请人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
发明人： Robert H. Miller , Nickki L. Parlet , Kent L. Cipollo , Madhup K. Dhaon , John A. Houbion , Edwin O. Lundell
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72 , A61K31/16
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酸 - 苯丙氨酸，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

3. 发明授权

US5312985A Method of synthesizing the precursor pyruvamide 失效
标题翻译：合成丙酮酸前体丙酮酰胺的方法
公开(公告)号：US5312985A
公开(公告)日：1994-05-17
申请号：US43699
申请日：1993-04-08
申请人： Madhup K. Dhaon , John A. Houbion
发明人： Madhup K. Dhaon , John A. Houbion
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61P3/04 , C07C231/02 , C07C235/72
CPC分类号： A61K31/40 , A61K31/195 , Y10S514/866 , Y10S514/909
摘要： A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
摘要翻译：公开了一种给予丙酮酸盐的方法，其包括给予哺乳动物治疗有效量的丙酮酸前体以丙酮酰胺或丙酮酸 - 氨基酸的形式。丙酮酸氨基酸优选选自丙酮酸 - 甘氨酸，丙酮酸 - 丙氨酸，丙酮酸 - 亮氨酸，丙酮酸 - 缬氨酸，丙酮酸 - 异亮氨酸，丙酮酸 - 苯丙氨酸，丙酮酸 - 脯氨酸和丙酮酸 - 肌氨酸，其酰胺和酯为以及它们的盐。与根据本发明的哺乳动物的丙酮酸前体的施用相关联的是改善的胰岛素抵抗，降低的空腹胰岛素水平和降低的脂肪增加。还公开了合成若干丙酮酸前体的新方法。

4. 发明授权

US4397790A Isophosphinolinone derivatives 失效
标题翻译：异膦基衍生物
公开(公告)号：US4397790A
公开(公告)日：1983-08-09
申请号：US212381
申请日：1980-12-03
申请人： John A. Houbion
发明人： John A. Houbion
IPC分类号： A01N57/36 , C07F9/32 , C07F9/6568
CPC分类号： A01N57/36 , C07F9/3241 , C07F9/65681
摘要： This invention relates to a new class of organic chemical compounds. More particularly this invention is concerned with derivatives of isophosphinolinone. Compounds of this invention may be employed as active ingredients in herbicides and/or as intermediates in the preparation of other isophosphinolinone derivatives useful to reduce herbicidal injury to treated crop plants.
摘要翻译：本发明涉及一类新的有机化合物。更具体地说，本发明涉及异膦宁酮的衍生物。本发明化合物可用作除草剂中的活性成分和/或作为制备用于减少对经处理的作物植物的除草损伤的其它异膦宁酮衍生物的中间体。

5. 发明授权

US4182622A 3-Phenacylidene phthalide safening agents 失效
标题翻译： 3-苯亚甲基苯酞安全剂
公开(公告)号：US4182622A
公开(公告)日：1980-01-08
申请号：US929133
申请日：1978-07-28
申请人： John A. Houbion , David E. Schafer
发明人： John A. Houbion , David E. Schafer
IPC分类号： A01N25/32 , A01N37/26 , A01N43/12 , C07D307/88 , A01N9/00 , A01N9/20
CPC分类号： C07D307/88 , A01N25/32 , A01N37/26 , A01N43/12
摘要： Certain 3-phenacylidene phthalides have been found useful as safening agents to reduce herbicidal injury to rice plants.
摘要翻译：已经发现某些3-苯亚基亚苯基酯可用作安全剂以减少对水稻植物的除草损伤。

6. 发明授权

US4255181A Use of substituted-3-phenacylidenephthalides as corn plant growth regulants 失效
标题翻译：取代-3-苯酰亚胺酞的用途是玉米植物生长调节剂
公开(公告)号：US4255181A
公开(公告)日：1981-03-10
申请号：US71919
申请日：1979-09-04
申请人： John A. Houbion , Miguel W. Dayawon
发明人： John A. Houbion , Miguel W. Dayawon
IPC分类号： A01N43/12 , C07D307/88
CPC分类号： A01N43/12 , C07D307/88
摘要： This disclousure relates to regulating the growth of corn plants utilizing substituted-3-phenacylidene-phthalides. More particularly the present disclosure is concerned with a method of treating a corn plant with a substituted-3-phenacylidenephthalide or composition containing such a compound in order to effectively alter the development of the reproductive components of the corn plant.
摘要翻译：这种情况涉及利用取代的3-苯亚基亚苯基酯来调节玉米植物的生长。更具体地，本公开涉及用取代的-3-苯基否苯二胺或含有这种化合物的组合物处理玉米植物以有效地改变玉米植物的生殖成分的发育的方法。

7. 发明授权

US4185989A 3-Phenacyl phthaldide safening agents 失效
标题翻译： 3-苯甲酰邻苯二甲酸酯安全剂
公开(公告)号：US4185989A
公开(公告)日：1980-01-29
申请号：US929132
申请日：1978-07-28
申请人： John A. Houbion , David E. Schafer
发明人： John A. Houbion , David E. Schafer
IPC分类号： A01N25/32 , A01N43/12 , C07D307/88 , A01N9/00 , A01N9/20
CPC分类号： C07D307/88 , A01N25/32 , A01N43/12
摘要： Certain 3-phenacyl phthalides have been found useful as safening agents to reduce herbicidal injury to rice plants.
摘要翻译：已经发现某些3-苯甲酰甲苯基苯酞可用作安全剂以减少对水稻植物的除草损伤。

8. 发明授权

US4129729A 3-Phenacyl and phenacylidene phthalimidines and corresponding naphthoyl derivatives 失效
标题翻译： 3-苯甲酰基和苯亚基亚苯基二亚胺基和相应的萘甲酰基衍生物
公开(公告)号：US4129729A
公开(公告)日：1978-12-12
申请号：US867721
申请日：1978-01-03
申请人： John A. Houbion
发明人： John A. Houbion
IPC分类号： A01N43/38 , C07D209/46 , C07D209/48 , A01N9/22
CPC分类号： C07D209/48 , A01N43/38 , C07D209/46
摘要： Certain 3-phenacyl and phenacylidene phthalimidines, and the corresponding naphthoyl derivatives, are novel compounds which possess biological activity in the treatment of plants to control their growth.
摘要翻译：某些3-苯甲酰甲酰基和苯甲酰亚胺基苯二酰亚胺以及相应的萘甲酰基衍生物是具有生物活性以控制植物生长的新型化合物。

9. 发明授权

US4128576A O-Aroylvinyl benzoyl chlorides 失效
标题翻译： O-芳酰基乙烯基苯甲酰氯
公开(公告)号：US4128576A
公开(公告)日：1978-12-05
申请号：US867722
申请日：1978-01-03
申请人： John A. Houbion
发明人： John A. Houbion
IPC分类号： A01N37/42 , C07C65/34 , C07C65/38 , C07C205/61 , C07C63/10
CPC分类号： A01N37/42 , C07C205/61 , C07C65/34 , C07C65/38
摘要： Certain novel o-aroylvinyl benzoyl chlorides have been found to possess herbicidal activity against various undesirable plant species.
摘要翻译：已经发现某些新的邻 - 芳酰基乙烯基苯甲酰氯对各种不希望的植物物种具有除草活性。

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