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1. 发明申请

US20080064946A1 Flexible Circuit Electrode Array 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：US20080064946A1
公开(公告)日：2008-03-13
申请号：US11928151
申请日：2007-10-30
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
IPC分类号： A61N1/04
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作用于神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

2. 发明授权

US10667404B2 Flexible circuit electrode array 有权
公开(公告)号：US10667404B2
公开(公告)日：2020-05-26
申请号：US11926046
申请日：2007-10-28
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/05 , H05K3/00 , A61N1/36
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

3. 发明申请

US20060247754A1 Flexible circuit electrode array 有权
公开(公告)号：US20060247754A1
公开(公告)日：2006-11-02
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

4. 发明授权

US08014878B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08014878B2
公开(公告)日：2011-09-06
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/36
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

5. 发明申请

US20060259112A1 Flexible circuit electrode array 有权
公开(公告)号：US20060259112A1
公开(公告)日：2006-11-16
申请号：US11413689
申请日：2006-04-28
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Ann Ripley
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Ann Ripley
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

6. 发明申请

US20080057179A1 Flexible Circuit Electrode Array 审中-公开
公开(公告)号：US20080057179A1
公开(公告)日：2008-03-06
申请号：US11926046
申请日：2007-10-28
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： B05D5/12
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

7. 发明授权

US08639344B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08639344B2
公开(公告)日：2014-01-28
申请号：US11413689
申请日：2006-04-28
申请人： Robert Jay Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech , Mark Humayun , Dilek Guven , Anne-Marie de Merlier Ripley
发明人： Robert Jay Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech , Mark Humayun , Dilek Guven , Anne-Marie de Merlier Ripley
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

8. 发明申请

US20070049987A1 Trans-retinal flexible circuit electrode array 有权
标题翻译：视网膜软电路电极阵列
公开(公告)号：US20070049987A1
公开(公告)日：2007-03-01
申请号：US11521281
申请日：2006-09-13
申请人： Robert Greenberg , Mark Humayun
发明人： Robert Greenberg , Mark Humayun
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/0543 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/28 , H05K2201/0133
摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally. The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.
摘要翻译：申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜的方法。本发明是用于视网膜下刺激的改进的电极阵列。诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。

9. 发明申请

US20080046032A1 Retinal Prosthesis with Separate Central Electrode Array and Peripheral Electrode Array 有权
标题翻译：具有独立中心电极阵列和外围电极阵列的视网膜假体
公开(公告)号：US20080046032A1
公开(公告)日：2008-02-21
申请号：US11924458
申请日：2007-10-25
申请人： Robert Greenberg , Mark Humayun
发明人： Robert Greenberg , Mark Humayun
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array eternal to the sclera near the periphery of the retina. The preferred method of manufacturing a high-resolution electrode array is through photolithography, which requires the array to be made flat. While it is possible to curve the array afterward, it is difficult and costly. I small high-resolution array can be implanted near the fovea. Due to its small size, curvature is less of an issue. A larger lower-resolution array can be molded in silicone or similar method and placed around the periphery, of the retina, where the retina is naturally lower resolution. Further, the lower-resolution array can be implanted external to the sclera reducing the number of electrical connectors passing through the sclera. Even if a separate lower-resolution array is implanted internal to the sclera, super-choroidal (between the choroid and sclera) or intra-scleral (between the layers of the sclera), it is easier to make a lower-resolution array in a curved shape.
摘要翻译：光的人造感知可以通过电刺激视网膜的神经元来产生。虽然在视网膜内部的光刻阵列提供优异的分辨率，但是视网膜外部的阵列提供更容易的植入和改进的可制造性。因此，在中央凹附近提供巩膜内部的高分辨率电极阵列和靠近视网膜周边的巩膜永久的较低分辨率的电极阵列是有利的。制造高分辨率电极阵列的优选方法是通过光刻法，其需要使阵列平坦。虽然以后可以对阵列进行曲线化，但是难度高昂。我小型高分辨率阵列可以植入中央凹附近。由于其体积小，曲率较少是一个问题。更大的较低分辨率阵列可以用硅树脂或类似的方法模制，并且放置在视网膜的周边周围，其中视网膜天然较低的分辨率。此外，较低分辨率阵列可以植入巩膜外部，从而减少通过巩膜的电连接器的数量。即使单独的较低分辨率阵列植入巩膜内部，超脉络膜（脉络膜和巩膜之间）或巩膜内（巩膜层之间），则更容易在较低分辨率阵列弯曲的形状。

10. 发明申请

US20060173511A1 Visual prosthesis for improved circadian rhythms and method of improving the circadian rhythms 有权
标题翻译：视觉假体改善昼夜节律和改善昼夜节律的方法
公开(公告)号：US20060173511A1
公开(公告)日：2006-08-03
申请号：US11293400
申请日：2005-12-01
申请人： Robert Greenberg , Mark Humayun
发明人： Robert Greenberg , Mark Humayun
IPC分类号： A61N1/32
CPC分类号： A61N1/0543 , A61N1/36046
摘要： Present invention is a method of improving circadian rhythms in blind people by stimulation the visual neural system. Ideally a retinal prosthesis of the type used to restore vision can be used to restore normal circadian rhythms. Additionally, brightness on the prosthesis can be increased in the morning and decreased in the evening to stimulate normal Circadian rhythms. Alternatively, if a retinal prosthesis is not preferable, the retina can be stimulated externally, during the day and not at night. While such eternal stimulation can not produced artificial vision, it can stimulate normal circadian rhythms.
摘要翻译：本发明是通过刺激视觉神经系统来改善盲人中的昼夜节律的方法。理想地，用于恢复视力的视网膜假体可用于恢复正常的昼夜节律。此外，假体上的亮度可以在早晨增加并在晚上减少以刺激正常的昼夜节律。或者，如果视网膜假体不是优选的，则视网膜可以在白天刺激，而不是在夜间刺激。虽然这种永恒的刺激不能产生人造视觉，但它可以刺激正常的昼夜节律。

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