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1. 发明授权

US09861809B2 Flexible circuit electrode array with wire or film support 有权
公开(公告)号：US09861809B2
公开(公告)日：2018-01-09
申请号：US12032627
申请日：2008-02-15
申请人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
发明人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
IPC分类号： A61N1/00 , A61N1/05 , H05K1/03 , H05K1/11
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

2. 发明授权

US08639344B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08639344B2
公开(公告)日：2014-01-28
申请号：US11413689
申请日：2006-04-28
申请人： Robert Jay Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech , Mark Humayun , Dilek Guven , Anne-Marie de Merlier Ripley
发明人： Robert Jay Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech , Mark Humayun , Dilek Guven , Anne-Marie de Merlier Ripley
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

3. 发明授权

US08588937B2 Electrode array for even neural pressure 有权
标题翻译：电极阵列甚至神经压力
公开(公告)号：US08588937B2
公开(公告)日：2013-11-19
申请号：US13360491
申请日：2012-01-27
申请人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
发明人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0558
摘要： An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention a central attachment point in the electrode field applies the most even pressure. Further, multiple and selective attachment points may be additionally provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
摘要翻译：附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。因此，有利的是在阵列场上获得相等的压力。在本发明中，电极领域中的中心附着点施加最均匀的压力。此外，可以在电极阵列上额外提供多个和选择性附着点，允许外科医生选择提供最佳电极组织接触的附接点。

4. 发明授权

US08423151B2 Method and apparatus to provide safety checks for neural stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US08423151B2
公开(公告)日：2013-04-16
申请号：US11926057
申请日：2007-10-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/08 , A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. Systems and stimulator control mechanisms to prevent damage to neural tissue.
摘要翻译：在电刺激神经组织中，重要的是防止过度刺激和不平衡刺激，这将导致对神经组织，电极或两者的损伤。至关重要的是神经组织不会受到高于安全阈值的任何直流或交流电流的影响。此外，重要的是识别有缺陷的电极，因为继续使用可能导致神经和电极损坏。系统和刺激物控制机制，以防止损伤神经组织。

5. 发明授权

US08391987B2 Implantable package to facilitate inspection 有权
公开(公告)号：US08391987B2
公开(公告)日：2013-03-05
申请号：US13360480
申请日：2012-01-27
申请人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.

6. 发明申请

US20130030508A1 Electrode Array for Even Neural Pressure 有权
标题翻译：用于均匀神经压力的电极阵列
公开(公告)号：US20130030508A1
公开(公告)日：2013-01-31
申请号：US13360491
申请日：2012-01-27
申请人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
发明人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0558
摘要： An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention a central attachment point in the electrode field applies the most even pressure. Further, multiple and selective attachment points may be additionally provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
摘要翻译：附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。因此，有利的是在阵列场上获得相等的压力。在本发明中，电极领域中的中心附着点施加最均匀的压力。此外，可以在电极阵列上额外提供多个和选择性附着点，允许外科医生选择提供最佳电极组织接触的附接点。

7. 发明申请

US20120192416A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20120192416A1
公开(公告)日：2012-08-02
申请号：US13422892
申请日：2012-03-16
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： H05K3/46 , H05K3/42 , H05K3/02
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

8. 发明授权

US08209023B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08209023B2
公开(公告)日：2012-06-26
申请号：US12163658
申请日：2008-06-27
申请人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada , Melody Tabada, legal representative
发明人： David Daomin Zhou , Robert J. Greenberg , Jordan Matthew Neysmith , Boon-Khai Ng , James Singleton Little , Neil Hamilton Talbot , Satinderpall Singh Pannu , James Courtney Davidson , Phillipe John Tabada
IPC分类号： A61N1/04 , A61N1/00
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A flexible circuit electrode array and method of fabrication having a polymer base layer; metal traces deposited on the polymer base layer, including electrodes to stimulate tissue; a polymer top layer deposited on the polymer base layer and metal traces; and a coating of the base and top layer by a soft polymer. A method of preparing a flexible circuit electrode array, comprising: providing a first soft polymer layer; depositing a first a base layer on the first soft polymer layer; providing a metal thin film on the base layer; depositing a top polymer layer on the metal thin film; providing holes in the top polymer layer; depositing a second soft polymer layer on the top polymer layer; providing holes in the second soft polymer layer for bond pads and electrodes; and preparing electrodes in the provided holes.
摘要翻译：柔性电路电极阵列和具有聚合物基底层的制造方法; 沉积在聚合物基层上的金属痕迹，包括刺激组织的电极; 沉积在聚合物基底层上的聚合物顶层和金属痕迹; 以及通过软聚合物涂覆基体和顶层。一种制备柔性电路电极阵列的方法，包括：提供第一软聚合物层; 在第一软质聚合物层上沉积第一基底层; 在基层上提供金属薄膜; 在金属薄膜上沉积顶部聚合物层; 在顶部聚合物层中提供孔; 在顶部聚合物层上沉积第二软聚合物层; 在第二软聚合物层中提供用于接合焊盘和电极的孔; 并在所提供的孔中制备电极。

9. 发明申请

US20110144731A1 Electrode Array for Even Neural Pressure 有权
标题翻译：用于均匀神经压力的电极阵列
公开(公告)号：US20110144731A1
公开(公告)日：2011-06-16
申请号：US13029955
申请日：2011-02-17
申请人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
发明人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0558
摘要： An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
摘要翻译：附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。因此，有利的是在阵列场上获得相等的压力。在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

10. 发明申请

US20100147702A1 Process for Cathodic Protection of Electrode Material 有权
标题翻译：电极材料阴极保护工艺
公开(公告)号：US20100147702A1
公开(公告)日：2010-06-17
申请号：US12708358
申请日：2010-02-18
申请人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
IPC分类号： C23F13/00
CPC分类号： C23F13/00 , A61N1/05 , A61N1/08 , C23F13/02
摘要： The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode. The negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
摘要翻译：本发明涉及对电极或电极材料进行阴极保护的方法，其中负电极施加在电极上。负偏压通过不对称电流脉冲获得。通过执行具有较高振幅的负相来获得非对称电流脉冲。通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相脉冲宽度大于阳极相。通过脉冲串获得更宽的脉冲宽度。

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